Trevor Burt * UCSF Profiles

Trevor Burt, MD

Title(s)	Assistant Professor, Pediatrics
School	School of Medicine
Phone	415-502-2525
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Biography

Education and Training

Harvard University

M.D.

2002

School of Medicine

Awards and Honors

American Society for Clinical Investigation	2014		Young Physician Scientist Award
Burroughs Wellcome Fund	2014 -	2018	Preterm Birth Initiative Award - Fetal Immune Activation and Lineage Switching in Preterm Birth
University of California San Francisco	2014 -	2015	A Novel Approach to Study Human Fetal T Cell Differentiation and Function in vitro using iPS cells.
UCSF-Gladstone Institute of Virology and Immunology Center for AIDS Research (CFAR)	2010 -	2011	“Outside the Box” AIDS Vaccine Discovery Award
Pediatric Scientist Development Program (PSDP)	2006 -	2009	PSDP Fellowship
Sarnoff Cardiovascular Research Foundation	2000 -	2001	Sarnoff Fellowship

Overview

Interests

Human immune system development, Mechanisms of fetal-maternal tolerance, Fetal and neonatal immune response to infections, Immunopathogenesis of preterm labor, Use of ES and iPS cell technologies to study immune development

Research

Research Activities and Funding

Understanding Molecular Pathways for Fetal T Cell Development and Function
NIH/NIAID R21AI120032Jul 1, 2015 - Jun 30, 2017
Role: Principal Investigator

Defining Transition from Fetal to Adult T Cell Predominance in the Human Fetus
NIH/NICHD K08HD067295Feb 10, 2011 - Jan 31, 2016
Role: Principal Investigator

ORNG Applications

Websites

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD. CD161 contributes to prenatal immune suppression of IFN?-producing PLZF+ T cells. J Clin Invest. 2019 May 30; 130. PMID: 31145102.

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Odorizzi PM, Jagannathan P, McIntyre TI, Budker R, Prahl M, Auma A, Burt TD, Nankya F, Nalubega M, Sikyomu E, Musinguzi K, Naluwu K, Kakuru A, Dorsey G, Kamya MR, Feeney ME. In utero priming of highly functional effector T cell responses to human malaria. Sci Transl Med. 2018 Oct 17; 10(463). PMID: 30333241.

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Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 07 31; 9(7):172. PMID: 30065242.

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Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 04 03; 9(4):143. PMID: 29618720.

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Bronevetsky Y, Burt TD, McCune JM. Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-ß Signaling. J Immunol. 2016 12 01; 197(11):4344-4350. PMID: 27793996.

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Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM. Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease. AIDS Res Ther. 2014; 11:27. PMID: 25180041; PMCID: PMC4150425.

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Krow-Lucal ER, Kim CC, Burt TD, McCune JM. Distinct functional programming of human fetal and adult monocytes. Blood. 2014 Mar 20; 123(12):1897-904. PMID: 24518760.

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Burt TD. Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease. Am J Reprod Immunol. 2013 Apr; 69(4):346-58. PMID: 23432802.

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Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM. Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans. Genes Immun. 2012 Apr; 13(3):258-67. PMID: 22048453; PMCID: PMC3330188.

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Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science. 2010 Dec 17; 330(6011):1695-9. PMID: 21164017; PMCID: PMC3276679.

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Burt TD, Seu L, Mold JE, Kappas A, McCune JM. Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol. 2010 Nov 01; 185(9):5279-88. PMID: 20921523; PMCID: PMC3314532.

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Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 05; 322(5907):1562-5. PMID: 19056990; PMCID: PMC2648820.

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Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23. PMID: 18562290.

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Napolitano LA, Burt TD, Bacchetti P, Barrón Y, French AL, Kovacs A, Anastos K, Young M, McCune JM, Greenblatt RM. Increased circulating interleukin-7 levels in HIV-1-infected women. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):581-4. PMID: 16284535; PMCID: PMC3119025.

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Hirsch GM, Kearsey J, Burt T, Karnovsky MJ, Lee T. Medial smooth muscle cell loss in arterial allografts occurs by cytolytic cell induced apoptosis. Eur J Cardiothorac Surg. 1998 Jul; 14(1):89-96; discussion 96-7. PMID: 9726621.

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