 Joanna Halkias, MD
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| Title(s) | Assistant Professor, Pediatrics |
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| School | School of Medicine |
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| Address | 550 16th. Street
San Francisco CA 94158
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| Phone | 415-502-2526 |
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| vCard | Download vCard |
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 Biography | University of Pennsylvania | BA | 1995 | Biology | | Albert Einstein College of Medicine | MD | 2001 | Medicine | | Children’s Hospital Los Angeles | Residency | 2004 | Pediatric | | Children’s Hospital Los Angeles/University of Southern California | Fellowship | 2007 | Neonatal-Perinatal Medicine | | University of California, Berkeley | Postdoc | 2013 | Immunology | | University of California, San Francisco, CA | | 2019 | Diversity, Equity, and Inclusion Champion Training |
Overview The Halkias lab studies the cellular and molecular signals that drive human immune development with a focus on understanding how early life host-microbe interactions influence adaptive immune responses to perinatal inflammatory disorders such as preterm birth. Early life is a critical time in immune development marked by rapid exposure to environmental antigens. Microbial colonization of mucosal tissues plays a key role in the development and education of the host immune system and influences the susceptibility to immune-mediated disease later in life. Infants born preterm are predisposed to prenatal immune activation and inflammation, critical risk factors underlying much of the pathophysiology in this vulnerable population. In utero infection is the most frequently identified cause of spontaneous preterm birth and fetal T cell activation is associated with severe neonatal disease, yet the signals that drive the activation, differentiation, and regulation of fetal adaptive immunity are not known. We utilize immune and microbial transcriptomics, high parameter flow and mass cytometry, and humanized mouse models to understand the cellular and molecular interactions that instruct human immune cells during this critical window of development.
Research ORNG Applications Bibliographic
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Corroborating evidence refutes batch effect as explanation for fetal bacteria. Microbiome. 2021 Jan 12; 9(1):10.
Rackaityte E, Halkias J, Fukui EM, Mendoza VF, Hayzelden C, Crawford ED, Fujimura KE, Burt TD, Lynch SV. PMID: 33436079.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Mechanisms of Fetal T Cell Tolerance and Immune Regulation. Front Immunol. 2020; 11:588.
Rackaityte E, Halkias J. PMID: 32328065.
View in: PubMed Mentions: Fields:
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Viable bacterial colonization is highly limited in the human intestine in utero. Nat Med. 2020 04; 26(4):599-607.
Rackaityte E, Halkias J, Fukui EM, Mendoza VF, Hayzelden C, Crawford ED, Fujimura KE, Burt TD, Lynch SV. PMID: 32094926.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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CD161 contributes to prenatal immune suppression of IFN?-producing PLZF+ T cells. J Clin Invest. 2019 05 30; 129(9):3562-3577.
Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD. PMID: 31145102.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Studying T Cell Development in Thymic Slices. Methods Mol Biol. 2016; 1323:131-40.
Ross JO, Melichar HJ, Halkias J, Robey EA. PMID: 26294404.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Conserved and divergent aspects of human T-cell development and migration in humanized mice. Immunol Cell Biol. 2015 Sep; 93(8):716-26.
Halkias J, Yen B, Taylor KT, Reinhartz O, Winoto A, Robey EA, Melichar HJ. PMID: 25744551.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Tracking migration during human T cell development. Cell Mol Life Sci. 2014 Aug; 71(16):3101-17.
Halkias J, Melichar HJ, Taylor KT, Robey EA. PMID: 24682469.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):E1913-22.
Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey EA. PMID: 23650399.
View in: PubMed Mentions: 38 Fields: Translation: AnimalsCells
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Opposing chemokine gradients control human thymocyte migration in situ. J Clin Invest. 2013 May; 123(5):2131-42.
Halkias J, Melichar HJ, Taylor KT, Ross JO, Yen B, Cooper SB, Winoto A, Robey EA. PMID: 23585474.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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T cells in cryptopatch aggregates share TCR gamma variable region junctional sequences with gamma delta T cells in the small intestinal epithelium of mice. J Immunol. 2006 Jun 01; 176(11):6532-42.
Podd BS, Thoits J, Whitley N, Cheng HY, Kudla KL, Taniguchi H, Halkias J, Goth K, Camerini V. PMID: 16709810.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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| Year | Publications |
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| 2006 | 1 | | 2013 | 2 | | 2014 | 1 | | 2015 | 1 | | 2016 | 1 | | 2019 | 1 | | 2020 | 2 | | 2021 | 1 |
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