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Tippi Mackenzie, MD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Phone415-476-2479
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityM.D.1997School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    T cell activation and the breakdown of maternal-fetal tolerance in preterm labor
    NIH/NIAID R01AI116880Jun 15, 2015 - May 31, 2020
    Role: Principal Investigator
    Maternal and fetal immune responses to in utero HSC transplantation
    NIH/NIAID K08AI085042Jul 1, 2010 - May 31, 2015
    Role: Principal Investigator
    IN UTERO MESENCHYMAL STEM CELL TRANSPLANTATION
    NIH/NHLBI F32HL010229Jan 5, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC. Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment. Blood Adv. 2018 Dec 26; 2(24):3602-3607. PMID: 30567724.
      View in: PubMed
    2. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 Oct 30; 25(5):1346-1358. PMID: 30380423.
      View in: PubMed
    3. Witt RG, Zobel M, Padilla B, Lee H, MacKenzie TC, Vu L. Evaluation of Clinical Outcomes of Sutureless vs Sutured Closure Techniques in Gastroschisis Repair. JAMA Surg. 2018 Sep 19. PMID: 30325977.
      View in: PubMed
    4. MacKenzie TC. Future AAVenues for In Utero Gene Therapy. Cell Stem Cell. 2018 Sep 06; 23(3):320-321. PMID: 30193130.
      View in: PubMed
    5. Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M. Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth. Front Immunol. 2018; 9:993. PMID: 29867970.
      View in: PubMed
    6. Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-? and TNF-a. Sci Transl Med. 2018 Apr 25; 10(438). PMID: 29695455.
      View in: PubMed
    7. Witt RG, Kreger EM, Buckman LB, Moradi PW, Ho PT, Derderian SC, Tsai P, Baker C, Schramm N, Cleary R, Garcia JV, MacKenzie TC. Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells. Blood Adv. 2018 01 09; 2(1):69-74. PMID: 29344586.
      View in: PubMed
    8. Chumfong I, Lee H, Padilla BE, MacKenzie TC, Vu LT. Esophagoesophagopexy technique for assisted fistulization of esophageal atresia. Pediatr Surg Int. 2018 Jan; 34(1):63-69. PMID: 29124403.
      View in: PubMed
    9. Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM. Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? J Ultrasound Med. 2018 May; 37(5):1185-1191. PMID: 29076544.
      View in: PubMed
    10. Padilla BE, Vu L, Lee H, MacKenzie T, Bratton B, O'Day M, Derderian S. Sacrococcygeal teratoma: late recurrence warrants long-term surveillance. Pediatr Surg Int. 2017 Nov; 33(11):1189-1194. PMID: 28894920.
      View in: PubMed
    11. Witt R, MacKenzie TC, Peranteau WH. Fetal stem cell and gene therapy. Semin Fetal Neonatal Med. 2017 12; 22(6):410-414. PMID: 28619624.
      View in: PubMed
    12. Steurer MA, Peyvandi S, Baer RJ, MacKenzie T, Li BC, Norton ME, Jelliffe-Pawlowski LL, Moon-Grady AJ. Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset. J Pediatr. 2017 08; 187:182-188.e3. PMID: 28533037.
      View in: PubMed
    13. Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E. Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature. Prenat Diagn. 2016 Dec; 36(13):1242-1249. PMID: 27862048.
      View in: PubMed
    14. Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujjavarapu C, Aaserude E, MacKenzie T, Forsberg EC. A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells. Cell Stem Cell. 2016 12 01; 19(6):768-783. PMID: 27666010.
      View in: PubMed
    15. Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J. Magnetic resonance imaging of Müllerian duct anomalies in children. Pediatr Radiol. 2016 May; 46(6):796-805. PMID: 27229498.
      View in: PubMed
    16. Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 06 15; 196(12):4957-66. PMID: 27183609; PMCID: PMC4977025 [Available on 06/15/17].
      View in: PubMed, PubMed Central
    17. Derderian SC, Jayme CM, Cheng LS, Keller RL, Moon-Grady AJ, MacKenzie TC. Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia. Fetal Diagn Ther. 2016; 39(2):117-24. PMID: 26667230.
      View in: PubMed
    18. MacKenzie TC. Fetal Surgical conditions and the unraveling of maternal-fetal tolerance. J Pediatr Surg. 2016 Feb; 51(2):197-9. PMID: 26653947.
      View in: PubMed
    19. Walters MC, MacKenzie TC. A booster shot to cure hemoglobinopathies. Blood. 2015 Sep 03; 126(10):1159-61. PMID: 26337353.
      View in: PubMed
    20. Baer RJ, Chambers CD, Jones KL, Shew SB, MacKenzie TC, Shaw GM, Jelliffe-Pawlowski LL. Maternal factors associated with the occurrence of gastroschisis. Am J Med Genet A. 2015 Jul; 167(7):1534-41. PMID: 25913847.
      View in: PubMed
    21. Wegorzewska M, Le T, Tang Q, MacKenzie TC. Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice. Chimerism. 2014; 5(3-4):68-74. PMID: 25779065.
      View in: PubMed
    22. MacKenzie TC, David AL, Flake AW, Almeida-Porada G. Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy. Front Pharmacol. 2015; 6:15. PMID: 25713535; PMCID: PMC4322602.
      View in: PubMed, PubMed Central
    23. Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC. In utero hematopoietic cell transplantation for hemoglobinopathies. Front Pharmacol. 2014; 5:278. PMID: 25628564; PMCID: PMC4290536.
      View in: PubMed, PubMed Central
    24. Derderian SC, Moradi PW, MacKenzie TC. Placental drug delivery for treatment of congenital hematopoietic disorders. J Pediatr Surg. 2015 Sep; 50(9):1517-20. PMID: 25783323.
      View in: PubMed
    25. Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, Farrell J, Hirose S, Gonzalez J, Keller RL, MacKenzie TC. The many faces of hydrops. J Pediatr Surg. 2015 Jan; 50(1):50-4; discussion 54. PMID: 25598092; PMCID: PMC4315667.
      View in: PubMed, PubMed Central
    26. Jeanty C, Kunisaki SM, MacKenzie TC. Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec; 19(6):349-56. PMID: 25456754.
      View in: PubMed
    27. Jeanty C, Derderian SC, Mackenzie TC. Maternal-fetal cellular trafficking: clinical implications and consequences. Curr Opin Pediatr. 2014 Jun; 26(3):377-82. PMID: 24759226; PMCID: PMC4079801.
      View in: PubMed, PubMed Central
    28. Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice. Blood. 2014 Aug 07; 124(6):973-80. PMID: 24879814; PMCID: PMC4126335.
      View in: PubMed, PubMed Central
    29. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar; 124(3):1027-36. PMID: 24509084; PMCID: PMC3934172.
      View in: PubMed, PubMed Central
    30. Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC. Outcomes of fetal intervention for primary hydrothorax. J Pediatr Surg. 2014 Jun; 49(6):900-3; discussion 903-4. PMID: 24888831.
      View in: PubMed
    31. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol. 2014 Feb 15; 192(4):1938-45. PMID: 24415782; PMCID: PMC4268439.
      View in: PubMed, PubMed Central
    32. Cheng LS, Courtier J, MacKenzie TC. Anal duplication in a one-year-old girl. J Pediatr Surg Case Rep. 2013 Oct 01; 1(10):373-374. PMID: 25774340.
      View in: PubMed
    33. Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatr Res. 2013 Sep; 74(3):290-8. PMID: 23770923.
      View in: PubMed
    34. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013 May 30; 121(22):4595-602. PMID: 23610372; PMCID: PMC3668492.
      View in: PubMed, PubMed Central
    35. Nijagal A, MacKenzie TC. Clinical implications of maternal-fetal cellular trafficking. Semin Pediatr Surg. 2013 Feb; 22(1):62-5. PMID: 23395148.
      View in: PubMed
    36. Schecter SC, Courtier J, Cho SJ, Saadai P, Hirose S, Mackenzie TC, Miniati D. Hepatic portocholecystostomy for biliary atresia: a 25-year follow-up and review. J Pediatr Surg. 2013 Jan; 48(1):262-6. PMID: 23331828.
      View in: PubMed
    37. Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC. Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin. J Pediatr Surg. 2012 Oct; 47(10):1938-42. PMID: 23084212.
      View in: PubMed
    38. Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC. The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases. J Pediatr Surg. 2012 Aug; 47(8):1501-5. PMID: 22901907.
      View in: PubMed
    39. Saadai P, MacKenzie TC. Increased maternal microchimerism after open fetal surgery. Chimerism. 2012 Jul-Dec; 3(3):1-3. PMID: 22992682; PMCID: PMC3545917.
      View in: PubMed, PubMed Central
    40. Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H. Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome. J Pediatr Surg. 2012 Jun; 47(6):1095-100. PMID: 22703776.
      View in: PubMed
    41. Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC. Alterations in maternal-fetal cellular trafficking after fetal surgery. J Pediatr Surg. 2012 Jun; 47(6):1089-94. PMID: 22703775; PMCID: PMC3377979.
      View in: PubMed, PubMed Central
    42. Nijagal A, Flake AW, MacKenzie TC. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun; 39(2):301-10. PMID: 22682381.
      View in: PubMed
    43. Nijagal A, Fleck S, MacKenzie TC. Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance. Chimerism. 2012 Apr-Jun; 3(2):37-9. PMID: 22772071; PMCID: PMC3442810.
      View in: PubMed, PubMed Central
    44. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep; 9(9):e1001143. PMID: 21909240; PMCID: PMC3167782.
      View in: PubMed, PubMed Central
    45. Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC. The maternal immune response inhibits the success of in utero hematopoietic cell transplantation. Chimerism. 2011 Apr; 2(2):55-7. PMID: 21912720.
      View in: PubMed
    46. Nijagal A, Le T, Wegorzewska M, Mackenzie TC. A mouse model of in utero transplantation. J Vis Exp. 2011 Jan 27; (47). PMID: 21307829; PMCID: PMC3182662.
      View in: PubMed, PubMed Central
    47. Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest. 2011 Feb; 121(2):582-92. PMID: 21245575; PMCID: PMC3026737.
      View in: PubMed, PubMed Central
    48. Zaid HB, Rhee SJ, Hirose S, Mackenzie TC. Image of the month--quiz case. Gastric duplication cyst. Arch Surg. 2010 Oct; 145(10):1019, 1020. PMID: 20956774.
      View in: PubMed
    49. Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution. J Pediatr Surg. 2010 Jan; 45(1):155-60; discussion 160. PMID: 20105597.
      View in: PubMed
    50. Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu YL, Flake AW, High KA. Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Mol Ther. 2007 Sep; 15(9):1677-85. PMID: 17565352.
      View in: PubMed
    51. Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery. Fetal Diagn Ther. 2005 Jul-Aug; 20(4):316-20. PMID: 15980648.
      View in: PubMed
    52. MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH, Sena-Esteves M, Wilson JM, Flake AW. Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors. J Gene Med. 2005 Jan; 7(1):50-8. PMID: 15515139.
      View in: PubMed
    53. Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW. Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice. J Gene Med. 2003 Nov; 5(11):941-50. PMID: 14601131.
      View in: PubMed
    54. MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S, Wilson JM, Verma IM, Flake AW. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Mol Ther. 2002 Sep; 6(3):349-58. PMID: 12231171.
      View in: PubMed
    55. MacKenzie TC, Crombleholme TM, Flake AW. The ex-utero intrapartum treatment. Curr Opin Pediatr. 2002 Aug; 14(4):453-8. PMID: 12130912.
      View in: PubMed
    56. Mackenzie TC, Shaaban AF, Radu A, Flake AW. Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice. J Pediatr Surg. 2002 Jul; 37(7):1058-64. PMID: 12077771.
      View in: PubMed
    57. Mackenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LJ, Adzick NS. The natural history of prenatally diagnosed conjoined twins. J Pediatr Surg. 2002 Mar; 37(3):303-9. PMID: 11877639.
      View in: PubMed
    58. MacKenzie TC, Flake AW. Human mesenchymal stem cells: insights from a surrogate in vivo assay system. Cells Tissues Organs. 2002; 171(1):90-5. PMID: 12021494.
      View in: PubMed
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