Jay Nadel, MD
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Title(s) | Professor Emeritus, Medicine |
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School | School of Medicine |
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vCard | Download vCard |
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Biography Cardiovascular Research Institute | Fellowship | 1960 | University of California, San Francisco | Philadelphia General Hospital | Internship | 1954 | Philadelphia General Hospital, Philadelphia, PA | Jefferson | MD | 1953 | Jefferson Medical College, Philadelphia, PA |
CHEST, Los Angeles, CA | 2016 | | Distinguished Scientist Honor Lecture in Cardiopulmonary Physiology and Distinguished Service Award | Japanese Society of Allergology (JSA), Tokyo, Japan | 2016 | | Honorary Lecture, 65th Annual Meeting of Japanese Society of Allergology (JSA) | University of California San Francisco School of Medicine | 2015 | | The Nadel Honorary Pulmonary Symposium | European Respiratory Society | 2014 | | Honorary Fellow | Karolinska Institute, Stockholm | 2013 | | Honorary Lecture in Lung Research | National Heart and Lung Institute, Imperial College, London, UK | 2012 | | Invited Lecture, 7th International Symposium on Cough | Catania, Italy | 2012 | | Invited Lecture, XIII National Conference of the Italian Union of Pneumology | National Heart and Lung Institute, Imperial College, London, UK | 2012 | | John Widdicombe Memorial Lecture, 7th International Symposium on Cough | Tokyo | 2011 | | Honorary Lecturer, Japanese Respiratory Society | Hawaii | 2011 | | Special Lecturer, Chest Meeting, Airways Network | Lucerne | 2010 | | Honorary Lecturer, Transatlantic Airway Conference 25th Anniversary | University of Paris | 2008 | | René Descartes Medal | Case Western Reserve University School of Medicine, Cleveland | 2005 | | Honorary Jerome I. Kleinerman Annual Lecture | University of Ferrara, Italy | 2002 | | Honorary Member Associazione Nicolo Copernico Alumni Dell Ateneo Estense | Free University of Berlin | 2002 | | Festschrift Honoring Prof. Gert Kunkel | Baylor College of Medicine | 2002 | | First Annual Honorary Joseph R. Rodarte Lectureship in Pulmonary Medicine | | 1999 | | Best Doctors of San Francisco Bay Area Nomination | Jefferson Medical College, Philadelphia | 1998 | | Alumni Achievement Award, JH Coley Lectureship | | 1998 | | Best Doctors of America Nomination | American Thoracic Society | 1997 | | Trudeau Medal | Dickinson Law School, Carlisle, PA | 1997 | | Honorary Degree in Law | University of Lund, Sweden | 1996 | | Honorary Doctorate of Medicine | German Society of Pulmonology | 1994 | | Honorary Membership, Society for Lung and Airway Research | Finnish Association of Pulmonary Physicians | 1994 | | Honorary Membership | University of Helsinki | 1994 | | Medal of the University | San Francisco | 1993 | | Amberson Lecturer, American Thoracic Society | Ben Gurion University | 1992 | | Distinguished Achievement Award | American Lung Association | 1992 | | Crocker Clean Air Award (for outstanding research in Air Pollution) | University of Southern California | 1992 | | Sam J. Sills Honorary Lectureship | University of Ferrara, Ferrara, Italy | 1991 | | Honorary Doctorate of Medicine | Aspen Lung Conferences | 1991 | | Giles S. Filley Lecture | Royal Society of Medicine Foundation | 1990 | | Pfizer Visiting Professor | University of Nebraska School of Medicine | 1990 | | Kass Lectureship and Medalist | Brown University School of Medicine | 1989 | | Distinguished Lecturer, The Ninth William P. Buffum Oration | American College of Chest Physicians | 1987 | | Distinguished Lecturer in Physiology | American Lung Association of California | 1984 | | Clean Air Award | American Lung Association of California | 1984 | | California Medal | California Thoracic Society | 1984 | | Honorary Membership | Hammersmith Hospital, London, England | 1973 | | Visiting Scientist | University of Oxford, Oxford, England | 1962 | | Visiting Scientist, University Laboratory of Physiology | Cardiovascular Research Institute, University of California, San Francisco | 1960
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| 1961 | Giannini Research Fellow | Philadelphia General Hospital | 1955 | | Blockley Award for Outstanding Publication | Jefferson Medical College | 1953 | | Medical Practice Prize |
Overview A. Background • 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF • Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute • Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine
B. Early Areas of Studies • Chronic airway diseases, including asthma, COPD, and CF • Air pollutants (sulfur dioxide and ozone) • Airway epithelium • Viruses, bacteria, air pollutants, allergens, cigarette smoke • Na+, Cl¯ exchange mechanism in the airway epithelium
C. Later Areas of Study • Cell and molecular biology • Antimuscarinic Therapy of Bronchospasm • Signaling pathways for mucin production
D. Recent Areas of Study • EGFR Signaling Pathways • Modulation of proinflammatory responses • Viral infections • CFTR and its role in inflammatory airway diseases • Bronchiolitis Obliterans Syndrome following lung transplantation
Research ORNG Applications Bibliographic
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Gelb AF, Yamamoto A, Verbeken EK, Schein MJ, Moridzadeh R, Tran D, Fraser C, Barbers R, Elatre W, Koss MN, Glassy EF, Nadel JA. Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction. Chest. 2018 03; 153(3):618-629. PMID: 29197547.
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Gelb AF, Nadel JA. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. J Allergy Clin Immunol. 2016 10; 138(4):1011-1013. PMID: 27527265.
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Gelb AF, Christenson SA, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5. PMID: 26717511.
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Gelb AF, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. J Allergy Clin Immunol. 2015 Sep; 136(3):553-5. PMID: 26343939.
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Gelb AF, Yamamoto A, Verbeken EK, Nadel JA. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Chest. 2015 Aug; 148(2):313-320. PMID: 25950858.
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Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96. PMID: 24838750.
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Nadel JA. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40. PMID: 24293414.
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Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-5.e1-3. PMID: 24290280.
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Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36. PMID: 23999497.
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Kim S, Beyer BA, Lewis C, Nadel JA. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981. PMID: 23977375.
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Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013 Mar 06; 9(1):6. PMID: 23497652.
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Nadel JA. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3. PMID: 23434445.
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Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 01; 317(18):2650-60. PMID: 21925169.
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Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400. PMID: 21300824.
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Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81. PMID: 18827153.
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Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75. PMID: 18375743.
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Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62. PMID: 17218812.
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Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700. PMID: 17142770.
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Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16. PMID: 16148149.
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Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72. PMID: 15640347.
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Nadel JA.. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.
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Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7. PMID: 15121636.
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Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23. PMID: 12972643.
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Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6. PMID: 10077640.
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Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 1991 Apr; 87(4):1139-45. PMID: 2010530.
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Vanderslice P, Craik CS, Nadel JA, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 1989 May 16; 28(10):4148-55. PMID: 2504277.
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Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol. 1989 Apr 01; 142(7):2450-6. PMID: 2494259.
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Ueki I, German VF, Nadel JA. Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis. 1980 Feb; 121(2):351-7. PMID: 7362142.
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Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J. Roentgenographic study of the human trachea with powdered tantalum. Radiology. 1970 Nov; 97(2):327-30. PMID: 5481137.
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Goldsmith JR, Nadel JA. Experimental exposure of human subjects to ozone. J Air Pollut Control Assoc. 1969 May; 19(5):329-30. PMID: 5797492.
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TOKIWA Y, TAMPLIN BR, NADEL JA. MONITORING HUMAN EXPOSURES TO SULFUR DIOXIDE IN A BODY PLETHYSMOGRAPH. J Air Pollut Control Assoc. 1965 Mar; 15:96-8. PMID: 14257517.
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NADEL JA, COMROE JH. Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol. 1961 Jul; 16:713-6. PMID: 13727341.
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