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Kazuhito Morioka, MD, PhD

Title(s)Associate Specialist, Orthopaedic Surgery
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-5407-8178 Additional info
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    Collapse Biography 
    Collapse Education and Training
    The Jikei University, School of Medicine, JapanMD03/2000School of Medicine
    The University of Tokyo, JapanResidency03/2004Orthopaedic Surgery
    The University of Tokyo, JapanPhD03/2009Graduate School of Medicine
    National Rehabilitation Center for Persons with Disabilities, JapanResearch Fellow03/2012Neuroscience
    University of California, San Francisco, CAVisiting Researcher03/2013Neurological Surgery
    University of California, San Francisco, CAPostdoctoral Research Fellow03/2018Neurological Surgery
    University of California, San Francisco, CAAssociate Specialist03/2019Neurological Surgery
    University of California, San Francisco, CAAssociate Specialist03/2020Orthopaedic Surgery
    Collapse Awards and Honors
    27th Annual Meeting of the Japanese Society for Bone and Mineral Research2009Young Investigator Award (Clinical Research)
    31st Annual Meeting of the American Society for Bone and Mineral Research2009Plenary Poster
    Japan Neuroscience Society & Society for Neuroscience2011JNS-SfN Exchange Travel Award
    32th Annual symposium of the National Neurotrauma Society2014Student Competition Finalist Presenter
    33rd Annual symposium of the National Neurotrauma Society2015Student Competition Finalist Presenter

    Collapse Overview 
    Collapse Overview
    Over the past 10 years, I have worked in clinical orthopaedic surgery from emergency to rehabilitation in spinal disorders and related projects in Japan. During my PhD in bone biology and oncology, I received training in molecular biology techniques and statistical genetics/genomics and translation methodology. My doctoral dissertation investigated the gene expression profiles using cDNA microarray analysis in osteosarcoma samples, identifying the tyrosine kinase orphan receptor with ligand Wnt as a candidate therapeutic target for human osteosarcoma. In my postdoctoral fellow in Japan, I received training in pre-clinical spinal cord injury (SCI) research at the University of Zurich, and took part in a pilot study to evaluate a novel biomarker for the severity of SCI patients at the National Rehabilitation Center, gaining an interest in spinal cord research. In my postdoctoral fellow in US, my current research focuses on the cellular mechanisms of neuronal plasticity and functional recovery following traumatic central nervous system injury at UCSF Brain and Spinal Injury Center. I hope that our fruitful projects might serve as patients for allowing to acquire essential functions again leading to improved quality of life.

    Collapse Research 
    Collapse Research Activities and Funding
    Investigation of loading-related spinal plasticity after spinal cord Injury (SCI)
    Wings for Life Spinal Cord Research Foundation Individual Research Grant WFL-US-013/13Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    The role of remyelination in functional recovery after spinal cord injury
    Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research (B) 23300204May 1, 2011 - Mar 31, 2013
    Role: Co-Investigator
    Investigating the mechanism and management of spasticity after spinal cord injury
    Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Young Scientists (B) 23700659May 1, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Induction of corticospinal tract regeneration in chronic spinal cord injury rats, using combination of gene transfer and motor training
    The Japanese Society for Musculoskeletal Medicine Scientific Project n/aJan 1, 2010 - Dec 31, 2011
    Role: Co-Investigator
    Identification of possible treatment effects of functional recovery by rehabilitation after spinal cord injury
    Mitsui Sumitomo Insurance Welfare Foundation Research Grant n/aJan 1, 2010 - Dec 31, 2010
    Role: Principal Investigator
    Investigating the mechanism for contribution of rehabilitation to functional recovery in the subacute phase of spinal cord injury
    Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Young Scientists 21800092Apr 1, 2009 - Mar 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS. Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma. Sci Rep. 2019 Aug 21; 9(1):12199. PMID: 31434912.
      View in: PubMed
    2. Morioka K.. Meaningful Experiences in Overseas Academia: Facing the Challenge of the Global Era. Journal of Saitama Medical University. 2019; 2(45):55-62.
    3. Ishii K, Morioka K, Shindo M.Spine and spinal cord injuries: Evaluation and treatment. The Journal of the Japan Medical Association. 2018; 146(11):2231-5.
    4. Morioka K.. Collaboration is a friend in need?: Academic communication all over the world. Experimental Medicine. 2018; 3(36):466-469.
    5. Pedoia V, Haefeli J, Morioka K, Teng HL, Nardo L, Souza RB, Ferguson AR, Majumdar S. MRI and biomechanics multidimensional data analysis reveals R2 -R1? as an early predictor of cartilage lesion progression in knee osteoarthritis. J Magn Reson Imaging. 2018 01; 47(1):78-90. PMID: 28471543.
      View in: PubMed
    6. V. Pedoia, J. Haefeli, K. Morioka, H.-L. Teng, L. Nardo, R.B. Souza, A.R. Ferguson, S. Majumdar. Topological Data Analysis to Predict Cartilage Lesion Progression in Knee Osteoarthritis. Osteoarthritis and Cartilage. 2017 Apr 1; 25:s240-s241.
      View in: Publisher Site
    7. Ryu Y, Ogata T, Nagao M, Kitamura T, Morioka K, Ichihara Y, Doi T, Sawada Y, Akai M, Nishimura R, Fujita N. The swimming test is effective for evaluating spasticity after contusive spinal cord injury. PLoS One. 2017; 12(2):e0171937. PMID: 28182676.
      View in: PubMed
    8. Huie JR, Morioka K, Haefeli J, Ferguson AR. What Is Being Trained? How Divergent Forms of Plasticity Compete To Shape Locomotor Recovery after Spinal Cord Injury. J Neurotrauma. 2017 05 15; 34(10):1831-1840. PMID: 27875927.
      View in: PubMed
    9. Haefeli J, Huie JR, Morioka K, Ferguson AR. Assessments of sensory plasticity after spinal cord injury across species. Neurosci Lett. 2017 Jun 23; 652:74-81. PMID: 28007646.
      View in: PubMed
    10. Ishii K, Morioka K.. Complication, rehabilitation, and pharmacological therapy in the patient with acute spinal cord injury. Orthopedic Surgery. 2016; 35(70):220-5.
    11. Okazaki R, Doi T, Hayakawa K, Morioka K, Imamura O, Takishima K, Hamanoue M, Sawada Y, Nagao M, Tanaka S, Ogata T. The crucial role of Erk2 in demyelinating inflammation in the central nervous system. J Neuroinflammation. 2016 09 05; 13(1):235. PMID: 27596241.
      View in: PubMed
    12. Ishii K, Morioka K.. Changes in treatment strategies for cervical spinal cord injury. Journal of Joint Surgery. 2016; 35(6):580-7.
    13. Hamanoue M, Morioka K, Ohsawa I, Ohsawa K, Kobayashi M, Tsuburaya K, Akasaka Y, Mikami T, Ogata T, Takamatsu K. Cell-permeable p38?MAP kinase promotes migration of adult neural stem/progenitor cells. Sci Rep. 2016 Apr 12; 6:24279. PMID: 27067799.
      View in: PubMed
    14. Hiroki Ota, Sam Emaminejad, Yuji Gao, Allan Zhao, Eric Wu, Samyuktha Challa, Kevin Chen, Hossain M. Fahad, Amit K. Jha, Daisuke Kiriya, Wei Gao, Hiroshi Shiraki, Kazuhito Morioka, Adam R. Ferguson, Kevin E. Healy, Ronald W. Davis, Ali Javey. Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems. Advanced Materials Technologies. 2016 Apr 1; 1(1):1600013.
      View in: Publisher Site
    15. Morioka K, Tazoe T, Huie JR, Guandique CF, Ma X, Sacramento JA, Tanaka S, Bresnahan JC, Beattie MS, Ogata T, Ferguson AR.Early hindlimb unloading produces chronic biomechanical, physiological and molecular signatures of maladaptive plasticity in SCI. Journal of Neurotrauma. 2015; 32(12):A2.
    16. Hayakawa K, Okazaki R, Morioka K, Nakamura K, Tanaka S, Ogata T. Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury. J Neurosci Res. 2014 Dec; 92(12):1647-58. PMID: 25044014.
      View in: PubMed
    17. Morioka K, Tazoe T, Ma X, Guandique CF, VanCitters L, Huie JR, Bresnahan JC, Beattie MS, Tanaka S, Ferguson AR, Ogata T.Early hindlimb unloading produces maladaptive plasticity that limits functional recovery after spinal cord injury (SCI). Journal of Neurotrauma. 2014; 31(12):A6.
    18. Hamanoue M, Morioka K, Ogata T, Nakajima K, Takamatsu K.p38 MAP kinase enhances secretion of GDNF and VEGF from rat spinal cord microglia. Journal of Neurochemistry. 2012; 123(s1):91–92.
    19. Ogata T, Morioka K, Tobimatsu Y, Nakamura K, Akai M, Okazaki R, Hayakawa K, Ueno T.Evaluating the Severity of Acute Spinal Cord Injuries using Blood Biomarkers. The Japanese Journal of Rehabilitation Medicine. 2012; 49(8):501-3.
    20. Hayakawa K, Okazaki R, Ishii K, Ueno T, Izawa N, Tanaka Y, Toyooka S, Matsuoka N, Morioka K, Ohori Y, Nakamura K, Akai M, Tobimatsu Y, Hamabe Y, Ogata T. Phosphorylated neurofilament subunit NF-H as a biomarker for evaluating the severity of spinal cord injury patients, a pilot study. Spinal Cord. 2012 Jul; 50(7):493-6. PMID: 22270191.
      View in: PubMed
    21. Toru Ogata, Kentaro Hayakawa, Rentaro Okazaki, Kazuhito Morioka, Keisuke Ishii, Yoshiko Tobimatsu. Phosphorylated neurofilament subunit NF-H (pNF-H) as a biomarker for evaluating severity of acute spinal cord injury patients. Neuroscience Research. 2011 Sep 1; 71:e59.
      View in: Publisher Site
    22. Morioka K, Tazoe T, Endoh T, Hayakawa K, Okazaki R, Kawaguchi H, Nakamura K, Ogata T.The pivotal role of load-related afferent input for the spontaneous recovery of locomotion after incomplete spinal cord injury. Journal of Neurotrauma. 2011; 28(6):A24–25.
    23. Ogata T, Morioka K.. Current status of central nervous system regeneration. Journal of therapy. 2011; 93(2):314-8.
    24. Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M. Hes1 functions downstream of growth factors to maintain oligodendrocyte lineage cells in the early progenitor stage. Neuroscience. 2011 Mar 10; 176:132-41. PMID: 21167918.
      View in: PubMed
    25. Morioka K, Tanikawa C, Ochi K, Daigo Y, Katagiri T, Kawano H, Kawaguchi H, Myoui A, Yoshikawa H, Naka N, Araki N, Kudawara I, Ieguchi M, Nakamura K, Nakamura Y, Matsuda K. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. Cancer Sci. 2009 Jul; 100(7):1227-33. PMID: 19486338.
      View in: PubMed
    26. Hodohara M, Asai J, Ando T, Hayashi H, Morioka K.. Two cases of pulmonary embolism which occurred during conservative treatment after rupture of the Achilles tendon. Orthop. Surg. Traumatol. 2003; 6(46):789-792.
    27. Morioka K, Takatori Y, Nagai I, Kuruta Y, Okazaki H, Goto T.Transient osteoporosis of the hip complicated by femoral neck fracture: A case report. Kanto Journal of Orthopedics and Traumatology. 2001; 6(32):379-382.