Jay Nadel, MD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Cardiovascular Research InstituteFellowship1960University of California, San Francisco
    Philadelphia General HospitalInternship1954Philadelphia General Hospital, Philadelphia, PA
    JeffersonMD1953Jefferson Medical College, Philadelphia, PA
    Collapse Awards and Honors
    CHEST, Los Angeles, CA2016 Distinguished Scientist Honor Lecture in Cardiopulmonary Physiology and Distinguished Service Award
    Japanese Society of Allergology (JSA), Tokyo, Japan2016Honorary Lecture, 65th Annual Meeting of Japanese Society of Allergology (JSA)
    University of California San Francisco School of Medicine2015The Nadel Honorary Pulmonary Symposium
    European Respiratory Society2014Honorary Fellow
    Karolinska Institute, Stockholm2013Honorary Lecture in Lung Research
    National Heart and Lung Institute, Imperial College, London, UK2012Invited Lecture, 7th International Symposium on Cough
    Catania, Italy2012 Invited Lecture, XIII National Conference of the Italian Union of Pneumology
    National Heart and Lung Institute, Imperial College, London, UK2012John Widdicombe Memorial Lecture, 7th International Symposium on Cough
    Tokyo2011Honorary Lecturer, Japanese Respiratory Society
    Hawaii2011Special Lecturer, Chest Meeting, Airways Network
    Lucerne2010Honorary Lecturer, Transatlantic Airway Conference 25th Anniversary
    University of Paris2008René Descartes Medal
    Case Western Reserve University School of Medicine, Cleveland2005Honorary Jerome I. Kleinerman Annual Lecture
    University of Ferrara, Italy2002Honorary Member Associazione Nicolo Copernico Alumni Dell Ateneo Estense
    Free University of Berlin2002Festschrift Honoring Prof. Gert Kunkel
    Baylor College of Medicine2002First Annual Honorary Joseph R. Rodarte Lectureship in Pulmonary Medicine
    1999Best Doctors of San Francisco Bay Area Nomination
    Jefferson Medical College, Philadelphia1998Alumni Achievement Award, JH Coley Lectureship
    1998Best Doctors of America Nomination
    American Thoracic Society1997Trudeau Medal
    Dickinson Law School, Carlisle, PA1997Honorary Degree in Law
    University of Lund, Sweden1996Honorary Doctorate of Medicine
    German Society of Pulmonology1994Honorary Membership, Society for Lung and Airway Research
    Finnish Association of Pulmonary Physicians1994Honorary Membership
    University of Helsinki1994Medal of the University
    San Francisco 1993Amberson Lecturer, American Thoracic Society
    Ben Gurion University1992Distinguished Achievement Award
    American Lung Association1992Crocker Clean Air Award (for outstanding research in Air Pollution)
    University of Southern California1992Sam J. Sills Honorary Lectureship
    University of Ferrara, Ferrara, Italy1991Honorary Doctorate of Medicine
    Aspen Lung Conferences1991Giles S. Filley Lecture
    Royal Society of Medicine Foundation1990Pfizer Visiting Professor
    University of Nebraska School of Medicine1990Kass Lectureship and Medalist
    Brown University School of Medicine1989Distinguished Lecturer, The Ninth William P. Buffum Oration
    American College of Chest Physicians1987Distinguished Lecturer in Physiology
    American Lung Association of California1984Clean Air Award
    American Lung Association of California1984California Medal
    California Thoracic Society1984Honorary Membership
    Hammersmith Hospital, London, England1973Visiting Scientist
    University of Oxford, Oxford, England1962Visiting Scientist, University Laboratory of Physiology
    Cardiovascular Research Institute, University of California, San Francisco1960  - 1961Giannini Research Fellow
    Philadelphia General Hospital1955Blockley Award for Outstanding Publication
    Jefferson Medical College1953Medical Practice Prize

    Collapse Overview 
    Collapse Overview
    A. Background
    • 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF
    • Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute
    • Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine

    B. Early Areas of Studies
    • Chronic airway diseases, including asthma, COPD, and CF
    • Air pollutants (sulfur dioxide and ozone)
    • Airway epithelium
    • Viruses, bacteria, air pollutants, allergens, cigarette smoke
    • Na+, Cl¯ exchange mechanism in the airway epithelium

    C. Later Areas of Study
    • Cell and molecular biology
    • Antimuscarinic Therapy of Bronchospasm
    • Signaling pathways for mucin production

    D. Recent Areas of Study
    • EGFR Signaling Pathways
    • Modulation of proinflammatory responses
    • Viral infections
    • CFTR and its role in inflammatory airway diseases
    • Bronchiolitis Obliterans Syndrome following lung transplantation

    Collapse Research 
    Collapse Research Activities and Funding
    Evolving Microenvironments in Airway Inflammation
    NIH/NHLBI P01HL024136Jul 1, 1979 - Mar 31, 2015
    Role: Co-Principal Investigator
    Multidisciplinary Training Program in Lung Disease
    NIH/NHLBI T32HL007185Jul 1, 1976 - Jun 30, 2022
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kalinowski A, Galen BT, Ueki IF, Sun Y, Mulenos A, Osafo-Addo A, Clark B, Joerns J, Liu W, Nadel J, Dela Cruz CS, Koff JL. Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium. Mucosal Immunol. 2018 Feb 07. PMID: 29411775.
      View in: PubMed
    2. Gelb AF, Yamamoto A, Verbeken EK, Schein MJ, Moridzadeh R, Tran D, Fraser C, Barbers R, Elatre W, Koss MN, Glassy EF, Nadel J. Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction. Chest. 2018 Mar; 153(3):618-629. PMID: 29197547.
      View in: PubMed
    3. Gelb AF, Nadel J. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. J Allergy Clin Immunol. 2016 Oct; 138(4):1011-1013. PMID: 27527265.
      View in: PubMed
    4. Gelb AF, Christenson SA, Nadel J. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5. PMID: 26717511.
      View in: PubMed
    5. Gelb AF, Nadel J. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. J Allergy Clin Immunol. 2015 Sep; 136(3):553-5. PMID: 26343939.
      View in: PubMed
    6. Gelb AF, Yamamoto A, Verbeken EK, Nadel J. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Chest. 2015 Aug; 148(2):313-320. PMID: 25950858.
      View in: PubMed
    7. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel J, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96. PMID: 24838750; PMCID: PMC4101792.
    8. Nadel J. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40. PMID: 24293414.
      View in: PubMed
    9. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel J. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-5.e1-3. PMID: 24290280.
      View in: PubMed
    10. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel J, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36. PMID: 23999497; PMCID: PMC3782052.
    11. Kim S, Beyer BA, Lewis C, Nadel J. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981. PMID: 23977375; PMCID: PMC3745379.
    12. Chung KF, Nadel J, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013 Mar 06; 9(1):6. PMID: 23497652; PMCID: PMC3601007.
    13. Nadel J. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3. PMID: 23434445.
      View in: PubMed
    14. Kim S, Lewis C, Nadel J. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 01; 317(18):2650-60. PMID: 21925169.
      View in: PubMed
    15. Kim S, Lewis C, Nadel J. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400. PMID: 21300824.
      View in: PubMed
    16. Burgel PR, Nadel J. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81. PMID: 18827153.
      View in: PubMed
    17. Koff JL, Shao MX, Ueki IF, Nadel J. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75. PMID: 18375743.
      View in: PubMed
    18. Nadel J. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62. PMID: 17218812.
      View in: PubMed
    19. Koff JL, Shao MX, Kim S, Ueki IF, Nadel J. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700. PMID: 17142770.
      View in: PubMed
    20. Shao MX, Nadel J. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16. PMID: 16148149.
      View in: PubMed
    21. Shao MX, Nadel J. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72. PMID: 15640347; PMCID: PMC545521.
    22. Nadel J . COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.
    23. Shao MX, Nakanaga T, Nadel J. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7. PMID: 15121636.
      View in: PubMed
    24. Shao MX, Ueki IF, Nadel J. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23. PMID: 12972643; PMCID: PMC208807.
    25. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel J. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000 Feb 01; 164(3):1546-52. PMID: 10640773.
      View in: PubMed
    26. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel J. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6. PMID: 10077640; PMCID: PMC15898.
    27. Li JD, Dohrman AF, Gallup M, Miyata S, Gum JR, Kim YS, Nadel J, Prince A, Basbaum CB. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):967-72. PMID: 9023366; PMCID: PMC19623.
    28. Rosenecker J, Zhang W, Hong K, Lausier J, Geppetti P, Yoshihara S, Papahadjopoulos D, Nadel J. Increased liposome extravasation in selected tissues: effect of substance P. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):7236-41. PMID: 8692975; PMCID: PMC38966.
    29. Inoue H, Massion PP, Ueki IF, Grattan KM, Hara M, Dohrman AF, Chan B, Lausier JA, Golden JA, Nadel J. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):651-63. PMID: 7946394.
      View in: PubMed
    30. Richman-Eisenstat JB, Jorens PG, Hébert CA, Ueki I, Nadel J. Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol. 1993 Apr; 264(4 Pt 1):L413-8. PMID: 8476069.
      View in: PubMed
    31. Jorens PG, Graf PD, Ueki IF, Olesch J, Nadel J. Interleukin-8 induces neutrophil accumulation in the trachea of allergic dogs. Trans Assoc Am Physicians. 1992; 105:190-6. PMID: 1308996.
      View in: PubMed
    32. Nadel J, Conrad DJ, Ueki IF, Schuster A, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 1991 Apr; 87(4):1139-45. PMID: 2010530; PMCID: PMC295116.
    33. Rubinstein I, Nadel J, Graf PD, Caughey GH. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs. J Clin Invest. 1990 Aug; 86(2):555-9. PMID: 2384602; PMCID: PMC296760.
    34. Jacoby DB, Nadel J. Parainfluenza virus infection of cultured airway epithelial cells. J Virol Methods. 1989 Nov; 26(2):199-208. PMID: 2559102.
      View in: PubMed
    35. Vanderslice P, Craik CS, Nadel J, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 1989 May 16; 28(10):4148-55. PMID: 2504277.
      View in: PubMed
    36. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel J. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol. 1989 Apr 01; 142(7):2450-6. PMID: 2494259.
      View in: PubMed
    37. Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel J. Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:156-9. PMID: 2526462.
      View in: PubMed
    38. Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel J. Molecular cloning and primary structure of human 15-lipoxygenase. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):457-64. PMID: 3202857.
      View in: PubMed
    39. Gruenert DC, Basbaum CB, Welsh MJ, Li M, Finkbeiner WE, Nadel J. Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5951-5. PMID: 2457904; PMCID: PMC281883.
    40. Jacoby DB, Tamaoki J, Borson DB, Nadel J. Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. J Appl Physiol (1985). 1988 Jun; 64(6):2653-8. PMID: 3042736.
      View in: PubMed
    41. Caughey GH, Viro NF, Lazarus SC, Nadel J. Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases. Biochim Biophys Acta. 1988 Jan 29; 952(2):142-9. PMID: 3122835.
      View in: PubMed
    42. Caughey GH, Viro NF, Ramachandran J, Lazarus SC, Borson DB, Nadel J. Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence. Arch Biochem Biophys. 1987 Nov 01; 258(2):555-63. PMID: 3118812.
      View in: PubMed
    43. Hunter JA, Finkbeiner WE, Nadel J, Goetzl EJ, Holtzman MJ. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A. 1985 Jul; 82(14):4633-7. PMID: 3927287; PMCID: PMC390440.
    44. Leikauf GD, Ueki IF, Nadel J. Autonomic regulation of viscoelasticity of cat tracheal gland secretions. J Appl Physiol Respir Environ Exerc Physiol. 1984 Feb; 56(2):426-30. PMID: 6706754.
      View in: PubMed
    45. Barnes PJ, Skoogh BE, Nadel J, Roberts JM. Postsynaptic alpha 2-adrenoceptors predominate over alpha 1-adrenoceptors in canine tracheal smooth muscle and mediate neuronal and hormonal alpha-adrenergic contraction. Mol Pharmacol. 1983 May; 23(3):570-5. PMID: 6135147.
      View in: PubMed
    46. Sheppard D, Epstein J, Holtzman MJ, Nadel J, Boushey HA. Effect of route of atropine delivery on bronchospasm from cold air and methacholine. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):130-3. PMID: 6337982.
      View in: PubMed
    47. Sheppard D, Epstein J, Holtzman MJ, Nadel J, Boushey HA. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul; 53(1):169-74. PMID: 6749773.
      View in: PubMed
    48. Sheppard D, Saisho A, Nadel J, Boushey HA. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1981 May; 123(5):486-91. PMID: 7235370.
      View in: PubMed
    49. German VF, Ueki IF, Nadel J. Micropipette measurement of airway submucosal gland secretion: laryngeal reflex. Am Rev Respir Dis. 1980 Sep; 122(3):413-6. PMID: 7416616.
      View in: PubMed
    50. Ueki I, German VF, Nadel J. Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis. 1980 Feb; 121(2):351-7. PMID: 7362142.
      View in: PubMed
    51. Golden JA, Nadel J, Boushey HA. Bronchial hyperirritability in healthy subjects after exposure to ozone. Am Rev Respir Dis. 1978 Aug; 118(2):287-94. PMID: 697179.
      View in: PubMed
    52. Newth CJ, Cotton DJ, Nadel J. Pulmonary diffusing capacity measured at multiple intervals during a single exhalation in man. J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct; 43(4):617-25. PMID: 908675.
      View in: PubMed
    53. Olver RE, Davis B, Marin MG, Nadel J. Active transport of Na+ and Cl- across the canine tracheal epithelium in vitro. Am Rev Respir Dis. 1975 Dec; 112(6):811-5. PMID: 1202998.
      View in: PubMed
    54. Jones JG, Fraser RB, Nadel J. Prediction of maximum expiratory flow rate from area-transmural pressure curve of compressed airway. J Appl Physiol. 1975 Jun; 38(6):1002-11. PMID: 1141112.
      View in: PubMed
    55. Gamsu G, Nadel J. New technique for roentgenographic study of airways and lungs using powdered tantalum. Cancer. 1972 Nov; 30(5):1353-7. PMID: 5083072.
      View in: PubMed
    56. Fallat RJ, Powell MR, Youker JE, Nadel J. Pulmonary deposition and clearance of 131-I-labeled oil after lymphography in man. Correlation with lung function. Radiology. 1970 Dec; 97(3):511-20. PMID: 4321609.
      View in: PubMed
    57. Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J. Roentgenographic study of the human trachea with powdered tantalum. Radiology. 1970 Nov; 97(2):327-30. PMID: 5481137.
      View in: PubMed
    58. Nadel J, Clarke SW. A new technique for studying airway deposition, morphology and mechanisms using powdered tantalum. Inhaled Part. 1970; 1:43-7. PMID: 5527720.
      View in: PubMed
    59. Lawson TL, Margulis AR, Nadel J, Rambo ON, Wolfe WG. Intraperitoneal introduction of tantalum powder. A roentgenographic and pathologic study. Invest Radiol. 1969 Sep-Oct; 4(5):293-300. PMID: 5346887.
      View in: PubMed
    60. Goldsmith JR, Nadel J. Experimental exposure of human subjects to ozone. J Air Pollut Control Assoc. 1969 May; 19(5):329-30. PMID: 5797492.
      View in: PubMed
    61. Nadel J, Wolfe WG, Graf PD. Powdered tantalum as a medium for bronchography in canine and human lungs. Invest Radiol. 1968 Jul-Aug; 3(4):229-38. PMID: 5678890.
      View in: PubMed
    62. Simonsson BG, Jacobs FM, Nadel J. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov; 46(11):1812-8. PMID: 6070326; PMCID: PMC292931.
    63. Gold WM, Kaufman HS, Nadel J. Elastic recoil of the lungs in chronic asthmatic patients before and after therapy. J Appl Physiol. 1967 Oct; 23(4):433-8. PMID: 6053669.
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    67. WIDDICOMBE JG, KENT DC, NADEL JA. Mechanism of bronchoconstriction during inhalation of dust. J Appl Physiol. 1962 Jul; 17:613-6. PMID: 14006723.
      View in: PubMed
    68. NADEL JA, COMROE JH. Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol. 1961 Jul; 16:713-6. PMID: 13727341.
      View in: PubMed
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