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Stephanie Christenson, MD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-443-9244
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    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin, Madison, Madison, WIB.S.05/2002
    Medical College of Wisconsin, WisconsinM.D.05/2006
    University of California, San FranciscoM.A.S.05/2015Clinical Research

    Collapse Overview 
    Collapse Overview
    Dr. Christenson is an Assistant Professor at the University of California, San Francisco in the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine. She serves as an attending physician in the Critical Care Unit and Adult Pulmonary Clinic. Dr. Christenson obtained her undergraduate degree at University of Wisconsin, Madison and her medical degree at the Medical College of Wisconsin. She completed her residency training as well as a year of research training in computational biology at Boston Medical Center. She then came to UCSF for fellowship in Pulmonary and Critical Care Medicine where she also obtained a Master’s in Clinical Research and has since joined faculty.

    Dr. Christenson’s research program focuses on airway genomics with an emphasis on using innovative computational tools and systems biology to study complex airway disease. She has primarily focused on dissecting the heterogeneity of airway disease by identifying biologically distinct subgroups (molecular phenotypes) that may respond better to targeted therapeutics using genomic signatures.


    Collapse Research 
    Collapse Research Activities and Funding
    Identifying the Th2 endotype in COPD: clinical and pathologic implications
    NIH/NHLBI K23HL123778Jul 1, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Common genomic mechanisms of disease across asthma and COPD
    NIH/NHLBI F32HL117598Jan 1, 2014 - Dec 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Maselli DJ, Hardin M, Christenson SA, Hanania NA, Hersh CP, Adams SG, Anzueto A, Peters JI, Han MK, Martinez FJ. Clinical Approach to the Therapy of Asthma-COPD Overlap. Chest. 2018 Aug 02. PMID: 30077690.
      View in: PubMed
    2. Li X, Ortega VE, Ampleford EJ, Graham Barr R, Christenson SA, Cooper CB, Couper D, Dransfield MT, Han MLK, Hansel NN, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association study of lung function and clinical implication in heavy smokers. BMC Med Genet. 2018 Aug 01; 19(1):134. PMID: 30068317.
      View in: PubMed
    3. Wang C, Reyes de Mochel NS, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 Jul 12. PMID: 29999500.
      View in: PubMed
    4. Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N. ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues. Genome Biol. 2018 Feb 15; 19(1):36. PMID: 29548336.
      View in: PubMed
    5. Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med. 2018 Feb 15; 197(4):524-528. PMID: 28686513.
      View in: PubMed
    6. Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley P, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine Iii R, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA. At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 Feb 06. PMID: 29406779.
      View in: PubMed
    7. Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 Feb 01; 197(3):313-324. PMID: 29064281.
      View in: PubMed
    8. Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER. Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017 Dec; 5(12):956-967. PMID: 29146301.
      View in: PubMed
    9. Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM. Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. J Allergy Clin Immunol. 2018 Jan; 141(1):429-432. PMID: 28916185.
      View in: PubMed
    10. Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R, Woodruff PG, O'Neal WK, Boucher RC. Airway Mucin Concentration as a Marker of Chronic Bronchitis. N Engl J Med. 2017 09 07; 377(10):911-922. PMID: 28877023.
      View in: PubMed
    11. Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA. American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report. Am J Respir Crit Care Med. 2017 Aug 01; 196(3):375-381. PMID: 28636425.
      View in: PubMed
    12. Bartel S, Bhakta N, Christenson S. More Than Meets the Eye: Cigarette Smoke Induces Genomic Changes in the Small Airway Epithelium Independent of Histologic Changes. Am J Respir Crit Care Med. 2017 08 01; 196(3):260-262. PMID: 28762786.
      View in: PubMed
    13. Christenson SA. Flipping the kill switch. Sci Transl Med. 2017 Jun 21; 9(395). PMID: 28637925.
      View in: PubMed
    14. Christenson SA. The path of least antibiotic resistance. Sci Transl Med. 2017 05 10; 9(389). PMID: 28490666.
      View in: PubMed
    15. Martinez CH, Murray S, Barr RG, Bleecker E, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper D, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Krishnan JA, Lazarus SC, Leidy NK, O'Neal W, Martinez FJ, Paine R, Rennard SI, Tashkin DP, Woodruff PG, Han MK. Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort. Ann Am Thorac Soc. 2017 May; 14(5):636-642. PMID: 28459622.
      View in: PubMed
    16. Christenson SA. Target practice in severe asthma. Sci Transl Med. 2017 Mar 29; 9(383). PMID: 28356505.
      View in: PubMed
    17. Christenson SA, Steiling K. Shifting from Correlation to Causation: Challenges for the Future of Unbiased Molecular Studies in Inflammatory Lung Disease. Am J Respir Crit Care Med. 2017 01 01; 195(1):5-7. PMID: 28035851.
      View in: PubMed
    18. Christenson SA. The Reemergence of the Asthma-COPD Overlap Syndrome: Characterizing a Syndrome in the Precision Medicine Era. Curr Allergy Asthma Rep. 2016 Nov; 16(11):81. PMID: 27796796.
      View in: PubMed
    19. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011. PMID: 27532455.
      View in: PubMed
    20. Woodruff PG, Barr RG, Bleecker E, Christenson SA, Couper D, Curtis JL, Gouskova NA, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Lazarus SC, Martinez FJ, Paine R, Rennard S, Tashkin DP, Han MK. Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function. N Engl J Med. 2016 May 12; 374(19):1811-21. PMID: 27168432; PMCID: PMC4968204 [Available on 11/12/16].
    21. Langelier C, Christenson SA. An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus. Am J Respir Crit Care Med. 2016 Apr 01; 193(7):710-2. PMID: 27035780; PMCID: PMC4824935 [Available on 04/01/17].
    22. Gelb AF, Christenson SA, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5. PMID: 26717511.
      View in: PubMed
    23. Steiling K, Christenson SA. Targeting 'types: Precision Medicine in Pulmonary Disease. Am J Respir Crit Care Med. 2015 May 15; 191(10):1093-4. PMID: 25978565.
      View in: PubMed
    24. Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Apr 01; 191(7):758-66. PMID: 25611785; PMCID: PMC4407484.
    25. Paulin LM, Diette GB, Blanc PD, Putcha N, Eisner MD, Kanner RE, Belli AJ, Christenson S, Tashkin DP, Han M, Barr RG, Hansel NN. Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Mar 01; 191(5):557-65. PMID: 25562375; PMCID: PMC4384767.
    26. Smith BM, Hoffman EA, Rabinowitz D, Bleecker E, Christenson S, Couper D, Donohue KM, Han MK, Hansel NN, Kanner RE, Kleerup E, Rennard S, Barr RG. Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax. 2014 Nov; 69(11):987-96. PMID: 24928812; PMCID: PMC4198462.
    27. O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R, Woodruff PG, Couper DJ, Davis SM. Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med. 2014 Jan 08; 12:9. PMID: 24397870; PMCID: PMC3928911.
    28. Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med. 2013; 5(12):114. PMID: 24380442; PMCID: PMC3971345.
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