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Brian Black, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Phone415-502-7628
ORCID ORCID Icon0000-0002-6664-8913 Additional info
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    Collapse Overview 
    Collapse Overview
    The molecular and developmental basis for the majority of birth defects is unknown. Tissues and organs form during embryonic development through the integration of numerous signaling and transcriptional pathways. Our major goal is to define pathways controlling organ formation to understand normal development, the molecular basis for congenital and other genetic defects, and potential mechanisms for organ regeneration and repair. Our focus is primarily on the cardiovascular system, but the development of other organs and tissues is also being investigated in our laboratory.

    We use a combination of gene knockouts, transgenic reporter assays, biochemical, computational, and genomic approaches to investigate basic developmental mechanisms. We primarily use the mouse as a model system, but several current projects also use cultured cells, zebrafish, and Drosophila as models to understand developmental gene regulation. Current work in the lab is focused primarily on cell autonomous mechanisms underlying gene regulation, tissue specification, organ formation during cardiovascular, craniofacial, neural crest, and skeletal muscle development and function.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of the sub-endothelial niche in hemogenic endothelial specification
    NIH/NIDDK R01DK119621Jul 3, 2019 - Apr 30, 2022
    Role: Principal Investigator
    NAVBO Workshops at Vascular Biology 2017
    NIH/NHLBI R13HL137350May 1, 2017 - Apr 30, 2018
    Role: Principal Investigator
    Identification and application of regulatory elements for heart regeneration
    NIH/NHLBI R01HL136182Dec 15, 2016 - Nov 30, 2020
    Role: Co-Principal Investigator
    NAVBO Workshops at Vascular Biology 2014
    NIH/NHLBI R13HL123272Aug 1, 2014 - Jul 31, 2015
    Role: Principal Investigator
    Molecular and Genetic Regulation of Craniofacial Development
    NIH/NIDCR R01DE019118Sep 25, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Transcriptional Networks During Cardiac Differentiation
    NIH/NHLBI P01HL089707Jul 1, 2007 - Jul 31, 2018
    Role: Co-Investigator
    Role of MEF2C in muscle development and regeneration
    NIH/NIAMS R01AR052130Aug 15, 2005 - Jul 31, 2012
    Role: Principal Investigator
    Regulation of cardiovascular transcription
    NIH/NHLBI R01HL064658Sep 28, 2000 - Jan 31, 2020
    Role: Principal Investigator
    Molecular and Cellular Basis of Cardiovascular Disease
    NIH/NHLBI T32HL007731Jul 1, 1992 - May 31, 2023
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Nov 04. PMID: 31513549.
      View in: PubMed
    2. Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, Reznik-Wolf H, Hartman C, Shamir R, Weiss B, Shapiro R, Pode-Shakked B, Tatarskyy P, Milgrom R, Schvimer M, Barshack I, Imai DM, Coleman-Derr D, Dickel DE, Nord AS, Afzal V, van Bueren KL, Barnes RM, Black BL, Mayhew CN, Kuhar MF, Pitstick A, Tekman M, Stanescu HC, Wells JM, Kleta R, de Laat W, Goldstein DB, Pras E, Visel A, Lancet D, Anikster Y, Pennacchio LA. Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019 07; 571(7763):107-111. PMID: 31217582.
      View in: PubMed
    3. Poltavski DM, Colombier P, Hu J, Duron A, Black BL, Makita T. Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin. Elife. 2019 02 08; 8. PMID: 30735130.
      View in: PubMed
    4. Materna SC, Sinha T, Barnes RM, Lammerts van Bueren K, Black BL. Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage. Dev Biol. 2019 01 15; 445(2):170-177. PMID: 30521808.
      View in: PubMed
    5. Sandberg M, Taher L, Hu J, Black BL, Nord AS, Rubenstein JLR. Genomic analysis of transcriptional networks directing progression of cell states during MGE development. Neural Dev. 2018 09 14; 13(1):21. PMID: 30217225.
      View in: PubMed
    6. Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL. Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development. 2017 04 01; 144(7):1235-1241. PMID: 28351867.
      View in: PubMed
    7. Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AA, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Smyth MJ, Cooper MA, Gambin Y, Francois M. Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. Elife. 2017 01 31; 6. PMID: 28137359.
      View in: PubMed
    8. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 01 10; 6. PMID: 28072389.
      View in: PubMed
    9. Marín-Juez R, Marass M, Gauvrit S, Rossi A, Lai SL, Materna SC, Black BL, Stainier DY. Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11237-11242. PMID: 27647901.
      View in: PubMed
    10. Kang J, Hu J, Karra R, Dickson AL, Tornini VA, Nachtrab G, Gemberling M, Goldman JA, Black BL, Poss KD. Modulation of tissue repair by regeneration enhancer elements. Nature. 2016 Apr 14; 532(7598):201-6. PMID: 27049946.
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    11. Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL. MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016 Mar 01; 143(5):774-9. PMID: 26811383.
      View in: PubMed
    12. Ralston M. Barnes, Brian L. Black. Nodal Signaling and Congenital Heart Defects. Etiology and Morphogenesis of Congenital Heart Disease. 2016 Jan 1; 183-192.
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    13. Hu J, Verzi MP, Robinson AS, Tang PL, Hua LL, Xu SM, Kwok PY, Black BL. Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway. Development. 2015 Aug 15; 142(16):2775-80. PMID: 26160899.
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    14. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan-Feb; 18(1):31-40. PMID: 26086993.
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    15. Hogan BM, Black BL. Developmental biology: Diversity in the lymphatic vasculature. Nature. 2015 Jun 04; 522(7554):37-8. PMID: 25992543.
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    16. Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA. Mef2c-F10N enhancer driven ß-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol. 2015 Jun 01; 402(1):3-16. PMID: 25794678.
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    17. Anderson CM, Hu J, Barnes RM, Heidt AB, Cornelissen I, Black BL. Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice. Skelet Muscle. 2015; 5:7. PMID: 25789156.
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    18. Ehlers ML, Celona B, Black BL. NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity. Cell Rep. 2014 Sep 25; 8(6):1639-1648. PMID: 25242327.
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    19. Robinson AS, Materna SC, Barnes RM, De Val S, Xu SM, Black BL. An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17, FoxC2, and Etv2. Dev Biol. 2014 Nov 15; 395(2):379-389. PMID: 25179465.
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    20. Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL. Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Dev Biol. 2014 Sep 15; 393(2):245-254. PMID: 25050930.
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    21. Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR, Akiyama JA, van Bueren KL, Chines PS, Narisu N, Black BL, Visel A, Pennacchio LA, Collins FS. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17921-6. PMID: 24127591.
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    22. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013 Jul 15; 26(1):45-58. PMID: 23830865.
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    23. Lammerts van Bueren K, Black BL. Regulation of endothelial and hematopoietic development by the ETS transcription factor Etv2. Curr Opin Hematol. 2012 May; 19(3):199-205. PMID: 22406820.
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    24. McCulley DJ, Black BL. Transcription factor pathways and congenital heart disease. Curr Top Dev Biol. 2012; 100:253-77. PMID: 22449847.
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    25. Benoit G. Bruneau, Brian L. Black. Chapter 3 Cardiac Myocyte Specification and Differentiation. Muscle. 2012 Jan 1; 25-34.
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    26. May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A. Large-scale discovery of enhancers from human heart tissue. Nat Genet. 2011 Dec 04; 44(1):89-93. PMID: 22138689.
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    27. Palencia-Desai S, Kohli V, Kang J, Chi NC, Black BL, Sumanas S. Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development. 2011 Nov; 138(21):4721-32. PMID: 21989916.
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    28. Schachterle W, Rojas A, Xu SM, Black BL. ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15; 361(2):439-49. PMID: 22056786.
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    29. Sharina Palencia-Desai, Vikram Kohli, Jione Kang, Neil C. Chi, Brian L. Black, Saulius Sumanas. Etsrp/Etv2 initiates endothelial/endocardial and inhibits myocardial differentiation by two distinct mechanisms in zebrafish embryos. Developmental Biology. 2011 Aug 1; 356(1):173.
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    30. Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M. FGF-dependent regulation of VEGF receptor 2 expression in mice. J Clin Invest. 2011 Jul; 121(7):2668-78. PMID: 21633168.
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    31. Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL. The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011 Jun; 138(12):2555-65. PMID: 21610032.
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    32. Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D. Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 01; 351(1):62-9. PMID: 21185281.
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    33. Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF. Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14; 19(6):903-12. PMID: 21145505.
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    34. Blow MJ, McCulley DJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Chen F, Afzal V, Bristow J, Ren B, Black BL, Rubin EM, Visel A, Pennacchio LA. ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet. 2010 Sep; 42(9):806-10. PMID: 20729851.
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    35. Rojas A, Schachterle W, Xu SM, Martín F, Black BL. Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer. Dev Biol. 2010 Oct 15; 346(2):346-55. PMID: 20692247.
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    36. Harris IS, Black BL. Development of the endocardium. Pediatr Cardiol. 2010 Apr; 31(3):391-9. PMID: 20135106.
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    37. Brian L. Black, Richard M. Cripps. Chapter 9.5 Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease. Heart Development and Regeneration. 2010 Jan 1; 673-699.
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    38. Rojas A, Schachterle W, Xu SM, Black BL. An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo. Dev Dyn. 2009 Oct; 238(10):2588-98. PMID: 19777593.
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    39. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct; 19(10):770-80. PMID: 19745787.
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    40. Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG. Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 03; 461(7260):95-8. PMID: 19727199.
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    41. Kazuko Koshiba-Takeuchi, Alessandro D. Mori, Bogac L. Kaynak, Judith Cebra-Thomas, Tatyana Sukonnik, Romain O. Georges, Stephany Latham, Laurel Beck, R. Mark Henkelman, Brian L. Black, Eric N. Olson, Juli Wade, Jun K. Takeuchi, Mona Nemer, Scott F. Gilbert, Benoit G. Bruneau. Erratum: Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 1; 461(7263):550-550.
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    42. Kang J, Nathan E, Xu SM, Tzahor E, Black BL. Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm. Dev Biol. 2009 Oct 15; 334(2):513-22. PMID: 19580802.
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    43. Lee Y, Hami D, De Val S, Kagermeier-Schenk B, Wills AA, Black BL, Weidinger G, Poss KD. Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol. 2009 Jul 15; 331(2):270-80. PMID: 19445916.
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    44. De Val S, Black BL. Transcriptional control of endothelial cell development. Dev Cell. 2009 Feb; 16(2):180-95. PMID: 19217421.
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    45. Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther. 2009 Mar; 328(3):699-707. PMID: 19098160.
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    46. De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, Harris IS, Ehlers ML, Agarwal P, Visel A, Xu SM, Pennacchio LA, Dubchak I, Krieg PA, Stainier DY, Black BL. Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell. 2008 Dec 12; 135(6):1053-64. PMID: 19070576.
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    47. McCulley DJ, Kang JO, Martin JF, Black BL. BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn. 2008 Nov; 237(11):3200-9. PMID: 18924235.
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    48. Khiem D, Cyster JG, Schwarz JJ, Black BL. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17067-72. PMID: 18955699.
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    49. Pooja Agarwal, Michael P. Verzi, Brian L. Black. Genetic and functional interaction between transcription factors MEF2C and Dlx5/6 is required for craniofacial development. Developmental Biology. 2008 Jul 1; 319(2):595.
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    50. Rojas A, Kong SW, Agarwal P, Gilliss B, Pu WT, Black BL. GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol. 2008 Sep; 28(17):5420-31. PMID: 18591257.
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    51. Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY. Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev. 2008 Mar 15; 22(6):734-9. PMID: 18347092.
      View in: PubMed
    52. Heidt AB, Rojas A, Harris IS, Black BL. Determinants of myogenic specificity within MyoD are required for noncanonical E box binding. Mol Cell Biol. 2007 Aug; 27(16):5910-20. PMID: 17562853.
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    53. Brian L. Black, Jione Kang, Ian S. Harris, Will Schachterle, Anabel Rojas. Transcriptional control of second heart field development. Developmental Biology. 2007 Jun 1; 306(1):291.
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    54. Verzi MP, Agarwal P, Brown C, McCulley DJ, Schwarz JJ, Black BL. The transcription factor MEF2C is required for craniofacial development. Dev Cell. 2007 Apr; 12(4):645-52. PMID: 17420000.
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    55. Bruneau BG, Black BL. The heart's Da Vinci code: a Renaissance at Keystone. Development. 2007 May; 134(9):1631-3. PMID: 17395645.
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    56. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 09; 128(5):947-59. PMID: 17350578.
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    57. Robert A. Schulz, Brian L. Black. Model systems for the study of heart development and disease. Seminars in Cell and Developmental Biology. 2007 Feb 1; 18(1):1-2.
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    58. Black BL. Transcriptional pathways in second heart field development. Semin Cell Dev Biol. 2007 Feb; 18(1):67-76. PMID: 17276708.
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    59. Anabel Rojas, Brian L. Black. Transcriptional Control of Cardiac Boundary Formation. Cardiovascular Development. 2007 Jan 1; 18:93-115.
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    60. Pennacchio LA, Ahituv N, Moses AM, Prabhakar S, Nobrega MA, Shoukry M, Minovitsky S, Dubchak I, Holt A, Lewis KD, Plajzer-Frick I, Akiyama J, De Val S, Afzal V, Black BL, Couronne O, Eisen MB, Visel A, Rubin EM. In vivo enhancer analysis of human conserved non-coding sequences. Nature. 2006 Nov 23; 444(7118):499-502. PMID: 17086198.
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    61. Jaehnig EJ, Heidt AB, Greene SB, Cornelissen I, Black BL. Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein. Mol Cell Biol. 2006 Dec; 26(24):9315-26. PMID: 17030629.
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    62. Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 2006 Aug 15; 296(2):437-49. PMID: 16836994.
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    63. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006 Jun; 133(12):2419-33. PMID: 16720879.
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    64. Black BL. A single mutation causes a spectrum of cardiovascular defects: the potential role of genetic modifiers, epigenetic influences, and stochastic events in phenotypic variability. J Mol Cell Cardiol. 2006 Feb; 40(2):201-4. PMID: 16337649.
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    65. Verzi MP, McCulley DJ, De Val S, Dodou E, Black BL. The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol. 2005 Nov 01; 287(1):134-45. PMID: 16188249.
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    66. Rojas A, De Val S, Heidt AB, Xu SM, Bristow J, Black BL. Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development. 2005 Aug; 132(15):3405-17. PMID: 15987774.
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    67. Heidt AB, Black BL. Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis. 2005 May; 42(1):28-32. PMID: 15828002.
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    68. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005 May; 132(10):2463-74. PMID: 15843409.
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    69. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May; 132(10):2451-62. PMID: 15843414.
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    70. De Val S, Anderson JP, Heidt AB, Khiem D, Xu SM, Black BL. Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. Dev Biol. 2004 Nov 15; 275(2):424-34. PMID: 15501228.
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    71. Dodou E, Verzi MP, Anderson JP, Xu SM, Black BL. Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development. 2004 Aug; 131(16):3931-42. PMID: 15253934.
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    72. Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL. HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. Mol Cell Biol. 2004 May; 24(9):3757-68. PMID: 15082771.
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    73. Dodou E, Xu SM, Black BL. mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo. Mech Dev. 2003 Sep; 120(9):1021-32. PMID: 14550531.
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    74. Naya FJ, Black BL, Wu H, Bassel-Duby R, Richardson JA, Hill JA, Olson EN. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med. 2002 Nov; 8(11):1303-9. PMID: 12379849.
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    75. Verzi MP, Anderson JP, Dodou E, Kelly KK, Greene SB, North BJ, Cripps RM, Black BL. N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. Dev Biol. 2002 Sep 01; 249(1):174-90. PMID: 12217327.
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    76. Liu D, Black BL, Derynck R. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 2001 Nov 15; 15(22):2950-66. PMID: 11711431.
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    77. Wilson-Rawls J, Molkentin JD, Black BL, Olson EN. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol. 1999 Apr; 19(4):2853-62. PMID: 10082551.
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    78. Brian L. Black, Eric N. Olson. 8 Control of Cardiac Development by the MEF2 Family of Transcription Factors. Heart Development. 1999 Jan 1; (J. Biol. Chem.2701995):131-142.
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    79. Cripps RM, Black BL, Zhao B, Lien CL, Schulz RA, Olson EN. The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis. Genes Dev. 1998 Feb 01; 12(3):422-34. PMID: 9450935.
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    80. Black BL, Olson EN. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol. 1998; 14:167-96. PMID: 9891782.
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    81. Black BL, Molkentin JD, Olson EN. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Mol Cell Biol. 1998 Jan; 18(1):69-77. PMID: 9418854.
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    82. Black BL, Lu J, Olson EN. The MEF2A 3' untranslated region functions as a cis-acting translational repressor. Mol Cell Biol. 1997 May; 17(5):2756-63. PMID: 9111346.
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    83. Black BL, Ligon KL, Zhang Y, Olson EN. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996 Oct 25; 271(43):26659-63. PMID: 8900141.
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    84. Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN. MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol. 1996 Jul; 16(7):3814-24. PMID: 8668199.
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    85. Molkentin JD, Black BL, Martin JF, Olson EN. Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol Cell Biol. 1996 Jun; 16(6):2627-36. PMID: 8649370.
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    86. Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell. 1995 Dec 29; 83(7):1125-36. PMID: 8548800.
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    87. Black BL, Martin JF, Olson EN. The mouse MRF4 promoter is trans-activated directly and indirectly by muscle-specific transcription factors. J Biol Chem. 1995 Feb 17; 270(7):2889-92. PMID: 7852366.
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    88. Black BL, Brewer G, Lyles DS. Effect of vesicular stomatitis virus matrix protein on host-directed translation in vivo. J Virol. 1994 Jan; 68(1):555-60. PMID: 8254771.
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    89. Black BL, Rhodes RB, McKenzie M, Lyles DS. The role of vesicular stomatitis virus matrix protein in inhibition of host-directed gene expression is genetically separable from its function in virus assembly. J Virol. 1993 Aug; 67(8):4814-21. PMID: 8392615.
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    90. Black BL, Lyles DS. Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo. J Virol. 1992 Jul; 66(7):4058-64. PMID: 1318397.
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