Trevor Burt, MD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Address35 Medical Center Way, #001
San Francisco CA 94143
Phone415-502-2525
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityM.D.2002School of Medicine
    Collapse Awards and Honors
    American Society for Clinical Investigation2014Young Physician Scientist Award
    Burroughs Wellcome Fund2014  - 2018Preterm Birth Initiative Award - Fetal Immune Activation and Lineage Switching in Preterm Birth
    University of California San Francisco2014  - 2015A Novel Approach to Study Human Fetal T Cell Differentiation and Function in vitro using iPS cells.
    UCSF-Gladstone Institute of Virology and Immunology Center for AIDS Research (CFAR) 2010  - 2011“Outside the Box” AIDS Vaccine Discovery Award
    Pediatric Scientist Development Program (PSDP)2006  - 2009PSDP Fellowship
    Sarnoff Cardiovascular Research Foundation2000  - 2001Sarnoff Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Understanding Molecular Pathways for Fetal T Cell Development and Function
    NIH R21AI120032Jul 1, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Defining Transition from Fetal to Adult T Cell Predominance in the Human Fetus
    NIH K08HD067295Feb 10, 2011 - Jan 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment. Cell Stem Cell. 2024 Apr 04; 31(4):467-483.e6. Epstein AA, Janos SN, Menozzi L, Pegram K, Jain V, Bisset LC, Davis JT, Morrison S, Shailaja A, Guo Y, Chao AS, Abdi K, Rikard B, Yao J, Gregory SG, Fisher K, Pittman R, Erkanli A, Gustafson KE, Carrico CWT, Malcolm WF, Inder TE, Cotten CM, Burt TD, Shinohara ML, Maxfield CM, Benner EJ. PMID: 38537631; PMCID: PMC11129818.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. An updated management approach of Pompe disease patients with high-sustained anti-rhGAA IgG antibody titers: experience with bortezomib-based immunomodulation. Front Immunol. 2024; 15:1360369. Desai AK, Shrivastava G, Grant CL, Wang RY, Burt TD, Kishnani PS. PMID: 38524130; PMCID: PMC10959098.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Immunophenotype associated with high sustained antibody titers against enzyme replacement therapy in infantile-onset Pompe disease. Front Immunol. 2023; 14:1301912. Desai AK, Smith PB, Yi JS, Rosenberg AS, Burt TD, Kishnani PS. PMID: 38250073; PMCID: PMC10798041.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans. JCI Insight. 2023 Nov 22; 8(22). Locher V, Park S, Bunis DG, Makredes S, Mayer M, Burt TD, Fragiadakis GK, Halkias J. PMID: 37856221; PMCID: PMC10721317.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. In utero human cytomegalovirus infection expands NK cell-like FcγRIII-expressing CD8+ T cells that mediate antibody-dependent functions. medRxiv. 2023 Sep 11. Semmes EC, Nettere DR, Nelson AN, Hurst JH, Cain D, Burt TD, Kurtzberg J, Reeves RK, Coyne CB, Fouda GG, Pollara J, Permar SR, Walsh KM. PMID: 37745390; PMCID: PMC10516071.
      View in: PubMed   Mentions:
    6. Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition. Immunol Rev. 2023 05; 315(1):126-153. Burt TD, McCune JM. PMID: 36960621.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy. Cell Rep Med. 2022 08 16; 3(8):100713. McCauley KE, Rackaityte E, LaMere B, Fadrosh DW, Fujimura KE, Panzer AR, Lin DL, Lynch KV, Halkias J, Mendoza VF, Burt TD, Bendixsen C, Barnes K, Kim H, Jones K, Ownby DR, Johnson CC, Seroogy CM, Gern JE, Boushey HA, Lynch SV, ECHO Children’s Respiratory and Environmental Workgroup. PMID: 35932762; PMCID: PMC9418802.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    8. Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ. Clin Epigenetics. 2022 03 14; 14(1):40. Aguilera J, Han X, Cao S, Balmes J, Lurmann F, Tyner T, Lutzker L, Noth E, Hammond SK, Sampath V, Burt T, Utz PJ, Khatri P, Aghaeepour N, Maecker H, Prunicki M, Nadeau K. PMID: 35287715; PMCID: PMC8919561.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    9. dittoSeq: universal user-friendly single-cell and bulk RNA sequencing visualization toolkit. Bioinformatics. 2021 Apr 01; 36(22-23):5535-5536. Bunis DG, Andrews J, Fragiadakis GK, Burt TD, Sirota M. PMID: 33313640; PMCID: PMC8016464.
      View in: PubMed   Mentions: 73     Fields:    
    10. Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096. Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV. PMID: 33597545; PMCID: PMC7889611.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    11. Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health. Front Immunol. 2020; 11:595297. Semmes EC, Chen JL, Goswami R, Burt TD, Permar SR, Fouda GG. PMID: 33552052; PMCID: PMC7858666.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    12. Corroborating evidence refutes batch effect as explanation for fetal bacteria. Microbiome. 2021 01 12; 9(1):10. Rackaityte E, Halkias J, Fukui EM, Mendoza VF, Hayzelden C, Crawford ED, Fujimura KE, Burt TD, Lynch SV. PMID: 33436079; PMCID: PMC7805121.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. Cell Rep. 2021 01 05; 34(1):108573. Bunis DG, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD. PMID: 33406429; PMCID: PMC10263444.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    14. Viable bacterial colonization is highly limited in the human intestine in utero. Nat Med. 2020 04; 26(4):599-607. Rackaityte E, Halkias J, Fukui EM, Mendoza VF, Hayzelden C, Crawford ED, Fujimura KE, Burt TD, Lynch SV. PMID: 32094926; PMCID: PMC8110246.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    15. Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells. Sci Immunol. 2019 11 22; 4(41). Ng MSF, Roth TL, Mendoza VF, Marson A, Burt TD. PMID: 31757834; PMCID: PMC7340007.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    16. Landscape of stimulation-responsive chromatin across diverse human immune cells. Nat Genet. 2019 10; 51(10):1494-1505. Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, Marson A, Pritchard JK. PMID: 31570894; PMCID: PMC6858557.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    17. CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells. J Clin Invest. 2019 05 30; 129(9):3562-3577. Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD. PMID: 31145102; PMCID: PMC6715406.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    18. In utero priming of highly functional effector T cell responses to human malaria. Sci Transl Med. 2018 10 17; 10(463). Odorizzi PM, Jagannathan P, McIntyre TI, Budker R, Prahl M, Auma A, Burt TD, Nankya F, Nalubega M, Sikyomu E, Musinguzi K, Naluwu K, Kakuru A, Dorsey G, Kamya MR, Feeney ME. PMID: 30333241; PMCID: PMC6321770.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    19. Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 07 31; 9(7):172. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. PMID: 30065242; PMCID: PMC6068199.
      View in: PubMed   Mentions:    Fields:    
    20. Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clin Transl Gastroenterol. 2018 04 03; 9(4):143. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. PMID: 29618720; PMCID: PMC5886978.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling. J Immunol. 2016 12 01; 197(11):4344-4350. Bronevetsky Y, Burt TD, McCune JM. PMID: 27793996; PMCID: PMC5123822.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    22. Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease. AIDS Res Ther. 2014; 11:27. Seu L, Ortiz GM, Burt TD, Deeks SG, Martin JN, McCune JM. PMID: 25180041; PMCID: PMC4150425.
      View in: PubMed   Mentions: 2     Fields:    
    23. Distinct functional programming of human fetal and adult monocytes. Blood. 2014 Mar 20; 123(12):1897-904. Krow-Lucal ER, Kim CC, Burt TD, McCune JM. PMID: 24518760; PMCID: PMC3962163.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    24. Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease. Am J Reprod Immunol. 2013 Apr; 69(4):346-58. Burt TD. PMID: 23432802; PMCID: PMC3951896.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    25. Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans. Genes Immun. 2012 Apr; 13(3):258-67. Seu L, Burt TD, Witte JS, Martin JN, Deeks SG, McCune JM. PMID: 22048453; PMCID: PMC3330188.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    26. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science. 2010 Dec 17; 330(6011):1695-9. Mold JE, Venkatasubrahmanyam S, Burt TD, Michaëlsson J, Rivera JM, Galkina SA, Weinberg K, Stoddart CA, McCune JM. PMID: 21164017; PMCID: PMC3276679.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimalsCells
    27. Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol. 2010 Nov 01; 185(9):5279-88. Burt TD, Seu L, Mold JE, Kappas A, McCune JM. PMID: 20921523; PMCID: PMC3314532.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    28. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science. 2008 Dec 05; 322(5907):1562-5. Mold JE, Michaëlsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee TH, Nixon DF, McCune JM. PMID: 19056990; PMCID: PMC2648820.
      View in: PubMed   Mentions: 412     Fields:    Translation:HumansCells
    29. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. PMID: 18562290; PMCID: PMC2438419.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    30. Increased circulating interleukin-7 levels in HIV-1-infected women. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):581-4. Napolitano LA, Burt TD, Bacchetti P, Barrón Y, French AL, Kovacs A, Anastos K, Young M, McCune JM, Greenblatt RM. PMID: 16284535; PMCID: PMC3119025.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    31. Medial smooth muscle cell loss in arterial allografts occurs by cytolytic cell induced apoptosis. Eur J Cardiothorac Surg. 1998 Jul; 14(1):89-96; discussion 96-7. Hirsch GM, Kearsey J, Burt T, Karnovsky MJ, Lee T. PMID: 9726621.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
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