Tippi Mackenzie, MD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-2479
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    Collapse Biography 
    Collapse Education and Training
    Children's Hospital of PhiladelphiaFellow2007Pediatric Surgery
    Brigham and Women's HospitalChief Resident2005Surgery
    Brigham and Women's HospitalResidency2004Surgery
    Children's Hospital of PhiladelphiaPostdoctoral Studies2002Fetal Therapy
    Stanford UniversityM.D.1997Medicine

    Collapse Overview 
    Collapse Overview
    Tippi MacKenzie is a pediatric and fetal surgeon who is focused on developing better ways to diagnose and treat genetic diseases before birth. She leads a translational research lab examining the unique biology between the mother and her fetus, with the idea that pregnancy complications such as preterm labor arise from a breakdown in maternal-fetal tolerance. At present, the MacKenzie group is focused on preterm labor and fetal therapies including stem cell transplantation, enzyme replacement therapy, and gene therapy.

    Collapse Research 
    Collapse Research Activities and Funding
    Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases
    NIH/NICHHD 1R01HD110270Sep 20, 2022 - Apr 30, 2027
    Role: Principal Investigator
    Developing gene therapy strategies to treat alpha thalassemia
    NIH/NHLBI 1R01HL161291-01Jan 1, 2022 - Dec 31, 2025
    Role: Principal Investigator
    Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens
    NIH R01AI145858Aug 21, 2019 - Jul 31, 2024
    Role: Principal Investigator
    In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial)
    California Institute for Regenerative Medicine (CIRM) CLIN2-09183Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    A precision medicine approach to detect dysbiosis and immune activation in preterm labor
    Burroughs Wellcome Fund Preterm Labor Initiative Jul 1, 2017 - Jun 30, 2021
    Role: Principal Investigator
    T cell activation and the breakdown of maternal-fetal tolerance in preterm labor
    NIH R01AI116880Jun 15, 2015 - May 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease. N Engl J Med. 2022 12 08; 387(23):2150-2158. Cohen JL, Chakraborty P, Fung-Kee-Fung K, Schwab ME, Bali D, Young SP, Gelb MH, Khaledi H, DiBattista A, Smallshaw S, Moretti F, Wong D, Lacroix C, El Demellawy D, Strickland KC, Lougheed J, Moon-Grady A, Lianoglou BR, Harmatz P, Kishnani PS, MacKenzie TC. PMID: 36351280.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry. Blood Adv. 2022 Oct 28. MacKenzie TC, Schwab ME, Lianoglou BR, Gano D, Gonzalez J, Arvon RL, Baschat AA, Bianchi DW, Bitanga M, Bourguignon A, Brown RN, Chen B, Chien M, Davis-Nelson S, de Laat MWM, Ekwattanakit S, Gollin Y, Hirata G, Jelin A, Jolley J, Meyer P, Miller J, Norton ME, Ogasawara KK, Panchalee T, Schindewolf E, Shaw SW, Stumbaugh TL, Thompson AA, Towner D, Tsai PS, Viprakasit V, Volanakis E, Vichinsky E, Allen IE, Zhang L. PMID: 36306387.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI-FDA Meeting). J Clin Pharmacol. 2022 09; 62 Suppl 1:S36-S52. Herzeg A, Almeida-Porada G, Charo RA, David AL, Gonzalez-Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC. PMID: 36106778; PMCID: PMC9547535.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Thymic and extrathymic Aire-expressing cells in maternal-fetal tolerance. Immunol Rev. 2022 07; 308(1):93-104. Sun IH, Gillis-Buck E, Mackenzie TC, Gardner JM. PMID: 35535447.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Fetal therapies and trials for lysosomal storage diseases: a survey of attitudes of parents and patients. Orphanet J Rare Dis. 2022 01 29; 17(1):25. Schwab ME, Brown JEH, Lianoglou B, Jin C, Conroy PC, Gallagher RC, Harmatz P, MacKenzie TC. PMID: 35093147; PMCID: PMC8800365.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Consensus statement for the perinatal management of patients with α thalassemia major. Blood Adv. 2021 12 28; 5(24):5636-5639. MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, Schwab M, Thompson A, Waye JS, Vichinsky E. PMID: 34749399; PMCID: PMC8714716.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Advances in the management of α-thalassemia major: reasons to be optimistic. Hematology Am Soc Hematol Educ Program. 2021 12 10; 2021(1):592-599. Horvei P, MacKenzie T, Kharbanda S. PMID: 34889445; PMCID: PMC8791144.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Prenatal Gene Therapy. Clin Obstet Gynecol. 2021 12 01; 64(4):876-885. Schwab ME, MacKenzie TC. PMID: 34618719.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants. J Immunol. 2021 11 15; 207(10):2445-2455. Le BL, Sper R, Nielsen SCA, Pineda S, Nguyen QH, Lee JY, Boyd SD, MacKenzie TC, Sirota M. PMID: 34654689; PMCID: PMC8578401.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants. Am J Surg. 2022 Jan; 223(1):182-186. Schwab ME, Dong S, Lianoglou BR, Aguilar Lucero AF, Schwartz GB, Norton ME, MacKenzie TC, Sanders SJ. PMID: 34315577.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Extrathymic Aire-expressing cells support maternal-fetal tolerance. Sci Immunol. 2021 07 16; 6(61). Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC. PMID: 34272228; PMCID: PMC9363019.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism. Clin Chem. 2021 01 30; 67(2):351-362. Bianchi DW, Khosrotehrani K, Way SS, MacKenzie TC, Bajema I, O'Donoghue K. PMID: 33417673.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement. Mol Ther. 2020 11 04; 28(11):2316-2319. Sagar R, Almeida-Porada G, Blakemore K, Chan JKY, Choolani M, Götherström C, Jaulent A, MacKenzie TC, Mattar C, Porada CD, Peranteau WH, Schneider H, Shaw SW, Waddington SN, Westgren M, David AL. PMID: 33069884; PMCID: PMC7647692.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis. N Engl J Med. 2020 10 29; 383(18):1746-1756. Sparks TN, Lianoglou BR, Adami RR, Pluym ID, Holliman K, Duffy J, Downum SL, Patel S, Faubel A, Boe NM, Field NT, Murphy A, Laurent LC, Jolley J, Uy C, Slavotinek AM, Devine P, Hodoglugil U, Van Ziffle J, Sanders SJ, MacKenzie TC, Norton ME, University of California Fetal–Maternal Consortium, University of California, San Francisco Center for Maternal–Fetal Precision Medicine. PMID: 33027564; PMCID: PMC7650529.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    15. Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing. PLoS One. 2020; 15(4):e0231239. Witt RG, Blair L, Frascoli M, Rosen MJ, Nguyen QH, Bercovici S, Zompi S, Romero R, Mackenzie TC. PMID: 32294121; PMCID: PMC7159194.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII. Sci Transl Med. 2020 02 26; 12(532). Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC. PMID: 32102934.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells. J Clin Invest. 2019 05 30; 129(9):3562-3577. Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD. PMID: 31145102; PMCID: PMC6715406.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    18. In Utero Gene Therapy Consensus Statement from the IFeTIS. Mol Ther. 2019 04 10; 27(4):705-707. Almeida-Porada G, Waddington SN, Chan JKY, Peranteau WH, MacKenzie T, Porada CD. PMID: 30837116; PMCID: PMC6453510.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    19. Evaluation of Clinical Outcomes of Sutureless vs Sutured Closure Techniques in Gastroschisis Repair. JAMA Surg. 2019 01 01; 154(1):33-39. Witt RG, Zobel M, Padilla B, Lee H, MacKenzie TC, Vu L. PMID: 30325977; PMCID: PMC6439850.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment. Blood Adv. 2018 12 26; 2(24):3602-3607. Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC. PMID: 30567724; PMCID: PMC6306881.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Large Differences in Small RNA Composition Between Human Biofluids. Cell Rep. 2018 10 30; 25(5):1346-1358. Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ. PMID: 30380423; PMCID: PMC6261476.
      View in: PubMed   Mentions: 84     Fields:    Translation:Humans
    22. Future AAVenues for In Utero Gene Therapy. Cell Stem Cell. 2018 09 06; 23(3):320-321. MacKenzie TC. PMID: 30193130.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth. Front Immunol. 2018; 9:993. Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M. PMID: 29867970; PMCID: PMC5954243.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α. Sci Transl Med. 2018 04 25; 10(438). Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC. PMID: 29695455; PMCID: PMC6449052.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    25. Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells. Blood Adv. 2018 01 09; 2(1):69-74. Witt RG, Kreger EM, Buckman LB, Moradi PW, Ho PT, Derderian SC, Tsai P, Baker C, Schramm N, Cleary R, Garcia JV, MacKenzie TC. PMID: 29344586; PMCID: PMC5761626.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    26. Esophagoesophagopexy technique for assisted fistulization of esophageal atresia. Pediatr Surg Int. 2018 Jan; 34(1):63-69. Chumfong I, Lee H, Padilla BE, MacKenzie TC, Vu LT. PMID: 29124403.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter? J Ultrasound Med. 2018 May; 37(5):1185-1191. Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM. PMID: 29076544; PMCID: PMC6029704.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Sacrococcygeal teratoma: late recurrence warrants long-term surveillance. Pediatr Surg Int. 2017 Nov; 33(11):1189-1194. Padilla BE, Vu L, Lee H, MacKenzie T, Bratton B, O'Day M, Derderian S. PMID: 28894920.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Fetal stem cell and gene therapy. Semin Fetal Neonatal Med. 2017 12; 22(6):410-414. Witt R, MacKenzie TC, Peranteau WH. PMID: 28619624.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    30. Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset. J Pediatr. 2017 08; 187:182-188.e3. Steurer MA, Peyvandi S, Baer RJ, MacKenzie T, Li BC, Norton ME, Jelliffe-Pawlowski LL, Moon-Grady AJ. PMID: 28533037.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    31. Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature. Prenat Diagn. 2016 Dec; 36(13):1242-1249. Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E. PMID: 27862048.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    32. A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells. Cell Stem Cell. 2016 12 01; 19(6):768-783. Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujjavarapu C, Aaserude E, MacKenzie T, Forsberg EC. PMID: 27666010; PMCID: PMC5524382.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    33. Magnetic resonance imaging of Müllerian duct anomalies in children. Pediatr Radiol. 2016 May; 46(6):796-805. Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J. PMID: 27229498.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 06 15; 196(12):4957-66. Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. PMID: 27183609; PMCID: PMC4977025.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    35. Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia. Fetal Diagn Ther. 2016; 39(2):117-24. Derderian SC, Jayme CM, Cheng LS, Keller RL, Moon-Grady AJ, MacKenzie TC. PMID: 26667230.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    36. Fetal Surgical conditions and the unraveling of maternal-fetal tolerance. J Pediatr Surg. 2016 Feb; 51(2):197-9. MacKenzie TC. PMID: 26653947.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. A booster shot to cure hemoglobinopathies. Blood. 2015 Sep 03; 126(10):1159-61. Walters MC, MacKenzie TC. PMID: 26337353.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    38. Maternal factors associated with the occurrence of gastroschisis. Am J Med Genet A. 2015 Jul; 167(7):1534-41. Baer RJ, Chambers CD, Jones KL, Shew SB, MacKenzie TC, Shaw GM, Jelliffe-Pawlowski LL. PMID: 25913847.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    39. Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice. Chimerism. 2014; 5(3-4):68-74. Wegorzewska M, Le T, Tang Q, MacKenzie TC. PMID: 25779065; PMCID: PMC5063068.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    40. Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy. Front Pharmacol. 2015; 6:15. MacKenzie TC, David AL, Flake AW, Almeida-Porada G. PMID: 25713535; PMCID: PMC4322602.
      View in: PubMed   Mentions: 10  
    41. In utero hematopoietic cell transplantation for hemoglobinopathies. Front Pharmacol. 2014; 5:278. Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC. PMID: 25628564; PMCID: PMC4290536.
      View in: PubMed   Mentions: 7  
    42. Placental drug delivery for treatment of congenital hematopoietic disorders. J Pediatr Surg. 2015 Sep; 50(9):1517-20. Derderian SC, Moradi PW, MacKenzie TC. PMID: 25783323.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. The many faces of hydrops. J Pediatr Surg. 2015 Jan; 50(1):50-4; discussion 54. Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, Farrell J, Hirose S, Gonzalez J, Keller RL, MacKenzie TC. PMID: 25598092; PMCID: PMC4315667.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    44. Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec; 19(6):349-56. Jeanty C, Kunisaki SM, MacKenzie TC. PMID: 25456754.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    45. Favorable outcomes in high-risk congenital pulmonary airway malformations treated with multiple courses of maternal betamethasone. J Pediatr Surg. 2015 Apr; 50(4):515-8. Derderian SC, Coleman AM, Jeanty C, Lim FY, Shaaban AM, Farrell JA, Hirose S, MacKenzie TC, Lee H. PMID: 25840053.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    46. Maternal-fetal cellular trafficking: clinical implications and consequences. Curr Opin Pediatr. 2014 Jun; 26(3):377-82. Jeanty C, Derderian SC, Mackenzie TC. PMID: 24759226; PMCID: PMC4079801.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    47. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice. Blood. 2014 Aug 07; 124(6):973-80. Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC. PMID: 24879814; PMCID: PMC4126335.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    48. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar; 124(3):1027-36. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. PMID: 24509084; PMCID: PMC3934172.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    49. Outcomes of fetal intervention for primary hydrothorax. J Pediatr Surg. 2014 Jun; 49(6):900-3; discussion 903-4. Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC. PMID: 24888831.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol. 2014 Feb 15; 192(4):1938-45. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC. PMID: 24415782; PMCID: PMC4268439.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    51. Anal duplication in a one-year-old girl. J Pediatr Surg Case Rep. 2013 Oct 01; 1(10):373-374. Cheng LS, Courtier J, MacKenzie TC. PMID: 25774340; PMCID: PMC4358227.
      View in: PubMed   Mentions: 1  
    52. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatr Res. 2013 Sep; 74(3):290-8. Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC. PMID: 23770923; PMCID: PMC4164304.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    53. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013 May 30; 121(22):4595-602. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC. PMID: 23610372; PMCID: PMC3668492.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    54. Clinical implications of maternal-fetal cellular trafficking. Semin Pediatr Surg. 2013 Feb; 22(1):62-5. Nijagal A, MacKenzie TC. PMID: 23395148.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Hepatic portocholecystostomy for biliary atresia: a 25-year follow-up and review. J Pediatr Surg. 2013 Jan; 48(1):262-6. Schecter SC, Courtier J, Cho SJ, Saadai P, Hirose S, Mackenzie TC, Miniati D. PMID: 23331828.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin. J Pediatr Surg. 2012 Oct; 47(10):1938-42. Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC. PMID: 23084212.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    57. The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases. J Pediatr Surg. 2012 Aug; 47(8):1501-5. Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC. PMID: 22901907.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    58. Increased maternal microchimerism after open fetal surgery. Chimerism. 2012 Jul-Dec; 3(3):1-3. Saadai P, MacKenzie TC. PMID: 22992682; PMCID: PMC3545917.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    59. Alterations in maternal-fetal cellular trafficking after fetal surgery. J Pediatr Surg. 2012 Jun; 47(6):1089-94. Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC. PMID: 22703775; PMCID: PMC3377979.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    60. Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome. J Pediatr Surg. 2012 Jun; 47(6):1095-100. Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H. PMID: 22703776.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    61. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun; 39(2):301-10. Nijagal A, Flake AW, MacKenzie TC. PMID: 22682381.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    62. Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance. Chimerism. 2012 Apr-Jun; 3(2):37-9. Nijagal A, Fleck S, MacKenzie TC. PMID: 22772071; PMCID: PMC3442810.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    63. Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia. Am J Transplant. 2012 Feb; 12(2):409-19. Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC. PMID: 22221561.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    64. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep; 9(9):e1001143. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M. PMID: 21909240; PMCID: PMC3167782.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    65. The maternal immune response inhibits the success of in utero hematopoietic cell transplantation. Chimerism. 2011 Apr; 2(2):55-7. Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC. PMID: 21912720; PMCID: PMC3166485.
      View in: PubMed   Mentions: 11     Fields:    
    66. A mouse model of in utero transplantation. J Vis Exp. 2011 Jan 27; (47). Nijagal A, Le T, Wegorzewska M, Mackenzie TC. PMID: 21307829; PMCID: PMC3182662.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    67. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest. 2011 Feb; 121(2):582-92. Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. PMID: 21245575; PMCID: PMC3026737.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    68. Image of the month--quiz case. Gastric duplication cyst. Arch Surg. 2010 Oct; 145(10):1019, 1020. Zaid HB, Rhee SJ, Hirose S, Mackenzie TC. PMID: 20956774.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution. J Pediatr Surg. 2010 Jan; 45(1):155-60; discussion 160. Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K. PMID: 20105597.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    70. Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Mol Ther. 2007 Sep; 15(9):1677-85. Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu YL, Flake AW, High KA. PMID: 17565352.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    71. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery. Fetal Diagn Ther. 2005 Jul-Aug; 20(4):316-20. Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS. PMID: 15980648.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    72. Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors. J Gene Med. 2005 Jan; 7(1):50-8. MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH, Sena-Esteves M, Wilson JM, Flake AW. PMID: 15515139.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    73. Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice. J Gene Med. 2003 Nov; 5(11):941-50. Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW. PMID: 14601131.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    74. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Mol Ther. 2002 Sep; 6(3):349-58. MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S, Wilson JM, Verma IM, Flake AW. PMID: 12231171.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    75. The ex-utero intrapartum treatment. Curr Opin Pediatr. 2002 Aug; 14(4):453-8. MacKenzie TC, Crombleholme TM, Flake AW. PMID: 12130912.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    76. Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice. J Pediatr Surg. 2002 Jul; 37(7):1058-64. Mackenzie TC, Shaaban AF, Radu A, Flake AW. PMID: 12077771.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    77. The natural history of prenatally diagnosed conjoined twins. J Pediatr Surg. 2002 Mar; 37(3):303-9. Mackenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LJ, Adzick NS. PMID: 11877639.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    78. Human mesenchymal stem cells: insights from a surrogate in vivo assay system. Cells Tissues Organs. 2002; 171(1):90-5. MacKenzie TC, Flake AW. PMID: 12021494.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    79. Risk factors for intermediate-term survival after coronary artery bypass grafting. Ann Thorac Surg. 2001 Dec; 72(6):2033-7. Gardner SC, Grunwald GK, Rumsfeld JS, Mackenzie T, Gao D, Perlin JB, McDonald G, Shroyer AL. PMID: 11789789.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    80. Large-volume paracentesis in the management of ascites in children. J Pediatr Gastroenterol Nutr. 2001 Sep; 33(3):245-9. Kramer RE, Sokol RJ, Yerushalmi B, Liu E, MacKenzie T, Hoffenberg EJ, Narkewicz MR. PMID: 11593116.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    81. Survival after first esophageal variceal hemorrhage in patients with biliary atresia. J Pediatr. 2001 Aug; 139(2):291-6. Miga D, Sokol RJ, Mackenzie T, Narkewicz MR, Smith D, Karrer FM. PMID: 11487759.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    82. The management of prenatally diagnosed choledochal cysts. J Pediatr Surg. 2001 Aug; 36(8):1241-3. Mackenzie TC, Howell LJ, Flake AW, Adzick NS. PMID: 11479866.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    83. A fetal lung lesion consisting of bronchogenic cyst, bronchopulmonary sequestration, and congenital cystic adenomatoid malformation: the missing link? Fetal Diagn Ther. 2001 Jul-Aug; 16(4):193-5. MacKenzie TC, Guttenberg ME, Nisenbaum HL, Johnson MP, Adzick NS. PMID: 11399876.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    84. Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep. Blood Cells Mol Dis. 2001 May-Jun; 27(3):601-4. Mackenzie TC, Flake AW. PMID: 11482873.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    85. Multilineage differentiation of human MSC after in utero transplantation. Cytotherapy. 2001; 3(5):403-5. Mackenzie TC, Flake AW. PMID: 11953022.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    86. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med. 2000 Nov; 6(11):1282-6. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW. PMID: 11062543.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansAnimalsCells
    87. Cerebrovascular deaths before and after the appearance of oral contraceptives. Acta Neurol Scand. 1987 Jun; 75(6):427-33. Lidegaard O. PMID: 3630638.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    88. Systemic and renal hemodynamic consequences of manipulation of serum calcium and/or parathyroid hormone in the intact conscious mongrel dog. J Am Coll Nutr. 1987 Apr; 6(2):131-8. Zawada ET, Johnson M, McClung D, TerWee J, MacKenzie T. PMID: 3294973.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    89. Hemoglobin A1 in renal transplant recipients. Arch Intern Med. 1985 Jan; 145(1):82-4. Zawada ET, Johnson M, Mackenzie T, Sica DA, Muakkassa W, Green SJ, Goldman M. PMID: 3882070.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    90. Effect of clonidine therapy on renal hemodynamics in renal transplant hypertension. Arch Intern Med. 1984 Jun; 144(6):1205-8. Green S, Zawada ET, Muakkassa W, Johnson M, Mackenzie T, McClanahan M, Graybill A, Goldman M. PMID: 6375612.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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