Jessica De Leon, MD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address1651 4th Street, #361H
San Francisco CA 94158
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoFellowship2019Behavioral Neurology
    University of California, San FranciscoResidency2016Neurology
    University of California, San FranciscoM.D.2012 Medicine

    Collapse Overview 
    Collapse Overview
    I am a behavioral neurologist with expertise in the evaluation and diagnosis of patients with primary progressive aphasia (PPA), frontotemporal dementia (FTD), and Alzheimer’s dementia. My research program aims to understand how bilingualism, language typology, and sociocultural factors affect the clinical, neuropsychological, and neuroimaging findings in neurodegenerative diseases. The underlying goal of my work is to improve dementia diagnosis in communities of different language and sociocultural backgrounds.

    Collapse Research 
    Collapse Research Activities and Funding
    Cognitive Assessment for Tagalog Speakers (CATS): A pilot study in healthy aging and ADRD
    Alzheimer's Association AARGD-22-923915Jul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator
    Description: The goal of this project is to develop and pilot a comprehensive neuropsychological battery for Tagalog speakers in healthy older adults and patients with ADRD and correlate findings with neuroimaging.
    Primary Progressive Aphasia: Beyond the Clinical Variants
    NIH K23DC018021Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Description: The goal of this study is to understand how neuropathology, genetic factors and linguistic factors (bilingualism, language typology) influence PPA phenotype through effects on neural networks.
    Frontotemporal Dementia: Genes, Images, and Emotions
    NIH P01AG019724Jul 1, 2001 - May 31, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech. Cortex. 2024 Apr; 173:34-48. Lukic S, Fan Z, García AM, Welch AE, Ratnasiri BM, Wilson SM, Henry ML, Vonk J, Deleon J, Miller BL, Miller Z, Mandelli ML, Gorno-Tempini ML. PMID: 38359511.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task. Cortex. 2024 Feb; 171:165-177. Gajardo-Vidal A, Montembeault M, Lorca-Puls DL, Licata AE, Bogley R, Erlhoff S, Ratnasiri B, Ezzes Z, Battistella G, Tsoy E, Pereira CW, DeLeon J, Tee BL, Henry ML, Miller ZA, Rankin KP, Mandelli ML, Possin KL, Gorno-Tempini ML. PMID: 38000139; PMCID: PMC10922977.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology. Neurocase. 2022 10; 28(5):419-431. Palser ER, Miller ZA, Licata AE, Yabut NA, Sudarsan SP, Tee BL, Deleon JA, Mandelli ML, Caverzasi E, Sturm VE, Hendren R, Possin KL, Miller BL, Gorno Tempini ML, Watson Pereira C. PMID: 36450280; PMCID: PMC9957930.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia. Neurology. 2022 08 02; 99(5):e500-e511. García AM, Welch AE, Mandelli ML, Henry ML, Lukic S, Torres Prioris MJ, Deleon J, Ratnasiri BM, Lorca-Puls DL, Miller BL, Seeley W, Vogel AP, Gorno-Tempini ML. PMID: 35914945; PMCID: PMC9421598.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    5. Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Non-fluent/agrammatic Variant Primary Progressive Aphasia. Neurology. 2022 May 27. García AM, Welch AE, Mandelli ML, Henry ML, Lukic S, Torres Prioris MJ, Deleon J, Ratnasiri BM, Lorca Puls DL, Miller BL, Seeley W, Vogel AP, Gorno-Tempini ML. PMID: 35623892.
      View in: PubMed   Mentions:    Fields:    
    6. Frontotemporal dementia: A unique window on the functional role of the temporal lobes. Handb Clin Neurol. 2022; 187:429-448. Borghesani V, DeLeon J, Gorno-Tempini ML. PMID: 35964986; PMCID: PMC9793689.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Children with developmental dyslexia show elevated parasympathetic nervous system activity at rest and greater cardiac deceleration during an empathy task. Biol Psychol. 2021 11; 166:108203. Palser ER, Morris NA, Roy ARK, Holley SR, Veziris CR, Watson C, Deleon J, Miller ZA, Miller BL, Gorno-Tempini ML, Sturm VE. PMID: 34653546.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia. Neurocase. 2022 02; 28(1):1-10. Tee BL, Deleon J, Chen Li Ying LK, Miller BL, Y Lo R, Europa E, Sudarsan S, Grasso S, Gorno-Tempini ML. PMID: 34404317; PMCID: PMC9345301.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex. J Neuroimaging. 2021 09; 31(5):962-972. Borghesani V, Wang C, Watson C, Bouhali F, Caverzasi E, Battistella G, Bogley R, Yabut NA, Deleon J, Miller ZA, Hoeft F, Mandelli ML, Gorno-Tempini ML. PMID: 34115429; PMCID: PMC10832296.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases. Cortex. 2021 09; 142:47-61. Lukic S, Borghesani V, Weis E, Welch A, Bogley R, Neuhaus J, Deleon J, Miller ZA, Kramer JH, Miller BL, Dronkers NF, Gorno-Tempini ML. PMID: 34182153; PMCID: PMC8556704.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    11. Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity. Cortex. 2021 01; 134:278-295. Sturm VE, Roy ARK, Datta S, Wang C, Sible IJ, Holley SR, Watson C, Palser ER, Morris NA, Battistella G, Rah E, Meyer M, Pakvasa M, Mandelli ML, Deleon J, Hoeft F, Caverzasi E, Miller ZA, Shapiro KA, Hendren R, Miller BL, Gorno-Tempini ML. PMID: 33316603; PMCID: PMC7880083.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants. Alzheimers Dement. 2020 12; 16(12):1704-1713. de Leon J, Grasso SM, Welch A, Miller Z, Shwe W, Rabinovici GD, Miller BL, Henry ML, Gorno-Tempini ML. PMID: 32881346; PMCID: PMC7902304.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Speech production differences in English and Italian speakers with nonfluent variant PPA. Neurology. 2020 03 10; 94(10):e1062-e1072. Canu E, Agosta F, Battistella G, Spinelli EG, DeLeon J, Welch AE, Mandelli ML, Hubbard HI, Moro A, Magnani G, Cappa SF, Miller BL, Filippi M, Gorno-Tempini ML. PMID: 31924679; PMCID: PMC7238919.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    14. Task-Free Functional Language Networks: Reproducibility and Clinical Application. J Neurosci. 2020 02 05; 40(6):1311-1320. Battistella G, Borghesani V, Henry M, Shwe W, Lauricella M, Miller Z, Deleon J, Miller BL, Dronkers N, Brambati SM, Seeley WW, Mandelli ML, Gorno-Tempini ML. PMID: 31852732; PMCID: PMC7002153.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    15. Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration. Aphasiology. 2020; 34(7):865-885. Vonk JMJ, Borghesani V, Battistella G, Younes K, DeLeon J, Welch A, Hubbard HI, Miller ZA, Miller BL, Gorno-Tempini ML. PMID: 33012947; PMCID: PMC7529336.
      View in: PubMed   Mentions: 10  
    16. Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Neurocase. 2019 Feb - Apr; 25(1-2):39-47. De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML. PMID: 31033382; PMCID: PMC6759324.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia. Neuroimage Clin. 2019; 22:101797. Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML. PMID: 31146321; PMCID: PMC6465769.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    18. Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA. Cortex. 2018 11; 108:252-264. Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML. PMID: 30292076; PMCID: PMC6317366.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    19. Frontotemporal dementia. Handb Clin Neurol. 2018; 148:409-430. Deleon J, Miller BL. PMID: 29478591.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    20. Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. Brain. 2015 Apr; 138(Pt 4):845-61. Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT, Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, Grossman M, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ. PMID: 25678562; PMCID: PMC5014076.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    21. Elicitation of specific syntactic structures in primary progressive aphasia. Brain Lang. 2012 Dec; 123(3):183-90. Deleon J, Gesierich B, Besbris M, Ogar J, Henry ML, Miller BL, Gorno-Tempini ML, Wilson SM. PMID: 23046707; PMCID: PMC3502680.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    22. Syntactic processing depends on dorsal language tracts. Neuron. 2011 Oct 20; 72(2):397-403. Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson DK, Henry ML, Ogar JM, DeLeon J, Miller BL, Gorno-Tempini ML. PMID: 22017996; PMCID: PMC3201770.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    23. Adult glial precursor proliferation in mutant SOD1G93A mice. Glia. 2008 Jan 15; 56(2):200-8. Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ. PMID: 18023016.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    24. Neural regions essential for distinct cognitive processes underlying picture naming. Brain. 2007 May; 130(Pt 5):1408-22. DeLeon J, Gottesman RF, Kleinman JT, Newhart M, Davis C, Heidler-Gary J, Lee A, Hillis AE. PMID: 17337482.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
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