Stephanie Christenson, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address505 Parnassus Avenue, #M1292A
San Francisco CA 94117
Phone415-476-0735
ORCID ORCID Icon0000-0003-1550-2815 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin, Madison, Madison, WIB.S.05/2002
    Medical College of Wisconsin, WisconsinM.D.05/2006
    University of California, San FranciscoM.A.S.05/2015Clinical Research

    Collapse Overview 
    Collapse Overview
    Dr. Christenson is an Associate Professor at the University of California, San Francisco in the Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine. She serves as an attending physician on the Pulmonary Consult Service and in the Pulmonary Clinic. Dr. Christenson obtained her undergraduate degree at University of Wisconsin, Madison and her medical degree at the Medical College of Wisconsin. She completed her residency training as well as a year of research training in computational biology at Boston Medical Center. She then came to UCSF for fellowship in Pulmonary and Critical Care Medicine where she also obtained a Master’s in Clinical Research, after which she joined faculty.

    Dr. Christenson’s research program integrates her expertise in genomics/bioinformatics and clinical research to study chronic airway disease and the associated risk factors. Her research emphasizes innovative computational tools, systems biology approaches, and ‘omics biomarkers to better inform our understanding of the biology underlying clinical traits and outcomes in asthma, smoking, and COPD. Dr. Christenson also serves in multiple leadership roles for multi-center studies and advises industry on trials of biologic and inhaled therapies for COPD. Leadership roles include co-director of the Genetics and Genomics Subcommittee for the multi-center SPIROMICS and SOURCE studies, the UCSF site PI for the American Lung Association (ALA) Airway Clinical Research Consortium, and Disease Study Site PI for the NHGRI-funded Multi-Omics in Health and Disease (MOHD) Consortium.

    Collapse Research 
    Collapse Research Activities and Funding
    EXposomic Profiling in Airway disease to uNravel Determinants of disease in Asthma (EXPAND-Asthma) Center
    NIH U01HG013276Sep 12, 2023 - May 31, 2028
    Role: Principal Investigator
    Dissecting the Acid Ceramidase Pathway in Hepatic Fibrogenesis
    NIH R01DK134723Aug 15, 2023 - May 31, 2028
    Role: Co-Investigator
    Understanding the Origins of Early COPD
    NIH R01HL144718May 1, 2020 - Apr 30, 2025
    Role: Co-Investigator
    Integrated Analysis of Microbial and Genomic data in Obstructive Lung Disease (I AM GOLD) Study
    NIH R01HL143998Sep 15, 2019 - Jul 31, 2023
    Role: Co-Principal Investigator
    SPIROMICS II: Biological underpinnings of COPD heterogeneity and progression
    NIH U01HL137880Sep 15, 2017 - May 31, 2022
    Role: Co-Investigator
    Airway trees in the Anthropocene: Defining resilient airway trees and identifying the candidate mechanisms and etiologic factors that increase susceptibility to tobacco smoke and air pollution
    NIH R01HL130506Jul 1, 2016 - Jul 31, 2026
    Role: Co-Investigator
    American Lung Association Airways Clinical Research Center (ACRC) at UCSF
    American Lung Association Jul 1, 2016 - Jun 30, 2024
    Role: UCSF Site PI
    Identifying the Th2 endotype in COPD: clinical and pathologic implications
    NIH K23HL123778Jul 1, 2015 - Mar 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial. Lancet Respir Med. 2024 Dec 06. Singh D, Brightling CE, Rabe KF, Han MK, Christenson SA, Drummond MB, Papi A, Pavord ID, Molfino NA, Almqvist G, Kotalik A, Hellqvist Å, Golabek M, Sindhwani NS, Ponnarambil SS, COURSE study investigators. PMID: 39653044.
      View in: PubMed   Mentions:
    2. Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS). Respir Med. 2024 Oct 29; 107846. Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Bafadhel M, Christenson SA, Papi A, Singh D, Laws E, Dakin P, Maloney J, Lu X, Bauer D, Bansal A, Robinson LB, Abdulai RM. PMID: 39481660.
      View in: PubMed   Mentions:    Fields:    
    3. Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study. Chronic Obstr Pulm Dis. 2024 Sep 27; 11(5):444-459. Curtis JL, Bateman LA, Murray S, Couper DJ, Labaki WW, Freeman CM, Arnold KB, Christenson SA, Alexis NE, Kesimer M, Boucher RC, Kaner RJ, Barjaktarevic I, Cooper CB, Hoffman EA, Barr RG, Bleecker ER, Bowler RP, Comellas A, Dransfield MT, Freedman MB, Hansel NN, Krishnan JA, Marchetti N, Meyers DA, Ohar J, O'Neal WK, Ortega VE, Paine Iii R, Peters SP, Smith BM, Wedzicha JA, Wells JM, Woodruff PG, Han MK, Martinez FJ. PMID: 39159077.
      View in: PubMed   Mentions:
    4. Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study. Thorax. 2024 Sep 18; 79(10):905-914. Karp T, Faiz A, van Nijnatten J, Kerstjens HAM, Boudewijn I, Kraft M, Vonk JM, Nawijn MC, Heijink IH, Beghé B, Rabe KF, Papi A, Brightling C, Singh D, van der Molen T, Siddiqui S, Christenson S, Guryev V, van den Berge M. PMID: 39009441.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine Reduces Exacerbation Rate and Risk in Patients With Moderate to Severe COPD. Chest. 2024 Aug 27. Sciurba FC, Christenson SA, Rheault T, Bengtsson T, Rickard K, Barjaktarevic IZ. PMID: 39197510.
      View in: PubMed   Mentions:    Fields:    
    6. Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2024 07 15; 210(2):186-200. Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators. PMID: 38261629; PMCID: PMC11273318.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan. Am J Respir Crit Care Med. 2024 Jun 27. Debban CL, Ambalavanan A, Ghosh A, Li Z, Buschur KL, Ma Y, George E, Pistenmaa C, Bertoni AG, Oelsner EC, Michos ED, Moraes TJ, Jacobs DR, Christenson S, Bhatt SP, Kaner RJ, Simons E, Turvey SE, Vameghestahbanati M, Engert JC, Kirby M, Bourbeau J, Tan WC, Gabriel SB, Gupta N, Woodruff PG, Subbarao P, Ortega VE, Bleecker ER, Meyers DA, Rich SS, Hoffman EA, Barr RG, Cho MH, Bossé Y, Duan Q, Manichaikul A, Smith BM. PMID: 38935874.
      View in: PubMed   Mentions:    Fields:    
    8. Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor. Am J Respir Crit Care Med. 2024 Jun 27. Boomer J, Choi J, Alsup A, McGregor MC, Lieu J, Johnson C, Hall C, Shi X, Kim T, Goss C, Lew D, Christenson S, Woodruff PG, Hastie A, Mauger D, Wenzel SE, Hoffman EA, Schechtman KB, Castro M. PMID: 38935626.
      View in: PubMed   Mentions:    Fields:    
    9. Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells. JCI Insight. 2024 Jun 18; 9(15). Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV. PMID: 38889046; PMCID: PMC11383604.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Investigation of lactotransferrin messenger RNA expression levels as an anti-type 2 asthma biomarker. J Allergy Clin Immunol. 2024 Sep; 154(3):609-618. Li NC, Iannuzo N, Christenson SA, Langlais PR, Kraft M, Ledford JG, Li X. PMID: 38797239; PMCID: PMC11380595.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation. N Engl J Med. 2024 Jun 27; 390(24):2274-2283. Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Bafadhel M, Christenson SA, Papi A, Singh D, Laws E, Patel N, Yancopoulos GD, Akinlade B, Maloney J, Lu X, Bauer D, Bansal A, Abdulai RM, Robinson LB, NOTUS Study Investigators. PMID: 38767614.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    12. Epigenetic Reprogramming Drives Epithelial Disruption in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2024 Mar; 70(3):165-177. Yeung-Luk BH, Wally A, Swaby C, Jauregui S, Lee E, Zhang R, Chen D, Luk SH, Upadya N, Tieng E, Wilmsen K, Sherman E, Sudhakar D, Luk M, Shrivastav AK, Cao S, Ghosh B, Christenson SA, Huang YJ, Ortega VE, Biswal S, Tang WY, Sidhaye VK. PMID: 37976469; PMCID: PMC10914773.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies. Int J Chron Obstruct Pulmon Dis. 2023; 18:2795-2817. Byanova KL, Abelman R, North CM, Christenson SA, Huang L. PMID: 38050482; PMCID: PMC10693779.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Phenotypes, Etiotypes, and Endotypes of Exacerbations of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2023 11 15; 208(10):1026-1041. Bhatt SP, Agusti A, Bafadhel M, Christenson SA, Bon J, Donaldson GC, Sin DD, Wedzicha JA, Martinez FJ. PMID: 37560988; PMCID: PMC10867924.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    15. Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations. Am J Respir Crit Care Med. 2023 08 01; 208(3):247-255. Ryu MH, Yun JH, Morrow JD, Saferali A, Castaldi P, Chase R, Stav M, Xu Z, Barjaktarevic I, Han M, Labaki W, Huang YJ, Christenson S, O'Neal W, Bowler R, Sin DD, Freeman CM, Curtis JL, Hersh CP. PMID: 37286295; PMCID: PMC10395718.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History. Chronic Obstr Pulm Dis. 2023 Jul 26; 10(3):199-210. Izquierdo M, Marion CR, Genese F, Newell JD, O'Neal WK, Li X, Hawkins GA, Barjaktarevic I, Barr RG, Christenson S, Cooper CB, Couper D, Curtis J, Han MK, Hansel NN, Kanner RE, Martinez FJ, Paine R, Tejwani V, Woodruff PG, Zein JG, Hoffman EA, Peters SP, Meyers DA, Bleecker ER, Ortega VE, SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) investigators. PMID: 37199731; PMCID: PMC10484491.
      View in: PubMed   Mentions: 1  
    17. COPD Phenotyping. Respir Care. 2023 07; 68(7):871-880. Christenson SA. PMID: 37353326; PMCID: PMC10289620.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes. PLoS Genet. 2023 06; 19(6):e1010445. Van Buren E, Radicioni G, Lester S, O'Neal WK, Dang H, Kasela S, Garudadri S, Curtis JL, Han MK, Krishnan JA, Wan ES, Silverman EK, Hastie A, Ortega VE, Lappalainen T, Nawijn MC, Berge MVD, Christenson SA, Li Y, Cho MH, Kesimer M, Kelada SNP. PMID: 37352370; PMCID: PMC10325042.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD. Sci Rep. 2023 05 22; 13(1):8228. DiLillo KM, Norman KC, Freeman CM, Christenson SA, Alexis NE, Anderson WH, Barjaktarevic IZ, Barr RG, Comellas AP, Bleecker ER, Boucher RC, Couper DJ, Criner GJ, Doerschuk CM, Wells JM, Han MK, Hoffman EA, Hansel NN, Hastie AT, Kaner RJ, Krishnan JA, Labaki WW, Martinez FJ, Meyers DA, O'Neal WK, Ortega VE, Paine R, Peters SP, Woodruff PG, Cooper CB, Bowler RP, Curtis JL, Arnold KB, SPIROMICS investigators. PMID: 37217548; PMCID: PMC10203309.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts. N Engl J Med. 2023 Jul 20; 389(3):205-214. Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Cole J, Bafadhel M, Christenson SA, Papi A, Singh D, Laws E, Mannent LP, Patel N, Staudinger HW, Yancopoulos GD, Mortensen ER, Akinlade B, Maloney J, Lu X, Bauer D, Bansal A, Robinson LB, Abdulai RM, BOREAS Investigators. PMID: 37272521.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCellsCTClinical Trials
    21. Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. J Asthma. 2023 10; 60(10):1824-1835. Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). PMID: 36946148; PMCID: PMC10524756.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. Front Immunol. 2023; 14:1076772. Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA. PMID: 36999019; PMCID: PMC10043316.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    23. Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomes. J Allergy Clin Immunol. 2023 06; 151(6):1513-1524. Ginebaugh SP, Hagner M, Ray A, Erzurum SC, Comhair SAA, Denlinger LC, Jarjour NN, Castro M, Woodruff PG, Christenson SA, Bleecker ER, Meyers DA, Hastie AT, Moore WC, Mauger DT, Israel E, Levy BD, Wenzel SE, Camiolo MJ. PMID: 36796454; PMCID: PMC10257752.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 12 22; 7(24). Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. PMID: 36346670; PMCID: PMC9869973.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults. Nat Microbiol. 2022 11; 7(11):1805-1816. Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR. PMID: 36266337; PMCID: PMC9613463.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    26. Chronic obstructive pulmonary disease. Lancet. 2022 06 11; 399(10342):2227-2242. Christenson SA, Smith BM, Bafadhel M, Putcha N. PMID: 35533707.
      View in: PubMed   Mentions: 254     Fields:    Translation:Humans
    27. Characterizing COPD Symptom Variability in the Stable State Utilizing the Evaluating Respiratory Symptoms in COPD Instrument. Chronic Obstr Pulm Dis. 2022 Apr 29; 9(2):195-208. Krishnan JK, Ancy KM, Oromendia C, Hoffman KL, Easthausen I, Leidy NK, Han MK, Bowler RP, Christenson SA, Couper DJ, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Iyer AS, Paine Iii R, Peters SP, Wedzicha JA, Woodruff PG, Ballman KV, Martinez FJ, SPIROMICS Investigators. PMID: 35403414; PMCID: PMC9166327.
      View in: PubMed   Mentions: 3  
    28. The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium. Am J Respir Cell Mol Biol. 2022 04; 66(4):391-401. Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Ghias K, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ. PMID: 34982656; PMCID: PMC8990122.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    29. 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation. J Clin Invest. 2022 01 04; 132(1). Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. PMID: 34762602; PMCID: PMC8718153.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    30. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Sci Rep. 2021 12 03; 11(1):23392. Dy ABC, Langlais PR, Barker NK, Addison KJ, Tanyaratsrisakul S, Boitano S, Christenson SA, Kraft M, Meyers D, Bleecker ER, Li X, Ledford JG. PMID: 34862427; PMCID: PMC8642528.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Nov 30. Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Detweiler A, Jones NG, Wu B, Darmanis S, Lynch SV, DeRisi JL, COMET Consortium, Matthay MA, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 33791731; PMCID: PMC8010763.
      View in: PubMed   Mentions: 1  
    32. Molecular programs of fibrotic change in aging human lung. Nat Commun. 2021 11 02; 12(1):6309. Lee S, Islam MN, Boostanpour K, Aran D, Jin G, Christenson S, Matthay MA, Eckalbar WL, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya J, Wolters PJ, Bhattacharya M. PMID: 34728633; PMCID: PMC8563941.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    33. Defining Resilience to Smoking-related Lung Disease: A Modified Delphi Approach from SPIROMICS. Ann Am Thorac Soc. 2021 11; 18(11):1822-1831. Oh AL, Mularski RA, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Criner GJ, Han MK, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Paine R, Parekh TM, Peters SP, Christenson SA, Woodruff PG, SPIROMICS Smoking Resilience Group. PMID: 33631079; PMCID: PMC8641833.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):1803-1817. Lakshman Kumar P, Wilson AC, Rocco A, Cho MH, Wan E, Hobbs BD, Washko GR, Ortega VE, Christenson SA, Li X, Wells JM, Bhatt SP, DeMeo DL, Lutz SM, Rossiter H, Casaburi R, Rennard SI, Lomas DA, Labaki WW, Tal-Singer R, Bowler RP, Hersh CP, Tiwari HK, Dransfield M, Thalacker-Mercer A, Meyers DA, Silverman EK, McDonald MN, COPDGene, ECLIPSE and SPIROMICS investigators. PMID: 34523824; PMCID: PMC8718068.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. Racial Segregation and Respiratory Outcomes among Urban Black Residents with and at Risk of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2021 09 01; 204(5):536-545. Woo H, Brigham EP, Allbright K, Ejike C, Galiatsatos P, Jones MR, Oates GR, Krishnan JA, Cooper CB, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner G, Barr RG, Martinez FJ, Han M, Ortega VE, Parekh TM, Christenson S, Belz D, Raju S, Gassett A, Paulin LM, Putcha N, Kaufman JD, Hansel NN. PMID: 33971109; PMCID: PMC8491265.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    36. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 34446707; PMCID: PMC8390461.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    37. High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis. ERJ Open Res. 2021 Jul; 7(3). Chakrabarti A, Mar JS, Choy DF, Cao Y, Rathore N, Yang X, Tew GW, Li O, Woodruff PG, Brightling CE, Grimbaldeston M, Christenson SA, Bafadhel M, Rosenberger CM. PMID: 34350278; PMCID: PMC8326681.
      View in: PubMed   Mentions: 2  
    38. The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils. ERJ Open Res. 2021 Jul; 7(3). Ditz B, Sarma A, Kerstjens HAM, Liesker JJW, Bathoorn E, Vonk JM, Bernal V, Horvatovich P, Guryev V, Caldera S, Langelier C, Faiz A, Christenson SA, van den Berge M. PMID: 34235210; PMCID: PMC8255541.
      View in: PubMed   Mentions: 6  
    39. Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2021 11; 9(11):1241-1254. Radicioni G, Ceppe A, Ford AA, Alexis NE, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez FJ, Ozkan E, Paine R, Woodruff PG, O'Neal WK, Boucher RC, Kesimer M. PMID: 34058148; PMCID: PMC8570975.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    40. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Res Sq. 2021 Apr 23. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 34013247; PMCID: PMC8132240.
      View in: PubMed   Mentions:
    41. Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium. Genome Med. 2021 Apr 21; 13(1):66. Kasela S, Ortega VE, Martorella M, Garudadri S, Nguyen J, Ampleford E, Pasanen A, Nerella S, Buschur KL, Barjaktarevic IZ, Barr RG, Bleecker ER, Bowler RP, Comellas AP, Cooper CB, Couper DJ, Criner GJ, Curtis JL, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Krishnan JA, Martinez FJ, McDonald MN, Meyers DA, Paine R, Peters SP, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy BD, Li X, Moore WC, Wenzel SE, Zein J, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Langelier C, Woodruff PG, Lappalainen T, Christenson SA. PMID: 33883027; PMCID: PMC8059115.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    42. Contribution of Individual and Neighborhood Factors to Racial Disparities in Respiratory Outcomes. Am J Respir Crit Care Med. 2021 04 15; 203(8):987-997. Ejike CO, Woo H, Galiatsatos P, Paulin LM, Krishnan JA, Cooper CB, Couper DJ, Kanner RE, Bowler RP, Hoffman EA, Comellas AP, Criner GJ, Barr RG, Martinez FJ, Han MK, Martinez CH, Ortega VE, Parekh TM, Christenson SA, Thakur N, Baugh A, Belz DC, Raju S, Gassett AJ, Kaufman JD, Putcha N, Hansel NN. PMID: 33007162; PMCID: PMC8048743.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    43. Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. Am J Respir Crit Care Med. 2021 04 15; 203(8):957-968. Dunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler R, Christenson SA, Comellas A, Cooper CB, Couper D, Criner GJ, Dransfield M, Doerschuk CM, Drummond MB, Hansel NN, Han MK, Hastie AT, Hoffman EA, Krishnan JA, Lazarus SC, Martinez FJ, McCulloch CE, O'Neal WK, Ortega VE, Paine R, Peters S, Schroeder JD, Woodruff PG, Fahy JV. PMID: 33180550; PMCID: PMC8048745.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    44. The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium. bioRxiv. 2021 Feb 25. Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ. PMID: 33655249; PMCID: PMC7924269.
      View in: PubMed   Mentions:
    45. Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort. NPJ Biofilms Microbiomes. 2021 02 05; 7(1):14. Opron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, Graham Barr R, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, Dransfield MT, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Krishnan J, O'Neal WK, Ortega VE, Paine R, Peters SP, Michael Wells J, Woodruff PG, Martinez FJ, Curtis JL, Huffnagle GB, Huang YJ. PMID: 33547327; PMCID: PMC7865064.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    46. COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14. Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 33469573; PMCID: PMC7814832.
      View in: PubMed   Mentions: 3  
    47. Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects. Sci Rep. 2020 11 18; 10(1):20133. Kim V, Jeong S, Zhao H, Kesimer M, Boucher RC, Wells JM, Christenson SA, Han MK, Dransfield M, Paine R, Cooper CB, Barjaktarevic I, Bowler R, Curtis JL, Kaner RJ, O'Beirne SL, O'Neal WK, Rennard SI, Martinez FJ, Woodruff PG. PMID: 33208859; PMCID: PMC7674445.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    48. Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses. Nat Commun. 2020 11 17; 11(1):5854. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Calfee CS, Christenson SA, Kistler A, Langelier C. PMID: 33203890; PMCID: PMC7673985.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCellsPHPublic Health
    49. Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort. Chronic Obstr Pulm Dis. 2020 Oct; 7(4):370-381. Burkes RM, Ceppe AS, Couper DJ, Comellas AP, Wells JM, Peters SP, Criner GJ, Kanner RE, Paine R, Christenson SA, Cooper CB, Barjaktarevic IZ, Krishnan JA, Labaki WW, Han MK, Curtis JL, Hansel NN, Wise RA, Drummond MB, SPIROMICS collaborators. PMID: 33108110; PMCID: PMC7883905.
      View in: PubMed   Mentions: 6  
    50. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557). Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. PMID: 32817366; PMCID: PMC7976849.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    51. Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. J Allergy Clin Immunol. 2021 03; 147(3):894-909. Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). PMID: 32795586; PMCID: PMC7876167.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    52. Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2020 08 01; 202(3):371-382. Jolliffe DA, Stefanidis C, Wang Z, Kermani NZ, Dimitrov V, White JH, McDonough JE, Janssens W, Pfeffer P, Griffiths CJ, Bush A, Guo Y, Christenson S, Adcock IM, Chung KF, Thummel KE, Martineau AR. PMID: 32186892; PMCID: PMC7397796.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    53. COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids. Am J Respir Crit Care Med. 2020 07 01; 202(1):83-90. Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV. PMID: 32348692; PMCID: PMC7328313.
      View in: PubMed   Mentions: 241     Fields:    Translation:HumansCellsPHPublic Health
    54. Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS. Sci Rep. 2020 06 29; 10(1):10562. Zhang WZ, Oromendia C, Kikkers SA, Butler JJ, O'Beirne S, Kim K, O'Neal WK, Freeman CM, Christenson SA, Peters SP, Wells JM, Doerschuk C, Putcha N, Barjaktarevic I, Woodruff PG, Cooper CB, Bowler RP, Comellas AP, Criner GJ, Paine R, Hansel NN, Han MK, Crystal RG, Kaner RJ, Ballman KV, Curtis JL, Martinez FJ, Cloonan SM. PMID: 32601308; PMCID: PMC7324559.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    55. Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv. 2020 May 19. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C. PMID: 32511476; PMCID: PMC7273244.
      View in: PubMed   Mentions: 1  
    56. Sputum microbiome profiling in COPD: beyond singular pathogen detection. Thorax. 2020 04; 75(4):338-344. Ditz B, Christenson S, Rossen J, Brightling C, Kerstjens HAM, van den Berge M, Faiz A. PMID: 31996401; PMCID: PMC7231454.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    57. The role of genomic profiling in identifying molecular phenotypes in obstructive lung diseases. Curr Opin Pulm Med. 2020 01; 26(1):84-89. Christenson SA. PMID: 31714272.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    58. Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis. Int J Chron Obstruct Pulmon Dis. 2019; 14:2927-2938. Barjaktarevic IZ, Buhr RG, Wang X, Hu S, Couper D, Anderson W, Kanner RE, Paine Iii R, Bhatt SP, Bhakta NR, Arjomandi M, Kaner RJ, Pirozzi CS, Curtis JL, O'Neal WK, Woodruff PG, Han MK, Martinez FJ, Hansel N, Wells JM, Ortega VE, Hoffman EA, Doerschuk CM, Kim V, Dransfield MT, Drummond MB, Bowler R, Criner G, Christenson SA, Ronish B, Peters SP, Krishnan JA, Tashkin DP, Cooper CB, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). PMID: 31908441; PMCID: PMC6930016.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    59. Found in Translation: Multi-omics Assessment of the Chronic Obstructive Pulmonary Disease-Lung Cancer Interaction. Am J Respir Crit Care Med. 2019 Aug 01; 200(3):276-277. Christenson S, Hersh CP. PMID: 30753788; PMCID: PMC6680298.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    60. Nasal gene expression changes with inhaled corticosteroid treatment in asthma. Allergy. 2020 01; 75(1):191-194. Boudewijn IM, Lan A, Faiz A, Cox CA, Brouwer S, Schokker S, Vroegop SJ, Nawijn MC, Woodruff PG, Christenson SA, Hagedoorn P, Frijlink HW, Choy DF, Brouwer U, Wisman M, Postma DS, Fingleton J, Beasley R, van den Berge M, Guryev V. PMID: 31230369.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    61. Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy. Ann Am Thorac Soc. 2019 04; 16(4):439-446. Wells JM, Arenberg DA, Barjaktarevic I, Bhatt SP, Bowler RP, Christenson SA, Couper DJ, Dransfield MT, Han MK, Hoffman EA, Kaner RJ, Kim V, Kleerup E, Martinez FJ, Moore WC, O'Beirne SL, Paine R, Putcha N, Raman SM, Barr RG, Rennard SI, Woodruff PG, Curtis JL. PMID: 30653926; PMCID: PMC6441692.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    62. Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS. Chest. 2019 05; 155(5):908-917. Garudadri S, Woodruff PG, Han MK, Curtis JL, Barr RG, Bleecker ER, Bowler RP, Comellas A, Cooper CB, Criner G, Dransfield MT, Hansel NN, Paine R, Krishnan JA, Peters SP, Hastie AT, Martinez FJ, O'Neal WK, Couper DJ, Alexis NE, Christenson SA. PMID: 30684474; PMCID: PMC6533449.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    63. Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12353-E12362. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. PMID: 30482864; PMCID: PMC6310811.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansCells
    64. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. J Clin Invest. 2019 01 02; 129(1):169-181. Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG. PMID: 30383540; PMCID: PMC6307967.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    65. Heterogeneous burden of lung disease in smokers with borderline airflow obstruction. Respir Res. 2018 Nov 20; 19(1):223. Pirozzi CS, Gu T, Quibrera PM, Carretta EE, Han MK, Murray S, Cooper CB, Tashkin DP, Kleerup EC, Barjaktarevic I, Hoffman EA, Martinez CH, Christenson SA, Hansel NN, Graham Barr R, Bleecker ER, Ortega VE, Martinez FJ, Kanner RE, Paine R, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS). PMID: 30454050; PMCID: PMC6245799.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    66. Clinical Approach to the Therapy of Asthma-COPD Overlap. Chest. 2019 01; 155(1):168-177. Maselli DJ, Hardin M, Christenson SA, Hanania NA, Hersh CP, Adams SG, Anzueto A, Peters JI, Han MK, Martinez FJ. PMID: 30077690; PMCID: PMC6688980.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    67. Genome-wide association study of lung function and clinical implication in heavy smokers. BMC Med Genet. 2018 08 01; 19(1):134. Li X, Ortega VE, Ampleford EJ, Graham Barr R, Christenson SA, Cooper CB, Couper D, Dransfield MT, Han MLK, Hansel NN, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Paine R, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA, SPIROMICS Research Group. PMID: 30068317; PMCID: PMC6090900.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    68. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. PMID: 29999500; PMCID: PMC6159975.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    69. At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 06 15; 197(12):1540-1551. Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA. PMID: 29406779; PMCID: PMC6006401.
      View in: PubMed   Mentions: 134     Fields:    Translation:Humans
    70. ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues. Genome Biol. 2018 02 15; 19(1):36. Mangul S, Yang HT, Strauli N, Gruhl F, Porath HT, Hsieh K, Chen L, Daley T, Christenson S, Wesolowska-Andersen A, Spreafico R, Rios C, Eng C, Smith AD, Hernandez RD, Ophoff RA, Santana JR, Levanon EY, Woodruff PG, Burchard E, Seibold MA, Shifman S, Eskin E, Zaitlen N. PMID: 29548336; PMCID: PMC5857127.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    71. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med. 2018 02 15; 197(4):524-528. Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL. PMID: 28686513; PMCID: PMC5821905.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    72. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2018 02 01; 197(3):313-324. Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. PMID: 29064281; PMCID: PMC5811952.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    73. Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. Lancet Respir Med. 2017 12; 5(12):956-967. Hastie AT, Martinez FJ, Curtis JL, Doerschuk CM, Hansel NN, Christenson S, Putcha N, Ortega VE, Li X, Barr RG, Carretta EE, Couper DJ, Cooper CB, Hoffman EA, Kanner RE, Kleerup E, O'Neal WK, Paine R, Peters SP, Alexis NE, Woodruff PG, Han MK, Meyers DA, Bleecker ER, SPIROMICS investigators. PMID: 29146301; PMCID: PMC5849066.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    74. Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. J Allergy Clin Immunol. 2018 01; 141(1):429-432. Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R, Putcha N, Rennard SI, Woodruff PG, Zeidler M, Curtis JL, Freeman CM, SPIROMICS Investigators. PMID: 28916185; PMCID: PMC5758424.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    75. Airway Mucin Concentration as a Marker of Chronic Bronchitis. N Engl J Med. 2017 09 07; 377(10):911-922. Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R, Woodruff PG, O'Neal WK, Boucher RC. PMID: 28877023; PMCID: PMC5706541.
      View in: PubMed   Mentions: 195     Fields:    Translation:Humans
    76. American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report. Am J Respir Crit Care Med. 2017 08 01; 196(3):375-381. Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA. PMID: 28636425; PMCID: PMC5549872.
      View in: PubMed   Mentions: 48     Fields:    
    77. More Than Meets the Eye: Cigarette Smoke Induces Genomic Changes in the Small Airway Epithelium Independent of Histologic Changes. Am J Respir Crit Care Med. 2017 08 01; 196(3):260-262. Bartel S, Bhakta N, Christenson S. PMID: 28762786; PMCID: PMC6850564.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    78. Flipping the kill switch. Sci Transl Med. 2017 06 21; 9(395). Christenson SA. PMID: 28637925.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    79. The path of least antibiotic resistance. Sci Transl Med. 2017 05 10; 9(389). Christenson SA. PMID: 28490666.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    80. Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort. Ann Am Thorac Soc. 2017 May; 14(5):636-642. Martinez CH, Murray S, Barr RG, Bleecker E, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper D, Criner GJ, Curtis JL, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Krishnan JA, Lazarus SC, Leidy NK, O'Neal W, Martinez FJ, Paine R, Rennard SI, Tashkin DP, Woodruff PG, Han MK, Subpopulations and Intermediate Outcome Measures in COPD Study Investigators. PMID: 28459622; PMCID: PMC5427740.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    81. Target practice in severe asthma. Sci Transl Med. 2017 03 29; 9(383). Christenson SA. PMID: 28356505.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    82. Shifting from Correlation to Causation: Challenges for the Future of Unbiased Molecular Studies in Inflammatory Lung Disease. Am J Respir Crit Care Med. 2017 01 01; 195(1):5-7. Christenson SA, Steiling K. PMID: 28035851; PMCID: PMC5439941.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    83. The Reemergence of the Asthma-COPD Overlap Syndrome: Characterizing a Syndrome in the Precision Medicine Era. Curr Allergy Asthma Rep. 2016 Nov; 16(11):81. Christenson SA. PMID: 27796796.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    84. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP, SPIROMICS Research Group, COPDGene Investigators. PMID: 27532455; PMCID: PMC4988780.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    85. Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function. N Engl J Med. 2016 May 12; 374(19):1811-21. Woodruff PG, Barr RG, Bleecker E, Christenson SA, Couper D, Curtis JL, Gouskova NA, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Lazarus SC, Martinez FJ, Paine R, Rennard S, Tashkin DP, Han MK, SPIROMICS Research Group. PMID: 27168432; PMCID: PMC4968204.
      View in: PubMed   Mentions: 324     Fields:    Translation:Humans
    86. An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus. Am J Respir Crit Care Med. 2016 Apr 01; 193(7):710-2. Langelier C, Christenson SA. PMID: 27035780; PMCID: PMC4824935.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    87. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5. Gelb AF, Christenson SA, Nadel JA. PMID: 26717511.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    88. Targeting 'types: Precision Medicine in Pulmonary Disease. Am J Respir Crit Care Med. 2015 May 15; 191(10):1093-4. Steiling K, Christenson SA. PMID: 25978565.
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