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Arthur Weiss, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-476-1291
ORCID ORCID Icon0000-0002-2414-9024 Additional info
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    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency Rheumatology
    Collapse Awards and Honors
    National Academy of Sciences2004Member
    UCSF2012Lifetime Achievement in Mentoring Award
    Institute of Medicine2004Member
    American Academy of Arts and Sciences2003Fellow
    UCSF1998Forty-first Faculty Research Lecturer
    European Molecular Biology Organization2017Associate Member
    American College of Rheumatology2016Ephraim P. Engleman Memorial Lecture
    University of Chicago2016Frank and Shirley Fitch Lecture
    American Association of Immunologists2012Lifetime Achievement Award
    American College of Rheumatology2004Distinguished Investigator Award
    American Association of Immunologists2001American Association of Immunologists-Huang Foundation Meritorious Career Award
    NIH, NIAID2016Merit Award
    Arthritis Foundation1997Lee C. Howley Prize
    American Association of Immunologists1993Junior Investigator Award
    Western Society for Clinical Investigation1990Young Investigator Award
    American College of Rheumatology1990Henry Kunkel Young Investigator Award
    UCSF2019Establishment of Arthur Weiss Lectureship in Rheumatology and Immunology
    U. Pittsburgh2019Eberly Lecture

    Collapse Overview 
    Collapse Overview
    Research Interest:

    The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.

    Collapse Research 
    Collapse Research Activities and Funding
    Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
    NIH/NIAID P01AI091580May 18, 2020 - Jun 30, 2021
    Role: Principal Investigator
    FASEB SRC on Signal Transduction in the Immune System
    NIH/NIAID R13AI131578May 1, 2017 - Apr 30, 2018
    Role: Principal Investigator
    The cell and molecular mechanisms underlying CD28 costimulation
    NIH/NIAID R01AI114575Dec 8, 2015 - Nov 30, 2020
    Role: Principal Investigator
    The cell and molecular mechanisms underlying CD28 costimulation
    NIH/NIAID R37AI114575Dec 8, 2015 - Nov 30, 2020
    Role: Principal Investigator
    FASEB SRC on Signal Transduction in the Immune System
    NIH/NIAID R13AI118149May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    An allosteric inhibitor of ZAP-70 as a novel therapeutic for autoimmune disease
    NIH/NIAMS RC2AR058947Sep 25, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Function of the RPTP CD148 in the Hematopoietic Lineage
    NIH/NIAID R01AI066120Feb 15, 2006 - Jan 31, 2012
    Role: Principal Investigator
    Conference Proposal: Receptors and Signal Transduction
    NIH/NCI R13CA094912Jun 1, 2002 - May 31, 2003
    Role: Principal Investigator
    HUMAN IMMUNE CELL MATURATION DURING ONTOGENY AND INFECTI
    NIH/NIAID P01AI045865Sep 30, 1999 - Aug 31, 2003
    Role: Co-Investigator
    FUNCTION OF THE VAV PROTOONCOGENE
    NIH/NCI R01CA072531Feb 20, 1997 - Jan 31, 2006
    Role: Principal Investigator
    FUNCTION OF THE CD28 MOLECULE
    NIH/NIGMS R01GM044493Feb 1, 1992 - Jan 31, 1996
    Role: Principal Investigator
    LCK AND CD45 IN T CELL RECEPTOR SIGNAL TRANSDUCTION
    NIH/NIGMS R01GM039553Feb 1, 1988 - Nov 30, 2001
    Role: Principal Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM007618Jul 1, 1978 - Jun 30, 2021
    Role: Co-Principal Investigator
    Immune Tolerance and Autoimmunity
    NIH/NIAID P01AI035297Sep 30, 1999
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bruton's Tyrosine Kinase Membrane Dynamics and Signaling. Biophysical Journal. 2020 Feb 1; 118(3):560a-561a. Laura M. Nocka, Jean K. Chung, Aubrianna Decker, Theresa Kadlecek, Arthur Weiss, John Kuriyan, Jay T. Groves. .
      View in: Publisher Site   Mentions:
    2. How the T Cell Signaling Network Processes Information to Discriminate between Self and Cognate Ligands. Biophysical Journal. 2020 Feb 1; 118(3):245a. Raman S. Ganti, Wan-Lin Lo, Darren McAffee, Jay T. Groves, Arthur Weiss, Arup K. Chakraborty. .
      View in: Publisher Site   Mentions:
    3. CD45 functions as a signaling gatekeeper in T cells. Sci Signal. 2019 10 22; 12(604). Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A. PMID: 31641081.
      View in: PubMed   Mentions:    Fields:    
    4. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol. 2019 11; 20(11):1481-1493. Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A. PMID: 31611699.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18517-18527. Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. PMID: 31455730.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. J Cell Biol. 2019 05 06; 218(5):1619-1633. Wang Y, Huynh W, Skokan TD, Lu W, Weiss A, Vale RD. PMID: 30814157.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions. Blood. 2019 01 24; 133(4):331-343. Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA. PMID: 30429161.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol. 2018 07; 19(7):733-741. Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A. PMID: 29915297.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen. Elife. 2018 03 16; 7. Shah NH, Löbel M, Weiss A, Kuriyan J. PMID: 29547119.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148. Blood. 2018 03 08; 131(10):1122-1144. Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA. PMID: 29301754.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. IL-2Rß abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells. Sci Signal. 2017 Dec 19; 10(510). Smith GA, Taunton J, Weiss A. PMID: 29259099.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. TCR Signaling: Mechanisms of Initiation and Propagation. Trends Biochem Sci. 2018 02; 43(2):108-123. Courtney AH, Lo WL, Weiss A. PMID: 29269020.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    13. A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. Mol Cell. 2017 Aug 03; 67(3):498-511.e6. Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A. PMID: 28735895.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. J Exp Med. 2017 03 06; 214(3):833-849. Hsu LY, Cheng DA, Chen Y, Liang HE, Weiss A. PMID: 28159798.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level. J Immunol. 2017 03 15; 198(6):2445-2456. Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J. PMID: 28159902.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 03; 22(3):324-331. Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. PMID: 27932698.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells. J Immunol. 2017 01 15; 198(2):657-668. Ashouri JF, Weiss A. PMID: 27940659.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells. Immunity. 2016 12 20; 45(6):1232-1244. Skrzypczynska KM, Zhu JW, Weiss A. PMID: 27889108.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife. 2016 10 04; 5. Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J. PMID: 27700984.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways. J Exp Med. 2016 06 27; 213(7):1114. Weiss A. PMID: 27353087.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. CD28 Costimulation: From Mechanism to Therapy. Immunity. 2016 05 17; 44(5):973-88. Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA. PMID: 27192564.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    22. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May; 12(5):373-9. Smith GA, Uchida K, Weiss A, Taunton J. PMID: 27018889.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70. J Exp Med. 2016 Feb 08; 213(2):155-65. Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM. PMID: 26783323.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia. Blood. 2015 Dec 3; 126(23):3716-3716. Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen. .
      View in: Publisher Site   Mentions:
    25. An extracatalytic function of CD45 in B cells is mediated by CD22. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6515-24. Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J. PMID: 26561584.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. Elife. 2015 Oct 30; 4. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. PMID: 26517880.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. Small molecule inhibition of Csk alters affinity recognition by T cells. Elife. 2015 Aug 24; 4. Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A. PMID: 26302204.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    28. The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Sci Signal. 2015 May 19; 8(377):ra49. Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A. PMID: 25990959.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Commentary: "The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level". Front Immunol. 2015; 6:163. Weiss A, Stobo JD. PMID: 25954271.
      View in: PubMed   Mentions: 2     Fields:    
    30. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. PMID: 25799995.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    31. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):E1594-603. Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T. PMID: 25829543.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    32. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. J Immunol. 2015 Apr 15; 194(8):3675-86. Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML. PMID: 25769918.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nature Immunology. 2015 Feb 1; 16(2):214-214. Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman, Kevan M Shokat, Ellen A Robey, Arthur Weiss. .
      View in: Publisher Site   Mentions:
    34. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. J Clin Immunol. 2015 Feb; 35(2):135-46. Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. PMID: 25627829.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    35. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem J. 2015 Jan 01; 465(1):149-61. Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. PMID: 25287889.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. Insights into the initiation of TCR signaling. Nat Immunol. 2014 Sep; 15(9):798-807. Chakraborty AK, Weiss A. PMID: 25137454.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    37. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):E3679-88. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. PMID: 25136127.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    38. Zap70 is essential for long-term survival of naive CD8 T cells. J Immunol. 2014 Sep 15; 193(6):2873-80. Schim van der Loeff I, Hsu LY, Saini M, Weiss A, Seddon B. PMID: 25092893.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    39. Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):E2550-8. Ross JO, Melichar HJ, Au-Yeung BB, Herzmark P, Weiss A, Robey EA. PMID: 24927565.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    40. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014 Jul; 15(7):687-94. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. PMID: 24908390.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    41. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife. 2014 May 13; 3:e02270. Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. PMID: 24843022.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    42. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nat Immunol. 2014 Apr; 15(4):393-401. Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A. PMID: 24608041.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    43. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. Elife. 2014 Mar 04; 3:e01310. Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM. PMID: 24596147.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    44. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. PMID: 24515435.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    45. Investigation of Novel Zap-70 Functionality in T Cell Signaling Pathways using Computational Modeling. Biophysical Journal. 2014 Jan 1; 106(2):376a-377a. Maria P. Frushicheva, Arthur Weiss, Arup K. Chakraborty. .
      View in: Publisher Site   Mentions:
    46. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb; 15(2):186-94. Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. PMID: 24317039.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    47. Tony Pawson: Modular protein domains and the links to intracellular signaling. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17604-5. Weiss A. PMID: 24135003.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    48. Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. Cold Spring Harb Symp Quant Biol. 2013; 78:131-139. Tan YX, Zikherman J, Weiss A. PMID: 24100586.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    49. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. PMID: 23993652.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    50. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 Jul; 45(7):836-41. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. PMID: 23708189.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    51. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. PMID: 23543053.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    52. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol. 2013 Jun; 33(11):2188-201. Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. PMID: 23530057.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    53. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J Immunol. 2013 Mar 15; 190(6):2527-35. Zikherman J, Parameswaran R, Hermiston M, Weiss A. PMID: 23396948.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    54. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal. 2013 Jan 01; 6(256):ra1. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. PMID: 23281368.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    55. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec; 122(12):4592-605. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. PMID: 23114597.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    56. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 06; 489(7414):160-4. Zikherman J, Parameswaran R, Weiss A. PMID: 22902503.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    57. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. PMID: 22820255.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    58. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. PMID: 22570807.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    59. The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B. 2012 Mar 22; 116(11):3630-40. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. PMID: 22332778.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    60. Lymphocyte signaling: a Tuscan affair. Nat Immunol. 2011 Dec 16; 13(1):3-6. Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A. PMID: 22179269.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    61. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):E3-12. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. PMID: 22135465.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    62. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest. 2011 Dec; 121(12):4618-21. Zikherman J, Weiss A. PMID: 22080861.
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    148. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem. 2001 Aug 03; 276(31):29588-95. Lin J, Weiss A. PMID: 11395491.
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    150. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Mol Cell Biol. 2001 Apr; 21(7):2393-403. Baker JE, Majeti R, Tangye SG, Weiss A. PMID: 11259588.
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    151. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001 Feb 01; 20(3):457-65. Ku GM, Yablonski D, Manser E, Lim L, Weiss A. PMID: 11157752.
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    152. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Gene. 2001 Jan 10; 262(1-2):267-73. Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A. PMID: 11179692.
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    153. Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. Adv Immunol. 2001; 79:93-128. Yablonski D, Weiss A. PMID: 11680012.
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    154. Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. J Immunol. 2001 Jan 01; 166(1):656-61. Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A. PMID: 11123350.
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    155. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol. 2001 Jan; 2(1):37-44. Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. PMID: 11135576.
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    156. T cell receptor signalling. J Cell Sci. 2001 Jan; 114(Pt 2):243-4. Lin J, Weiss A. PMID: 11148124.
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    157. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 2000 Dec 22; 103(7):1059-70. Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. PMID: 11163182.
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    158. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunol Today. 2000 Nov; 21(11):584-91. Tomlinson MG, Lin J, Weiss A. PMID: 11094263.
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    159. Signal transduction by the TCR for antigen. Curr Opin Immunol. 2000 Jun; 12(3):242-9. Kane LP, Lin J, Weiss A. PMID: 10781399.
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    160. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity. 2000 Apr; 12(4):399-408. Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. PMID: 10795738.
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    161. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med. 2000 Feb 07; 191(3):463-74. Sosinowski T, Pandey A, Dixit VM, Weiss A. PMID: 10662792.
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    162. A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J Biol Chem. 2000 Jan 21; 275(3):2185-90. Kuhne MR, Ku G, Weiss A. PMID: 10636924.
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    163. Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. J Exp Med. 2000 Jan 17; 191(2):355-64. Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D. PMID: 10637279.
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    164. A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol Cell Biol. 2000 Jan; 20(1):70-80. Lynch KW, Weiss A. PMID: 10594010.
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    165. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem. 1999 Oct 08; 274(41):28861-4. Lin J, Weiss A, Finco TS. PMID: 10506128.
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    166. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J Immunol. 1999 Sep 01; 163(5):2610-20. Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A. PMID: 10453000.
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    167. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5704-9. Lagunoff M, Majeti R, Weiss A, Ganem D. PMID: 10318948.
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    168. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol. 1999 Jan; 19(1):948-56. Zhao Q, Williams BL, Abraham RT, Weiss A. PMID: 9858619.
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    169. The adapter proteins LAT and SLP-76 are required for T-cell activation. Cold Spring Harb Symp Quant Biol. 1999; 64:265-74. Finco TS, Yablonski D, Lin J, Weiss A. PMID: 11232295.
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    170. Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. J Immunol. 1998 Dec 15; 161(12):6455-8. Shapiro VS, Mollenauer MN, Weiss A. PMID: 9862666.
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    171. Differential requirements for ZAP-70 in TCR signaling and T cell development. J Immunol. 1998 Nov 01; 161(9):4688-94. Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A. PMID: 9794398.
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    172. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity. 1998 Nov; 9(5):617-26. Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A. PMID: 9846483.
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    173. A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J. 1998 Oct 01; 17(19):5647-57. Yablonski D, Kane LP, Qian D, Weiss A. PMID: 9755165.
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    174. Switching signals on or off by receptor dimerization. Cell. 1998 Aug 07; 94(3):277-80. Weiss A, Schlessinger J. PMID: 9708728.
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    175. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science. 1998 Jul 17; 281(5375):413-6. Yablonski D, Kuhne MR, Kadlecek T, Weiss A. PMID: 9665884.
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    176. Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions. J Biol Chem. 1998 Apr 10; 273(15):8916-21. Grazioli L, Germain V, Weiss A, Acuto O. PMID: 9535874.
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    177. Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs. J Immunol. 1998 Jan 01; 160(1):163-70. van Oers NS, Love PE, Shores EW, Weiss A. PMID: 9551968.
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    179. Itk negatively regulates induction of T cell proliferation by CD28 costimulation. J Exp Med. 1997 Jul 21; 186(2):221-8. Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR. PMID: 9221751.
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    180. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol. 1997 Jul; 17(7):4051-8. Shapiro VS, Truitt KE, Imboden JB, Weiss A. PMID: 9199340.
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    181. ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. J Cell Biol. 1997 Jun 30; 137(7):1639-49. Huby RD, Iwashima M, Weiss A, Ley SC. PMID: 9199177.
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    182. The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction. J Exp Med. 1997 May 19; 185(10):1877-82. Wu J, Zhao Q, Kurosaki T, Weiss A. PMID: 9151714.
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    183. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J Exp Med. 1997 Apr 07; 185(7):1253-9. Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A. PMID: 9104812.
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    184. T cell antigen receptor signal transduction. Curr Opin Cell Biol. 1997 Apr; 9(2):205-12. Qian D, Weiss A. PMID: 9069257.
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    185. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 1996 Nov 15; 15(22):6251-61. Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A. PMID: 8947048.
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    186. c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1. J Exp Med. 1996 Nov 01; 184(5):1663-9. Shapiro VS, Mollenauer MN, Greene WC, Weiss A. PMID: 8920856.
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    187. Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene. J Exp Med. 1996 Nov 01; 184(5):2031-6. Taylor N, Bacon KB, Smith S, Jahn T, Kadlecek TA, Uribe L, Kohn DB, Gelfand EW, Weiss A, Weinberg K. PMID: 8920891.
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    188. alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity. 1996 Nov; 5(5):429-36. van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A. PMID: 8934570.
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    189. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J Exp Med. 1996 Jul 01; 184(1):295-300. Fry AM, Lanier LL, Weiss A. PMID: 8691146.
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    194. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol Cell Biol. 1995 Dec; 15(12):6820-8. Crooks ME, Littman DR, Carter RH, Fearon DT, Weiss A, Stein PH. PMID: 8524248.
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    195. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. J Exp Med. 1995 Oct 01; 182(4):1057-65. Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A. PMID: 7561679.
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    198. A functional T-cell receptor signaling pathway is required for p95vav activity. Mol Cell Biol. 1995 Aug; 15(8):4337-46. Wu J, Katzav S, Weiss A. PMID: 7623828.
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    199. Multiple kinases mediate T-cell-receptor signaling. Trends Biochem Sci. 1995 Feb; 20(2):59-64. Howe LR, Weiss A. PMID: 7701563.
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    203. The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation. EMBO J. 1994 Sep 01; 13(17):4002-10. Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A. PMID: 8076596.
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    204. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol. 1994 Jul; 14(7):4435-42. Sieh M, Batzer A, Schlessinger J, Weiss A. PMID: 7516467.
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    208. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase. Mol Cell Biol. 1994 May; 14(5):3392-402. Stein PH, Fraser JD, Weiss A. PMID: 8164687.
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    242. T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med. 1990 Feb 22; 322(8):510-7. Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. PMID: 2405272.
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    243. A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction. Int Immunol. 1990; 2(7):615-20. Desai DM, Goldsmith MA, Weiss A. PMID: 1980618.
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    250. At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8613-7. Goldsmith MA, Dazin PF, Weiss A. PMID: 3263650.
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    251. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J Immunol. 1988 Sep 15; 141(6):1904-11. Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. PMID: 2459194.
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    257. Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation. The T-Cell Receptors. 1988 Jan 1; 133-149. Bernard Manger, John Imboden, Arthur Weiss. .
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    258. CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR. Interleukin. 1988 Jan 1; 85-98. John B. Imboden, Arthur Weiss. .
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    261. Functional competency of T cell antigen receptors in human thymus. J Immunol. 1987 Nov 15; 139(10):3245-50. Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL. PMID: 3500209.
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    263. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. Biochem J. 1987 Nov 01; 247(3):695-700. Imboden JB, Weiss A. PMID: 3426556.
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    268. Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. J Immunol. 1987 Jul 15; 139(2):625-8. Saito T, Weiss A, Gunter KC, Shevach EM, Germain RN. PMID: 2955045.
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    273. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. Nature. 1987 Mar 5-11; 326(6108):85-8. Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A. PMID: 3102973.
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    274. A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J Exp Med. 1987 Feb 01; 165(2):395-407. Durand DB, Bush MR, Morgan JG, Weiss A, Crabtree GR. PMID: 3102668.
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    277. Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature. 1987 Jan 8-14; 325(7000):125-30. Saito T, Weiss A, Miller J, Norcross MA, Germain RN. PMID: 3027582.
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    287. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. J Immunol. 1985 Mar; 134(3):1599-603. Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J. PMID: 3918105.
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    289. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med. 1984 Nov 01; 160(5):1284-99. Weiss A, Stobo JD. PMID: 6208306.
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    293. Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction. J Immunol. 1981 Feb; 126(2):482-5. Weiss A, MacDonald HR, Cerottini JC, Brunner KT. PMID: 6450244.
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    294. Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens. J Exp Med. 1980 Nov 01; 152(5):1210-25. Weiss A, Brunner KT, MacDonald HR, Cerottini JC. PMID: 6159445.
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    295. Suppression of rat renal allograft rejection by antigen and antibody. Immunol Rev. 1980; 49:127-65. Stuart FP, McKearn TJ, Weiss A, Fitch FW. PMID: 6989746.
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    296. Selective suppression of humoral and cell-mediated immune responses to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines. Transplant Proc. 1979 Mar; 11(1):932-5. McKearn TJ, Weiss A, Stuart FP, Fitch FW. PMID: 377725.
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    297. Immune reactivity of cells from long-term rat renal allograft survivors. Transplantation. 1978 Nov; 26(5):346-52. Weiss A, Stuart FP, Fitch FW. PMID: 151955.
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    298. Immunological memory is regulated in the enhanced rat renal allograft recipient. Nature. 1978 Jun 22; 273(5664):662-4. Weiss A, Fitch FW, McKearn TJ, Stuart FP. PMID: 351414.
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    299. Graft enhancement and antiidiotypic antibody. Lymphocytes from long-term rat renal allograft recipients have normal responsiveness in vitro. Transplant Proc. 1978 Jun; 10(2):367-72. Fitch FW, Weiss A, McKearn TJ, Stuart FP. PMID: 79259.
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    300. Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen. J Immunol. 1978 Feb; 120(2):357-9. Weiss A, Fitch FW. PMID: 621383.
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    301. Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies. Curr Top Microbiol Immunol. 1978; 81:61-5. McKearn TJ, Sarmiento M, Weiss A, Stuart FP, Fitch FW. PMID: 308442.
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    302. Absence of immunologic memory in recipients of enhanced renal allografts. Surg Forum. 1978; 29:330-3. Weiss A, Stuart FP, Fitch FW. PMID: 162608.
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    303. Macrophages suppress CTL generation in rat mixed leukocyte cultures. J Immunol. 1977 Aug; 119(2):510-6. Weiss A, Fitch FW. PMID: 142114.
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    304. Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum. J Immunol. 1977 Mar; 118(3):1121-3. Weiss A. PMID: 139446.
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    305. Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. Proc Natl Acad Sci U S A. 1972 Sep; 69(9):2456-9. Edidin M, Weiss A. PMID: 4560687.
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