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Jennifer Rose-Nussbaumer, MD

TitleAssistant Professor
SchoolUCSF Chancellor/EVC/FAS
DepartmentProctor Foundation
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-502-2666
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    Collapse Biography 
    Collapse Education and Training
    University Of California, San FranciscoCornea, External Disease, Refractive Surgery and Uveitis Fellowship2013Proctor Foundation/Ophthalmology
    Oregon Health Science UniversityOphthalmology Residency2012Ophthalmology
    University of California, San FranciscoM.D.2008 Medicine

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    Collapse Overview
    Jennifer Rose-Nussbaumer is a board-certified ophthalmologist and fellowship-trained cornea specialist at the University of California, San Francisco. Her clinical practice focuses on lamellar keratoplasty such as Ultrathin-Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK), Descemet Membrane Endothelial Keratoplasty (DMEK) and Deep Anterior Lamellar Keratoplasty (DALK), as well as Boston Keratoprosthesis and cataract surgery. She is the Francis I Proctor Cornea Fellowship Co-director, which has a long tradition of training academic cornea specialists and has become one of the most sought after fellowship programs in the country.

    In addition to her clinical work Dr. Rose-Nussbaumer is an NIH-funded researcher who focuses on surgical randomized clinical trials in ophthalmology. She is the primary investigator at UCSF on Descemet Endothelial Thickness Comparison Trial (DETECT) a randomized clinical trial comparing UT-DSAEK to DMEK in patients with isolated endothelial disease such as Fuchs Endothelial Dystrophy. This trial found that those randomized to DMEK had almost two lines of visual acuity improvement compared with UT-DSAEK. Her other research interests include optimal treatment of corneal infections.


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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ray KJ, Prajna NV, Lalitha P, Rajaraman R, Krishnan T, Patel S, Das M, Shah R, Dhakhwa K, McLeod SD, Zegans ME, Acharya NR, Lietman TM, Rose-Nussbaumer J. The Significance of Repeat Cultures in the Treatment of Severe Fungal Keratitis. Am J Ophthalmol. 2018 Feb 10. PMID: 29438654.
      View in: PubMed
    2. Peng MY, Cevallos V, McLeod SD, Lietman TM, Rose-Nussbaumer J. Bacterial Keratitis: Isolated Organisms and Antibiotic Resistance Patterns in San Francisco. Cornea. 2018 Jan; 37(1):84-87. PMID: 29053557.
      View in: PubMed
    3. Ramirez DA, Brodie FL, Rose-Nussbaumer J, Ramanathan S. Anxiety in patients undergoing cataract surgery: a pre- and postoperative comparison. Clin Ophthalmol. 2017; 11:1979-1986. PMID: 29184388.
      View in: PubMed
    4. Austin A, Lietman T, Rose-Nussbaumer J. Update on the Management of Infectious Keratitis. Ophthalmology. 2017 Nov; 124(11):1678-1689. PMID: 28942073.
      View in: PubMed
    5. Prajna NV, Krishnan T, Rajaraman R, Patel S, Shah R, Srinivasan M, Das M, Ray KJ, Oldenburg CE, McLeod SD, Zegans ME, Acharya NR, Lietman TM, Rose-Nussbaumer J. Predictors of Corneal Perforation or Need for Therapeutic Keratoplasty in Severe Fungal Keratitis: A Secondary Analysis of the Mycotic Ulcer Treatment Trial II. JAMA Ophthalmol. 2017 Sep 01; 135(9):987-991. PMID: 28817744.
      View in: PubMed
    6. Austin A, Schallhorn J, Geske M, Mannis M, Lietman T, Rose-Nussbaumer J. Empirical treatment of bacterial keratitis: an international survey of corneal specialists. BMJ Open Ophthalmol. 2017 Aug; 2. PMID: 29226254.
      View in: PubMed
    7. Prajna NV, Krishnan T, Rajaraman R, Patel S, Shah R, Srinivasan M, Devi L, Das M, Ray KJ, O'Brien KS, Oldenburg CE, McLeod SD, Zegans ME, Acharya NR, Lietman TM, Rose-Nussbaumer J. Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis: A Secondary Analysis From the Mycotic Ulcer Treatment Trial II. JAMA Ophthalmol. 2017 Jun 01; 135(6):520-525. PMID: 28426856.
      View in: PubMed
    8. Ray KJ, Lalitha P, Prajna NV, Rajaraman R, Krishnan T, Srinivasan M, Ryg P, McLeod S, Acharya NR, Lietman TM, Rose-Nussbaumer J. The Utility of Repeat Culture in Fungal Corneal Ulcer Management: A Secondary Analysis of the MUTT-I Randomized Clinical Trial. Am J Ophthalmol. 2017 Jun; 178:157-162. PMID: 28385473.
      View in: PubMed
    9. Oatts JT, Keenan JD, Mannis T, Lietman TM, Rose-Nussbaumer J. Multimodal Assessment of Corneal Thinning Using Optical Coherence Tomography, Scheimpflug Imaging, Pachymetry, and Slit-Lamp Examination. Cornea. 2017 Apr; 36(4):425-430. PMID: 28129300.
      View in: PubMed
    10. Prajna NV, Krishnan T, Rajaraman R, Patel S, Srinivasan M, Das M, Ray KJ, O'Brien KS, Oldenburg CE, McLeod SD, Zegans ME, Porco TC, Acharya NR, Lietman TM, Rose-Nussbaumer J. Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic Ulcer Treatment Trial II (MUTT II): A Randomized Clinical Trial. JAMA Ophthalmol. 2016 12 01; 134(12):1365-1372. PMID: 27787540.
      View in: PubMed
    11. Chamberlain W, Austin A, Terry M, Jeng BH, Rose-Nussbaumer J. Survey of Experts on Current Endothelial Keratoplasty Techniques. J Clin Exp Ophthalmol. 2016 Oct; 7(5). PMID: 28149669.
      View in: PubMed
    12. Rose-Nussbaumer J, Alloju S, Chamberlain W. Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty During the Surgeon Learning Curve Versus Descemet Stripping Endothelial Keratoplasty Performed at the Same Time. J Clin Exp Ophthalmol. 2016 Oct; 7(5). PMID: 28018708.
      View in: PubMed
    13. Cui QN, Hsia YC, Lin SC, Stamper RL, Rose-Nussbaumer J, Mehta N, Porco TC, Naseri A, Han Y. Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation. Clin Exp Ophthalmol. 2017 Mar; 45(2):128-134. PMID: 27490793.
      View in: PubMed
    14. Sun CQ, Prajna NV, Krishnan T, Rajaraman R, Srinivasan M, Raghavan A, O'Brien KS, McLeod SD, Acharya NR, Rose-Nussbaumer J. Effect of pretreatment with antifungal agents on clinical outcomes in fungal keratitis. Clin Exp Ophthalmol. 2016 Dec; 44(9):763-767. PMID: 27329780.
      View in: PubMed
    15. Ni N, Srinivasan M, McLeod SD, Acharya NR, Lietman TM, Rose-Nussbaumer J. Use of adjunctive topical corticosteroids in bacterial keratitis. Curr Opin Ophthalmol. 2016 Jul; 27(4):353-7. PMID: 27096374.
      View in: PubMed
    16. Prajna NV, Lalitha P, Rajaraman R, Krishnan T, Raghavan A, Srinivasan M, O'Brien KS, Zegans M, McLeod SD, Acharya NR, Keenan JD, Lietman TM, Rose-Nussbaumer J. Changing Azole Resistance: A Secondary Analysis of the MUTT I Randomized Clinical Trial. JAMA Ophthalmol. 2016 Jun 01; 134(6):693-6. PMID: 27054515; PMCID: PMC4962688 [Available on 06/01/17].
    17. Mannis TE, Mannis GN, Waterhouse EG, Aldave AJ, Rose-Nussbaumer J. Paraproteinemic keratopathy as the presenting sign of hematologic malignancy. Am J Hematol. 2016 Sep; 91(9):961-2. PMID: 26872417.
      View in: PubMed
    18. Rose-Nussbaumer J, Prajna NV, Krishnan T, Mascarenhas J, Rajaraman R, Srinivasan M, Raghavan A, Oldenburg CE, O'Brien KS, Ray KJ, Porco TC, McLeod SD, Acharya NR, Keenan JD, Lietman TM, et al. Risk factors for low vision related functioning in the Mycotic Ulcer Treatment Trial: a randomised trial comparing natamycin with voriconazole. Br J Ophthalmol. 2016 Jul; 100(7):929-932. PMID: 26531051.
      View in: PubMed
    19. Sy A, O'Brien KS, Liu MP, Cuddapah PA, Acharya NR, Lietman TM, Rose-Nussbaumer J. Expert opinion in the management of aqueous Deficient Dry Eye Disease (DED). BMC Ophthalmol. 2015 Oct 13; 15:133. PMID: 26462481; PMCID: PMC4604775.
    20. Prajna NV, Prajna L, O'Brien KS, Sun CQ, Acharya N, Lietman TM, Rose-Nussbaumer J. Association of pretreatment with antifungal medication and fungal resistance in the mycotic ulcer treatment trial I. JAMA Ophthalmol. 2015 Oct; 133(10):1210-1. PMID: 26110254; PMCID: PMC4962690 [Available on 10/01/16].
    21. Rose-Nussbaumer J, Lietman TM, Shiboski CH, Shiboski SC, Bunya VY, Akpek EK, Srinivasan M, Mascarenhas J, Massaro-Giordano G, McNamara NA, Whitcher JP, Gaynor BD. Inter-grader Agreement of the Ocular Staining Score in the Sjögren's International Clinical Collaborative Alliance (SICCA) Registry. Am J Ophthalmol. 2015 Dec; 160(6):1150-1153.e3. PMID: 26302236; PMCID: PMC4651820 [Available on 12/01/16].
    22. Schallhorn JM, Rose-Nussbaumer J. Current Concepts in the Management of Unique Post-keratoplasty Infections. Curr Ophthalmol Rep. 2015 Sep; 3(3):184-191. PMID: 26618075.
      View in: PubMed
    23. Rose-Nussbaumer J, Prajna NV, Krishnan KT, Mascarenhas J, Rajaraman R, Srinivasan M, Raghavan A, Oldenburg CE, O'Brien KS, Ray KJ, McLeod SD, Porco TC, Lietman TM, Acharya NR, Keenan JD. Vision-Related Quality-of-Life Outcomes in the Mycotic Ulcer Treatment Trial I: A Randomized Clinical Trial. JAMA Ophthalmol. 2015 Jun; 133(6):642-6. PMID: 25764482; PMCID: PMC4962866.
    24. Rose-Nussbaumer J, Li Y, Lin P, Suhler E, Asquith M, Rosenbaum JT, Huang D. Aqueous cell differentiation in anterior uveitis using Fourier-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2015 Feb 03; 56(3):1430-6. PMID: 25650415; PMCID: PMC4347308.
    25. Heiden D, Tun N, Maningding E, Heiden M, Rose-Nussbaumer J, Chan KN, Khizniak T, Yakubenko A, Lewallen S, Keenan JD, Saranchuk P. Training clinicians treating HIV to diagnose cytomegalovirus retinitis. Bull World Health Organ. 2014 Dec 01; 92(12):903-8. PMID: 25552774; PMCID: PMC4264397.
    26. Rose-Nussbaumer J, Goldstein DA, Thorne JE, Arantes TE, Acharya NR, Shakoor A, Jeng BH, Yeh S, Rahman H, Vemulakonda GA, Flaxel CJ, West SK, Holland GN, Smith JR. Uveitis in human immunodeficiency virus-infected persons with CD4+ T-lymphocyte count over 200 cells/mL. Clin Exp Ophthalmol. 2014 Mar; 42(2):118-25. PMID: 23777456.
      View in: PubMed
    27. Clavijo RI, Rose-Nussbaumer J, Turek PJ. Clinically symptomatic vasitis: clinical correlations in a rare condition. Syst Biol Reprod Med. 2010 Dec; 56(6):445-9. PMID: 20964559.
      View in: PubMed
    28. Mariotti SP, Pascolini D, Rose-Nussbaumer J. Trachoma: global magnitude of a preventable cause of blindness. Br J Ophthalmol. 2009 May; 93(5):563-8. PMID: 19098034.
      View in: PubMed
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