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John Fahy, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
AddressCore Campus, HSE
San Francisco CA 94143
Phone415-476-9940
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Sequential, Multiple Assignment, Randomized Trial in Severe Asthma Protocol (SMART-SA)
    NIH/NHLBI UG1HL139106Sep 23, 2017 - Jun 30, 2023
    Role: Principal Investigator
    Carbohydrate-based Therapy for Lung Disease
    NIH/NHLBI P01HL128191Sep 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    INNATE AND ADAPTIVE IMMUNE RESPONSES IN TH2-HIGH ASTHMA
    NIH/NHLBI P01HL107202Aug 15, 2012 - May 31, 2017
    Role: Principal Investigator
    Clinical and Molecular Phenotypes of Severe Asthma
    NIH/NHLBI U10HL109146Aug 8, 2011 - Jul 31, 2017
    Role: Principal Investigator
    Preventing fucose-dependent binding of aspergillus and pseudomonas to lung mucin
    NIH/NHLBI P50HL107191May 1, 2011 - Apr 30, 2014
    Role: Principal Investigator
    Mechanism of mucus pathology in asthma exacerbations
    NIH/NHLBI R01HL080414Jul 1, 2005 - Apr 30, 2020
    Role: Principal Investigator
    T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPD
    NIH/NHLBI R01HL066564Aug 1, 2001 - Jul 31, 2005
    Role: Principal Investigator
    GOBLET CELL DYSFUNCTION IN ASTHMA
    NIH/NHLBI R01HL061662Dec 7, 1998 - Nov 30, 2003
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy J, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR. Pruning of the Pulmonary Vasculature in Asthma: The SARP Cohort. Am J Respir Crit Care Med. 2018 Apr 19. PMID: 29672122.
      View in: PubMed
    2. DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy J, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10; 18(1):58. PMID: 29631584.
      View in: PubMed
    3. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy J, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 Mar 22; 3(6). PMID: 29563345.
      View in: PubMed
    4. Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy J. Refractory Airway Type-2 Inflammation in a Large Subgroup of Asthmatics treated with Inhaled Corticosteroids. J Allergy Clin Immunol. 2018 Mar 07. PMID: 29524537.
      View in: PubMed
    5. Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy J. Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov. 2018; 4:7. PMID: 29449961.
      View in: PubMed
    6. Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy J. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest. 2018 Mar 01; 128(3):997-1009. PMID: 29400693.
      View in: PubMed
    7. Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy J, Woodruff PG. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 Feb 01; 197(3):313-324. PMID: 29064281.
      View in: PubMed
    8. MacNee W, Fahy J, Nicod LP, Kolls J. Purpose of the Conference: The 2017 Transatlantic Conference on Lung Diseases. Ann Am Thorac Soc. 2017 Nov; 14(Supplement_5):S313. PMID: 29161085.
      View in: PubMed
    9. Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy J, Peters MC. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2018 Feb; 153(2):378-386. PMID: 29080709.
      View in: PubMed
    10. Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy J, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A. After asthma: redefining airways diseases. Lancet. 2018 01 27; 391(10118):350-400. PMID: 28911920.
      View in: PubMed
    11. Teague WG, Phillips BR, Fahy J, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):545-554.e4. PMID: 28866107.
      View in: PubMed
    12. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy J, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724795.
      View in: PubMed
    13. Dunican EM, Fahy J. Asthma and corticosteroids: time for a more precise approach to treatment. Eur Respir J. 2017 Jun; 49(6). PMID: 28663322.
      View in: PubMed
    14. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 Jun 01; 195(11):1439-1448. PMID: 27967215.
      View in: PubMed
    15. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy J, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). PMID: 28783702.
      View in: PubMed
    16. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy J, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):302-313. PMID: 27556234.
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    17. MacNee W, Fahy J, Nicod LP, Kolls JK. Purpose of the Conference: 2016 Transatlantic Airway Conference. Ann Am Thorac Soc. 2016 Dec; 13(Supplement_5):S395. PMID: 28005426.
      View in: PubMed
    18. Lachowicz-Scroggins ME, Yuan S, Kerr SC, Dunican EM, Yu M, Carrington SD, Fahy J. Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma. Am J Respir Crit Care Med. 2016 11 15; 194(10):1296-1299. PMID: 27845589.
      View in: PubMed
    19. Dickey BF, Fahy J, Kesimer M, Boucher RC, Evans CM, Thornton D. Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016 Nov; 13(11):2103-2104. PMID: 27831803.
      View in: PubMed
    20. Luyster FS, Strollo PJ, Holguin F, Castro M, Dunican EM, Fahy J, Gaston B, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. Chest. 2016 Dec; 150(6):1242-1250. PMID: 27720882.
      View in: PubMed
    21. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy J, Seibold MA. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 Sep 08; 1(14):e87871. PMID: 27699235.
      View in: PubMed
    22. Peters MC, Fahy J. Metabolic consequences of obesity as an "outside in" mechanism of disease severity in asthma. Eur Respir J. 2016 Aug; 48(2):291-3. PMID: 27478182.
      View in: PubMed
    23. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy J. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8765-70. PMID: 27432971; PMCID: PMC4978244.
    24. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy J. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 07; 4(7):574-584. PMID: 27283230.
      View in: PubMed
    25. Gordon ED, Locksley RM, Fahy J. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 05 01; 193(9):935-6. PMID: 27128698; PMCID: PMC4872659 [Available on 05/01/17].
    26. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy J, Frank JA. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin Immunol. 2017 Jan; 139(1):72-81.e1. PMID: 27215490.
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    27. Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy J. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr; 12(4):e1005555. PMID: 27058347; PMCID: PMC4825926.
    28. Reber LL, Fahy J. Mast cells in asthma: biomarker and therapeutic target. Eur Respir J. 2016 Apr; 47(4):1040-2. PMID: 27037311.
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    29. Fahy J. Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S78-82. PMID: 27027957; PMCID: PMC5015736 [Available on 03/01/17].
    30. Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy J, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma. An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Dec 01; 192(11):1366-72. PMID: 26305520; PMCID: PMC4731702 [Available on 12/01/16].
    31. Dunican EM, Fahy J. The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S144-9. PMID: 26595730.
      View in: PubMed
    32. MacNee W, Fahy J, Nicod L, Kolls J. Purpose of the Conference: 2015 Transatlantic Airway Conference. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S111. PMID: 26595725.
      View in: PubMed
    33. Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy J. Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med. 2015 Feb 25; 7(276):276ra27. PMID: 25717100; PMCID: PMC4403633.
    34. Fahy J. Type 2 inflammation in asthma--present in most, absent in many. Nat Rev Immunol. 2015 Jan; 15(1):57-65. PMID: 25534623; PMCID: PMC4390063.
    35. MacNee W, Fahy J, Nicod L, Kolls J. Twenty-Ninth Transatlantic Airway Conference. Innate and adaptive immune responses in airway disease. Purpose of the conference. Ann Am Thorac Soc. 2014 Dec; 11 Suppl 5:S233. PMID: 25525724.
      View in: PubMed
    36. Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy J, Arron JR, Woodruff PG, Ansel KM. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70. PMID: 25362490; PMCID: PMC4233009.
    37. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy J, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147; PMCID: PMC4051692.
    38. Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy J. Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1005-7. PMID: 24735037; PMCID: PMC4098098.
    39. Locksley RM, Fahy J. Asthma and the flu: a tricky two-step. Immunol Cell Biol. 2014 May-Jun; 92(5):389-91. PMID: 24687019; PMCID: PMC4396068.
    40. Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy J. Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S139-45. PMID: 24754822; PMCID: PMC4112503.
    41. Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy J, Chignard M, Imberty A, Wimmerova M. A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity. PLoS One. 2013; 8(12):e83077. PMID: 24340081; PMCID: PMC3858362.
    42. Fahy J. Chair's summary: Mechanisms of relevance to clinical heterogeneity of asthma and chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S108. PMID: 24313759.
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    43. MacNee W, Fahy J, Nicod L, Wanner A. Purpose of the conference. Ann Am Thorac Soc. 2013 Dec; 10 Suppl:S107. PMID: 24313758.
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    44. Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy J. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb; 133(2):388-94. PMID: 24075231.
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    45. Peters MC, Fahy J. Type 2 immune responses in obese individuals with asthma. Am J Respir Crit Care Med. 2013 Sep 15; 188(6):633-4. PMID: 24032378.
      View in: PubMed
    46. Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy J, Woodruff PG. A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013 Jul 17; 3(1):24. PMID: 23866775; PMCID: PMC3724712.
    47. Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy J, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. An integrated nano-scale approach to profile miRNAs in limited clinical samples. Am J Clin Exp Immunol. 2012 Nov 30; 1(2):70-89. PMID: 23304658.
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    48. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy J, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 01; 187(1):28-33. PMID: 23144325; PMCID: PMC3570642.
    49. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy J, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16354-9. PMID: 22988107; PMCID: PMC3479591.
    50. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy J, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12; 308(10):987-97. PMID: 22968888; PMCID: PMC3697088.
    51. Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy J, Woodruff PG, Harris JM, Arron JR. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012 Sep; 130(3):647-654.e10. PMID: 22857879.
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    52. Diez D, Goto S, Fahy J, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE. Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. BMC Med Genomics. 2012 Jun 19; 5:27. PMID: 22713245; PMCID: PMC3408345.
    53. Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy J, Leung DY. Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012; 7(5):e36631. PMID: 22606276; PMCID: PMC3350517.
    54. Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy J, Hamilton RG, Hunt JF, Kita H, Liu AH, Panettieri RA, Schleimer RP, Minnicozzi M. Asthma outcomes: biomarkers. J Allergy Clin Immunol. 2012 Mar; 129(3 Suppl):S9-23. PMID: 22386512; PMCID: PMC3390196.
    55. McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, Fahy J. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):612-9. PMID: 22268133; PMCID: PMC3326288.
    56. Fahy J, Locksley RM. The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):390-2. PMID: 21844510.
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    57. Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, Kocan KM, Fahy J, Nganga LW, Ronmark E, Cooper PJ, Platts-Mills TA. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-a-1,3-galactose. J Allergy Clin Immunol. 2011 May; 127(5):1286-93.e6. PMID: 21453959.
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    58. Chabre YM, Brisebois PP, Abbassi L, Kerr SC, Fahy J, Marcotte I, Roy R. Hexaphenylbenzene as a rigid template for the straightforward syntheses of "star-shaped" glycodendrimers. J Org Chem. 2011 Jan 21; 76(2):724-7. PMID: 21190367; PMCID: PMC3981551.
    59. Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy J, Woodruff PG, Arron JR. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol. 2011 Feb 01; 186(3):1861-9. PMID: 21187436; PMCID: PMC3981556.
    60. Fahy J, Dickey BF. Airway mucus function and dysfunction. N Engl J Med. 2010 Dec 02; 363(23):2233-47. PMID: 21121836; PMCID: PMC4048736.
    61. Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy J, Israel E, Jarjour N, Kraft M, Lazarus SC, Lemanske RF, Peters SP, Ramsdell J, Sorkness CA, Szefler SJ, Walter MJ, Wasserman SI, Wechsler ME, Chu HW, Martin RJ. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010 Oct; 126(4):747-53. PMID: 20920764; PMCID: PMC2950827.
    62. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy J, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010 Oct 28; 363(18):1715-26. PMID: 20979471.
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    63. Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy J. The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):189-94. PMID: 20732988; PMCID: PMC3040389.
    64. Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy J. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14170-5. PMID: 20660732; PMCID: PMC2922596.
    65. Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy J. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. J Allergy Clin Immunol. 2010 May; 125(5):1046-1053.e8. PMID: 20451039; PMCID: PMC2918406.
    66. Fahy J. Identifying clinical phenotypes of asthma: steps in the right direction. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):296-7. PMID: 20130143.
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    85. Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy J, Erle DJ. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug; 116(2):305-11. PMID: 16083784.
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    90. Djukanovic R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, Holgate ST, Fahy J. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):583-93. PMID: 15172898.
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    91. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy J. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004 May 01; 169(9):1001-6. PMID: 14726423.
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    92. Janson SL, Fahy J, Covington JK, Paul SM, Gold WM, Boushey HA. Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma. Am J Med. 2003 Dec 01; 115(8):620-6. PMID: 14656614.
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    93. Ferrando RE, Nyengaard JR, Hays SR, Fahy J, Woodruff PG. Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol. 2003 Dec; 112(6):1243-5. PMID: 14657892.
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    95. Hays SR, Fahy J. The role of mucus in fatal asthma. Am J Med. 2003 Jul; 115(1):68-9. PMID: 12867239.
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    96. Fahy J. Goblet cell and mucin gene abnormalities in asthma. Chest. 2002 Dec; 122(6 Suppl):320S-326S. PMID: 12475809.
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    97. Woodruff PG, Fahy J. Airway remodeling in asthma. Semin Respir Crit Care Med. 2002 Aug; 23(4):361-7. PMID: 16088629.
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    99. Woodruff PG, Fahy J. A role for neutrophils in asthma? Am J Med. 2002 Apr 15; 112(6):498-500. PMID: 11959064.
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