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In office sampling of eosinophil peroxidase to diagnose eosinophilic chronic rhinosinusitis. Int Forum Allergy Rhinol. 2024 Sep 13.
Callander JK, Charbit AR, Khanna K, Fahy JV, Tang M, Liegeois M, Pletcher SD, Goldberg AN, Gurrola JG, Murr AH, Butrymowicz A, Loftus PA. PMID: 39269218.
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PubMed Mentions: Fields:
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Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations. J Allergy Clin Immunol. 2024 Sep 03.
Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC, National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program and TOPMed mtDNA Wo. PMID: 39237012.
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PubMed Mentions: Fields:
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Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells. JCI Insight. 2024 Jun 18; 9(15).
Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV. PMID: 38889046; PMCID: PMC11383604.
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HumansCells
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Reply to Mozaffaripour et al.: Dose Modulation, Body Mass Index, and Computed Tomography Air Trapping. Am J Respir Crit Care Med. 2024 06 01; 209(11):1413-1414.
Leung C, Fain SB, Hoffman EA, Fahy JV. PMID: 38574365; PMCID: PMC11146563.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma. Am J Respir Crit Care Med. 2024 05 15; 209(10):1196-1207.
Leung C, Tang M, Huang BK, Fain SB, Hoffman EA, Choi J, Dunican EM, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Levy BD, Wenzel SE, Sumino K, Hastie AT, Schirm J, McCulloch CE, Peters MC, Woodruff PG, Sorkness RL, Castro M, Fahy JV. PMID: 38113166; PMCID: PMC11146546.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nat Commun. 2024 May 09; 15(1):3900.
Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA. PMID: 38724552; PMCID: PMC11082194.
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HumansCells
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A novel DNase assay reveals low DNase activity in severe asthma. Am J Physiol Lung Cell Mol Physiol. 2024 Jun 01; 326(6):L796-L804.
Charbit AR, Liegeois MA, Raymond WW, Comhair SAA, Johansson MW, Hastie AT, Bleecker ER, Fajt M, Castro M, Sumino K, Erzurum SC, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE, Woodruff PG, Levy BD, Tang MC, Fahy JV. PMID: 38651338; PMCID: PMC11380938.
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Humans
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Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma. J Allergy Clin Immunol. 2024 Sep; 154(3):580-591.e6.
Tang M, Charbit AR, Johansson MW, Jarjour NN, Denlinger LC, Raymond WW, Peters MC, Dunican EM, Castro M, Sumino K, Erzurum SC, Comhair SA, Moore WC, Levy BD, Israel E, Phipatanakul W, Phillips BR, Mauger DT, Bleecker ER, Wenzel SE, Fajt ML, Woodruff PG, Hastie AT, Fahy JV, National Heart Lung and Blood Institute Severe Asthma Research Program. PMID: 38663815.
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1 Fields:
Translation:
HumansCells
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The Year in Perioperative Echocardiography: Selected Highlights from 2023. J Cardiothorac Vasc Anesth. 2024 Sep; 38(9):1851-1859.
Khoche S, Ellis S, Kellogg L, Fahy J, Her B, Maus TM. PMID: 38890085.
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Humans
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Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma. JCI Insight. 2024 Feb 08; 9(3).
Huang BK, Elicker BM, Henry TS, Kallianos KG, Hahn LD, Tang M, Heng F, McCulloch CE, Bhakta NR, Majumdar S, Choi J, Denlinger LC, Fain SB, Hastie AT, Hoffman EA, Israel E, Jarjour NN, Levy BD, Mauger DT, Sumino K, Wenzel SE, Castro M, Woodruff PG, Fahy JV, Sarp FTNSARP. PMID: 38127464; PMCID: PMC10967478.
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PubMed Mentions:
1 Fields:
Translation:
HumansCTClinical Trials
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Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma. Clin Exp Allergy. 2024 Apr; 54(4):265-277.
Hastie AT, Bishop AC, Khan MS, Bleecker ER, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Levy BD, Mauger DT, Meyers DA, Moore WC, Ortega VE, Peters SP, Wenzel SE, Steele CH. PMID: 38253462; PMCID: PMC11075125.
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Humans
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Mitochondrial DNA Copy Number Variation in Asthma Risk, Severity, and Exacerbations. medRxiv. 2023 Dec 05.
Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC, National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program (SARP) and TOPMed m. PMID: 38106101; PMCID: PMC10723502.
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Immune treatment tackles chronic obstructive pulmonary disease. Nature. 2023 Sep; 621(7979):476-477.
Fahy JV, Locksley RM. PMID: 37587279.
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Humans
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A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases. Eur Respir J. 2023 05; 61(5).
Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA. PMID: 37080569; PMCID: PMC10209473.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. J Asthma. 2023 10; 60(10):1824-1835.
Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). PMID: 36946148; PMCID: PMC10524756.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes. J Asthma. 2023 10; 60(10):1843-1852.
Li H, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Wenzel SE, Zein J, Bleecker ER, Meyers DA, Chen Y, Li X, NHLBI Severe Asthma Research Program (SARP). PMID: 36940238; PMCID: PMC10528448.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma. J Allergy Clin Immunol. 2023 07; 152(1):94-106.e12.
Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A. PMID: 36893862; PMCID: PMC10330021.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. Am J Respir Crit Care Med. 2023 02 15; 207(4):438-451.
Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. PMID: 36066606; PMCID: PMC9940145.
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12 Fields:
Translation:
HumansCells
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Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2023 02 15; 207(4):475-484.
Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore WC, Bleecker ER, Phillips BR, Mauger DT, Hoffman EA, Fain SB, Reeder SB, Sorkness RL, Jarjour NN, Denlinger LC, Schiebler ML. PMID: 36194556; PMCID: PMC9940151.
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5 Fields:
Translation:
Humans
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Reply to Nie et al. and Bhammar et al. Am J Respir Crit Care Med. 2023 01 01; 207(1):111-112.
Peters MC, Schiebler ML, Mauger DT, Fahy JV. PMID: 36029296; PMCID: PMC9952864.
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Reply to Ikeda and Tomita. Am J Respir Crit Care Med. 2022 11 15; 206(10):1299-1300.
Tang M, Mauger DT, Fahy JV, Dunican EM. PMID: 35876128; PMCID: PMC9746837.
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The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma. Am J Respir Crit Care Med. 2022 11 01; 206(9):1096-1106.
Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3. PMID: 35687105; PMCID: PMC9704842.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk. Am J Physiol Lung Cell Mol Physiol. 2022 11 01; 323(5):L548-L557.
Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC. PMID: 36126269; PMCID: PMC9602918.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L372-L389.
Khanna K, Raymond WW, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, Simmons G, Fahy JV. PMID: 35762590; PMCID: PMC9448286.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program. Pediatr Pulmonol. 2022 07; 57(7):1782-1788.
Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, Wenzel SE, Woodruff P, Bleecker ER, Meyers DA, Ortega VE. PMID: 35451201; PMCID: PMC9443928.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time. Am J Respir Crit Care Med. 2022 05 01; 205(9):1036-1045.
Tang M, Elicker BM, Henry T, Gierada DS, Schiebler ML, Huang BK, Peters MC, Castro M, Hoffman EA, Fain SB, Ash SY, Choi J, Hall C, Phillips BR, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Phipatanakul W, Levy BD, Wenzel SE, Bleecker ER, Woodruff PG, Fahy JV, Dunican EM. PMID: 35104436; PMCID: PMC9851493.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts. Radiology. 2022 08; 304(2):450-459.
Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, Leader JK, Wenzel SE, Fahy JV, Schiebler ML, Fain SB, Jarjour NN, Mauger DT, Reinhardt JM, Newell JD, Hoffman EA, Castro M, Sheshadri A, NHLBI Severe Asthma Research Program (SARP). PMID: 35471111; PMCID: PMC9340243.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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The Mucin Gene MUC5B Is Required for Normal Lung Function. Am J Respir Crit Care Med. 2022 04 01; 205(7):737-739.
Liegeois MA, Fahy JV. PMID: 35148488; PMCID: PMC9836220.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342.
Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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Mucus secretion blocked at its source in the lungs. Nature. 2022 03; 603(7903):798-799.
Gitlin I, Fahy JV. PMID: 35322214.
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PubMed Mentions: Fields:
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15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation. J Clin Invest. 2022 01 04; 132(1).
Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. PMID: 34762602; PMCID: PMC8718153.
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PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at 3He MRI. Radiology. 2022 04; 303(1):184-190.
Mummy DG, Dunican EM, Carey KJ, Evans MD, Elicker BM, Newell JD, Gierada DS, Nagle SK, Schiebler ML, Sorkness RL, Jarjour NN, Denlinger LC, Fahy JV, Fain SB. PMID: 34931858; PMCID: PMC8962781.
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10 Fields:
Translation:
Humans
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The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 02; 149(2):488-516.e9.
Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P, PrecISE Study Team. PMID: 34848210; PMCID: PMC8821377.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro. bioRxiv. 2021 Nov 11.
Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, Simmons G, Fahy JV. PMID: 33330868; PMCID: PMC7743076.
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Benefits of Airway Androgen Receptor Expression in Human Asthma. Am J Respir Crit Care Med. 2021 08 01; 204(3):285-293.
Zein JG, McManus JM, Sharifi N, Erzurum SC, Marozkina N, Lahm T, Giddings O, Davis MD, DeBoer MD, Comhair SA, Bazeley P, Kim HJ, Busse W, Calhoun W, Castro M, Chung KF, Fahy JV, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Ortega VE, Peters M, Bleecker ER, Meyers DA, Zhao Y, Wenzel SE, Gaston B. PMID: 33779531; PMCID: PMC8513596.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 04 21; 13(1):66.
Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. PMID: 33883027; PMCID: PMC8059115.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. Am J Respir Crit Care Med. 2021 04 15; 203(8):957-968.
Dunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler R, Christenson SA, Comellas A, Cooper CB, Couper D, Criner GJ, Dransfield M, Doerschuk CM, Drummond MB, Hansel NN, Han MK, Hastie AT, Hoffman EA, Krishnan JA, Lazarus SC, Martinez FJ, McCulloch CE, O'Neal WK, Ortega VE, Paine R, Peters S, Schroeder JD, Woodruff PG, Fahy JV. PMID: 33180550; PMCID: PMC8048745.
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PubMed Mentions:
49 Fields:
Translation:
Humans
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Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2021 04 01; 203(7):882-892.
Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips BR, Wenzel SE, Fahy JV, Israel E, Bleecker ER. PMID: 33545021; PMCID: PMC8017570.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma. Am J Respir Crit Care Med. 2021 04 01; 203(7):841-852.
Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Levy BD, Meyers DA, Ross K, Teague WG, Wenzel SE, Woodruff PG, Zein J, Jarjour NN, Mauger DT, Israel E. PMID: 33290668; PMCID: PMC8017577.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment. J Allergy Clin Immunol. 2021 05; 147(5):1594-1601.
Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. PMID: 33667479; PMCID: PMC8113113.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Quantitative CT metrics are associated with longitudinal lung function decline and future asthma exacerbations: Results from SARP-3. J Allergy Clin Immunol. 2021 09; 148(3):752-762.
Krings JG, Goss CW, Lew D, Samant M, McGregor MC, Boomer J, Bacharier LB, Sheshadri A, Hall C, Brownell J, Schechtman KB, Peterson S, McEleney S, Mauger DT, Fahy JV, Fain SB, Denlinger LC, Israel E, Washko G, Hoffman E, Wenzel SE, Castro M, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program Investigators. PMID: 33577895; PMCID: PMC8349941.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Erratum: COVID-19-related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids. Am J Respir Crit Care Med. 2020 12 15; 202(12):1744-1746.
Peters MC, Fahy JV. PMID: 33320072; PMCID: PMC7737596.
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3 Fields:
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The Use of a Three-Fluid Atomising Nozzle in the Production of Spray-Dried Theophylline/Salbutamol Sulphate Powders Intended for Pulmonary Delivery. Pharmaceutics. 2020 Nov 20; 12(11).
Focaroli S, Jiang G, O'Connell P, Fahy JV, Healy AM. PMID: 33233520; PMCID: PMC7699582.
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3
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Reply to Nannini and to Lipworth et al. Am J Respir Crit Care Med. 2020 11 01; 202(9):1325-1326.
Peters MC, Fahy JV, Denlinger LC. PMID: 32687407; PMCID: PMC7605204.
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Humans
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Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency. Am J Respir Crit Care Med. 2020 10 01; 202(7):973-982.
Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC. PMID: 32479111; PMCID: PMC7528796.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
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The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. J Biopharm Stat. 2020 11 01; 30(6):1026-1037.
Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR. PMID: 32941098; PMCID: PMC7954787.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCTClinical Trials
-
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. J Allergy Clin Immunol. 2021 03; 147(3):894-909.
Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). PMID: 32795586; PMCID: PMC7876167.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells. Clin Exp Allergy. 2020 08; 50(8):904-914.
Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV. PMID: 32542913; PMCID: PMC7610812.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. Am J Respir Crit Care Med. 2020 07 01; 202(1):83-90.
Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV. PMID: 32348692; PMCID: PMC7328313.
View in:
PubMed Mentions:
240 Fields:
Translation:
HumansCellsPHPublic Health
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Baseline sputum eosinophil + neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) cohort. J Allergy Clin Immunol. 2020 07; 146(1):222-226.
Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips B, Wenzel SE, Fahy JV, Israel E, Bleecker ER, NHLBI SARP 3 Investigators. PMID: 32032631; PMCID: PMC7343602.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCellsCTClinical Trials
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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 2020 Jan 23; 180(2):406.
Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. PMID: 31978350.
View in:
PubMed Mentions:
2 Fields:
-
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2187-2193.
Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, Fahy JV, Fitzpatrick AM, Israel E, Jarjour NN, Levy B, Mauger DT, Moore WC, Noel P, Peters SP, Teague WG, Wenzel SE, Erzurum SC, Sharifi N. PMID: 31932420; PMCID: PMC6995013.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCTClinical Trials
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Severe asthma during childhood and adolescence: A longitudinal study. J Allergy Clin Immunol. 2020 01; 145(1):140-146.e9.
Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B. PMID: 31622688.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCellsCTClinical Trials
-
Development and initial validation of the Asthma Severity Scoring System (ASSESS). J Allergy Clin Immunol. 2020 01; 145(1):127-139.
Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN. PMID: 31604088; PMCID: PMC6949388.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCTClinical Trials
-
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 2019 Oct 03; 179(2):417-431.e19.
Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. PMID: 31585081; PMCID: PMC8403554.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
-
The use of hydrophobic amino acids in protecting spray dried trehalose formulations against moisture-induced changes. Eur J Pharm Biopharm. 2019 Nov; 144:139-153.
Mah PT, O'Connell P, Focaroli S, Lundy R, O'Mahony TF, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM. PMID: 31536784; PMCID: PMC6938683.
View in:
PubMed Mentions:
9 Fields:
-
Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort. Chest. 2020 02; 157(2):258-267.
Ash SY, Sanchez-Ferrero GV, Schiebler ML, Rahaghi FN, Rai A, Come CE, Ross JC, Colon AG, Cardet JC, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Lempel JK, Mauger DT, Tattersall MC, Wenzel SE, Levy BD, Washko GR, Israel E, San Jose Estepar R, SARP Investigators. PMID: 31521672; PMCID: PMC7005378.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma. J Allergy Clin Immunol. 2020 01; 145(1):430-433.
Li X, Hastie AT, Peters MC, Hawkins GA, Phipatanakul W, Li H, Moore WC, Busse WW, Castro M, Erzurum SC, Gaston B, Israel E, Jarjour NN, Levy BD, Wenzel SE, Meyers DA, Fahy JV, Bleecker ER, National Heart, Lung, and Blood Institute's Severe Asthma Research Program (SARP) Networks. PMID: 31513878; PMCID: PMC7469890.
View in:
PubMed Mentions:
23 Fields:
Translation:
Humans
-
Making Asthma Crystal Clear. N Engl J Med. 2019 08 29; 381(9):882-884.
Fahy JV, Locksley RM. PMID: 31461600.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Clinical significance of the bronchodilator response in children with severe asthma. Pediatr Pulmonol. 2019 11; 54(11):1694-1703.
Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston BM, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-DeClue H, Boomer JS, Castro M. PMID: 31424170; PMCID: PMC7015037.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma. Am J Respir Crit Care Med. 2019 06 01; 199(11):1358-1367.
Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE. PMID: 30682261; PMCID: PMC6543720.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 05 23; 380(21):2009-2019.
Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA, National Heart, Lung, and Blood Institute AsthmaNet. PMID: 31112384; PMCID: PMC6711475.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansCells
-
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 05 01; 199(9):1076-1085.
Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. PMID: 30888839; PMCID: PMC6515873.
View in:
PubMed Mentions:
111 Fields:
Translation:
HumansCells
-
The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium. JCI Insight. 2019 04 18; 4(8).
Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW. PMID: 30996135; PMCID: PMC6538329.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
The Cytokines of Asthma. Immunity. 2019 04 16; 50(4):975-991.
Lambrecht BN, Hammad H, Fahy JV. PMID: 30995510.
View in:
PubMed Mentions:
384 Fields:
Translation:
HumansAnimalsCells
-
A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery. Int J Pharm. 2019 May 01; 562:228-240.
Focaroli S, Mah PT, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM. PMID: 30849470; PMCID: PMC6562166.
View in:
PubMed Mentions:
18 Fields:
Translation:
Cells
-
A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma. Am J Respir Crit Care Med. 2019 02 15; 199(4):465-477.
Peters MC, Ringel L, Dyjack N, Herrin R, Woodruff PG, Rios C, O'Connor B, Fahy JV, Seibold MA. PMID: 30371106; PMCID: PMC6376622.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansCells
-
Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2019 06; 143(6):2052-2061.
Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG. PMID: 30635198; PMCID: PMC6556425.
View in:
PubMed Mentions:
37 Fields:
Translation:
Humans
-
Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction. Ann Am Thorac Soc. 2018 11; 15(Suppl 3):S184-S191.
Dunican EM, Watchorn DC, Fahy JV. PMID: 30431352; PMCID: PMC6322032.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Purpose of the Conference: The 2018 Transatlantic Conference on Lung Diseases. Ann Am Thorac Soc. 2018 11; 15(Suppl 3):S139.
MacNee W, Fahy JV, Nicod LP, Kolls J. PMID: 30431342.
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PubMed Mentions: Fields:
Translation:
Humans
-
Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26).
Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators. PMID: 30076281; PMCID: PMC6320225.
View in:
PubMed Mentions:
110 Fields:
-
Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort. Am J Respir Crit Care Med. 2018 07 01; 198(1):39-50.
Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR, SARP Investigators. PMID: 29672122; PMCID: PMC6034125.
View in:
PubMed Mentions:
30 Fields:
Translation:
Humans
-
Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10; 18(1):58.
DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. PMID: 29631584; PMCID: PMC5891903.
View in:
PubMed Mentions:
48 Fields:
Translation:
Humans
-
ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 03 22; 3(6).
Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD, National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators. PMID: 29563345; PMCID: PMC5926903.
View in:
PubMed Mentions:
3 Fields:
-
Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol. 2019 01; 143(1):104-113.e14.
Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV, National Heart, Lung and Blood Institute Severe Asthma Research Program 3. PMID: 29524537; PMCID: PMC6128784.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
-
Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov. 2018; 4:7.
Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV. PMID: 29449961; PMCID: PMC5809386.
View in:
PubMed Mentions:
10
-
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 03 01; 128(3):997-1009.
Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV, National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP). PMID: 29400693; PMCID: PMC5824874.
View in:
PubMed Mentions:
174 Fields:
Translation:
Humans
-
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 02 01; 197(3):313-324.
Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. PMID: 29064281; PMCID: PMC5811952.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCells
-
Purpose of the Conference: The 2017 Transatlantic Conference on Lung Diseases. Ann Am Thorac Soc. 2017 11; 14(Suppl_5):S313.
MacNee W, Fahy JV, Nicod LP, Kolls J. PMID: 29161085; PMCID: PMC5946628.
View in:
PubMed Mentions: Fields:
-
Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2018 02; 153(2):378-386.
Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC, National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. PMID: 29080709; PMCID: PMC5815875.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clin Exp Allergy. 2017 Dec; 47(12):1534-1545.
Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA. PMID: 28833774.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
After asthma: redefining airways diseases. Lancet. 2018 01 27; 391(10118):350-400.
Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A. PMID: 28911920.
View in:
PubMed Mentions:
334 Fields:
Translation:
HumansPHPublic Health
-
Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):545-554.e4.
Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. PMID: 28866107; PMCID: PMC5832534.
View in:
PubMed Mentions:
116 Fields:
Translation:
Humans
-
ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14).
Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD, National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. PMID: 28724795; PMCID: PMC5518567.
View in:
PubMed Mentions:
16 Fields:
-
Asthma and corticosteroids: time for a more precise approach to treatment. Eur Respir J. 2017 06; 49(6).
Dunican EM, Fahy JV. PMID: 28663322.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
-
Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 06 01; 195(11):1439-1448.
Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E, Severe Asthma Research Program. PMID: 27967215; PMCID: PMC5470749.
View in:
PubMed Mentions:
48 Fields:
Translation:
Humans
-
Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9).
Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. PMID: 28783702; PMCID: PMC5561743.
View in:
PubMed Mentions:
47 Fields:
-
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 02 01; 195(3):302-313.
Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. PMID: 27556234; PMCID: PMC5328178.
View in:
PubMed Mentions:
184 Fields:
Translation:
HumansCellsCTClinical Trials
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Purpose of the Conference: 2016 Transatlantic Airway Conference. Ann Am Thorac Soc. 2016 12; 13 Suppl 5:S395.
MacNee W, Fahy JV, Nicod LP, Kolls JK. PMID: 28005426; PMCID: PMC5946651.
View in:
PubMed Mentions:
1 Fields:
-
Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma. Am J Respir Crit Care Med. 2016 11 15; 194(10):1296-1299.
Lachowicz-Scroggins ME, Yuan S, Kerr SC, Dunican EM, Yu M, Carrington SD, Fahy JV. PMID: 27845589; PMCID: PMC5114443.
View in:
PubMed Mentions:
69 Fields:
Translation:
Humans
-
Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016 11; 13(11):2103-2104.
Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D. PMID: 27831803; PMCID: PMC5802559.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. Chest. 2016 Dec; 150(6):1242-1250.
Luyster FS, Strollo PJ, Holguin F, Castro M, Dunican EM, Fahy J, Gaston B, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE. PMID: 27720882; PMCID: PMC5310183.
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PubMed Mentions:
28 Fields:
Translation:
HumansCTClinical Trials
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IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 09 08; 1(14):e87871.
Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. PMID: 27699235; PMCID: PMC5033813.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Metabolic consequences of obesity as an "outside in" mechanism of disease severity in asthma. Eur Respir J. 2016 08; 48(2):291-3.
Peters MC, Fahy JV. PMID: 27478182; PMCID: PMC6020152.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
-
Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70.
Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. PMID: 27432971; PMCID: PMC4978244.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansCells
-
Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 07; 4(7):574-584.
Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV, National Heart, Lung, and Blood Institute Severe Asthma Research Program. PMID: 27283230; PMCID: PMC5007068.
View in:
PubMed Mentions:
208 Fields:
Translation:
Humans
-
Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 05 01; 193(9):935-6.
Gordon ED, Locksley RM, Fahy JV. PMID: 27128698; PMCID: PMC4872659.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 01; 139(1):72-81.e1.
Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. PMID: 27215490; PMCID: PMC5073041.
View in:
PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr; 12(4):e1005555.
Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. PMID: 27058347; PMCID: PMC4825926.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Mast cells in asthma: biomarker and therapeutic target. Eur Respir J. 2016 Apr; 47(4):1040-2.
Reber LL, Fahy JV. PMID: 27037311.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S78-82.
Fahy JV. PMID: 27027957; PMCID: PMC5015736.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Future Research Directions in Asthma. An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Dec 01; 192(11):1366-72.
Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. PMID: 26305520; PMCID: PMC4731702.
View in:
PubMed Mentions:
37 Fields:
Translation:
Humans
-
Purpose of the Conference: 2015 Transatlantic Airway Conference. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S111.
MacNee W, Fahy J, Nicod L, Kolls J. PMID: 26595725; PMCID: PMC5467081.
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PubMed Mentions: Fields:
-
The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S144-9.
Dunican EM, Fahy JV. PMID: 26595730; PMCID: PMC5467082.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med. 2015 Feb 25; 7(276):276ra27.
Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV. PMID: 25717100; PMCID: PMC4403633.
View in:
PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol. 2015 Jan; 15(1):57-65.
Fahy JV. PMID: 25534623; PMCID: PMC4390063.
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PubMed Mentions:
610 Fields:
Translation:
HumansAnimalsCells
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Twenty-Ninth Transatlantic Airway Conference. Innate and adaptive immune responses in airway disease. Purpose of the conference. Ann Am Thorac Soc. 2014 Dec; 11 Suppl 5:S233.
MacNee W, Fahy J, Nicod L, Kolls J. PMID: 25525724.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70.
Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. PMID: 25362490; PMCID: PMC4233009.
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PubMed Mentions:
127 Fields:
Translation:
HumansAnimalsCells
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View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1005-7.
Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV. PMID: 24735037; PMCID: PMC4098098.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S139-45.
Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy JV. PMID: 24754822; PMCID: PMC4112503.
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PubMed Mentions:
26 Fields:
Translation:
HumansPHPublic Health
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Asthma and the flu: a tricky two-step. Immunol Cell Biol. 2014 May-Jun; 92(5):389-91.
Locksley RM, Fahy JV. PMID: 24687019; PMCID: PMC4396068.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity. PLoS One. 2013; 8(12):e83077.
Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy JV, Chignard M, Imberty A, Wimmerova M. PMID: 24340081; PMCID: PMC3858362.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Purpose of the conference. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S107.
MacNee W, Fahy J, Nicod L, Wanner A. PMID: 24313758.
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PubMed Mentions: Fields:
Translation:
Humans
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Chair's summary: Mechanisms of relevance to clinical heterogeneity of asthma and chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S108.
Fahy JV. PMID: 24313759; PMCID: PMC5478182.
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Translation:
HumansCells
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Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb; 133(2):388-94.
Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. PMID: 24075231; PMCID: PMC3981552.
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PubMed Mentions:
134 Fields:
Translation:
HumansCells
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Type 2 immune responses in obese individuals with asthma. Am J Respir Crit Care Med. 2013 Sep 15; 188(6):633-4.
Peters MC, Fahy JV. PMID: 24032378.
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PubMed Mentions:
12 Fields:
Translation:
Humans
-
A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013 Jul 17; 3(1):24.
Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. PMID: 23866775; PMCID: PMC3724712.
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PubMed Mentions:
35
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An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89.
Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. PMID: 23304658; PMCID: PMC3538381.
View in:
PubMed Mentions:
25
-
P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 01; 187(1):28-33.
Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF, NHLBI Asthma Clinical Research Network Investigators. PMID: 23144325; PMCID: PMC3570642.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9.
Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. PMID: 22988107; PMCID: PMC3479591.
View in:
PubMed Mentions:
180 Fields:
Translation:
HumansAnimalsCells
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Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12; 308(10):987-97.
Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA, Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. PMID: 22968888; PMCID: PMC3697088.
View in:
PubMed Mentions:
52 Fields:
Translation:
Humans
-
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012 Sep; 130(3):647-654.e10.
Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR, Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) . PMID: 22857879; PMCID: PMC3626285.
View in:
PubMed Mentions:
203 Fields:
Translation:
HumansCells
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Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. BMC Med Genomics. 2012 Jun 19; 5:27.
Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE. PMID: 22713245; PMCID: PMC3408345.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012; 7(5):e36631.
Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV, Leung DY, Asthma Clinical Research Network. PMID: 22606276; PMCID: PMC3350517.
View in:
PubMed Mentions:
89 Fields:
Translation:
HumansCTClinical Trials
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Asthma outcomes: biomarkers. J Allergy Clin Immunol. 2012 Mar; 129(3 Suppl):S9-23.
Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Panettieri RA, Schleimer RP, Minnicozzi M. PMID: 22386512; PMCID: PMC3390196.
View in:
PubMed Mentions:
133 Fields:
Translation:
HumansCells
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A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):612-9.
McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, Fahy JV, Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. PMID: 22268133; PMCID: PMC3326288.
View in:
PubMed Mentions:
172 Fields:
Translation:
HumansCTClinical Trials
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Genetic association between human chitinases and lung function in COPD. Hum Genet. 2012 Jul; 131(7):1105-14.
Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ. PMID: 22200767; PMCID: PMC3771523.
View in:
PubMed Mentions:
9 Fields:
Translation:
Humans
-
A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55.
Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. PMID: 22093101; PMCID: PMC3271792.
View in:
PubMed Mentions:
46 Fields:
Translation:
Animals
-
The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):390-2.
Fahy JV, Locksley RM. PMID: 21844510.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. J Allergy Clin Immunol. 2011 May; 127(5):1286-93.e6.
Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, Kocan KM, Fahy JV, Nganga LW, Ronmark E, Cooper PJ, Platts-Mills TA. PMID: 21453959; PMCID: PMC3085643.
View in:
PubMed Mentions:
211 Fields:
Translation:
HumansAnimals
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Hexaphenylbenzene as a rigid template for the straightforward syntheses of "star-shaped" glycodendrimers. J Org Chem. 2011 Jan 21; 76(2):724-7.
Chabre YM, Brisebois PP, Abbassi L, Kerr SC, Fahy JV, Marcotte I, Roy R. PMID: 21190367; PMCID: PMC3981551.
View in:
PubMed Mentions:
4 Fields:
Translation:
Cells
-
Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol. 2011 Feb 01; 186(3):1861-9.
Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR. PMID: 21187436; PMCID: PMC3981556.
View in:
PubMed Mentions:
70 Fields:
Translation:
HumansCells
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Airway mucus function and dysfunction. N Engl J Med. 2010 Dec 02; 363(23):2233-47.
Fahy JV, Dickey BF. PMID: 21121836; PMCID: PMC4048736.
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PubMed Mentions:
719 Fields:
Translation:
Humans
-
Negative methacholine challenge tests in subjects who report physician-diagnosed asthma. Clin Exp Allergy. 2011 Jan; 41(1):46-51.
McGrath KW, Fahy JV. PMID: 21105916; PMCID: PMC3059141.
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PubMed Mentions:
8 Fields:
Translation:
Humans
-
A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010 Oct; 126(4):747-53.
Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy JV, Israel E, Jarjour N, Kraft M, Lazarus SC, Lemanske RF, Peters SP, Ramsdell J, Sorkness CA, Szefler SJ, Walter MJ, Wasserman SI, Wechsler ME, Chu HW, Martin RJ, National Heart, Lung and Blood Institute's Asthma Clinical Research Network. PMID: 20920764; PMCID: PMC2950827.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010 Oct 28; 363(18):1715-26.
Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER, National Heart, Lung, and Blood Institute Asthma Clinical Research Network. PMID: 20979471; PMCID: PMC3011177.
View in:
PubMed Mentions:
147 Fields:
Translation:
Humans
-
The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):189-94.
Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV. PMID: 20732988; PMCID: PMC3040389.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
-
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14170-5.
Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV. PMID: 20660732; PMCID: PMC2922596.
View in:
PubMed Mentions:
169 Fields:
Translation:
HumansCells
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Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol. 2010 May; 125(5):1046-1053.e8.
Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV. PMID: 20451039; PMCID: PMC2918406.
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PubMed Mentions:
118 Fields:
Translation:
HumansCells
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Identifying clinical phenotypes of asthma: steps in the right direction. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):296-7.
Fahy JV. PMID: 20130143.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Mar 01; 181(5):438-45.
Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV. PMID: 20007923.
View in:
PubMed Mentions:
41 Fields:
Translation:
Humans
-
Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009 Nov 21; 374(9703):1754-64.
Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman SI, Israel E, National Heart, Lung and Blood Institute's Asthma Clinical Research Network. PMID: 19932356; PMCID: PMC2914569.
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PubMed Mentions:
62 Fields:
Translation:
Humans
-
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):603-10.
Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. PMID: 19628779; PMCID: PMC2753788.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009 Sep 01; 180(5):388-95.
Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. PMID: 19483109; PMCID: PMC2742757.
View in:
PubMed Mentions:
747 Fields:
Translation:
HumansCells
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Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8.
Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. PMID: 19435888; PMCID: PMC2740590.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med. 2009 Aug 01; 180(3):203-10.
Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV. PMID: 19423716; PMCID: PMC2724713.
View in:
PubMed Mentions:
53 Fields:
Translation:
Humans
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Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc. 2009 May 01; 6(3):256-9.
Fahy JV. PMID: 19387026.
View in:
PubMed Mentions:
159 Fields:
Translation:
HumansCells
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Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy. 2009 Feb; 39(2):193-202.
Dougherty RH, Fahy JV. PMID: 19187331; PMCID: PMC2730743.
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PubMed Mentions:
142 Fields:
Translation:
Humans
-
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. J Allergy Clin Immunol. 2008 Nov; 122(5):944-950.e3.
Seibold MA, Donnelly S, Solon M, Innes A, Woodruff PG, Boot RG, Burchard EG, Fahy JV. PMID: 18845328; PMCID: PMC2666777.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Predicting worsening asthma control following the common cold. Eur Respir J. 2008 Dec; 32(6):1548-54.
Walter MJ, Castro M, Kunselman SJ, Chinchilli VM, Reno M, Ramkumar TP, Avila PC, Boushey HA, Ameredes BT, Bleecker ER, Calhoun WJ, Cherniack RM, Craig TJ, Denlinger LC, Israel E, Fahy JV, Jarjour NN, Kraft M, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Ramsdell JW, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Wechsler ME, National Heart, Lung and Blood Institute's Asthma Clinical Research Network. PMID: 18768579; PMCID: PMC2592508.
View in:
PubMed Mentions:
22 Fields:
Translation:
Humans
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Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15858-63.
Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. PMID: 17898169; PMCID: PMC2000427.
View in:
PubMed Mentions:
363 Fields:
Translation:
HumansCells
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Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):783-90.
Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone FT, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy JV, National Heart Lung and Blood Institute's Asthma Clinical Research Network. PMID: 17204725; PMCID: PMC1899291.
View in:
PubMed Mentions:
121 Fields:
Translation:
Humans
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The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol. 2007 Jan; 119(1):73-80.
Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA, Wechsler ME, National Heart, Lung, and Blood Institute's Asthma Clinical Research Center. PMID: 17208587; PMCID: PMC2872157.
View in:
PubMed Mentions:
80 Fields:
Translation:
Humans
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Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest. 2006 Oct; 130(4):1102-8.
Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV. PMID: 17035444.
View in:
PubMed Mentions:
85 Fields:
Translation:
HumansCells
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Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am J Respir Crit Care Med. 2007 Feb 01; 175(3):228-34.
Deykin A, Wechsler ME, Boushey HA, Chinchilli VM, Kunselman SJ, Craig TJ, DiMango E, Fahy JV, Kraft M, Leone F, Lazarus SC, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. PMID: 16973987; PMCID: PMC1899264.
View in:
PubMed Mentions:
23 Fields:
Translation:
Humans
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Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils. Am J Respir Crit Care Med. 2006 Nov 01; 174(9):1018-24.
Hays SR, Fahy JV. PMID: 16917116; PMCID: PMC2648101.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation. J Allergy Clin Immunol. 2006 Jun; 117(6):1230-2.
Fahy JV. PMID: 16750979.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
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Effects of multiday exposure to ozone on airway inflammation as determined using sputum induction. Environ Health Perspect. 2006 Feb; 114(2):209-12.
Ratto J, Wong H, Liu J, Fahy J, Boushey H, Solomon C, Balmes J. PMID: 16451856; PMCID: PMC1367833.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCellsPHPublic Health
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beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med. 2006 Mar 01; 173(5):519-26.
Wechsler ME, Lehman E, Lazarus SC, Lemanske RF, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. PMID: 16322642; PMCID: PMC2662935.
View in:
PubMed Mentions:
65 Fields:
Translation:
Humans
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Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug; 116(2):305-11.
Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. PMID: 16083784.
View in:
PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Induced sputum evaluation in microwave popcorn production workers. Chest. 2005 Aug; 128(2):991-7.
Akpinar-Elci M, Stemple KJ, Enright PL, Fahy JV, Bledsoe TA, Kreiss K, Weissman DN. PMID: 16100197.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsPHPublic Health
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Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 2005 Apr 14; 352(15):1519-28.
Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. PMID: 15829533.
View in:
PubMed Mentions:
98 Fields:
Translation:
HumansCTClinical Trials
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Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005 Apr; 115(4):720-7.
Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E, Asthma Clinical Research Network, National Heart, Lung, and Blood Institute/NIH. PMID: 15805990.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansCellsCTClinical Trials
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Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004 Oct 23-29; 364(9444):1505-12.
Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. PMID: 15500895.
View in:
PubMed Mentions:
152 Fields:
Translation:
HumansCTClinical Trials
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Adenosine up-regulation of the mucin gene, MUC2, in asthma. FASEB J. 2004 Nov; 18(14):1770-2.
McNamara N, Gallup M, Khong A, Sucher A, Maltseva I, Fahy J, Basbaum C. PMID: 15345696.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):583-93.
Djukanovic R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, Holgate ST, Fahy JV. PMID: 15172898.
View in:
PubMed Mentions:
167 Fields:
Translation:
HumansCTClinical Trials
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Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004 May 01; 169(9):1001-6.
Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. PMID: 14726423.
View in:
PubMed Mentions:
123 Fields:
Translation:
HumansCells
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Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses. Clin Exp Allergy. 2004 Jan; 34(1):77-84.
Avila PC, Boushey HA, Wong H, Grundland H, Liu J, Fahy JV. PMID: 14720266.
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PubMed Mentions:
4 Fields:
Translation:
HumansCTClinical Trials
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Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma. Am J Med. 2003 Dec 01; 115(8):620-6.
Janson SL, Fahy JV, Covington JK, Paul SM, Gold WM, Boushey HA. PMID: 14656614.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCellsCTClinical Trials
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Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol. 2003 Dec; 112(6):1243-5.
Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG. PMID: 14657892.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
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The role of mucus in fatal asthma. Am J Med. 2003 Jul; 115(1):68-9.
Hays SR, Fahy JV. PMID: 12867239.
View in:
PubMed Mentions:
21 Fields:
Translation:
Humans
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Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. Chest. 2003 Jul; 124(1):42-50.
Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF, Szefler SJ, Asthma Clinical Research Network. PMID: 12853500.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCellsCTClinical Trials
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Goblet cell and mucin gene abnormalities in asthma. Chest. 2002 Dec; 122(6 Suppl):320S-326S.
Fahy JV. PMID: 12475809.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Standardised methodology of sputum induction and processing. Eur Respir J Suppl. 2002 Sep; 37:1s-2s.
Djukanovic R, Sterk PJ, Fahy JV, Hargreave FE. PMID: 12361359.
View in:
PubMed Mentions:
81 Fields:
Translation:
Humans
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Airway remodeling in asthma. Semin Respir Crit Care Med. 2002 Aug; 23(4):361-7.
Woodruff PG, Fahy JV. PMID: 16088629.
View in:
PubMed Mentions:
9 Fields:
-
Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med. 2002 May 15; 165(10):1377-83.
Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Peters SP, Sorkness CA. PMID: 12016099.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCTClinical Trials
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A role for neutrophils in asthma? Am J Med. 2002 Apr 15; 112(6):498-500.
Woodruff PG, Fahy JV. PMID: 11959064.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002 Mar; 109(3):410-8.
Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF, Mauger E, Peters SP, Sorkness CA, Asthma Clinical Research Network of the National Heart Lung, and Blood Institute. PMID: 11897984.
View in:
PubMed Mentions:
157 Fields:
Translation:
HumansCTClinical Trials
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Practical management of acute asthma in adults. Respir Care. 2002 Feb; 47(2):171-82.
Hallstrand TS, Fahy JV. PMID: 11812274.
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PubMed Mentions: Fields:
Translation:
Humans
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Quality control within the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec; 22(6 Suppl):207S-21S.
Martin RJ, Kephart DK, Dyer AM, Fahy J, Kraft M, Asthma Clinical Trials Network. PMID: 11728625.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
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Epithelial desquamation in asthma. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 1):1997.
Ordoñez CL, Fahy JV. PMID: 11780603.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Remodeling of the airway epithelium in asthma. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S46-51.
Fahy JV. PMID: 11734466.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol. 2001 Nov; 108(5):753-8.
Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. PMID: 11692100.
View in:
PubMed Mentions:
77 Fields:
Translation:
Humans
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Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects. J Allergy Clin Immunol. 2001 Nov; 108(5):784-90.
Hays SR, Woodruff PG, Khashayar R, Ferrando RE, Liu J, Fung P, Zhao CQ, Wong HH, Fahy JV. PMID: 11692105.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
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A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects. Genome Res. 2001 Sep; 11(9):1473-83.
Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV. PMID: 11544191.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Asthma: prevalence, pathogenesis, and prospects for novel therapies. JAMA. 2001 Jul 25; 286(4):395-8.
Woodruff PG, Fahy JV. PMID: 11466111.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCellsPHPublic Health
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Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA. 2001 May 23-30; 285(20):2583-93.
Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ, Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute. PMID: 11368732.
View in:
PubMed Mentions:
94 Fields:
Translation:
HumansCTClinical Trials
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Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med. 2001 May; 163(6):1470-5.
Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ, NHLBI Asthma Clinical Research Network. PMID: 11371420.
View in:
PubMed Mentions:
53 Fields:
Translation:
HumansCellsCTClinical Trials
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Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA. 2001 May 23-30; 285(20):2594-603.
Lemanske RF, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ, Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute. PMID: 11368733.
View in:
PubMed Mentions:
71 Fields:
Translation:
HumansCTClinical Trials
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The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research. Chest. 2001 Apr; 119(4):1027-33.
Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ, Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. PMID: 11296165.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
"Reactive airways disease". A lazy term of uncertain meaning that should be abandoned. Am J Respir Crit Care Med. 2001 Mar; 163(4):822-3.
Fahy JV, O'Byrne PM. PMID: 11282751.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med. 2001 Feb; 163(2):517-23.
Ordoñez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV. PMID: 11179133.
View in:
PubMed Mentions:
178 Fields:
Translation:
HumansCells
-
Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med. 2001 Feb; 163(2):511-6.
Takeyama K, Fahy JV, Nadel JA. PMID: 11179132.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansCells
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Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol. 2001 Jan-Mar; 124(1-3):183-6.
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. PMID: 11306963.
View in:
PubMed Mentions:
24 Fields:
Translation:
Humans
-
Histopathology of fatal asthma: drowning in mucus. Pediatr Pulmonol. 2001; Suppl 23:88-9.
Rubin BK, Tomkiewicz R, Fahy JV, Green FH. PMID: 11886162; PMCID: PMC7167957.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Use of biological markers of airway inflammation to detect the efficacy of nurse-delivered asthma education. Heart Lung. 2001 Jan-Feb; 30(1):39-46.
Janson S, Hardie G, Fahy J, Boushey H. PMID: 11174366.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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Targeting cytokines in asthma therapy: round one. Lancet. 2000 Dec 23-30; 356(9248):2114-6.
Boushey HA, Fahy JV. PMID: 11191533.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Epithelial desquamation in asthma: artifact or pathology? Am J Respir Crit Care Med. 2000 Dec; 162(6):2324-9.
Ordoñez C, Ferrando R, Hyde DM, Wong HH, Fahy JV. PMID: 11112158.
View in:
PubMed Mentions:
29 Fields:
Translation:
Humans
-
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000 Jul; 162(1):75-80.
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. PMID: 10903223.
View in:
PubMed Mentions:
122 Fields:
Translation:
HumansCTClinical Trials
-
Predictors of late asthmatic response. Logistic regression and classification tree analyses. Am J Respir Crit Care Med. 2000 Jun; 161(6):2092-5.
Avila PC, Segal MR, Wong HH, Boushey HA, Fahy JV. PMID: 10852792.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Reducing IgE levels as a strategy for the treatment of asthma. Clin Exp Allergy. 2000 Jun; 30 Suppl 1:16-21.
Fahy JV. PMID: 10849469.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med. 2000 Apr; 161(4 Pt 1):1185-90.
Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV. PMID: 10764310.
View in:
PubMed Mentions:
134 Fields:
Translation:
HumansCells
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Cytotoxic prenylxanthones from Garcinia bracteata. J Nat Prod. 2000 Apr; 63(4):441-6.
Thoison O, Fahy J, Dumontet V, Chiaroni A, Riche C, Tri MV, Sévenet T. PMID: 10785410.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Low- and high-dose fluticasone propionate in asthma; effects during and after treatment. Eur Respir J. 2000 Jan; 15(1):11-8.
Gershman NH, Wong HH, Liu JT, Fahy JV. PMID: 10678614.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCTClinical Trials
-
Airway inflammation and remodeling in asthma. Curr Opin Pulm Med. 2000 Jan; 6(1):15-20.
Fahy JV, Corry DB, Boushey HA. PMID: 10608420.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansCells
-
Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J Clin Invest. 1999 Nov; 104(10):1375-82.
Longphre M, Li D, Gallup M, Drori E, Ordoñez CL, Redman T, Wenzel S, Bice DE, Fahy JV, Basbaum C. PMID: 10562299; PMCID: PMC409835.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects. Am J Respir Crit Care Med. 1999 Sep; 160(3):1023-7.
Fahy JV, Cockcroft DW, Boulet LP, Wong HH, Deschesnes F, Davis EE, Ruppel J, Su JQ, Adelman DC. PMID: 10471635.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCTClinical Trials
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Fractional analysis of sequential induced sputum samples during sputum induction: evidence that different lung compartments are sampled at different time points. J Allergy Clin Immunol. 1999 Aug; 104(2 Pt 1):322-8.
Gershman NH, Liu H, Wong HH, Liu JT, Fahy JV. PMID: 10452752.
View in:
PubMed Mentions:
20 Fields:
Translation:
Humans
-
The effect of methacholine challenge on the cellular composition of induced sputum. J Allergy Clin Immunol. 1999 May; 103(5 Pt 1):957-9.
Gershman NH, Fahy JV. PMID: 10329838.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
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Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro. Am J Physiol. 1999 01; 276(1):L28-34.
Liu H, Lazarus SC, Caughey GH, Fahy JV. PMID: 9887052.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
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A safe, simple, standardized method should be used for sputum induction for research purposes. Clin Exp Allergy. 1998 Sep; 28(9):1047-9.
Fahy JV. PMID: 9761006.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Targeting IgE with monoclonal antibodies: the future is now. Clin Exp Allergy. 1998 Jun; 28(6):664-7.
Fahy JV, Boushey HA. PMID: 9677128.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation. Eur Respir J. 1998 Jun; 11(6):1240-7.
Fahy JV, Boushey HA. PMID: 9657561.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCTClinical Trials
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Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma. Eur Respir J Suppl. 1998 Mar; 26:9S-12S.
Kips JC, Fahy JV, Hargreave FE, Ind PW, in't Veen JC. PMID: 9585872.
View in:
PubMed Mentions:
14 Fields:
Translation:
Humans
-
An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Am J Respir Crit Care Med. 1997 Oct; 156(4 Pt 1):1165-71.
Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ. PMID: 9351617.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCTClinical Trials
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Safety of one method of sputum induction in asthmatic subjects. Am J Respir Crit Care Med. 1997 Jul; 156(1):299-303.
Wong HH, Fahy JV. PMID: 9230765.
View in:
PubMed Mentions:
16 Fields:
Translation:
Humans
-
The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med. 1997 Jun; 155(6):1828-34.
Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, Fick RB, Boushey HA. PMID: 9196082.
View in:
PubMed Mentions:
114 Fields:
Translation:
HumansCTClinical Trials
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Similar RANTES levels in healthy and asthmatic airways by immunoassay and in situ hybridization. Am J Respir Crit Care Med. 1997 Mar; 155(3):1095-100.
Fahy JV, Figueroa DJ, Wong HH, Liu JT, Abrams JS. PMID: 9116993.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Comparison of two methods of collecting induced sputum in asthmatic subjects. Eur Respir J. 1996 Dec; 9(12):2448-53.
Gershman NH, Wong HH, Liu JT, Mahlmeister MJ, Fahy JV. PMID: 8980952.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med. 1996 Sep 19; 335(12):841-7.
Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. PMID: 8778601.
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PubMed Mentions:
62 Fields:
Translation:
HumansCTClinical Trials
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High-resolution computed tomography of airway changes after induced bronchoconstriction and bronchodilation in asthmatic volunteers. Acad Radiol. 1996 May; 3(5):389-94.
Kee ST, Fahy JV, Chen DR, Gamsu G. PMID: 8796690.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Controversies involving inhaled beta-agonists and inhaled corticosteroids in the treatment of asthma. Clin Chest Med. 1995 Dec; 16(4):715-33.
Fahy JV, Boushey HA. PMID: 8565410.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. Am J Respir Crit Care Med. 1995 Sep; 152(3):879-84.
Fahy JV, Wong HH, Geppetti P, Reis JM, Harris SC, Maclean DB, Nadel JA, Boushey HA. PMID: 7663799.
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PubMed Mentions:
25 Fields:
Translation:
HumansCTClinical Trials
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Basic mechanisms of asthma. Environ Health Perspect. 1995 Sep; 103 Suppl 6:229-33.
Boushey HA, Fahy JV. PMID: 8549478; PMCID: PMC1518922.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Analysis of induced sputum after air and ozone exposures in healthy subjects. Environ Res. 1995 Aug; 70(2):77-83.
Fahy JV, Wong HH, Liu JT, Boushey HA. PMID: 8674483.
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PubMed Mentions:
7 Fields:
Translation:
HumansCellsCTClinical Trials
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Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. Am J Respir Crit Care Med. 1995 Jul; 152(1):53-8.
Fahy JV, Wong H, Liu J, Boushey HA. PMID: 7599862.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol. 1995 Apr; 95(4):843-52.
Fahy JV, Kim KW, Liu J, Boushey HA. PMID: 7722165.
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PubMed Mentions:
171 Fields:
Translation:
HumansCells
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Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors. Eur Respir J. 1995 Jan; 8(1):10-4.
Schuster A, Fahy JV, Ueki I, Nadel JA. PMID: 7744174.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Chronic pulmonary disorders in sickle cell disease: findings at thin-section CT. Radiology. 1994 Dec; 193(3):807-11.
Aquino SL, Gamsu G, Fahy JV, Claster S, Embury SH, Mentzer WC, Vichinsky EP. PMID: 7972829.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol. 1994 Nov; 94(5):861-9.
Claman DM, Boushey HA, Liu J, Wong H, Fahy JV. PMID: 7963155.
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PubMed Mentions:
18 Fields:
Translation:
HumansCellsCTClinical Trials
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Analysis of cellular and biochemical constituents of induced sputum after allergen challenge: a method for studying allergic airway inflammation. J Allergy Clin Immunol. 1994 Jun; 93(6):1031-9.
Fahy JV, Liu J, Wong H, Boushey HA. PMID: 8006308.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways. Am J Respir Cell Mol Biol. 1994 May; 10(5):538-45.
Steiger D, Fahy J, Boushey H, Finkbeiner WE, Basbaum C. PMID: 8179917.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis. 1993 May; 147(5):1132-7.
Fahy JV, Steiger DJ, Liu J, Basbaum CB, Finkbeiner WE, Boushey HA. PMID: 8484621.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Disappearance of eosinophils from bronchoalveolar lavage fluid after patient education and high-dose inhaled corticosteroids: a case report. Heart Lung. 1993 May-Jun; 22(3):235-8.
Janson-Bjerklie S, Fahy J, Geaghan S, Golden J. PMID: 8491659.
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Translation:
HumansCells
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Lack of effect of prophylactic aerosolized pentamidine on the detection of Pneumocystis carinii in induced sputum or bronchoalveolar lavage specimens. Arch Pathol Lab Med. 1993 May; 117(5):493-6.
Ng VL, Geaghan SM, Leoung G, Shiboski S, Fahy J, Schnapp L, Yajko DM, Hopewell PC, Hadley WK. PMID: 8489338.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis. 1993 May; 147(5):1126-31.
Fahy JV, Liu J, Wong H, Boushey HA. PMID: 8484620.
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PubMed Mentions:
55 Fields:
Translation:
Humans
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Chronic eosinophilic pneumonia. A long-term follow-up of 12 patients. Chest. 1993 Jan; 103(1):162-5.
Naughton M, Fahy J, FitzGerald MX. PMID: 8031327.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Mucus hypersecretion in bronchiectasis. The role of neutrophil proteases. Am Rev Respir Dis. 1992 Dec; 146(6):1430-3.
Fahy JV, Schuster A, Ueki I, Boushey HA, Nadel JA. PMID: 1280928.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Effect of aerosolized pentamidine prophylaxis on the clinical severity and diagnosis of Pneumocystis carinii pneumonia. Am Rev Respir Dis. 1992 Oct; 146(4):844-8.
Fahy JV, Chin DP, Schnapp LM, Steiger DJ, Schaumberg TH, Geaghan SM, Klein JS, Hopewell PC. PMID: 1416408.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus. Arch Intern Med. 1992 May; 152(5):1073-7.
Schnapp LM, Geaghan SM, Campagna A, Fahy J, Steiger D, Ng V, Hadley WK, Hopewell PC, Stansell JD. PMID: 1304722.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Ir J Med Sci. 1991 Jun; 160(6):173-5.
Mulherin D, Fahy J, Grant W, Keogan M, Kavanagh B, FitzGerald M. PMID: 1752740.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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"Slurry lung": a report of three cases. Thorax. 1991 May; 46(5):394-5.
Fahy JV, Walley T, Gibney RT, McCabe M, FitzGerald MX. PMID: 2068701; PMCID: PMC1020977.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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A chest radiograph scoring system in adult cystic fibrosis: correlation with pulmonary function. Clin Radiol. 1991 May; 43(5):308-10.
O'Laoide RM, Fahy J, Coffey M, Ward K, Malone D, Fitzgerald MX, Masterson J. PMID: 2036754.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Bacteraemia and fungaemia in adults with cystic fibrosis. J Infect. 1991 May; 22(3):241-5.
Fahy JV, Keoghan MT, Crummy EJ, FitzGerald MX. PMID: 1906505.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Haemopericardium and cardiac tamponade complicating pulmonary lymphangioleiomyomatosis. Thorax. 1991 Mar; 46(3):222.
Fahy J, Toner M, O'Sullivan J, FitzGerald MX. PMID: 2028440; PMCID: PMC463055.
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Translation:
Humans