Kazuhito Morioka, MD, PhD
Biography
| The Jikei University, School of Medicine, Japan | MD | 03/2000 | School of Medicine |
| The University of Tokyo and the affiliated hospitals, Japan | Residency | 06/2002 | Orthopaedic Surgery |
| The University of Tokyo, Japan | PhD | 03/2009 | Graduate School of Medicine |
| National Rehabilitation Center for Persons with Disabilities, Japan | Research Fellow | 03/2012 | Neuroscience |
| University of California, San Francisco, CA | Postdoctoral Research Fellow | 03/2018 | Neurological Surgery |
| University of California, San Francisco, CA | | 03/2021 | Diversity, Equity, and Inclusion Champion Training |
| University of California, San Francisco, CA | | 12/2021 | Entrepreneurship for Life Science/Healthcare Startups: Master Class Direct from Silicon Valley |
| 27th Annual Meeting of the Japanese Society for Bone and Mineral Research | 2009 | | Young Investigator Award (Clinical Research) |
| 31st Annual Meeting of the American Society for Bone and Mineral Research | 2009 | | Plenary Poster |
| Japan Neuroscience Society & Society for Neuroscience | 2011 | | JNS-SfN Exchange Travel Award |
| 32th Annual symposium of the National Neurotrauma Society | 2014 | | Student Competition Finalist Presenter |
| 33rd Annual symposium of the National Neurotrauma Society | 2015 | | Student Competition Finalist Presenter |
Overview
Over the past 10 years, Dr. Morioka has worked in clinical orthopaedic surgery from an emergency to rehabilitation as a board-certified orthopaedic surgeon at the University of Tokyo. In the Ph.D., he focused my clinical scientist training on better understanding orthopaedic disorders and developing innovative therapies at Dr. Yusuke Nakamura’s Laboratory, University of Tokyo. After training of pre-clinical central nervous system trauma research at Dr. Martin E. Schwab’s Laboratory, University of Zurich, he conducted the funded projects on spinal cord injury (SCI) research focusing on disuse and spasticity at Japanese National Rehabilitation Center. His mentoring and grantsmanship skills were developed through these experiences.
As a postdoctoral fellow in the UCSF Brain and Spinal Injury Center (BASIC), Dr. Morioka performed research on synaptic plasticity after injury using a comprehensive approach to identify the mechanisms underlying the pathological alternations, which was supported by an Austrian research grant. Leveraging his broad background and expertise, he conducted the collaborative research on polytrauma (traumatic brain injury with concomitant bone fracture) with the UCSF Orthopaedic Trauma Institute (OTI), osteoarthritis with the UCSF Radiology & Biomedical Imaging, microgravity with the UCSD Clinical Physiology Laboratory, and translational SCI with the VA Gordon Mansfield SCI Consortium. These experiences formulated his scientific approach as well as strengthened his mentoring ability.
Dr. Morioka’s current research at the OTI focuses on endochondral fracture healing to study pathological mechanisms and therapeutic intervention for intractable bone fractures, such as delayed, mal, non-union in terms of the interaction between the musculoskeletal and nervous systems. His future research interests are shaped by all experiences toward the cross-interaction within both systems for further understanding of systematical mechanisms of orthopaedic disorders. He hopes that his works might improve patients' quality of life by addressing significant unmet clinical needs.
Bone fracture,
Spinal cord injury,
Traumatic brain injury,
Polytrauma,
Plasticity,
Musculoskeletal system,
Central nervous system,
Microgravity,
Low back pain,
Nociception,
Innervation,
Regeneration,
Surgical infection,
Translational research,
Rehabilitation,
Neurological surgery,
Orthopaedic surgery
Research
ORNG Applications
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Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Improving rigor and reproducibility in western blot experiments with the blotRig analysis software. bioRxiv. 2023 Aug 05.
Omondi C, Chou A, Fond KA, Morioka K, Joseph NR, Sacramento JA, Iorio E, Torres-Espin A, Radabaugh HL, Davis JA, Gumbel JH, Russell Huie J, Ferguson AR. PMID: 37577570; PMCID: PMC10418285.
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PubMed Mentions:
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The biomechanical implications of neck position in cervical contusion animal models of SCI. Front Neurol. 2023; 14:1152472.
Obaid N, Morioka K, Sinopoulou E, Lomas YN, Salegio E, Bresnahan JC, Beattie MS, Sparrey CJ. PMID: 37346165; PMCID: PMC10280737.
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PubMed Mentions:
1
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Altered early immune response after fracture and traumatic brain injury. Front Immunol. 2023; 14:1074207.
Haffner-Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, Ignatius A, Kalbitz M, Marcucio R, Miclau T. PMID: 36761764; PMCID: PMC9905106.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study. J Neurotrauma. 2022 08; 39(15-16):1030-1038.
Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR, Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) Investigators. PMID: 35255740; PMCID: PMC9536347.
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PubMed Mentions: Fields:
Translation:
Humans
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Promoting FAIR Data Through Community-driven Agile Design: the Open Data Commons for Spinal Cord Injury (odc-sci.org). Neuroinformatics. 2022 01; 20(1):203-219.
Torres-Espín A, Almeida CA, Chou A, Huie JR, Chiu M, Vavrek R, Sacramento J, Orr MB, Gensel JC, Grethe JS, Martone ME, Fouad K, Ferguson AR, STREET-FAIR Workshop Participants. PMID: 34347243; PMCID: PMC9537193.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Systemic and local cardiac inflammation after experimental long bone fracture, traumatic brain injury and combined trauma in mice. Journal of Orthopaedic Translation. 2021 May 1; 28:39-46.
Lackner LI, Weber WB, Haffner-Luntzer HM, Hristova HS, Gebhard GF, Lam LC, Morioka MK, Marcucio MR, Miclau MT, Kalbitz KM. .
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Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307.
Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183; PMCID: PMC7497028.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma. Sci Rep. 2019 08 21; 9(1):12199.
Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS. PMID: 31434912; PMCID: PMC6704103.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Meaningful Experiences in Overseas Academia: Facing the Challenge of the Global Era. Journal of Saitama Medical University. 2019; 2(45):55-62.
Morioka K. View Publication.
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Spine and spinal cord injuries: Evaluation and treatment. The Journal of the Japan Medical Association. 2018; 146(11):2231-5.
Ishii K, Morioka K, Shindo M. View Publication.
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Collaboration is a friend in need?: Academic communication all over the world. Experimental Medicine. 2018; 3(36):466-469.
Morioka K. View Publication.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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Topological Data Analysis to Predict Cartilage Lesion Progression in Knee Osteoarthritis. Osteoarthritis and Cartilage. 2017 Apr 1; 25:s240-s241.
Pedoia PV, Haefeli HJ, Morioka MK, Teng TH, Nardo NL, Souza SR, Ferguson FA, Majumdar MS. .
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The swimming test is effective for evaluating spasticity after contusive spinal cord injury. PLoS One. 2017; 12(2):e0171937.
Ryu Y, Ogata T, Nagao M, Kitamura T, Morioka K, Ichihara Y, Doi T, Sawada Y, Akai M, Nishimura R, Fujita N. PMID: 28182676; PMCID: PMC5300247.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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What Is Being Trained? How Divergent Forms of Plasticity Compete To Shape Locomotor Recovery after Spinal Cord Injury. J Neurotrauma. 2017 05 15; 34(10):1831-1840.
Huie JR, Morioka K, Haefeli J, Ferguson AR. PMID: 27875927; PMCID: PMC5444482.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Assessments of sensory plasticity after spinal cord injury across species. Neurosci Lett. 2017 Jun 23; 652:74-81.
Haefeli J, Huie JR, Morioka K, Ferguson AR. PMID: 28007646; PMCID: PMC5466896.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Complication, rehabilitation, and pharmacological therapy in the patient with acute spinal cord injury. Orthopedic Surgery. 2016; 35(70):220-5.
Ishii K, Morioka K. View Publication.
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The crucial role of Erk2 in demyelinating inflammation in the central nervous system. J Neuroinflammation. 2016 09 05; 13(1):235.
Okazaki R, Doi T, Hayakawa K, Morioka K, Imamura O, Takishima K, Hamanoue M, Sawada Y, Nagao M, Tanaka S, Ogata T. PMID: 27596241; PMCID: PMC5011945.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Changes in treatment strategies for cervical spinal cord injury. Journal of Joint Surgery. 2016; 35(6):580-7.
Ishii K, Morioka K. View Publication.
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Cell-permeable p38 MAP kinase promotes migration of adult neural stem/progenitor cells. Sci Rep. 2016 Apr 12; 6:24279.
Hamanoue M, Morioka K, Ohsawa I, Ohsawa K, Kobayashi M, Tsuburaya K, Akasaka Y, Mikami T, Ogata T, Takamatsu K. PMID: 27067799; PMCID: PMC4828673.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems. Advanced Materials Technologies. 2016 Apr 1; 1(1):1600013.
Ota OH, Emaminejad ES, Gao GY, Zhao ZA, Wu WE, Challa CS, Chen CK, Fahad FH, Jha JA, Kiriya KD, Gao GW, Shiraki SH, Morioka MK, Ferguson FA, Healy HK, Davis DR, Javey JA. .
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Early hindlimb unloading produces chronic biomechanical, physiological and molecular signatures of maladaptive plasticity in SCI. Journal of Neurotrauma. 2015; 32(12):A2.
Morioka K, Tazoe T, Huie JR, Guandique CF, Ma X, Sacramento JA, Tanaka S, Bresnahan JC, Beattie MS, Ogata T, Ferguson AR. View Publication.
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Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury. J Neurosci Res. 2014 Dec; 92(12):1647-58.
Hayakawa K, Okazaki R, Morioka K, Nakamura K, Tanaka S, Ogata T. PMID: 25044014.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Early hindlimb unloading produces maladaptive plasticity that limits functional recovery after spinal cord injury (SCI). Journal of Neurotrauma. 2014; 31(12):A6.
Morioka K, Tazoe T, Ma X, Guandique CF, VanCitters L, Huie JR, Bresnahan JC, Beattie MS, Tanaka S, Ferguson AR, Ogata T. View Publication.
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p38 MAP kinase enhances secretion of GDNF and VEGF from rat spinal cord microglia. Journal of Neurochemistry. 2012; 123(s1):91–92.
Hamanoue M, Morioka K, Ogata T, Nakajima K, Takamatsu K. View Publication.
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Evaluating the Severity of Acute Spinal Cord Injuries using Blood Biomarkers. The Japanese Journal of Rehabilitation Medicine. 2012; 49(8):501-3.
Ogata T, Morioka K, Tobimatsu Y, Nakamura K, Akai M, Okazaki R, Hayakawa K, Ueno T. View Publication.
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Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study. Spinal Cord. 2012 Jul; 50(7):493-6.
Hayakawa K, Okazaki R, Ishii K, Ueno T, Izawa N, Tanaka Y, Toyooka S, Matsuoka N, Morioka K, Ohori Y, Nakamura K, Akai M, Tobimatsu Y, Hamabe Y, Ogata T. PMID: 22270191.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Phosphorylated neurofilament subunit NF-H (pNF-H) as a biomarker for evaluating severity of acute spinal cord injury patients. Neuroscience Research. 2011 Sep 1; 71:e59.
Ogata OT, Hayakawa HK, Okazaki OR, Morioka MK, Ishii IK, Tobimatsu TY. .
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The pivotal role of load-related afferent input for the spontaneous recovery of locomotion after incomplete spinal cord injury. Journal of Neurotrauma. 2011; 28(6):A24–25.
Morioka K, Tazoe T, Endoh T, Hayakawa K, Okazaki R, Kawaguchi H, Nakamura K, Ogata T. View Publication.
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Current status of central nervous system regeneration. Journal of therapy. 2011; 93(2):314-8.
Ogata T, Morioka K. View Publication.
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Hes1 functions downstream of growth factors to maintain oligodendrocyte lineage cells in the early progenitor stage. Neuroscience. 2011 Mar 10; 176:132-41.
Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M. PMID: 21167918.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci. 2009 Jul; 100(7):1227-33.
Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, Kawaguchi H, Myoui A, Yoshikawa H, Naka N, Araki N, Kudawara I, Ieguchi M, Nakamura K, Nakamura Y, Matsuda K. PMID: 19486338.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Two cases of pulmonary embolism which occurred during conservative treatment after rupture of the Achilles tendon. Orthop. Surg. Traumatol. 2003; 6(46):789-792.
Hodohara M, Asai J, Ando T, Hayashi H, Morioka K. View Publication.
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Transient osteoporosis of the hip complicated by femoral neck fracture: A case report. Kanto Journal of Orthopedics and Traumatology. 2001; 6(32):379-382.
Morioka K, Takatori Y, Nagai I, Kuruta Y, Okazaki H, Goto T. View Publication.
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
|---|
| 2001 | 1 |
| 2003 | 1 |
| 2009 | 1 |
| 2010 | 1 |
| 2011 | 3 |
| 2012 | 3 |
| 2014 | 2 |
| 2015 | 1 |
| 2016 | 6 |
| 2017 | 4 |
| 2018 | 2 |
| 2019 | 2 |
| 2020 | 1 |
| 2021 | 2 |
| 2022 | 1 |
| 2023 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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