Jay Nadel, MD

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Cardiovascular Research InstituteFellowship1960University of California, San Francisco
    Philadelphia General HospitalInternship1954Philadelphia General Hospital, Philadelphia, PA
    JeffersonMD1953Jefferson Medical College, Philadelphia, PA
    Collapse Awards and Honors
    CHEST, Los Angeles, CA2016 Distinguished Scientist Honor Lecture in Cardiopulmonary Physiology and Distinguished Service Award
    Japanese Society of Allergology (JSA), Tokyo, Japan2016Honorary Lecture, 65th Annual Meeting of Japanese Society of Allergology (JSA)
    University of California San Francisco School of Medicine2015The Nadel Honorary Pulmonary Symposium
    European Respiratory Society2014Honorary Fellow
    Karolinska Institute, Stockholm2013Honorary Lecture in Lung Research
    National Heart and Lung Institute, Imperial College, London, UK2012Invited Lecture, 7th International Symposium on Cough
    Catania, Italy2012 Invited Lecture, XIII National Conference of the Italian Union of Pneumology
    National Heart and Lung Institute, Imperial College, London, UK2012John Widdicombe Memorial Lecture, 7th International Symposium on Cough
    Tokyo2011Honorary Lecturer, Japanese Respiratory Society
    Hawaii2011Special Lecturer, Chest Meeting, Airways Network
    Lucerne2010Honorary Lecturer, Transatlantic Airway Conference 25th Anniversary
    University of Paris2008René Descartes Medal
    Case Western Reserve University School of Medicine, Cleveland2005Honorary Jerome I. Kleinerman Annual Lecture
    University of Ferrara, Italy2002Honorary Member Associazione Nicolo Copernico Alumni Dell Ateneo Estense
    Free University of Berlin2002Festschrift Honoring Prof. Gert Kunkel
    Baylor College of Medicine2002First Annual Honorary Joseph R. Rodarte Lectureship in Pulmonary Medicine
    1999Best Doctors of San Francisco Bay Area Nomination
    Jefferson Medical College, Philadelphia1998Alumni Achievement Award, JH Coley Lectureship
    1998Best Doctors of America Nomination
    American Thoracic Society1997Trudeau Medal
    Dickinson Law School, Carlisle, PA1997Honorary Degree in Law
    University of Lund, Sweden1996Honorary Doctorate of Medicine
    German Society of Pulmonology1994Honorary Membership, Society for Lung and Airway Research
    Finnish Association of Pulmonary Physicians1994Honorary Membership
    University of Helsinki1994Medal of the University
    San Francisco 1993Amberson Lecturer, American Thoracic Society
    Ben Gurion University1992Distinguished Achievement Award
    American Lung Association1992Crocker Clean Air Award (for outstanding research in Air Pollution)
    University of Southern California1992Sam J. Sills Honorary Lectureship
    University of Ferrara, Ferrara, Italy1991Honorary Doctorate of Medicine
    Aspen Lung Conferences1991Giles S. Filley Lecture
    Royal Society of Medicine Foundation1990Pfizer Visiting Professor
    University of Nebraska School of Medicine1990Kass Lectureship and Medalist
    Brown University School of Medicine1989Distinguished Lecturer, The Ninth William P. Buffum Oration
    American College of Chest Physicians1987Distinguished Lecturer in Physiology
    American Lung Association of California1984Clean Air Award
    American Lung Association of California1984California Medal
    California Thoracic Society1984Honorary Membership
    Hammersmith Hospital, London, England1973Visiting Scientist
    University of Oxford, Oxford, England1962Visiting Scientist, University Laboratory of Physiology
    Cardiovascular Research Institute, University of California, San Francisco1960  - 1961Giannini Research Fellow
    Philadelphia General Hospital1955Blockley Award for Outstanding Publication
    Jefferson Medical College1953Medical Practice Prize

    Collapse Overview 
    Collapse Overview
    A. Background
    • 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF
    • Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute
    • Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine

    B. Early Areas of Studies
    • Chronic airway diseases, including asthma, COPD, and CF
    • Air pollutants (sulfur dioxide and ozone)
    • Airway epithelium
    • Viruses, bacteria, air pollutants, allergens, cigarette smoke
    • Na+, Cl¯ exchange mechanism in the airway epithelium

    C. Later Areas of Study
    • Cell and molecular biology
    • Antimuscarinic Therapy of Bronchospasm
    • Signaling pathways for mucin production

    D. Recent Areas of Study
    • EGFR Signaling Pathways
    • Modulation of proinflammatory responses
    • Viral infections
    • CFTR and its role in inflammatory airway diseases
    • Bronchiolitis Obliterans Syndrome following lung transplantation

    Collapse Research 
    Collapse Research Activities and Funding
    Evolving Microenvironments in Airway Inflammation
    NIH P01HL024136Jul 1, 1979 - Mar 31, 2016
    Role: Co-Principal Investigator
    Multidisciplinary Training Program in Lung Disease
    NIH T32HL007185Jul 1, 1976 - Jun 30, 2022
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Normal Routine Spirometry Can Mask COPD/Emphysema in Symptomatic Smokers. Chronic Obstr Pulm Dis. 2021 Jan; 8(1). Gelb AF, Yamamoto A, Verbeken EK, Hogg JC, Tashkin DP, Tran DNT, Moridzadeh RM, Fraser C, Schein MJ, Decramer M, Glassy EF, Nadel JA. PMID: 33513660; PMCID: PMC8047618.
      View in: PubMed   Mentions: 1  
    2. Asthma and emphysema overlap in nonsmokers. Ann Allergy Asthma Immunol. 2020 12; 125(6):711-713. Gelb AF, Yamamoto A, Verbeken E, Grigorian SR, Nadel JA. PMID: 32791102.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Further Studies of Unsuspected Emphysema in Nonsmoking Patients With Asthma With Persistent Expiratory Airflow Obstruction. Chest. 2018 03; 153(3):618-629. Gelb AF, Yamamoto A, Verbeken EK, Schein MJ, Moridzadeh R, Tran D, Fraser C, Barbers R, Elatre W, Koss MN, Glassy EF, Nadel JA. PMID: 29197547.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    4. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. J Allergy Clin Immunol. 2016 10; 138(4):1011-1013. Gelb AF, Nadel JA. PMID: 27527265.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5. Gelb AF, Christenson SA, Nadel JA. PMID: 26717511.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. J Allergy Clin Immunol. 2015 Sep; 136(3):553-5. Gelb AF, Nadel JA. PMID: 26343939.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Chest. 2015 Aug; 148(2):313-320. Gelb AF, Yamamoto A, Verbeken EK, Nadel JA. PMID: 25950858.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    8. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. PMID: 24838750; PMCID: PMC4101792.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    9. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40. Nadel JA. PMID: 24293414.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    10. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-5.e1-3. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. PMID: 24290280.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    11. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. PMID: 23999497; PMCID: PMC3782052.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    12. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981. Kim S, Beyer BA, Lewis C, Nadel JA. PMID: 23977375; PMCID: PMC3745379.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    13. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013 Mar 06; 9(1):6. Chung KF, Nadel JA, Fontana G. PMID: 23497652; PMCID: PMC3601007.
      View in: PubMed   Mentions: 1  
    14. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3. Nadel JA. PMID: 23434445.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 01; 317(18):2650-60. Kim S, Lewis C, Nadel JA. PMID: 21925169.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400. Kim S, Lewis C, Nadel JA. PMID: 21300824.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    17. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81. Burgel PR, Nadel JA. PMID: 18827153.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    18. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75. Koff JL, Shao MX, Ueki IF, Nadel JA. PMID: 18375743.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    19. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62. Nadel JA. PMID: 17218812.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. PMID: 17142770.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    21. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16. Shao MX, Nadel JA. PMID: 16148149.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    22. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72. Shao MX, Nadel JA. PMID: 15640347; PMCID: PMC545521.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    23. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287. Nadel JA.
    24. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7. Shao MX, Nakanaga T, Nadel JA. PMID: 15121636.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    25. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23. Shao MX, Ueki IF, Nadel JA. PMID: 12972643; PMCID: PMC208807.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    26. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. PMID: 10077640; PMCID: PMC15898.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    27. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 1991 Apr; 87(4):1139-45. Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. PMID: 2010530; PMCID: PMC295116.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    28. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 1989 May 16; 28(10):4148-55. Vanderslice P, Craik CS, Nadel JA, Caughey GH. PMID: 2504277.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol. 1989 Apr 01; 142(7):2450-6. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. PMID: 2494259.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis. 1980 Feb; 121(2):351-7. Ueki I, German VF, Nadel JA. PMID: 7362142.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    31. Roentgenographic study of the human trachea with powdered tantalum. Radiology. 1970 Nov; 97(2):327-30. Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J. PMID: 5481137.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Experimental exposure of human subjects to ozone. J Air Pollut Control Assoc. 1969 May; 19(5):329-30. Goldsmith JR, Nadel JA. PMID: 5797492.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    34. Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol. 1961 Jul; 16:713-6. NADEL JA, COMROE JH. PMID: 13727341.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
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