Kira Poskanzer, PhD

Title(s)Assistant Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Brown UniversityScBBiology
    Collapse Awards and Honors
    Kavli Faculty Service Award
    Charles H. Revson Senior Fellowship in Life Sciences
    Robert Leet and Clara Guthrie Patterson Trust Fellowship in Brain Circuitry
    NSF Graduate Research Fellowship
    Brown University Class of 1873 Award for Academic Excellence in the Biological Sciences

    Collapse Research 
    Collapse Research Activities and Funding
    Role of DNA double-strand breaks in neural function and homeostasis
    NIH/NIA R56AG064363Sep 1, 2019 - Aug 31, 2020
    Role: Co-Principal Investigator
    Dissecting Monoaminergic Physiology of Prefrontal Cortical Astrocytes
    NIH/NIDA R21DA048497Apr 15, 2019 - Mar 31, 2021
    Role: Principal Investigator
    A Functional Taxonomy of Cortical Astrocytes
    NIH/NINDS R01NS099254Dec 1, 2016 - Nov 30, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang Y, DelRosso NV, Vaidyanathan TV, Cahill MK, Reitman ME, Pittolo S, Mi X, Yu G, Poskanzer KE. Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology. Nat Neurosci. 2019 Nov; 22(11):1936-1944. PMID: 31570865.
      View in: PubMed
    2. Pittolo S, Lee H, Lladó A, Tosi S, Bosch M, Bardia L, Gómez-Santacana X, Llebaria A, Soriano E, Colombelli J, Poskanzer KE, Perea G, Gorostiza P. Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology. Proc Natl Acad Sci U S A. 2019 Jul 02; 116(27):13680-13689. PMID: 31196955.
      View in: PubMed
    3. Kastanenka KV, Moreno-Bote R, De Pittà M, Perea G, Eraso-Pichot A, Masgrau R, Poskanzer KE, Galea E. A roadmap to integrate astrocytes into Systems Neuroscience. Glia. 2020 01; 68(1):5-26. PMID: 31058383.
      View in: PubMed
    4. Kim EH, Chin G, Rong G, Poskanzer KE, Clark HA. Optical Probes for Neurobiological Sensing and Imaging. Acc Chem Res. 2018 05 15; 51(5):1023-1032. PMID: 29652127.
      View in: PubMed
    5. Poskanzer KE, Molofsky AV. Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Annu Rev Physiol. 2018 02 10; 80:143-157. PMID: 29166242.
      View in: PubMed
    6. Rong G, Kim EH, Poskanzer KE, Clark HA. A method for estimating intracellular ion concentration using optical nanosensors and ratiometric imaging. Sci Rep. 2017 09 07; 7(1):10819. PMID: 28883429.
      View in: PubMed
    7. Cabrera R, Filevich O, García-Acosta B, Athilingam J, Bender KJ, Poskanzer KE, Etchenique R. A Visible-Light-Sensitive Caged Serotonin. ACS Chem Neurosci. 2017 05 17; 8(5):1036-1042. PMID: 28460173.
      View in: PubMed
    8. Wang D, Miller D, Poskanzer K, Tian L, Yu G .Graphical time warping for joint alignment of multiple curves. Advances in Neural Information Processing Systems (NIPS). 2016; (29):3648–3656.
    9. Poskanzer KE, Yuste R. Astrocytes regulate cortical state switching in vivo. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):E2675-84. PMID: 27122314.
      View in: PubMed
    10. Pnevmatikakis EA, Gao Y, Soudry D, Pfau D, Lacefield C, Poskanzer K, Bruno R, Yuste R, Paninski L.A structured matrix factorization framework for large scale calcium imaging data analysis. arXiv. 2014; 2903 :[q-bio.NC].
    11. Izquierdo-Serra M, Gascón-Moya M, Hirtz JJ, Pittolo S, Poskanzer KE, Ferrer È, Alibés R, Busqué F, Yuste R, Hernando J, Gorostiza P. Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches. J Am Chem Soc. 2014 Jun 18; 136(24):8693-701. PMID: 24857186.
      View in: PubMed
    12. Poskanzer KE, Yuste R. Astrocytic regulation of cortical UP states. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18453-8. PMID: 22027012.
      View in: PubMed
    13. Nikolenko V, Poskanzer KE, Yuste R. Two-photon photostimulation and imaging of neural circuits. Nat Methods. 2007 Nov; 4(11):943-50. PMID: 17965719.
      View in: PubMed
    14. Poskanzer KE, Fetter RD, Davis GW. Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size. Neuron. 2006 Apr 06; 50(1):49-62. PMID: 16600855.
      View in: PubMed
    15. Thompson SM, Kao JP, Kramer RH, Poskanzer KE, Silver RA, Digregorio D, Wang SS. Flashy science: controlling neural function with light. J Neurosci. 2005 Nov 09; 25(45):10358-65. PMID: 16280572.
      View in: PubMed
    16. Bozdagi O, Valcin M, Poskanzer K, Tanaka H, Benson DL. Temporally distinct demands for classic cadherins in synapse formation and maturation. Mol Cell Neurosci. 2004 Dec; 27(4):509-21. PMID: 15555928.
      View in: PubMed
    17. Poskanzer KE, Davis GW. Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade. Neuropharmacology. 2004 Oct; 47(5):714-23. PMID: 15458843.
      View in: PubMed
    18. Marie B, Sweeney ST, Poskanzer KE, Roos J, Kelly RB, Davis GW. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Neuron. 2004 Jul 22; 43(2):207-19. PMID: 15260957.
      View in: PubMed
    19. Poskanzer KE, Marek KW, Sweeney ST, Davis GW. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature. 2003 Dec 04; 426(6966):559-63. PMID: 14634669.
      View in: PubMed
    20. Poskanzer K, Needleman LA, Bozdagi O, Huntley GW. N-cadherin regulates ingrowth and laminar targeting of thalamocortical axons. J Neurosci. 2003 Mar 15; 23(6):2294-305. PMID: 12657688.
      View in: PubMed