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Renaud La Joie, PhD

Title(s)Assistant Researcher, Neurology
SchoolSchool of Medicine
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-476-6749
ORCID ORCID Icon0000-0003-2581-8100 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, USApost doc2020Clinical Neuroscience
    University of California, Berkeley, USApost doc2014Neuroscience
    Université de Caen Basse-Normandie, FrancePhD2013Psychology
    Université Pierre et Marie Curie (Paris 6), FranceMSc2009Neuroscience
    Université de Caen Basse-Normandie, FranceBS2008Medicine (premed)
    Collapse Awards and Honors
    Alzheimer's Association, International Society to Advance Alzheimer's Research and Treatment 2020de Leon Prize in Neuroimaging
    UCSF2020Dean’s Awards for Excellence in Mentoring
    UCSF Alzheimer's Disease Research Center2019research education component scholarship
    Human Amyloid Imaging2018Young Investigator Award
    Alzheimer's Association2017Young Scientist Award
    Alzheimer's Imaging Consortium2017Best datablitz/poster presentation
    Alzheimer's Association International Conference2017Post-doc poster competition winner
    Réunion Francophone sur la Maladie d'Alzheimer & les syndromes apparentés2016Best Poster

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Connectome-based spread of neurodegenerative processes in Alzheimer?s disease
    NIH K99AG065501Feb 1, 2020 - Jan 31, 2022
    Role: Principal Investigator
    Multimodal imaging of neurodegeneration processes and their propagation
    Alzheimer's Association AARF-16-443577Nov 1, 2016 - Oct 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Rapid Naming Test: Development and initial validation in typically aging adults. Clin Neuropsychol. 2021 Mar 26; 1-22. Stiver J, Staffaroni AM, Walters SM, You MY, Casaletto KB, Erlhoff SJ, Possin KL, Lukic S, La Joie R, Rabinovici GD, Zimmerman ME, Gorno-Tempini ML, Kramer JH. PMID: 33771087.
      View in: PubMed   Mentions:    Fields:    
    2. Crossed cerebellar diaschisis on 18F-FDG PET: Frequency across neurodegenerative syndromes and association with 11C-PIB and 18F-Flortaucipir. J Cereb Blood Flow Metab. 2021 Mar 10; 271678X211001216. Provost K, La Joie R, Strom A, Iaccarino L, Edwards L, Mellinger TJ, Pham J, Baker SL, Miller BL, Jagust WJ, Rabinovici GD. PMID: 33691512.
      View in: PubMed   Mentions:    Fields:    
    3. Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease. Brain. 2021 Mar 09. Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, Hepker M, Hwang JH, Miller ZA, Huang EJ, Karydas AM, Grant H, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Rabinovici GD, Grinberg LT. PMID: 33693619.
      View in: PubMed   Mentions:    Fields:    
    4. Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET. Alzheimers Res Ther. 2021 Feb 08; 13(1):36. Tsoy E, Strom A, Iaccarino L, Erlhoff SJ, Goode CA, Rodriguez AM, Rabinovici GD, Miller BL, Kramer JH, Rankin KP, La Joie R, Possin KL. PMID: 33557905.
      View in: PubMed   Mentions:    Fields:    
    5. Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults. Brain Imaging Behav. 2021 Jan 11. Asken BM, Mantyh WG, La Joie R, Strom A, Casaletto KB, Staffaroni AM, Apple AC, Lindbergh CA, Iaccarino L, You M, Grant H, Fonseca C, Windon C, Younes K, Tanner J, Rabinovici GD, Kramer JH, Gardner RC. PMID: 33432536.
      View in: PubMed   Mentions:    Fields:    
    6. Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts. Eur J Nucl Med Mol Imaging. 2021 Jan 04. Provost K, Iaccarino L, Soleimani-Meigooni DN, Baker S, Edwards L, Eichenlaub U, Hansson O, Jagust W, Janabi M, La Joie R, Lesman-Segev O, Mellinger TJ, Miller BL, Ossenkoppele R, Pham J, Smith R, Sonni I, Strom A, Mattsson-Carlgren N, Rabinovici GD. PMID: 33398408.
      View in: PubMed   Mentions:    Fields:    
    7. Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum. Cereb Cortex. 2021 Jan 01; 31(1):1-14. Iaccarino L, La Joie R, Edwards L, Strom A, Schonhaut DR, Ossenkoppele R, Pham J, Mellinger T, Janabi M, Baker SL, Soleimani-Meigooni D, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. PMID: 32808011.
      View in: PubMed   Mentions:    Fields:    
    8. Diagnostic Accuracy of Amyloid versus 18 F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia. Ann Neurol. 2021 Feb; 89(2):389-401. Lesman-Segev OH, La Joie R, Iaccarino L, Lobach I, Rosen HJ, Seo SW, Janabi M, Baker SL, Edwards L, Pham J, Olichney J, Boxer A, Huang E, Gorno-Tempini M, DeCarli C, Hepker M, Hwang JL, Miller BL, Spina S, Grinberg LT, Seeley WW, Jagust WJ, Rabinovici GD. PMID: 33219525.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. 18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases. Brain. 2020 Dec 05; 143(11):3477-3494. Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL, Edwards L, Eser R, Gorno-Tempini ML, Jagust WJ, Janabi M, Kramer JH, Lesman-Segev OH, Mellinger T, Miller BL, Pham J, Rosen HJ, Spina S, Seeley WW, Strom A, Grinberg LT, Rabinovici GD. PMID: 33141172.
      View in: PubMed   Mentions:    Fields:    
    10. Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET. Neurology. 2020 Dec 01. La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, Soleimani-Meigooni DN, Mellinger T, Janabi M, Miller ZA, Perry DC, Pham J, Strom A, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. PMID: 33262228.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment. JAMA Neurol. 2020 Nov 30. Iaccarino L, La Joie R, Lesman-Segev OH, Lee E, Hanna L, Allen IE, Hillner BE, Siegel BA, Whitmer RA, Carrillo MC, Gatsonis C, Rabinovici GD. PMID: 33252608.
      View in: PubMed   Mentions:    Fields:    
    12. Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir. Alzheimers Dement (Amst). 2020; 12(1):e12133. Sonni I, Lesman Segev OH, Baker SL, Iaccarino L, Korman D, Rabinovici GD, Jagust WJ, Landau SM, La Joie R. PMID: 33313377.
      View in: PubMed   Mentions:
    13. The impact of demographic, clinical, genetic, and imaging variables on tau PET status. Eur J Nucl Med Mol Imaging. 2020 Nov 19. Ossenkoppele R, Leuzy A, Cho H, Sudre CH, Strandberg O, Smith R, Palmqvist S, Mattsson-Carlgren N, Olsson T, Jögi J, Stormrud E, Ryu YH, Choi JY, Boxer AL, Gorno-Tempini ML, Miller BL, Soleimani-Meigooni D, Iaccarino L, La Joie R, Borroni E, Klein G, Pontecorvo MJ, Devous MD, Villeneuve S, Lyoo CH, Rabinovici GD, Hansson O. PMID: 33215319.
      View in: PubMed   Mentions:    Fields:    
    14. Plasma tau and neurofilament light in frontotemporal lobar degeneration and Alzheimer's disease. Neurology. 2020 Nov 16. Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer J, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley W, Miller BL, Rosen HJ, Blennow K, Boxer AL, Rojas JC. PMID: 33199433.
      View in: PubMed   Mentions:    Fields:    
    15. Investigating the clinico-anatomical dissociation in the behavioral variant of Alzheimer disease. Alzheimers Res Ther. 2020 11 14; 12(1):148. Singleton EH, Pijnenburg YAL, Sudre CH, Groot C, Kochova E, Barkhof F, La Joie R, Rosen HJ, Seeley WW, Miller B, Cardoso MJ, Papma J, Scheltens P, Rabinovici GD, Ossenkoppele R. PMID: 33189136.
      View in: PubMed   Mentions:    Fields:    
    16. Hippocampal subfield volumetry from structural isotropic 1?mm3 MRI scans: A note of caution. Hum Brain Mapp. 2020 Oct 15. Wisse LEM, Chételat G, Daugherty AM, de Flores R, la Joie R, Mueller SG, Stark CEL, Wang L, Yushkevich PA, Berron D, Raz N, Bakker A, Olsen RK, Carr VA. PMID: 33058385.
      View in: PubMed   Mentions:    Fields:    
    17. Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults. J Int Neuropsychol Soc. 2020 Oct 14; 1-7. Lindbergh CA, Walker N, La Joie R, Weiner-Light S, Staffaroni AM, Casaletto KB, Elahi F, Walters SM, You M, Cotter D, Asken B, Apple AC, Tsoy E, Neuhaus J, Fonseca C, Wolf A, Cobigo Y, Rosen H, Kramer JH. PMID: 33050976.
      View in: PubMed   Mentions:    Fields:    
    18. Symptomatic amyloid-related imaging abnormalities in an APOE e4/e4 patient treated with aducanumab. Alzheimers Dement (Amst). 2020; 12(1):e12101. VandeVrede L, Gibbs DM, Koestler M, La Joie R, Ljubenkov PA, Provost K, Soleimani-Meigooni D, Strom A, Tsoy E, Rabinovici GD, Boxer AL. PMID: 33072846.
      View in: PubMed   Mentions:
    19. Sex-related differences in the relationship between ß-amyloid and cognitive trajectories in older adults. Neuropsychology. 2020 Nov; 34(8):835-850. Lindbergh CA, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Edwards L, Tsoy E, Elahi F, Walters SM, Cotter D, You M, Apple AC, Asken B, Neuhaus J, Rexach JE, Wojta KJ, Rabinovici G, Kramer JH. PMID: 33030915.
      View in: PubMed   Mentions:    Fields:    
    20. Normalization of CSF pTau measurement by Aß40 improves its performance as a biomarker of Alzheimer's disease. Alzheimers Res Ther. 2020 08 15; 12(1):97. Guo T, Korman D, La Joie R, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM. PMID: 32799929.
      View in: PubMed   Mentions:    Fields:    
    21. Latent atrophy factors related to phenotypical variants of posterior cortical atrophy. Neurology. 2020 09 22; 95(12):e1672-e1685. Groot C, Yeo BTT, Vogel JW, Zhang X, Sun N, Mormino EC, Pijnenburg YAL, Miller BL, Rosen HJ, La Joie R, Barkhof F, Scheltens P, van der Flier WM, Rabinovici GD, Ossenkoppele R. PMID: 32675078.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. BHA-CS: A novel cognitive composite for Alzheimer's disease and related disorders. Alzheimers Dement (Amst). 2020; 12(1):e12042. Tsoy E, Erlhoff SJ, Goode CA, Dorsman KA, Kanjanapong S, Lindbergh CA, La Joie R, Strom A, Rabinovici GD, Lanata SC, Miller BL, Tomaszewski Farias SE, Kramer JH, Rankin KP, Possin KL. PMID: 32582835.
      View in: PubMed   Mentions:
    23. Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease. JAMA Neurol. 2020 May 01; 77(5):632-642. Ossenkoppele R, Lyoo CH, Jester-Broms J, Sudre CH, Cho H, Ryu YH, Choi JY, Smith R, Strandberg O, Palmqvist S, Kramer J, Boxer AL, Gorno-Tempini ML, Miller BL, La Joie R, Rabinovici GD, Hansson O. PMID: 32091549.
      View in: PubMed   Mentions: 1     Fields:    
    24. An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders. Nat Rev Neurol. 2020 May; 16(5):265-284. Ashton NJ, Hye A, Rajkumar AP, Leuzy A, Snowden S, Suárez-Calvet M, Karikari TK, Schöll M, La Joie R, Rabinovici GD, Höglund K, Ballard C, Hortobágyi T, Svenningsson P, Blennow K, Zetterberg H, Aarsland D. PMID: 32322100.
      View in: PubMed   Mentions: 7     Fields:    
    25. Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy. JAMA Neurol. 2020 04 01; 77(4):517-521. Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici GD. PMID: 31904765.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Temporal variant of frontotemporal dementia in C9orf72 repeat expansion carriers: two case studies. Brain Imaging Behav. 2020 Apr; 14(2):336-345. Caso F, Agosta F, Magnani G, Cardamone R, Borghesani V, Miller Z, Riva N, La Joie R, Coppola G, Grinberg LT, Seeley WW, Miller BL, Gorno-Tempini ML, Filippi M. PMID: 32180125.
      View in: PubMed   Mentions:    Fields:    
    27. Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration. Nat Med. 2020 03; 26(3):387-397. Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL. PMID: 32123386.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    28. Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia. JAMA Neurol. 2020 Mar 01; 77(3):358-366. Liu AJ, Staffaroni AM, Rojas-Martinez JC, Olney NT, Alquezar-Burillo C, Ljubenkov PA, La Joie R, Fong JC, Taylor J, Karydas A, Ramos EM, Coppola G, Boxer AL, Rabinovici GD, Miller BL, Kao AW. PMID: 31860018.
      View in: PubMed   Mentions:    Fields:    
    29. A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems. Nat Commun. 2020 02 19; 11(1):960. Vogel JW, La Joie R, Grothe MJ, Diaz-Papkovich A, Doyle A, Vachon-Presseau E, Lepage C, Vos de Wael R, Thomas RA, Iturria-Medina Y, Bernhardt B, Rabinovici GD, Evans AC. PMID: 32075960.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. Morphometric network differences in ageing versus Alzheimer's disease dementia. Brain. 2020 02 01; 143(2):635-649. Pichet Binette A, Gonneaud J, Vogel JW, La Joie R, Rosa-Neto P, Collins DL, Poirier J, Breitner JCS, Villeneuve S, Vachon-Presseau E. PMID: 32040564.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease. Alzheimers Dement. 2020 04; 16(4):681-695. Elahi FM, Casaletto KB, La Joie R, Walters SM, Harvey D, Wolf A, Edwards L, Rivera-Contreras W, Karydas A, Cobigo Y, Rosen HJ, DeCarli C, Miller BL, Rabinovici GD, Kramer JH. PMID: 31879236.
      View in: PubMed   Mentions: 7     Fields:    
    32. Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults. Eur J Nucl Med Mol Imaging. 2020 Aug; 47(9):2155-2164. Pereira JB, Harrison TM, La Joie R, Baker SL, Jagust WJ. PMID: 31915896.
      View in: PubMed   Mentions: 1     Fields:    
    33. Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease. Alzheimers Dement. 2020 02; 16(2):335-344. Ossenkoppele R, Lyoo CH, Sudre CH, van Westen D, Cho H, Ryu YH, Choi JY, Smith R, Strandberg O, Palmqvist S, Westman E, Tsai R, Kramer J, Boxer AL, Gorno-Tempini ML, La Joie R, Miller BL, Rabinovici GD, Hansson O. PMID: 31672482.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET. Sci Transl Med. 2020 01 01; 12(524). La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, Chaudhary K, Edwards L, Iaccarino L, Janabi M, Lesman-Segev OH, Miller ZA, Perry DC, O'Neil JP, Pham J, Rojas JC, Rosen HJ, Seeley WW, Tsai RM, Miller BL, Jagust WJ, Rabinovici GD. PMID: 31894103.
      View in: PubMed   Mentions: 21     Fields:    
    35. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage. J Alzheimers Dis. 2020; 78(1):265-276. Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB. PMID: 32986672.
      View in: PubMed   Mentions:    Fields:    
    36. Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia. Brain Commun. 2019; 1(1):fcz027. Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML. PMID: 32699834.
      View in: PubMed   Mentions:
    37. Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy. Neuroimage Clin. 2019; 24:102025. Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V, Visani AV, Edwards L, O'Neil JP, Baker SL, Gardner RC, Janabi M, Chaudhary K, Perry DC, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD. PMID: 31670152.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain. 2019 08 01; 142(8):2492-2509. Maass A, Berron D, Harrison TM, Adams JN, La Joie R, Baker S, Mellinger T, Bell RK, Swinnerton K, Inglis B, Rabinovici GD, Düzel E, Jagust WJ. PMID: 31199481.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    39. Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time. Alzheimers Res Ther. 2019 07 08; 11(1):61. Kuhn E, Moulinet I, Perrotin A, La Joie R, Landeau B, Tomadesso C, Bejanin A, Sherif S, De La Sayette V, Desgranges B, Vivien D, Poisnel G, Chételat G. PMID: 31286994.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Progress update from the hippocampal subfields group. Alzheimers Dement (Amst). 2019 Dec; 11:439-449. Olsen RK, Carr VA, Daugherty AM, La Joie R, Amaral RSC, Amunts K, Augustinack JC, Bakker A, Bender AR, Berron D, Boccardi M, Bocchetta M, Burggren AC, Chakravarty MM, Chételat G, de Flores R, DeKraker J, Ding SL, Geerlings MI, Huang Y, Insausti R, Johnson EG, Kanel P, Kedo O, Kennedy KM, Keresztes A, Lee JK, Lindenberger U, Mueller SG, Mulligan EM, Ofen N, Palombo DJ, Pasquini L, Pluta J, Raz N, Rodrigue KM, Schlichting ML, Lee Shing Y, Stark CEL, Steve TA, Suthana NA, Wang L, Werkle-Bergner M, Yushkevich PA, Yu Q, Wisse LEM. PMID: 31245529.
      View in: PubMed   Mentions:
    41. An Opioid-Related Amnestic Syndrome With Persistent Effects on Hippocampal Structure and Function. J Neuropsychiatry Clin Neurosci. 2019 Fall; 31(4):392-396. Butler PM, Barash JA, Casaletto KB, Cotter DL, La Joie R, Geschwind MD, Rosen HJ, Kramer JH, Miller BL. PMID: 31177905.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages. J Alzheimers Dis Rep. 2019 May 15; 3(1):103-112. Pasquini L, Rahmani F, Maleki-Balajoo S, La Joie R, Zarei M, Sorg C, Drzezga A, Tahmasian M. PMID: 31259307.
      View in: PubMed   Mentions:
    43. Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. Neuroimage Clin. 2019; 23:101848. Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O'Neil JP, Janabi M, Baker SL, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW, Jagust WJ, Rabinovici GD. PMID: 31077982.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    44. Distinct Interplay Between Atrophy and Hypometabolism in Alzheimer's Versus Semantic Dementia. Cereb Cortex. 2019 05 01; 29(5):1889-1899. Bejanin A, La Joie R, Landeau B, Belliard S, de La Sayette V, Eustache F, Desgranges B, Chételat G. PMID: 29668866.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    45. Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Neurocase. 2019 Feb - Apr; 25(1-2):39-47. De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML. PMID: 31033382.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life Span. J Nucl Med. 2019 10; 60(10):1444-1451. Baker SL, Harrison TM, Maass A, La Joie R, Jagust WJ. PMID: 30877180.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Is there a specific memory signature associated with Aß-PET positivity in patients with amnestic mild cognitive impairment? Neurobiol Aging. 2019 05; 77:94-103. Tomadesso C, Gonneaud J, Egret S, Perrotin A, Pélerin A, de Flores R, de la Sayette V, Desgranges B, Chételat G, La Joie R. PMID: 30784816.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes. Alzheimers Res Ther. 2019 01 31; 11(1):13. Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD. PMID: 30704514.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    49. Longitudinal tau accumulation and atrophy in aging and alzheimer disease. Ann Neurol. 2019 02; 85(2):229-240. Harrison TM, La Joie R, Maass A, Baker SL, Swinnerton K, Fenton L, Mellinger TJ, Edwards L, Pham J, Miller BL, Rabinovici GD, Jagust WJ. PMID: 30597624.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    50. Superior explicit memory despite severe developmental amnesia: In-depth case study and neural correlates. Hippocampus. 2018 12; 28(12):867-885. Jonin PY, Besson G, La Joie R, Pariente J, Belliard S, Barillot C, Barbeau EJ. PMID: 29995351.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement. 2019 02; 15(2):205-216. La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD. PMID: 30347188.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    52. Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA. 2018 09 18; 320(11):1151-1162. Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Schöll M, Strandberg O, Palmqvist S, Mattsson N, Janelidze S, Santillo A, Ohlsson T, Jögi J, Tsai R, La Joie R, Kramer J, Boxer AL, Gorno-Tempini ML, Miller BL, Choi JY, Ryu YH, Lyoo CH, Hansson O. PMID: 30326496.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    53. Brain properties predict proximity to symptom onset in sporadic Alzheimer's disease. Brain. 2018 06 01; 141(6):1871-1883. Vogel JW, Vachon-Presseau E, Pichet Binette A, Tam A, Orban P, La Joie R, Savard M, Picard C, Poirier J, Bellec P, Breitner JCS, Villeneuve S. PMID: 29688388.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    54. Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample. Neurology. 2018 01 23; 90(4):e282-e290. La Joie R, Bejanin A, Fagan AM, Ayakta N, Baker SL, Bourakova V, Boxer AL, Cha J, Karydas A, Jerome G, Maass A, Mensing A, Miller ZA, O'Neil JP, Pham J, Rosen HJ, Tsai R, Visani AV, Miller BL, Jagust WJ, Rabinovici GD. PMID: 29282337.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease. Brain. 2017 Dec 01; 140(12):3286-3300. Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O'Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. PMID: 29053874.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    56. Regional patterns of gray matter volume, hypometabolism, and beta-amyloid in groups at risk of Alzheimer's disease. Neurobiol Aging. 2018 03; 63:140-151. Wirth M, Bejanin A, La Joie R, Arenaza-Urquijo EM, Gonneaud J, Landeau B, Perrotin A, Mézenge F, de La Sayette V, Desgranges B, Chételat G. PMID: 29203090.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    57. Subjective cognitive decline and ß-amyloid burden predict cognitive change in healthy elderly. Neurology. 2017 Nov 07; 89(19):2002-2009. Vogel JW, Varga Doležalová M, La Joie R, Marks SM, Schwimmer HD, Landau SM, Jagust WJ. PMID: 28986416.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    58. Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation. Neurobiol Aging. 2017 11; 59:72-79. Arenaza-Urquijo EM, Bejanin A, Gonneaud J, Wirth M, La Joie R, Mutlu J, Gaubert M, Landeau B, de la Sayette V, Eustache F, Chételat G. PMID: 28764930.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    59. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. Neuroimage. 2017 08 15; 157:448-463. Maass A, Landau S, Baker SL, Horng A, Lockhart SN, La Joie R, Rabinovici GD, Jagust WJ, . PMID: 28587897.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    60. Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings. Neurology. 2017 03 14; 88(11):1095-1097. Lockhart SN, Ayakta N, Winer JR, La Joie R, Rabinovici GD, Jagust WJ. PMID: 28188303.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    61. Qualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders: Association with medical help seeking, cognitive deficits, and ß-amyloid imaging. Alzheimers Dement (Amst). 2016; 5:23-34. La Joie R, Perrotin A, Egret S, Pasquier F, Tomadesso C, Mézenge F, Desgranges B, de La Sayette V, Chételat G. PMID: 28054025.
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    62. Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia. Hum Brain Mapp. 2017 04; 38(4):1791-1800. Bejanin A, Desgranges B, La Joie R, Landeau B, Perrotin A, Mézenge F, Belliard S, de La Sayette V, Eustache F, Chételat G. PMID: 27981671.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    63. A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus. 2017 01; 27(1):3-11. Wisse LEM, Daugherty AM, Olsen RK, Berron D, Carr VA, Stark CEL, Amaral RSC, Amunts K, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren A, Chakravarty MM, Chupin M, Ekstrom A, de Flores R, Insausti R, Kanel P, Kedo O, Kennedy KM, Kerchner GA, LaRocque KF, Liu X, Maass A, Malykhin N, Mueller SG, Ofen N, Palombo DJ, Parekh MB, Pluta JB, Pruessner JC, Raz N, Rodrigue KM, Schoemaker D, Shafer AT, Steve TA, Suthana N, Wang L, Winterburn JL, Yassa MA, Yushkevich PA, la Joie R, . PMID: 27862600.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    64. Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates. Alzheimers Dement. 2017 May; 13(5):550-560. Perrotin A, La Joie R, de La Sayette V, Barré L, Mézenge F, Mutlu J, Guilloteau D, Egret S, Eustache F, Chételat G. PMID: 27693187.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    65. Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease. Brain. 2016 09; 139(Pt 9):2528-39. Chételat G, Ossenkoppele R, Villemagne VL, Perrotin A, Landeau B, Mézenge F, Jagust WJ, Dore V, Miller BL, Egret S, Seeley WW, van der Flier WM, La Joie R, Ames D, van Berckel BN, Scheltens P, Barkhof F, Rowe CC, Masters CL, de La Sayette V, Bouwman F, Rabinovici GD. PMID: 27357349.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    66. Hippocampal Subfield Volumetry and 3D Surface Mapping in Subjective Cognitive Decline. J Alzheimers Dis. 2015 Sep 24; 48 Suppl 1:S141-50. Perrotin A, de Flores R, Lamberton F, Poisnel G, La Joie R, de la Sayette V, Mézenge F, Tomadesso C, Landeau B, Desgranges B, Chételat G. PMID: 26402076.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    67. FDG-PET Contributions to the Pathophysiology of Memory Impairment. Neuropsychol Rev. 2015 Sep; 25(3):326-55. Segobin S, La Joie R, Ritz L, Beaunieux H, Desgranges B, Chételat G, Pitel AL, Eustache F. PMID: 26319237.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    68. Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease. Neuroscience. 2015 Nov 19; 309:29-50. de Flores R, La Joie R, Chételat G. PMID: 26306871.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    69. Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease. Hum Brain Mapp. 2015 Nov; 36(11):4421-37. Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Möller C, Lehmann M, van Berckel BN, Seeley WW, Pijnenburg YA, Gorno-Tempini ML, Kramer JH, Barkhof F, Rosen HJ, van der Flier WM, Jagust WJ, Miller BL, Scheltens P, Rabinovici GD. PMID: 26260856.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    70. Cognitive and Brain Profiles Associated with Current Neuroimaging Biomarkers of Preclinical Alzheimer's Disease. J Neurosci. 2015 Jul 22; 35(29):10402-11. Besson FL, La Joie R, Doeuvre L, Gaubert M, Mézenge F, Egret S, Landeau B, Barré L, Abbas A, Ibazizene M, de La Sayette V, Desgranges B, Eustache F, Chételat G. PMID: 26203136.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    71. Anosognosia in Alzheimer disease: Disconnection between memory and self-related brain networks. Ann Neurol. 2015 Sep; 78(3):477-86. Perrotin A, Desgranges B, Landeau B, Mézenge F, La Joie R, Egret S, Pélerin A, de la Sayette V, Eustache F, Chételat G. PMID: 26085009.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    72. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain. 2015 Sep; 138(Pt 9):2732-49. Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. PMID: 26141491.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    73. Why musical memory can be preserved in advanced Alzheimer's disease. Brain. 2015 Aug; 138(Pt 8):2438-50. Jacobsen JH, Stelzer J, Fritz TH, Chételat G, La Joie R, Turner R. PMID: 26041611.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    74. Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation. Brain. 2015 Jul; 138(Pt 7):2020-33. Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin LW, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust W. PMID: 25953778.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    75. Are AD-Typical Regions the Convergence Point of Multiple Pathologies? Front Aging Neurosci. 2015; 7:42. Villeneuve S, Wirth M, La Joie R. PMID: 25859215.
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    76. Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol. Neuroimage. 2015 May 01; 111:526-41. Yushkevich PA, Amaral RS, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren AC, Carr VA, Chakravarty MM, Chételat G, Daugherty AM, Davachi L, Ding SL, Ekstrom A, Geerlings MI, Hassan A, Huang Y, Iglesias JE, La Joie R, Kerchner GA, LaRocque KF, Libby LA, Malykhin N, Mueller SG, Olsen RK, Palombo DJ, Parekh MB, Pluta JB, Preston AR, Pruessner JC, Ranganath C, Raz N, Schlichting ML, Schoemaker D, Singh S, Stark CE, Suthana N, Tompary A, Turowski MM, Van Leemput K, Wagner AD, Wang L, Winterburn JL, Wisse LE, Yassa MA, Zeineh MM, . PMID: 25596463.
      View in: PubMed   Mentions: 83     Fields:    Translation:Humans
    77. Effects of age and Alzheimer's disease on hippocampal subfields: comparison between manual and FreeSurfer volumetry. Hum Brain Mapp. 2015 Feb; 36(2):463-74. de Flores R, La Joie R, Landeau B, Perrotin A, Mézenge F, de La Sayette V, Eustache F, Desgranges B, Chételat G. PMID: 25231681.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    78. Imaging brain effects of APOE4 in cognitively normal individuals across the lifespan. Neuropsychol Rev. 2014 Sep; 24(3):290-9. Fouquet M, Besson FL, Gonneaud J, La Joie R, Chételat G. PMID: 25146994.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    79. Toward a better understanding of the injured hippocampus: multimodal imaging in functionally relevant substructures. J Neurosci. 2014 Aug 13; 34(33):10793-4. La Joie R. PMID: 25122881.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    80. Gene-environment interactions: lifetime cognitive activity, APOE genotype, and ß-amyloid burden. J Neurosci. 2014 Jun 18; 34(25):8612-7. Wirth M, Villeneuve S, La Joie R, Marks SM, Jagust WJ. PMID: 24948815.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    81. Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks. Neuron. 2014 Mar 19; 81(6):1417-1428. La Joie R, Landeau B, Perrotin A, Bejanin A, Egret S, Pélerin A, Mézenge F, Belliard S, de La Sayette V, Eustache F, Desgranges B, Chételat G. PMID: 24656258.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    82. Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia. Neuroimage Clin. 2013; 3:155-62. La Joie R, Perrotin A, de La Sayette V, Egret S, Doeuvre L, Belliard S, Eustache F, Desgranges B, Chételat G. PMID: 24179859.
      View in: PubMed   Mentions: 67     Fields:    
    83. Readiness to change and brain damage in patients with chronic alcoholism. Psychiatry Res. 2013 Sep 30; 213(3):202-9. Le Berre AP, Rauchs G, La Joie R, Segobin S, Mézenge F, Boudehent C, Vabret F, Viader F, Eustache F, Pitel AL, Beaunieux H. PMID: 23838052.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    84. Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders. Neuroimage. 2013 Dec; 83:450-7. Arenaza-Urquijo EM, Landeau B, La Joie R, Mevel K, Mézenge F, Perrotin A, Desgranges B, Bartrés-Faz D, Eustache F, Chételat G. PMID: 23796547.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    85. Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease. Neuroimage Clin. 2013; 2:356-65. Chételat G, La Joie R, Villain N, Perrotin A, de La Sayette V, Eustache F, Vandenberghe R. PMID: 24179789.
      View in: PubMed   Mentions: 77     Fields:    
    86. Impaired decision-making and brain shrinkage in alcoholism. Eur Psychiatry. 2014 Mar; 29(3):125-33. Le Berre AP, Rauchs G, La Joie R, Mézenge F, Boudehent C, Vabret F, Segobin S, Viader F, Allain P, Eustache F, Pitel AL, Beaunieux H. PMID: 23182846.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    87. Region-specific hierarchy between atrophy, hypometabolism, and ß-amyloid (Aß) load in Alzheimer's disease dementia. J Neurosci. 2012 Nov 14; 32(46):16265-73. La Joie R, Perrotin A, Barré L, Hommet C, Mézenge F, Ibazizene M, Camus V, Abbas A, Landeau B, Guilloteau D, de La Sayette V, Eustache F, Desgranges B, Chételat G. PMID: 23152610.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    88. Age effect on the default mode network, inner thoughts, and cognitive abilities. Neurobiol Aging. 2013 Apr; 34(4):1292-301. Mevel K, Landeau B, Fouquet M, La Joie R, Villain N, Mézenge F, Perrotin A, Eustache F, Desgranges B, Chételat G. PMID: 23084083.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    89. The hippocampus remains activated over the long term for the retrieval of truly episodic memories. PLoS One. 2012; 7(8):e43495. Harand C, Bertran F, La Joie R, Landeau B, Mézenge F, Desgranges B, Peigneux P, Eustache F, Rauchs G. PMID: 22937055.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    90. Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment. Eur J Nucl Med Mol Imaging. 2012 Apr; 39(4):621-31. Camus V, Payoux P, Barré L, Desgranges B, Voisin T, Tauber C, La Joie R, Tafani M, Hommet C, Chételat G, Mondon K, de La Sayette V, Cottier JP, Beaufils E, Ribeiro MJ, Gissot V, Vierron E, Vercouillie J, Vellas B, Eustache F, Guilloteau D. PMID: 22252372.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCTClinical Trials
    91. Role of hippocampal CA1 atrophy in memory encoding deficits in amnestic Mild Cognitive Impairment. Neuroimage. 2012 Feb 15; 59(4):3309-15. Fouquet M, Desgranges B, La Joie R, Rivière D, Mangin JF, Landeau B, Mézenge F, Pélerin A, de La Sayette V, Viader F, Baron JC, Eustache F, Chételat G. PMID: 22119654.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    92. When music and long-term memory interact: effects of musical expertise on functional and structural plasticity in the hippocampus. PLoS One. 2010 Oct 05; 5(10). Groussard M, La Joie R, Rauchs G, Landeau B, Chételat G, Viader F, Desgranges B, Eustache F, Platel H. PMID: 20957158.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    93. Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence. Neuroimage. 2010 Nov 01; 53(2):506-14. La Joie R, Fouquet M, Mézenge F, Landeau B, Villain N, Mevel K, Pélerin A, Eustache F, Desgranges B, Chételat G. PMID: 20600996.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
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