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Jay Nadel, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Cardiovascular Research InstituteFellowship1960University of California, San Francisco
    Philadelphia General HospitalInternship1954Philadelphia General Hospital, Philadelphia, PA
    JeffersonMD1953Jefferson Medical College, Philadelphia, PA
    Collapse Awards and Honors
    CHEST, Los Angeles, CA2016 Distinguished Scientist Honor Lecture in Cardiopulmonary Physiology and Distinguished Service Award
    Japanese Society of Allergology (JSA), Tokyo, Japan2016Honorary Lecture, 65th Annual Meeting of Japanese Society of Allergology (JSA)
    University of California San Francisco School of Medicine2015The Nadel Honorary Pulmonary Symposium
    European Respiratory Society2014Honorary Fellow
    Karolinska Institute, Stockholm2013Honorary Lecture in Lung Research
    National Heart and Lung Institute, Imperial College, London, UK2012Invited Lecture, 7th International Symposium on Cough
    Catania, Italy2012 Invited Lecture, XIII National Conference of the Italian Union of Pneumology
    National Heart and Lung Institute, Imperial College, London, UK2012John Widdicombe Memorial Lecture, 7th International Symposium on Cough
    Tokyo2011Honorary Lecturer, Japanese Respiratory Society
    Hawaii2011Special Lecturer, Chest Meeting, Airways Network
    Lucerne2010Honorary Lecturer, Transatlantic Airway Conference 25th Anniversary
    University of Paris2008René Descartes Medal
    Case Western Reserve University School of Medicine, Cleveland2005Honorary Jerome I. Kleinerman Annual Lecture
    University of Ferrara, Italy2002Honorary Member Associazione Nicolo Copernico Alumni Dell Ateneo Estense
    Free University of Berlin2002Festschrift Honoring Prof. Gert Kunkel
    Baylor College of Medicine2002First Annual Honorary Joseph R. Rodarte Lectureship in Pulmonary Medicine
    1999Best Doctors of San Francisco Bay Area Nomination
    Jefferson Medical College, Philadelphia1998Alumni Achievement Award, JH Coley Lectureship
    1998Best Doctors of America Nomination
    American Thoracic Society1997Trudeau Medal
    Dickinson Law School, Carlisle, PA1997Honorary Degree in Law
    University of Lund, Sweden1996Honorary Doctorate of Medicine
    German Society of Pulmonology1994Honorary Membership, Society for Lung and Airway Research
    Finnish Association of Pulmonary Physicians1994Honorary Membership
    University of Helsinki1994Medal of the University
    San Francisco 1993Amberson Lecturer, American Thoracic Society
    Ben Gurion University1992Distinguished Achievement Award
    American Lung Association1992Crocker Clean Air Award (for outstanding research in Air Pollution)
    University of Southern California1992Sam J. Sills Honorary Lectureship
    University of Ferrara, Ferrara, Italy1991Honorary Doctorate of Medicine
    Aspen Lung Conferences1991Giles S. Filley Lecture
    Royal Society of Medicine Foundation1990Pfizer Visiting Professor
    University of Nebraska School of Medicine1990Kass Lectureship and Medalist
    Brown University School of Medicine1989Distinguished Lecturer, The Ninth William P. Buffum Oration
    American College of Chest Physicians1987Distinguished Lecturer in Physiology
    American Lung Association of California1984Clean Air Award
    American Lung Association of California1984California Medal
    California Thoracic Society1984Honorary Membership
    Hammersmith Hospital, London, England1973Visiting Scientist
    University of Oxford, Oxford, England1962Visiting Scientist, University Laboratory of Physiology
    Cardiovascular Research Institute, University of California, San Francisco1960  - 1961Giannini Research Fellow
    Philadelphia General Hospital1955Blockley Award for Outstanding Publication
    Jefferson Medical College1953Medical Practice Prize

    Collapse Overview 
    Collapse Overview
    A. Background
    • 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF
    • Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute
    • Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine

    B. Early Areas of Studies
    • Chronic airway diseases, including asthma, COPD, and CF
    • Air pollutants (sulfur dioxide and ozone)
    • Airway epithelium
    • Viruses, bacteria, air pollutants, allergens, cigarette smoke
    • Na+, Cl¯ exchange mechanism in the airway epithelium

    C. Later Areas of Study
    • Cell and molecular biology
    • Antimuscarinic Therapy of Bronchospasm
    • Signaling pathways for mucin production

    D. Recent Areas of Study
    • EGFR Signaling Pathways
    • Modulation of proinflammatory responses
    • Viral infections
    • CFTR and its role in inflammatory airway diseases
    • Bronchiolitis Obliterans Syndrome following lung transplantation

    Collapse Research 
    Collapse Research Activities and Funding
    Evolving Microenvironments in Airway Inflammation
    NIH/NHLBI P01HL024136Jul 1, 1979 - Mar 31, 2015
    Role: Co-Principal Investigator
    Multidisciplinary Training Program in Lung Disease
    NIH/NHLBI T32HL007185Jul 1, 1976 - Jun 30, 2022
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Gelb AF, Yamamoto A, Verbeken EK, Schein MJ, Moridzadeh R, Tran D, Fraser C, Barbers R, Elatre W, Koss MN, Glassy EF, Nadel JA. Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction. Chest. 2018 03; 153(3):618-629. PMID: 29197547.
      View in: PubMed
    2. Gelb AF, Nadel JA. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. J Allergy Clin Immunol. 2016 10; 138(4):1011-1013. PMID: 27527265.
      View in: PubMed
    3. Gelb AF, Christenson SA, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5. PMID: 26717511.
      View in: PubMed
    4. Gelb AF, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. J Allergy Clin Immunol. 2015 Sep; 136(3):553-5. PMID: 26343939.
      View in: PubMed
    5. Gelb AF, Yamamoto A, Verbeken EK, Nadel JA. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Chest. 2015 Aug; 148(2):313-320. PMID: 25950858.
      View in: PubMed
    6. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96. PMID: 24838750.
      View in: PubMed
    7. Nadel JA. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40. PMID: 24293414.
      View in: PubMed
    8. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-5.e1-3. PMID: 24290280.
      View in: PubMed
    9. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36. PMID: 23999497.
      View in: PubMed
    10. Kim S, Beyer BA, Lewis C, Nadel JA. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981. PMID: 23977375.
      View in: PubMed
    11. Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013 Mar 06; 9(1):6. PMID: 23497652.
      View in: PubMed
    12. Nadel JA. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3. PMID: 23434445.
      View in: PubMed
    13. Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 01; 317(18):2650-60. PMID: 21925169.
      View in: PubMed
    14. Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400. PMID: 21300824.
      View in: PubMed
    15. Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81. PMID: 18827153.
      View in: PubMed
    16. Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75. PMID: 18375743.
      View in: PubMed
    17. Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62. PMID: 17218812.
      View in: PubMed
    18. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700. PMID: 17142770.
      View in: PubMed
    19. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16. PMID: 16148149.
      View in: PubMed
    20. Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72. PMID: 15640347.
      View in: PubMed
    21. Nadel JA.. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.
    22. Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7. PMID: 15121636.
      View in: PubMed
    23. Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23. PMID: 12972643.
      View in: PubMed
    24. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6. PMID: 10077640.
      View in: PubMed
    25. Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 1991 Apr; 87(4):1139-45. PMID: 2010530.
      View in: PubMed
    26. Vanderslice P, Craik CS, Nadel JA, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 1989 May 16; 28(10):4148-55. PMID: 2504277.
      View in: PubMed
    27. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol. 1989 Apr 01; 142(7):2450-6. PMID: 2494259.
      View in: PubMed
    28. Ueki I, German VF, Nadel JA. Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis. 1980 Feb; 121(2):351-7. PMID: 7362142.
      View in: PubMed
    29. Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J. Roentgenographic study of the human trachea with powdered tantalum. Radiology. 1970 Nov; 97(2):327-30. PMID: 5481137.
      View in: PubMed
    30. Goldsmith JR, Nadel JA. Experimental exposure of human subjects to ozone. J Air Pollut Control Assoc. 1969 May; 19(5):329-30. PMID: 5797492.
      View in: PubMed
      View in: PubMed
    32. NADEL JA, COMROE JH. Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol. 1961 Jul; 16:713-6. PMID: 13727341.
      View in: PubMed