Arthur Weiss, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
ORCID ORCID Icon0000-0002-2414-9024 Additional info
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    Other Positions
    Title(s)Howard Hughes Investigator

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency Rheumatology
    Collapse Awards and Honors
    National Academy of Sciences2004Member
    UCSF2012Lifetime Achievement in Mentoring Award
    Institute of Medicine2004Member
    American Academy of Arts and Sciences2003Fellow
    UCSF1998Forty-first Faculty Research Lecturer
    European Molecular Biology Organization2017Associate Member
    American College of Rheumatology2016Ephraim P. Engleman Memorial Lecture
    University of Chicago2016Frank and Shirley Fitch Lecture
    American Association of Immunologists2012Lifetime Achievement Award
    American College of Rheumatology2004Distinguished Investigator Award
    American Association of Immunologists2001American Association of Immunologists-Huang Foundation Meritorious Career Award
    NIH, NIAID2016Merit Award
    Arthritis Foundation1997Lee C. Howley Prize
    American Association of Immunologists1993Junior Investigator Award
    Western Society for Clinical Investigation1990Young Investigator Award
    American College of Rheumatology1990Henry Kunkel Young Investigator Award
    UCSF2019Establishment of Arthur Weiss Lectureship in Rheumatology and Immunology
    U. Pittsburgh2019Eberly Lecture

    Collapse Overview 
    Collapse Overview
    Research Interest:

    The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.

    Collapse Research 
    Collapse Research Activities and Funding
    Academic Rheumatology and Clinical Immunology
    NIH T32AR079068Jun 1, 2021 - May 31, 2026
    Role: Principal Investigator
    FASEB SRC on Signal Transduction in the Immune System
    NIH R13AI131578May 1, 2017 - Apr 30, 2018
    Role: Principal Investigator
    The cell and molecular mechanisms underlying CD28 costimulation
    NIH R37AI114575Dec 8, 2015 - Nov 30, 2025
    Role: Principal Investigator
    The cell and molecular mechanisms underlying CD28 costimulation
    NIH/NIAID R01AI114575Dec 8, 2015 - Nov 30, 2020
    Role: Principal Investigator
    FASEB SRC on Signal Transduction in the Immune System
    NIH R13AI118149May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
    NIH P01AI091580Jul 15, 2011 - Jun 30, 2021
    Role: Principal Investigator
    An allosteric inhibitor of ZAP-70 as a novel therapeutic for autoimmune disease
    NIH RC2AR058947Sep 25, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Function of the RPTP CD148 in the Hematopoietic Lineage
    NIH R01AI066120Feb 15, 2006 - Jan 31, 2012
    Role: Principal Investigator
    Conference Proposal: Receptors and Signal Transduction
    NIH R13CA094912Jun 1, 2002 - May 31, 2003
    Role: Principal Investigator
    NIH P01AI045865Sep 30, 1999 - Aug 31, 2003
    Role: Co-Investigator
    Immune Tolerance and Autoimmunity
    NIH P01AI035297Sep 1, 1997 - Jul 31, 2012
    Role: Co-Investigator
    NIH R01CA072531Feb 20, 1997 - Jan 31, 2006
    Role: Principal Investigator
    NIH R01GM044493Feb 1, 1992 - Jan 31, 1996
    Role: Principal Investigator
    NIH R01GM039553Feb 1, 1988 - Nov 30, 2001
    Role: Principal Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator
    Medical Scientist Training Program
    NIH T32GM007618Jul 1, 1978 - Jun 30, 2021
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bruton's Tyrosine Kinase Membrane Dynamics and Signaling. Biophysical Journal. 2020 Feb 1; 118(3):560a-561a. Laura M. Nocka, Jean K. Chung, Aubrianna Decker, Theresa Kadlecek, Arthur Weiss, John Kuriyan, Jay T. Groves. .
      View in: Publisher Site   Mentions:
    2. How the T Cell Signaling Network Processes Information to Discriminate between Self and Cognate Ligands. Biophysical Journal. 2020 Feb 1; 118(3):245a. Raman S. Ganti, Wan-Lin Lo, Darren McAffee, Jay T. Groves, Arthur Weiss, Arup K. Chakraborty. .
      View in: Publisher Site   Mentions:
    3. The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions. Blood. 2019 01 24; 133(4):331-343. Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA. PMID: 30429161.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    4. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol. 2018 07; 19(7):733-741. Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A. PMID: 29915297.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    5. Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. Elife. 2018 03 16; 7. Shah NH, Löbel M, Weiss A, Kuriyan J. PMID: 29547119.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    6. Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. Blood. 2018 03 08; 131(10):1122-1144. Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA. PMID: 29301754.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. IL-2Rß abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells. Sci Signal. 2017 Dec 19; 10(510). Smith GA, Taunton J, Weiss A. PMID: 29259099.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. TCR Signaling: Mechanisms of Initiation and Propagation. Trends Biochem Sci. 2018 02; 43(2):108-123. Courtney AH, Lo WL, Weiss A. PMID: 29269020.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    9. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 03; 22(3):324-331. Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. PMID: 27932698.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife. 2016 10 04; 5. Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. PMID: 27700984.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    11. Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):3716-3716. Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen. .
      View in: Publisher Site   Mentions:
    12. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. 2015 Aug 24; 4. Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. PMID: 26302204.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nature Immunology. 2015 Feb 1; 16(2):214-214. Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman, Kevan M Shokat, Ellen A Robey, Arthur Weiss. .
      View in: Publisher Site   Mentions:
    14. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem J. 2015 Jan 01; 465(1):149-61. Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. PMID: 25287889.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Insights into the initiation of TCR signaling. Nat Immunol. 2014 Sep; 15(9):798-807. Chakraborty AK, Weiss A. PMID: 25137454.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    16. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. PMID: 25136127.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    17. Zap70 is essential for long-term survival of naive CD8 T cells. J Immunol. 2014 Sep 15; 193(6):2873-80. Schim van der Loeff I, Hsu LY, Saini M, Weiss A, Seddon B. PMID: 25092893.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):E2550-8. Ross JO, Melichar HJ, Au-Yeung BB, Herzmark P, Weiss A, Robey EA. PMID: 24927565.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife. 2014 May 13; 3:e02270. Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. PMID: 24843022.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. Elife. 2014 Mar 04; 3:e01310. Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM. PMID: 24596147.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. PMID: 24515435.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Investigation of Novel Zap-70 Functionality in T Cell Signaling Pathways using Computational Modeling. Biophysical Journal. 2014 Jan 1; 106(2):376a-377a. Maria P. Frushicheva, Arthur Weiss, Arup K. Chakraborty. .
      View in: Publisher Site   Mentions:
    23. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb; 15(2):186-94. Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. PMID: 24317039.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    24. Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. Cold Spring Harb Symp Quant Biol. 2013; 78:131-139. Tan YX, Zikherman J, Weiss A. PMID: 24100586.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 Jul; 45(7):836-41. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. PMID: 23708189.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    26. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol. 2013 Jun; 33(11):2188-201. Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. PMID: 23530057.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    27. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal. 2013 Jan 01; 6(256):ra1. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. PMID: 23281368.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    28. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec; 122(12):4592-605. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. PMID: 23114597.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    29. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 06; 489(7414):160-4. Zikherman J, Parameswaran R, Weiss A. PMID: 22902503.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    30. The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B. 2012 Mar 22; 116(11):3630-40. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. PMID: 22332778.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    31. Lymphocyte signaling: a Tuscan affair. Nat Immunol. 2011 Dec 16; 13(1):3-6. Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A. PMID: 22179269.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    32. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. Mol Cell Biol. 2011 Nov; 31(22):4550-62. Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T. PMID: 21930792.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    33. Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells. Small GTPases. 2011 Sep; 2(5):282-288. Limnander A, Weiss A. PMID: 22292132.
      View in: PubMed   Mentions: 9     Fields:    
    34. Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. J Biol Chem. 2011 Jun 24; 286(25):22101-12. Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T. PMID: 21543337.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011 Apr 28; 472(7344):471-5. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. PMID: 21525931.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimalsCells
    36. Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood. 2011 Mar 17; 117(11):3087-95. Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL. PMID: 21245479.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J Immunol. 2011 Feb 15; 186(4):1923-33. Liontos LM, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, McGlade CJ. PMID: 21220694.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    38. Chapter 95 CD45. Handbook of Cell Signaling. 2010 Jan 1; 743-748. Michelle L. Hermiston, Vikas Gupta, Arthur Weiss. .
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    39. Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20699-704. Deindl S, Kadlecek TA, Cao X, Kuriyan J, Weiss A. PMID: 19920178.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    40. SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunol Rev. 2009 Nov; 232(1):218-28. Dragone LL, Shaw LA, Myers MD, Weiss A. PMID: 19909366.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    41. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal. 2009 Apr 14; 2(66):pt2. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. PMID: 19366993.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood. 2009 May 14; 113(20):4942-54. Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP. PMID: 19246339.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    43. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell. 2009 Jan 23; 136(2):337-51. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. PMID: 19167334.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    44. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):528-33. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. PMID: 19098101.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    45. The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol. 2008 May; 9(5):522-32. Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B. PMID: 18408722.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    46. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity. 2007 Dec; 27(6):912-26. Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, Weiss A, Liston A, Goodnow CC. PMID: 18093540.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    47. Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J Histochem Cytochem. 2007 Oct; 55(10):1039-48. Schmalzigaug R, Phee H, Davidson CE, Weiss A, Premont RT. PMID: 17565117.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    48. Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell. 2007 May 18; 129(4):735-46. Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J. PMID: 17512407.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    49. The Phenotypic Consequences of an Activating Mutation in the Juxtamembrane Wedge of CD45 Is Sensitive to Genetic Modifiers. Blood. 2006 Nov 16; 108(11):1730-1730. Michelle L. Hermiston, Nicole M. Cresalia, Viola Lam, Allison L. Tan, Arthur Weiss. .
      View in: Publisher Site   Mentions:
    50. ZAP-70 Enhances IgM Signaling in Chronic Lymphocytic Leukemia Cells Independent of Its Tyrosine Kinase Activity. Blood. 2006 Nov 16; 108(11):585-585. Liguang Chen, Lang Huynh, Arthur Weiss, Thomas J. Kipps. .
      View in: Publisher Site   Mentions:
    51. Small molecule inhibition of ZAP-70 kinase activity. The FASEB Journal. 2006 Mar 1; 20(5):lb64-lb65. Susan E Levin, Chao Zhang, Kevan Shokat, Arthur Weiss. .
      View in: Publisher Site   Mentions:
    52. Lymphocyte activation. Current Opinion in Immunology. 2004 Jun 1; 16(3):285-287. Arthur Weiss, John C Cambier. .
      View in: Publisher Site   Mentions:
    53. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 2004 Apr; 4(4):301-8. Abraham RT, Weiss A. PMID: 15057788.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    54. Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J Biol Chem. 2003 May 30; 278(22):20389-94. Hartgroves LC, Lin J, Langen H, Zech T, Weiss A, Harder T. PMID: 12646565.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    55. Chapter 114 CD45. Handbook of Cell Signaling. 2003 Jan 1; (Annu. Rev. Immunol.121994):689-691. Zheng Xu, Michelle L. Hermiston, Arthur Weiss. .
      View in: Publisher Site   Mentions:
    56. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 2002 Dec; 17(6):809-22. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. PMID: 12479826.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    57. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet. 2001 Sep; 29(1):23-4. Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg JR. PMID: 11528386.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    58. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 2001 Sep; 15(3):457-66. Sosinowski T, Killeen N, Weiss A. PMID: 11567635.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    59. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. J Biol Chem. 2001 Nov 30; 276(48):45207-16. Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM. PMID: 11487585.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    60. Regulatory mechanisms for receptor protein tyrosine phosphatases. Chem Rev. 2001 Aug; 101(8):2441-8. Majeti R, Weiss A. PMID: 11749382.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    61. Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Mol Cell Biol. 2001 Jul; 21(13):4208-18. Yablonski D, Kadlecek T, Weiss A. PMID: 11390650.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    62. Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression. Blood. 2001 Jul 01; 98(1):187-93. Shapiro VS, Mollenauer MN, Weiss A. PMID: 11418479.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    63. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem. 2001 Aug 03; 276(31):29588-95. Lin J, Weiss A. PMID: 11395491.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    64. A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer. J Biol Chem. 2001 Jun 29; 276(26):24341-7. Lynch KW, Weiss A. PMID: 11306584.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    65. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Mol Cell Biol. 2001 Apr; 21(7):2393-403. Baker JE, Majeti R, Tangye SG, Weiss A. PMID: 11259588.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    66. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001 Feb 01; 20(3):457-65. Ku GM, Yablonski D, Manser E, Lim L, Weiss A. PMID: 11157752.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    67. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Gene. 2001 Jan 10; 262(1-2):267-73. Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A. PMID: 11179692.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
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    82. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5704-9. Lagunoff M, Majeti R, Weiss A, Ganem D. PMID: 10318948.
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    163. Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines. Protein kinase C-beta is not required for several T cell functions. J Immunol. 1989 Sep 01; 143(5):1692-5. Koretzky GA, Wahi M, Newton ME, Weiss A. PMID: 2788192.
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    165. The lysine residue in the membrane-spanning domain of the beta chain is necessary for cell surface expression of the T cell antigen receptor. J Exp Med. 1988 Dec 01; 168(6):1971-8. Morley BJ, Chin KN, Newton ME, Weiss A. PMID: 2974063.
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    166. At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8613-7. Goldsmith MA, Dazin PF, Weiss A. PMID: 3263650.
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    167. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J Immunol. 1988 Sep 15; 141(6):1904-11. Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. PMID: 2459194.
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    169. The Initiation of Human T Lymphocyte Activation (Part 2 of 2). . 1988 Jul 1; 42:262-279. John B. Imboden, Arthur Weiss. .
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    175. Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation. The T-Cell Receptors. 1988 Jan 1; 133-149. Bernard Manger, John Imboden, Arthur Weiss. .
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    176. CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR. Interleukin. 1988 Jan 1; 85-98. John B. Imboden, Arthur Weiss. .
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    177. The activation of T lymphocytes. Rheum Dis Clin North Am. 1987 Dec; 13(3):411-30. Bockenstedt LK, Goldsmith MA, Koretzky GA, Weiss A. PMID: 2963355.
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    179. Functional competency of T cell antigen receptors in human thymus. J Immunol. 1987 Nov 15; 139(10):3245-50. Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL. PMID: 3500209.
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    180. Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. J Exp Med. 1987 Nov 01; 166(5):1579-84. Phillips JH, Weiss A, Gemlo BT, Rayner AA, Lanier LL. PMID: 3500263.
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    181. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. Biochem J. 1987 Nov 01; 247(3):695-700. Imboden JB, Weiss A. PMID: 3426556.
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    186. Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. J Immunol. 1987 Jul 15; 139(2):625-8. Saito T, Weiss A, Gunter KC, Shevach EM, Germain RN. PMID: 2955045.
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    188. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature. 1987 Apr 2-8; 326(6112):505-7. Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM. PMID: 3104795.
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    191. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. Nature. 1987 Mar 5-11; 326(6108):85-8. Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A. PMID: 3102973.
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    192. A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J Exp Med. 1987 Feb 01; 165(2):395-407. Durand DB, Bush MR, Morgan JG, Weiss A, Crabtree GR. PMID: 3102668.
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    193. Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature. 1987 Jan 8-14; 325(7000):125-30. Saito T, Weiss A, Miller J, Norcross MA, Germain RN. PMID: 3027582.
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    205. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. J Immunol. 1985 Mar; 134(3):1599-603. Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J. PMID: 3918105.
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    207. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med. 1984 Nov 01; 160(5):1284-99. Weiss A, Stobo JD. PMID: 6208306.
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    211. Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction. J Immunol. 1981 Feb; 126(2):482-5. Weiss A, MacDonald HR, Cerottini JC, Brunner KT. PMID: 6450244.
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    212. Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens. J Exp Med. 1980 Nov 01; 152(5):1210-25. Weiss A, Brunner KT, MacDonald HR, Cerottini JC. PMID: 6159445.
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    213. Suppression of rat renal allograft rejection by antigen and antibody. Immunol Rev. 1980; 49:127-65. Stuart FP, McKearn TJ, Weiss A, Fitch FW. PMID: 6989746.
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    214. Selective suppression of humoral and cell-mediated immune responses to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines. Transplant Proc. 1979 Mar; 11(1):932-5. McKearn TJ, Weiss A, Stuart FP, Fitch FW. PMID: 377725.
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    215. Immune reactivity of cells from long-term rat renal allograft survivors. Transplantation. 1978 Nov; 26(5):346-52. Weiss A, Stuart FP, Fitch FW. PMID: 151955.
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    216. Immunological memory is regulated in the enhanced rat renal allograft recipient. Nature. 1978 Jun 22; 273(5664):662-4. Weiss A, Fitch FW, McKearn TJ, Stuart FP. PMID: 351414.
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    217. Graft enhancement and antiidiotypic antibody. Lymphocytes from long-term rat renal allograft recipients have normal responsiveness in vitro. Transplant Proc. 1978 Jun; 10(2):367-72. Fitch FW, Weiss A, McKearn TJ, Stuart FP. PMID: 79259.
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    218. Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen. J Immunol. 1978 Feb; 120(2):357-9. Weiss A, Fitch FW. PMID: 621383.
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    219. Absence of immunologic memory in recipients of enhanced renal allografts. Surg Forum. 1978; 29:330-3. Weiss A, Stuart FP, Fitch FW. PMID: 162608.
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    220. Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies. Curr Top Microbiol Immunol. 1978; 81:61-5. McKearn TJ, Sarmiento M, Weiss A, Stuart FP, Fitch FW. PMID: 308442.
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    221. Macrophages suppress CTL generation in rat mixed leukocyte cultures. J Immunol. 1977 Aug; 119(2):510-6. Weiss A, Fitch FW. PMID: 142114.
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    222. Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum. J Immunol. 1977 Mar; 118(3):1121-3. Weiss A. PMID: 139446.
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    223. Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. Proc Natl Acad Sci U S A. 1972 Sep; 69(9):2456-9. Edidin M, Weiss A. PMID: 4560687.
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