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Lamorna Swigart, PhD

Title(s)Associate Professor, Laboratory Medicine
SchoolSchool of Medicine
Phone415-476-3461
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Annibali D, Whitfield JR, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir NM, Massó-Vallés D, Beaulieu ME, Swigart LB, Mc Gee MM, Somma MP, Nasi S, Seoane J, Evan GI, Soucek L. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nat Commun. 2014 Aug 18; 5:4632. PMID: 25130259.
      View in: PubMed
    2. Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1480-9. PMID: 23542378; PMCID: PMC3631679.
      View in: PubMed, PubMed Central
    3. Soucek L, Whitfield JR, Sodir NM, Massó-Vallés D, Serrano E, Karnezis AN, Swigart LB, Evan GI. Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev. 2013 Mar 01; 27(5):504-13. PMID: 23475959; PMCID: PMC3605464.
      View in: PubMed, PubMed Central
    4. O'Donovan DS, MacFhearraigh S, Whitfield J, Swigart LB, Evan GI, Mc Gee MM. Sequential Cdk1 and Plk1 phosphorylation of protein tyrosine phosphatase 1B promotes mitotic cell death. Cell Death Dis. 2013 Jan 24; 4:e468. PMID: 23348582; PMCID: PMC3563996.
      View in: PubMed, PubMed Central
    5. Pello OM, De Pizzol M, Mirolo M, Soucek L, Zammataro L, Amabile A, Doni A, Nebuloni M, Swigart LB, Evan GI, Mantovani A, Locati M. Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. Blood. 2012 Jan 12; 119(2):411-21. PMID: 22067385.
      View in: PubMed
    6. Soucek L, Buggy JJ, Kortlever R, Adimoolam S, Monclús HA, Allende MT, Swigart LB, Evan GI. Modeling pharmacological inhibition of mast cell degranulation as a therapy for insulinoma. Neoplasia. 2011 Nov; 13(11):1093-100. PMID: 22131884; PMCID: PMC3226942.
      View in: PubMed, PubMed Central
    7. Sodir NM, Swigart LB, Karnezis AN, Hanahan D, Evan GI, Soucek L. Endogenous Myc maintains the tumor microenvironment. Genes Dev. 2011 May 01; 25(9):907-16. PMID: 21478273; PMCID: PMC3084025.
      View in: PubMed, PubMed Central
    8. Finch AJ, Soucek L, Junttila MR, Swigart LB, Evan GI. Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation. Mol Cell Biol. 2009 Oct; 29(19):5306-15. PMID: 19635809; PMCID: PMC2747972.
      View in: PubMed, PubMed Central
    9. Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI. Modelling Myc inhibition as a cancer therapy. Nature. 2008 Oct 02; 455(7213):679-83. PMID: 18716624; PMCID: PMC4485609.
      View in: PubMed, PubMed Central
    10. Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, Hebrok M. Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes. 2008 Apr; 57(4):958-66. PMID: 18083786.
      View in: PubMed
    11. Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med. 2007 Oct; 13(10):1211-8. PMID: 17906636.
      View in: PubMed
    12. Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell. 2006 Dec; 10(6):501-14. PMID: 17157790.
      View in: PubMed
    13. Finch A, Prescott J, Shchors K, Hunt A, Soucek L, Dansen TB, Swigart LB, Evan GI. Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms. Cancer Cell. 2006 Aug; 10(2):113-20. PMID: 16904610.
      View in: PubMed
    14. Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI. Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage. J Biol Chem. 2005 Apr 01; 280(13):12486-93. PMID: 15615731.
      View in: PubMed
    15. Flores I, Murphy DJ, Swigart LB, Knies U, Evan GI. Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia. Oncogene. 2004 Aug 05; 23(35):5923-30. PMID: 15208685.
      View in: PubMed
    16. Murphy DJ, Swigart LB, Israel MA, Evan GI. Id2 is dispensable for Myc-induced epidermal neoplasia. Mol Cell Biol. 2004 Mar; 24(5):2083-90. PMID: 14966287; PMCID: PMC350569.
      View in: PubMed, PubMed Central
    17. Juin P, Hunt A, Littlewood T, Griffiths B, Swigart LB, Korsmeyer S, Evan G. c-Myc functionally cooperates with Bax to induce apoptosis. Mol Cell Biol. 2002 Sep; 22(17):6158-69. PMID: 12167710; PMCID: PMC133996.
      View in: PubMed, PubMed Central
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