Jessica De Leon, MD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address1651 4th Street, #361H
San Francisco CA 94158
PronounsShe/Her/Hers
vCardDownload vCard
    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    University of California, San FranciscoFellowship2019Behavioral Neurology
    University of California, San FranciscoResidency2016Neurology
    University of California, San FranciscoM.D.2012 Medicine

    Collapse Overview 
    Collapse overview
    I am a behavioral neurologist with expertise in the evaluation and diagnosis of patients with primary progressive aphasia (PPA), frontotemporal dementia (FTD), and Alzheimer’s dementia. My research program aims to understand how bilingualism, language typology, and sociocultural factors affect the clinical, neuropsychological, and neuroimaging findings in neurodegenerative diseases. The underlying goal of my work is to improve dementia diagnosis in communities of different language and sociocultural backgrounds.

    Collapse Research 
    Collapse research activities and funding
    The Role of Bilingualism in Cognitive and Brain Resilience: Addressing the Complexity
    NIH 1R01AG080396Apr 15, 2023 - Mar 31, 2028
    Role: Principal Investigator
    Description: The overarching goal of this multidisciplinary study is to provide a framework for bilingualism’s effect on the trajectory of healthy aging and Alzheimer’s disease, while accounting for the complexity underlying language experiences, executive functioning measures, and dementia types. The findings will improve care for people with diverse language backgrounds and give important insight into whether speaking more than one language can help prevent or slow the symptoms of Alzheimer’s disease and related dementias (ADRD).
    Cognitive Assessment for Tagalog Speakers (CATS): A pilot study in healthy aging and ADRD
    Alzheimer's Association AARGD-22-923915Jul 1, 2022 - Jun 30, 2025
    Role: Principal Investigator
    Description: The goal of this project is to develop and pilot a comprehensive neuropsychological battery for Tagalog speakers in healthy older adults and patients with ADRD and correlate findings with neuroimaging.
    Primary Progressive Aphasia: Beyond the Clinical Variants
    NIH K23DC018021Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Description: The goal of this study is to understand how neuropathology, genetic factors and linguistic factors (bilingualism, language typology) influence PPA phenotype through effects on neural networks.
    Frontotemporal Dementia: Genes, Images, and Emotions
    NIH P01AG019724Jul 1, 2001 - May 31, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anatomical and behavioural correlates of auditory perception in developmental dyslexia. Brain. 2025 Mar 06; 148(3):833-844. Qi T, Mandelli ML, Watson Pereira CL, Wellman E, Bogley R, Licata AE, Miller ZA, Tee BL, de Leon J, Chang EF, Oganian Y, Gorno-Tempini ML. PMID: 39300826; PMCID: PMC11884757.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Non-right-handedness, male sex, and regional, network-specific, ventral occipito-temporal anomalous lateralization in adults with a history of reading disability. Cortex. 2025 Feb; 183:116-130. Miller ZA, Hinkley LBN, Borghesani V, Mauer E, Shwe W, Mizuiri D, Bogley R, Mandelli ML, de Leon J, Pereira CW, Allen I, Houde J, Kramer J, Miller BL, Nagarajan SS, Gorno-Tempini ML. PMID: 39631179; PMCID: PMC11936465.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research. Alzheimers Dement. 2024 Dec; 20(12):9014-9036. Nuytemans K, Franzen S, Broce IJ, Caramelli P, Ellajosyula R, Finger E, Gupta V, Gupta V, Illán-Gala I, Loi SM, Morhardt D, Pijnenburg Y, Rascovsky K, Williams MM, Yokoyama JS, Acosta-Uribe J, Akinyemi R, Alladi S, Ayele BA, Ayhan Y, Bourdage R, Castro-Suarez S, de Souza LC, Dacks P, de Boer SCM, de Leon J, Dodge S, Grasso S, Ghoshal N, Kamath V, Kumfor F, Matias-Guiu JA, Narme P, Nielsen TR, Okhuevbie D, Piña-Escudero S, Ruiz-Garcia R, Ryan B, Scarioni M, Slachevsky A, Suarez-Gonzalez A, Tee BL, Tsoy E, Ulugut H, Onyike CU, Babulal GM, ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA. PMID: 39535468; PMCID: PMC11667558.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Perceptual and semantic deficits in face recognition in semantic dementia. Neuropsychologia. 2024 12 15; 205:109020. Yadollahikhales G, Mandelli ML, Ezzes Z, Pillai J, Ratnasiri B, Baquirin DP, Miller Z, de Leon J, Tee BL, Seeley W, Rosen H, Miller B, Kramer J, Sturm V, Gorno-Tempini ML, Montembeault M. PMID: 39447739; PMCID: PMC11609019.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Cross-Linguistic Analysis of Speech Markers: Insights from English, Chinese, and Italian Speakers. medRxiv. 2024 Oct 16. Santi GC, Catricalà E, Kwan S, Wong A, Ezzes Z, Wauters L, Esposito V, Conca F, Gibbons D, Fernandez E, Santos-Santos MA, TaFu C, Li-Ying KC, R L, J T, Chan LT, Garcia AM, de Leon J, Miller Z, Vonk JMJ, Bruffaerts R, Grasso SM, Allen IE, Cappa SF, Gorno-Tempini ML, Tee BL. PMID: 39484241; PMCID: PMC11527062.
      View in: PubMed   Mentions:
    6. Digital language markers distinguish frontal from right anterior temporal lobe atrophy in frontotemporal dementia. medRxiv. 2024 Aug 30. Vonk JMJ, Morin BT, Pillai J, Rolon DR, Bogley R, Baquirin DP, Ezzes Z, Tee BL, DeLeon J, Wauters L, Lukic S, Montembeault M, Younes K, Miller Z, García AM, Mandelli ML, Sturm VE, Miller BL, Gorno-Tempini ML. PMID: 39252889; PMCID: PMC11383468.
      View in: PubMed   Mentions: 1  
    7. Perceptual and semantic deficits in face recognition in semantic dementia. medRxiv. 2024 Jul 12. Yadollahikhales G, Mandelli ML, Ezzes Z, Pillai J, Ratnasiri B, Baquirin DP, Miller Z, de Leon J, Tee BL, Seeley W, Rosen H, Miller B, Kramer J, Sturm V, Gorno-Tempini ML, Montembeault M. PMID: 39040182; PMCID: PMC11261910.
      View in: PubMed   Mentions:
    8. Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum. Brain. 2024 Apr 04; 147(4):1511-1525. Illán-Gala I, Lorca-Puls DL, Tee BL, Ezzes Z, de Leon J, Miller ZA, Rubio-Guerra S, Santos-Santos M, Gómez-Andrés D, Grinberg LT, Spina S, Kramer JH, Wauters LD, Henry ML, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Mandelli ML, Gorno-Tempini ML. PMID: 37988272; PMCID: PMC10994525.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech. Cortex. 2024 04; 173:34-48. Lukic S, Fan Z, García AM, Welch AE, Ratnasiri BM, Wilson SM, Henry ML, Vonk J, Deleon J, Miller BL, Miller Z, Mandelli ML, Gorno-Tempini ML. PMID: 38359511; PMCID: PMC11246552.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Speech and language markers of neurodegeneration: a call for global equity. Brain. 2023 12 01; 146(12):4870-4879. García AM, de Leon J, Tee BL, Blasi DE, Gorno-Tempini ML. PMID: 37497623; PMCID: PMC10690018.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    11. Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task. Cortex. 2024 02; 171:165-177. Gajardo-Vidal A, Montembeault M, Lorca-Puls DL, Licata AE, Bogley R, Erlhoff S, Ratnasiri B, Ezzes Z, Battistella G, Tsoy E, Pereira CW, DeLeon J, Tee BL, Henry ML, Miller ZA, Rankin KP, Mandelli ML, Possin KL, Gorno-Tempini ML. PMID: 38000139; PMCID: PMC10922977.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. The development of the Cognitive Assessment for Tagalog Speakers (CATS): A culturally and linguistically tailored test battery for Filipino Americans. Alzheimers Dement (N Y). 2023 Jul-Sep; 9(3):e12418. de Leon J, Bondoc I, Mamuyac E, Posecion L, Europa E, Kintanar LC, Roco N, Lamoca M, Escueta DP, Park VMT. PMID: 37662963; PMCID: PMC10474327.
      View in: PubMed   Mentions: 1  
    13. Network anatomy in logopenic variant of primary progressive aphasia. Hum Brain Mapp. 2023 08 01; 44(11):4390-4406. Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL, De Leon J, Henry ML, Miller Z, Gorno-Tempini ML. PMID: 37306089; PMCID: PMC10318204.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research. Alzheimers Dement. 2023 12; 19(12):5817-5836. Franzen S, Nuytemans K, Bourdage R, Caramelli P, Ellajosyula R, Finger E, Illán-Gala I, Loi SM, Morhardt D, Pijnenburg Y, Rascovsky K, Williams MM, Yokoyama JS, Alladi S, Ayhan Y, Broce I, Castro-Suarez S, Coleman K, de Souza LC, Dacks PA, de Boer SCM, de Leon J, Dodge S, Grasso S, Gupta V, Gupta V, Ghoshal N, Kamath V, Kumfor F, Matias-Guiu JA, Narme P, Nielsen TR, Okhuevbie D, Piña-Escudero SD, Garcia RR, Scarioni M, Slachevsky A, Suarez-Gonzalez A, Tee BL, Tsoy E, Ulugut H, Babulal GM, Onyike CU, ISTAART FTD PIA and ISTAART Diversity and Disparities PIA. PMID: 37270665; PMCID: PMC10693651.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    15. Network anatomy in logopenic variant of primary progressive aphasia. medRxiv. 2023 May 16. Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL, De Leon J, Henry ML, Miller Z, Gorno-Tempini ML. PMID: 37292690; PMCID: PMC10246009.
      View in: PubMed   Mentions:
    16. Examining the relation between bilingualism and age of symptom onset in frontotemporal dementia. Biling (Camb Engl). 2024 Mar; 27(2):274-286. de Leon J, Grasso S, Allen IE, Escueta DP, Vega Y, Eshghavi M, Watson C, Dronkers N, Gorno-Tempini ML, Henry ML. PMID: 38707508; PMCID: PMC11065430.
      View in: PubMed   Mentions: 3  
    17. Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology. Neurocase. 2022 10; 28(5):419-431. Palser ER, Miller ZA, Licata AE, Yabut NA, Sudarsan SP, Tee BL, Deleon JA, Mandelli ML, Caverzasi E, Sturm VE, Hendren R, Possin KL, Miller BL, Gorno Tempini ML, Watson Pereira C. PMID: 36450280; PMCID: PMC9957930.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia. Neurology. 2022 08 02; 99(5):e500-e511. García AM, Welch AE, Mandelli ML, Henry ML, Lukic S, Torres Prioris MJ, Deleon J, Ratnasiri BM, Lorca-Puls DL, Miller BL, Seeley W, Vogel AP, Gorno-Tempini ML. PMID: 35914945; PMCID: PMC9421598.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Non-fluent/agrammatic Variant Primary Progressive Aphasia. Neurology. 2022 May 27. García AM, Welch AE, Mandelli ML, Henry ML, Lukic S, Torres Prioris MJ, Deleon J, Ratnasiri BM, Lorca Puls DL, Miller BL, Seeley W, Vogel AP, Gorno-Tempini ML. PMID: 35623892.
      View in: PubMed   Mentions:    Fields:    
    20. Frontotemporal dementia: A unique window on the functional role of the temporal lobes. Handb Clin Neurol. 2022; 187:429-448. Borghesani V, DeLeon J, Gorno-Tempini ML. PMID: 35964986; PMCID: PMC9793689.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Children with developmental dyslexia show elevated parasympathetic nervous system activity at rest and greater cardiac deceleration during an empathy task. Biol Psychol. 2021 11; 166:108203. Palser ER, Morris NA, Roy ARK, Holley SR, Veziris CR, Watson C, Deleon J, Miller ZA, Miller BL, Gorno-Tempini ML, Sturm VE. PMID: 34653546; PMCID: PMC11721162.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Tonal and orthographic analysis in a Cantonese-speaking individual with nonfluent/agrammatic variant primary progressive aphasia. Neurocase. 2022 02; 28(1):1-10. Tee BL, Deleon J, Chen Li Ying LK, Miller BL, Y Lo R, Europa E, Sudarsan S, Grasso S, Gorno-Tempini ML. PMID: 34404317; PMCID: PMC9345301.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex. J Neuroimaging. 2021 09; 31(5):962-972. Borghesani V, Wang C, Watson C, Bouhali F, Caverzasi E, Battistella G, Bogley R, Yabut NA, Deleon J, Miller ZA, Hoeft F, Mandelli ML, Gorno-Tempini ML. PMID: 34115429; PMCID: PMC10832296.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases. Cortex. 2021 09; 142:47-61. Lukic S, Borghesani V, Weis E, Welch A, Bogley R, Neuhaus J, Deleon J, Miller ZA, Kramer JH, Miller BL, Dronkers NF, Gorno-Tempini ML. PMID: 34182153; PMCID: PMC8556704.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    25. Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity. Cortex. 2021 01; 134:278-295. Sturm VE, Roy ARK, Datta S, Wang C, Sible IJ, Holley SR, Watson C, Palser ER, Morris NA, Battistella G, Rah E, Meyer M, Pakvasa M, Mandelli ML, Deleon J, Hoeft F, Caverzasi E, Miller ZA, Shapiro KA, Hendren R, Miller BL, Gorno-Tempini ML. PMID: 33316603; PMCID: PMC7880083.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    26. Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants. Alzheimers Dement. 2020 12; 16(12):1704-1713. de Leon J, Grasso SM, Welch A, Miller Z, Shwe W, Rabinovici GD, Miller BL, Henry ML, Gorno-Tempini ML. PMID: 32881346; PMCID: PMC7902304.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Speech production differences in English and Italian speakers with nonfluent variant PPA. Neurology. 2020 03 10; 94(10):e1062-e1072. Canu E, Agosta F, Battistella G, Spinelli EG, DeLeon J, Welch AE, Mandelli ML, Hubbard HI, Moro A, Magnani G, Cappa SF, Miller BL, Filippi M, Gorno-Tempini ML. PMID: 31924679; PMCID: PMC7238919.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    28. Task-Free Functional Language Networks: Reproducibility and Clinical Application. J Neurosci. 2020 02 05; 40(6):1311-1320. Battistella G, Borghesani V, Henry M, Shwe W, Lauricella M, Miller Z, Deleon J, Miller BL, Dronkers N, Brambati SM, Seeley WW, Mandelli ML, Gorno-Tempini ML. PMID: 31852732; PMCID: PMC7002153.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    29. Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration. Aphasiology. 2020; 34(7):865-885. Vonk JMJ, Borghesani V, Battistella G, Younes K, DeLeon J, Welch A, Hubbard HI, Miller ZA, Miller BL, Gorno-Tempini ML. PMID: 33012947; PMCID: PMC7529336.
      View in: PubMed   Mentions: 10  
    30. Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Neurocase. 2019 Feb - Apr; 25(1-2):39-47. De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML. PMID: 31033382; PMCID: PMC6759324.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia. Neuroimage Clin. 2019; 22:101797. Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML. PMID: 31146321; PMCID: PMC6465769.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    32. Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA. Cortex. 2018 11; 108:252-264. Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML. PMID: 30292076; PMCID: PMC6317366.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    33. Frontotemporal dementia. Handb Clin Neurol. 2018; 148:409-430. Deleon J, Miller BL. PMID: 29478591.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    34. Defects of mutant DNMT1 are linked to a spectrum of neurological disorders. Brain. 2015 Apr; 138(Pt 4):845-61. Baets J, Duan X, Wu Y, Smith G, Seeley WW, Mademan I, McGrath NM, Beadell NC, Khoury J, Botuyan MV, Mer G, Worrell GA, Hojo K, DeLeon J, Laura M, Liu YT, Senderek J, Weis J, Van den Bergh P, Merrill SL, Reilly MM, Houlden H, Grossman M, Scherer SS, De Jonghe P, Dyck PJ, Klein CJ. PMID: 25678562; PMCID: PMC5014076.
      View in: PubMed   Mentions: 43     Fields:    
    35. Elicitation of specific syntactic structures in primary progressive aphasia. Brain Lang. 2012 Dec; 123(3):183-90. Deleon J, Gesierich B, Besbris M, Ogar J, Henry ML, Miller BL, Gorno-Tempini ML, Wilson SM. PMID: 23046707; PMCID: PMC3502680.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    36. Syntactic processing depends on dorsal language tracts. Neuron. 2011 Oct 20; 72(2):397-403. Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson DK, Henry ML, Ogar JM, DeLeon J, Miller BL, Gorno-Tempini ML. PMID: 22017996; PMCID: PMC3201770.
      View in: PubMed   Mentions: 130     Fields:    
    37. Adult glial precursor proliferation in mutant SOD1G93A mice. Glia. 2008 Jan 15; 56(2):200-8. Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ. PMID: 18023016.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    38. Neural regions essential for distinct cognitive processes underlying picture naming. Brain. 2007 May; 130(Pt 5):1408-22. DeLeon J, Gottesman RF, Kleinman JT, Newhart M, Davis C, Heidler-Gary J, Lee A, Hillis AE. PMID: 17337482.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    Jessica's Networks
    Concepts (119)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (35)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-15-g9ae42700 on PROFILES-PWEB03.

    Copyright © The Regents of the University of California.