search, discover, network

Research Interests

I. Mentoring in Translational Research
Supported by K24HL137013, Mentoring research in precision medicine for lung disease.

II. The identification of molecular sub-phenotypes of asthma and COPD:
These studies are funded by:
1) An R01 from the NIH/NHLBI, entitled “Molecular Phenotyping of Asthma” (R01 HL-095372) which has applied genomic analyses to airway samples from patients with asthma to distinguish Th2-driven and non-Th2-driven sub-phenotypes of asthma that have distinct clinical, pathological and treatment-related characteristics.

2) The NHLBI SPIROMICS longitudinal study of COPD (R01HL137880). The goal of the Spiromics project is to identify molecular phenotypes of COPD and to link these phenotypes to disease progression and exacerbations.

III. Mechanisms of airway inflammation and remodeling in lung diseases:
These studies apply innovative methods for quantitative morphometry and gene expression analyses to human tissue samples obtained at fiberoptic bronchoscopy. In work to date, we have applied these methods to study mechanisms of disease in asthma, COPD and sarcoidosis.

IV. Development of blood-based diagnostic tests for lung disease using genomic approaches:
These studies apply gene expression profiling and miRNA profiling in blood cells and plasma/serum to develop diagnostic tests in asthma, COPD and sarcoidosis and are supported by U01HL126493, Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA.

V. Clinical Trials in asthma and COPD
Ongoing: U01HL128952, Redefining Therapy In Early COPD: RETHINC