Kira Poskanzer, PhD

Title(s)Associate Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address1550 Fourth Street, #381
San Francisco CA 94158
Phone415-921-9229
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    Collapse Biography 
    Collapse Education and Training
    Brown UniversityScBBiology
    UCSFPhDNeuroscience
    Columbia Universitypostdoctoral fellowshipNeuroscience
    Collapse Awards and Honors
    NSF CAREER Award
    Kavli Faculty Service Award
    Charles H. Revson Senior Fellowship in Life Sciences
    Robert Leet and Clara Guthrie Patterson Trust Fellowship in Brain Circuitry
    NSF Graduate Research Fellowship
    Brown University Class of 1873 Award for Academic Excellence in the Biological Sciences

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Role of DNA double-strand breaks in neural function and homeostasis
    NIH R01AG064363Sep 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Non-Neuronal Sleep/Wake Control in Cortex
    NIH R01MH121446May 6, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Dissecting Monoaminergic Physiology of Prefrontal Cortical Astrocytes
    NIH R21DA048497Apr 15, 2019 - Mar 31, 2021
    Role: Principal Investigator
    A Functional Taxonomy of Cortical Astrocytes
    NIH R01NS099254Dec 1, 2016 - Nov 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Astrocyte Calcium Signaling. Cold Spring Harb Perspect Biol. 2024 Oct 01; 16(10). Ahrens MB, Khakh BS, Poskanzer KE. PMID: 38768971; PMCID: PMC11444304.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals. bioRxiv. 2024 Jun 01. Mi X, Chen AB, Duarte D, Carey E, Taylor CR, Braaker PN, Bright M, Almeida RG, Lim JX, Ruetten VMS, Zheng W, Wang M, Reitman ME, Wang Y, Poskanzer KE, Lyons DA, Nimmerjahn A, Ahrens MB, Yu G. PMID: 38766026; PMCID: PMC11100599.
      View in: PubMed   Mentions:
    3. Publisher Correction: Network-level encoding of local neurotransmitters in cortical astrocytes. Nature. 2024 May; 629(8014):E17. Cahill MK, Collard M, Tse V, Reitman ME, Etchenique R, Kirst C, Poskanzer KE. PMID: 38740948; PMCID: PMC11136647.
      View in: PubMed   Mentions:    Fields:    
    4. Network-level encoding of local neurotransmitters in cortical astrocytes. Nature. 2024 May; 629(8010):146-153. Cahill MK, Collard M, Tse V, Reitman ME, Etchenique R, Kirst C, Poskanzer KE. PMID: 38632406; PMCID: PMC11062919.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Network-level encoding of local neurotransmitters in cortical astrocytes. bioRxiv. 2023 Dec 04. Cahill MK, Collard M, Tse V, Reitman ME, Etchenique R, Kirst C, Poskanzer KE. PMID: 38106119; PMCID: PMC10723263.
      View in: PubMed   Mentions:
    6. A Photoactivatable Norepinephrine for Probing Adrenergic Neural Circuits. bioRxiv. 2023 Nov 16. Cahill MK, Perez YR, Larpthaveesarp A, Etchenique R, Poskanzer KE. PMID: 38014204; PMCID: PMC10680792.
      View in: PubMed   Mentions:
    7. Norepinephrine links astrocytic activity to regulation of cortical state. Nat Neurosci. 2023 04; 26(4):579-593. Reitman ME, Tse V, Mi X, Willoughby DD, Peinado A, Aivazidis A, Myagmar BE, Simpson PC, Bayraktar OA, Yu G, Poskanzer KE. PMID: 36997759; PMCID: PMC10089924.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    8. Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep. 2022 09 27; 40(13):111426. Pittolo S, Yokoyama S, Willoughby DD, Taylor CR, Reitman ME, Tse V, Wu Z, Etchenique R, Li Y, Poskanzer KE. PMID: 36170823; PMCID: PMC9555850.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    9. Astrocytic Gi-GPCR activation enhances stimulus-evoked extracellular glutamate. bioRxiv. 2022; (May 13). Trisha V. Vaidyanathan, Vincent Tse, Esther M. Lim, Kira E. Poskanzer. . View Publication.
    10. Imaging in vivo acetylcholine release in the peripheral nervous system with a fluorescent nanosensor. Proc Natl Acad Sci U S A. 2021 04 06; 118(14). Xia J, Yang H, Mu M, Micovic N, Poskanzer KE, Monaghan JR, Clark HA. PMID: 33795516; PMCID: PMC8040656.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    11. Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways. Elife. 2021 03 17; 10. Vaidyanathan TV, Collard M, Yokoyama S, Reitman ME, Poskanzer KE. PMID: 33729913; PMCID: PMC7968927.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    12. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. PMID: 33589835; PMCID: PMC8007081.
      View in: PubMed   Mentions: 839     Fields:    Translation:HumansAnimalsCells
    13. Deformable mirror-based axial scanning for two-photon mammalian brain imaging. Neurophotonics. 2021 Jan; 8(1):015003. Peinado A, Bendek E, Yokoyama S, Poskanzer KE. PMID: 33437848; PMCID: PMC7778453.
      View in: PubMed   Mentions: 1  
    14. Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nat Neurosci. 2020 10; 23(10):1297-1306. Chen J, Poskanzer KE, Freeman MR, Monk KR. PMID: 32895565; PMCID: PMC7530038.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    15. Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology. Nat Neurosci. 2019 11; 22(11):1936-1944. Wang Y, DelRosso NV, Vaidyanathan TV, Cahill MK, Reitman ME, Pittolo S, Mi X, Yu G, Poskanzer KE. PMID: 31570865; PMCID: PMC6858541.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    16. Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13680-13689. Pittolo S, Lee H, Lladó A, Tosi S, Bosch M, Bardia L, Gómez-Santacana X, Llebaria A, Soriano E, Colombelli J, Poskanzer KE, Perea G, Gorostiza P. PMID: 31196955; PMCID: PMC6613107.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    17. A roadmap to integrate astrocytes into Systems Neuroscience. Glia. 2020 01; 68(1):5-26. Kastanenka KV, Moreno-Bote R, De Pittà M, Perea G, Eraso-Pichot A, Masgrau R, Poskanzer KE, Galea E. PMID: 31058383; PMCID: PMC6832773.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    18. Optical Probes for Neurobiological Sensing and Imaging. Acc Chem Res. 2018 05 15; 51(5):1023-1032. Kim EH, Chin G, Rong G, Poskanzer KE, Clark HA. PMID: 29652127; PMCID: PMC6128814.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    19. Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Annu Rev Physiol. 2018 02 10; 80:143-157. Poskanzer KE, Molofsky AV. PMID: 29166242; PMCID: PMC5811396.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. A method for estimating intracellular ion concentration using optical nanosensors and ratiometric imaging. Sci Rep. 2017 09 07; 7(1):10819. Rong G, Kim EH, Poskanzer KE, Clark HA. PMID: 28883429; PMCID: PMC5589868.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. A Visible-Light-Sensitive Caged Serotonin. ACS Chem Neurosci. 2017 05 17; 8(5):1036-1042. Cabrera R, Filevich O, García-Acosta B, Athilingam J, Bender KJ, Poskanzer KE, Etchenique R. PMID: 28460173; PMCID: PMC5573591.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    22. Graphical time warping for joint alignment of multiple curves. Advances in Neural Information Processing Systems (NIPS). 2016; (29):3648–3656. Wang D, Miller D, Poskanzer K, Tian L, Yu G . View Publication.
    23. Astrocytes regulate cortical state switching in vivo. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):E2675-84. Poskanzer KE, Yuste R. PMID: 27122314; PMCID: PMC4868485.
      View in: PubMed   Mentions: 175     Fields:    Translation:AnimalsCells
    24. A structured matrix factorization framework for large scale calcium imaging data analysis. arXiv. 2014; 2903 :[q-bio.NC]. Pnevmatikakis EA, Gao Y, Soudry D, Pfau D, Lacefield C, Poskanzer K, Bruno R, Yuste R, Paninski L. View Publication.
    25. Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches. J Am Chem Soc. 2014 Jun 18; 136(24):8693-701. Izquierdo-Serra M, Gascón-Moya M, Hirtz JJ, Pittolo S, Poskanzer KE, Ferrer È, Alibés R, Busqué F, Yuste R, Hernando J, Gorostiza P. PMID: 24857186; PMCID: PMC4096865.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    26. Astrocytic regulation of cortical UP states. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18453-8. Poskanzer KE, Yuste R. PMID: 22027012; PMCID: PMC3215035.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    27. Two-photon photostimulation and imaging of neural circuits. Nat Methods. 2007 Nov; 4(11):943-50. Nikolenko V, Poskanzer KE, Yuste R. PMID: 17965719.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    28. Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size. Neuron. 2006 Apr 06; 50(1):49-62. Poskanzer KE, Fetter RD, Davis GW. PMID: 16600855.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    29. Flashy science: controlling neural function with light. J Neurosci. 2005 Nov 09; 25(45):10358-65. Thompson SM, Kao JP, Kramer RH, Poskanzer KE, Silver RA, Digregorio D, Wang SS. PMID: 16280572; PMCID: PMC6725808.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    30. Temporally distinct demands for classic cadherins in synapse formation and maturation. Mol Cell Neurosci. 2004 Dec; 27(4):509-21. Bozdagi O, Valcin M, Poskanzer K, Tanaka H, Benson DL. PMID: 15555928; PMCID: PMC2910522.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    31. Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade. Neuropharmacology. 2004 Oct; 47(5):714-23. Poskanzer KE, Davis GW. PMID: 15458843.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    32. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Neuron. 2004 Jul 22; 43(2):207-19. Marie B, Sweeney ST, Poskanzer KE, Roos J, Kelly RB, Davis GW. PMID: 15260957.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    33. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature. 2003 Dec 04; 426(6966):559-63. Poskanzer KE, Marek KW, Sweeney ST, Davis GW. PMID: 14634669.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    34. N-cadherin regulates ingrowth and laminar targeting of thalamocortical axons. J Neurosci. 2003 Mar 15; 23(6):2294-305. Poskanzer K, Needleman LA, Bozdagi O, Huntley GW. PMID: 12657688; PMCID: PMC4415263.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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