Kathleen Liu, MD, PhD

SchoolUCSF School of Medicine
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.A.S. in Clinical Research2007 Graduate Division (Advance Training in Clinical Research)
    University of California, San FranciscoM.D.1999 Medicine
    University of California, San FranciscoPh.D.1997 Graduate Division (Biochemistry)

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    College: Harvard University, AB
    Medical/Graduate School: University of California, San Francisco, MD, PhD


    My current research areas of interest focus on the predictive and pathogenetic role of biomarkers for both acute and chronic disease states. My long term goal is to identify and validate novel biomarkers of organ injury (specifically, the kidney and lung) that may have predictive value for disease outcomes as well as shed important insight into disease pathogenesis. In addition, I have a major interest in clinical trials in the Intensive Care Unit, with a particular focus on acute lung injury and acute kidney injury.

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    Advancing acute kidney injury phenotyping using biological and clinical criteria
    NIH/NIDDK K24DK113381Jul 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Acute Kidney Injury: A Novel Risk Factor for Cardiovascular Events
    NIH/NIDDK R01DK098233Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Identifying opportunities to lower rates of AKI and improve outcomes
    NIH/NIDDK R01DK101507Jun 1, 2014 - May 31, 2018
    Role: Principal Investigator
    "Validation of Novel CKD Biomarkers in CRIC"
    NIH/NIDDK U01DK085649Sep 30, 2009 - Apr 30, 2014
    Role: Co-Principal Investigator
    Role of Par3/Par6/aPKC Complex in Cell Polarity
    NIH/NIDDK F32DK069031Jul 1, 2004 - Jun 30, 2005
    Role: Principal Investigator

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    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Federspiel CK, Itenov TS, Mehta K, Hsu RK, Bestle MH, Liu K. Duration of acute kidney injury in critically ill patients. Ann Intensive Care. 2018 Feb 23; 8(1):30. PMID: 29473104.
      View in: PubMed
    2. Moore PK, Hsu RK, Liu K. Management of Acute Kidney Injury: Core Curriculum 2018. Am J Kidney Dis. 2018 Feb 22. PMID: 29478864.
      View in: PubMed
    3. Lee BJ, Go AS, Parikh R, Leong TK, Tan TC, Walia S, Hsu RK, Liu K, Hsu CY. Pre-admission proteinuria impacts risk of non-recovery after dialysis-requiring acute kidney injury. Kidney Int. 2018 Jan 09. PMID: 29352593.
      View in: PubMed
    4. Schell-Chaple HM, Liu K, Matthay MA, Puntillo KA. Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. Am J Crit Care. 2018 Jan; 27(1):43-50. PMID: 29292274.
      View in: PubMed
    5. Thornton KC, Schwarz JJ, Gross AK, Anderson WG, Liu K, Romig MC, Schell-Chaple H, Pronovost PJ, Sapirstein A, Gropper MA, Lipshutz AKM. Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families. Crit Care Med. 2017 09; 45(9):1531-1537. PMID: 28640023.
      View in: PubMed
    6. Thompson BT, Chambers RC, Liu K. Acute Respiratory Distress Syndrome. N Engl J Med. 2017 Aug 10; 377(6):562-572. PMID: 28792873.
      View in: PubMed
    7. Schell-Chaple HM, Liu K, Matthay MA, Sessler DI, Puntillo KA. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Crit Care Med. 2017 Jul; 45(7):1199-1207. PMID: 28319467.
      View in: PubMed
    8. Kwong YD, Liu K. AKI Adjudication: Do We Need It? Nephron. 2017 Jun 15. PMID: 28614829.
      View in: PubMed
    9. Liu K, Humphreys BD, Endre ZH. The ten barriers for translation of animal data on AKI to the clinical setting. Intensive Care Med. 2017 Jun; 43(6):898-900. PMID: 28451772.
      View in: PubMed
    10. Park M, Hsu CY, Go AS, Feldman HI, Xie D, Zhang X, Mifflin T, Waikar SS, Sabbisetti VS, Bonventre JV, Coresh J, Nelson RG, Kimmel PL, Kusek JW, Rahman M, Schelling JR, Vasan RS, Liu K. Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clin J Am Soc Nephrol. 2017 May 08; 12(5):761-771. PMID: 28254771.
      View in: PubMed
    11. Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, Bittleman D, Cruz D, Endre Z, Fitzgerald RL, Forni L, Kane-Gill SL, Hoste E, Koyner J, Liu K, Macedo E, Mehta R, Murray P, Nadim M, Ostermann M, Palevsky PM, Pannu N, Rosner M, Wald R, Zarbock A, Ronco C, Kellum JA. Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nat Rev Nephrol. 2017 04; 13(4):241-257. PMID: 28239173.
      View in: PubMed
    12. Hendrickson CM, Abbott J, Zhuo H, Liu K, Calfee CS, Matthay MA. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Am J Physiol Lung Cell Mol Physiol. 2017 May 01; 312(5):L579-L585. PMID: 28213470.
      View in: PubMed
    13. Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu K, Thompson BT, Calfee CS, et al. Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):331-338. PMID: 27513822.
      View in: PubMed
    14. Huang DT, Angus DC, Moss M, Thompson BT, Ferguson ND, Ginde A, Gong MN, Gundel S, Hayden DL, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Liu K, Talmor DS, Yealy DM. Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome. Ann Am Thorac Soc. 2017 Jan; 14(1):124-133. PMID: 27779896.
      View in: PubMed
    15. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu K, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care. 2016 Nov 17; 20(1):372. PMID: 27852290.
      View in: PubMed
    16. Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu K. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney Int. 2017 Jan; 91(1):196-203. PMID: 28029431.
      View in: PubMed
    17. Liu K, Siew ED, Reeves WB, Himmelfarb J, Go AS, Hsu CY, Bennett MR, Devarajan P, Ikizler TA, Kaufman JS, Kimmel PL, Chinchilli VM, Parikh CR. Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study. PLoS One. 2016; 11(10):e0164832. PMID: 27788160.
      View in: PubMed
    18. Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, Mason AJ, Cross M, Al-Beidh F, Best-Lane J, Brealey D, Nutt CL, McNamee JJ, Reschreiter H, Breen A, Liu K, Ashby D. Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis. N Engl J Med. 2016 10 27; 375(17):1638-1648. PMID: 27705084.
      View in: PubMed
    19. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu K, Matthay MA, Flori HR. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):917-923. PMID: 27513687.
      View in: PubMed
    20. Liu K, Palevsky PM. RRT in AKI: Start Early or Wait? Clin J Am Soc Nephrol. 2016 Oct 07; 11(10):1867-1871. PMID: 27672218.
      View in: PubMed
    21. Roy J, Shou H, Xie D, Hsu JY, Yang W, Anderson AH, Landis JR, Jepson C, He J, Liu K, Hsu CY, Feldman HI. Statistical Methods for Cohort Studies of CKD: Prediction Modeling. Clin J Am Soc Nephrol. 2017 Jun 07; 12(6):1010-1017. PMID: 27660302.
      View in: PubMed
    22. Federspiel CK, Liu K. Does Changing the Volume Matter? The Relationship of Urine Volume and Dialysis Intensity. Clin J Am Soc Nephrol. 2016 Aug 08; 11(8):1321-3. PMID: 27449662; PMCID: PMC4974883 [Available on 08/08/17].
    23. Liu K, Vijayan A, Rosner MH, Shi J, Chawla LS, Kellum JA. Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2*IGFBP7 biomarker study. Nephrol Dial Transplant. 2016 Oct; 31(10):1641-6. PMID: 27342580.
      View in: PubMed
    24. Waikar SS, Sabbisetti V, Ärnlöv J, Carlsson AC, Coresh J, Feldman HI, Foster MC, Fufaa GD, Helmersson-Karlqvist J, Hsu CY, Kimmel PL, Larsson A, Liu Y, Lind L, Liu K, Mifflin TE, Nelson RG, Risérus U, Vasan RS, Xie D, Zhang X, Bonventre JV. Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies. Nephrol Dial Transplant. 2016 Sep; 31(9):1460-70. PMID: 27270293; PMCID: PMC5009290 [Available on 09/01/17].
    25. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu K, Manley GT, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 Jun; 80(6):989-97. PMID: 26881489.
      View in: PubMed
    26. Sapru A, Liu K, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016 May 23; 20(1):151. PMID: 27215212; PMCID: PMC4876559.
    27. Pérez XL, Liu K. Critical Care Updates for the Nephrologist, 2016. Adv Chronic Kidney Dis. 2016 May; 23(3):136-40. PMID: 27113688.
      View in: PubMed
    28. Liu K. Changing Faces of Critical Care Nephrology. Adv Chronic Kidney Dis. 2016 05; 23(3):134-5. PMID: 27113687.
      View in: PubMed
    29. McSparron JI, Hayes MM, Poston JT, Thomson CC, Fessler HE, Stapleton RD, Carlos WG, Hinkle L, Liu K, Shieh S, Ali A, Rogers A, Shah NG, Slack D, Patel B, Wolfe K, Schweickert WD, Bakhru RN, Shin S, Sell RE, Luks AM. ATS Core Curriculum 2016: Part II. Adult Critical Care Medicine. Ann Am Thorac Soc. 2016 May; 13(5):731-40. PMID: 27144797.
      View in: PubMed
    30. Parks M, Liu K. Acute kidney injury: Clinical trials in AKI: is the end in sight? Nat Rev Nephrol. 2016 May; 12(5):263-4. PMID: 27026352.
      View in: PubMed
    31. Weyker PD, Pérez XL, Liu K. Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient. Clin Chest Med. 2016 06; 37(2):277-88. PMID: 27229644.
      View in: PubMed
    32. Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu K, Mour G, Nolin TD, Bihorac A. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment. Am J Kidney Dis. 2016 Jul; 68(1):19-28. PMID: 26948834; PMCID: PMC4921267 [Available on 07/01/17].
    33. Matthay MA, Liu K. New Strategies for Effective Therapeutics in Critically Ill Patients. JAMA. 2016 Feb 23; 315(8):747-8. PMID: 26903328.
      View in: PubMed
    34. de Caestecker M, Humphreys BD, Liu K, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE, Pullen N, Okusa MD, Faubel S. Bridging Translation by Improving Preclinical Study Design in AKI. J Am Soc Nephrol. 2015 Dec; 26(12):2905-16. PMID: 26538634; PMCID: PMC4657852 [Available on 12/01/16].
    35. Bansal N, Carpenter MA, Weiner DE, Levey AS, Pfeffer M, Kusek JW, Cai J, Hunsicker LG, Park M, Bennett M, Liu K, Hsu CY. Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial. J Am Soc Nephrol. 2016 Jul; 27(7):2109-21. PMID: 26538631; PMCID: PMC4926968 [Available on 07/01/17].
    36. Ghannoum M, Calello DP, Lavergne V, Gosselin S, Liu K, Roberts DM. The authors reply. Crit Care Med. 2015 Nov; 43(11):e534-5. PMID: 26468727.
      View in: PubMed
    37. Foster MC, Coresh J, Bonventre JV, Sabbisetti VS, Waikar SS, Mifflin TE, Nelson RG, Grams M, Feldman HI, Vasan RS, Kimmel PL, Hsu CY, Liu K. Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):1956-63. PMID: 26350438; PMCID: PMC4633784 [Available on 11/06/16].
    38. Leventhal TM, Liu K. What a Nephrologist Needs to Know About Acute Liver Failure. Adv Chronic Kidney Dis. 2015 Sep; 22(5):376-81. PMID: 26311599.
      View in: PubMed
    39. Calello DP, Liu K, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, Ghannoum M. Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. Crit Care Med. 2015 Aug; 43(8):1716-30. PMID: 25860205.
      View in: PubMed
    40. Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu K, Cerda J, Okusa MD, Lukaszewski M, Vijayan A. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clin J Am Soc Nephrol. 2015 Oct 07; 10(10):1868-74. PMID: 26220818; PMCID: PMC4594066 [Available on 10/07/16].
    41. Cerdá J, Liu K, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015 Oct 07; 10(10):1859-67. PMID: 26138260; PMCID: PMC4594060 [Available on 10/07/16].
    42. Liu K, Hsu CY. When change is not a good thing. Clin Chem. 2015 Jul; 61(7):897-9. PMID: 25991825.
      View in: PubMed
    43. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu K, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35. PMID: 25738857; PMCID: PMC4400228 [Available on 05/01/16].
    44. Shieh SC, Liu K. Finding the key to dialysis catheter lock. Am J Respir Crit Care Med. 2015 May 01; 191(9):972-4. PMID: 25932759.
      View in: PubMed
    45. Wilson J, McKenna D, Liu K, Matthay MA. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. Lancet Respir Med. 2015 Apr; 3(4):e12-3. PMID: 25890655.
      View in: PubMed
    46. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu K, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. PMID: 25795726; PMCID: PMC4451399.
    47. Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu K, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol. 2015 May 07; 10(5):894-902. PMID: 25739849; PMCID: PMC4422251.
    48. Sapru A, Calfee CS, Liu K, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. PMID: 25708422.
      View in: PubMed
    49. Ghannoum M, Wiegand TJ, Liu K, Calello DP, Godin M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS. Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015 May; 53(4):215-29. PMID: 25715736.
      View in: PubMed
    50. Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu K, Koyner JL, Conner MJ. Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood Purif. 2014; 38(3-4):276-85. PMID: 25675963.
      View in: PubMed
    51. Sapru A, Calfee CS, Liu K, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. PMID: 25643902; PMCID: PMC4500527.
    52. Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu K, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR, Morris AH. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med. 2015 Feb; 43(2):288-95. PMID: 25599463; PMCID: PMC4675623.
    53. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu K. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan; 24(1):15-23. PMID: 25554550; PMCID: PMC4464553.
    54. Wilson JG, Liu K, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32. PMID: 25529339; PMCID: PMC4297579.
    55. Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu K. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia. 2015 Jan; 58(1):188-98. PMID: 25316431; PMCID: PMC4258130.
    56. Liu K, Yang W, Go AS, Anderson AH, Feldman HI, Fischer MJ, He J, Kallem RR, Kusek JW, Master SR, Miller ER, Rosas SE, Steigerwalt S, Tao K, Weir MR, Hsu CY. Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2015 Feb; 65(2):267-74. PMID: 25311702; PMCID: PMC4353671.
    57. Liu K. Therapeutic strategies for clinical trials targeting renal recovery. Nephron Clin Pract. 2014; 127(1-4):113-6. PMID: 25343832.
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    58. Liu K, Dong N, Truwit JD. Rosuvastatin for sepsis-associated ARDS. N Engl J Med. 2014 Sep 04; 371(10):968-9. PMID: 25184876.
      View in: PubMed
    59. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu K, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med. 2014 Sep; 42(9):2058-68. PMID: 24942512; PMCID: PMC4134734.
    60. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu K, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48. PMID: 25085625; PMCID: PMC4166786.
    61. Huddleston LL, Liu K. Propofol as a panacea for acute kidney injury? Kidney Int. 2014 Aug; 86(2):240-3. PMID: 25079022.
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    62. Liu K, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. PMID: 25593740; PMCID: PMC4273700.
    63. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu K, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40. PMID: 25960880; PMCID: PMC4424730.
    64. Orme RM, Perkins GD, McAuley DF, Liu K, Mason AJ, Morelli A, Singer M, Ashby D, Gordon AC. An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. Trials. 2014 Jun 02; 15:199. PMID: 24894386; PMCID: PMC4061524.
    65. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu K, Matthay MA, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax. 2014 Sep; 69(9):819-25. PMID: 24891325; PMCID: PMC4284068.
    66. Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu K, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 05; 370(23):2191-200. PMID: 24835849; PMCID: PMC4241052.
    67. Koyner JL, Cerdá J, Goldstein SL, Jaber BL, Liu K, Shea JA, Faubel S. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. Am J Kidney Dis. 2014 Sep; 64(3):394-401. PMID: 24815216.
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    68. Wong HR, Liu K, Kangelaris KN, Lahni P, Calfee CS. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 2014 Oct; 29(5):718-22. PMID: 24848949; PMCID: PMC4141017.
    69. Hsu CY, Liu K. Cardiovascular events after AKI: a new dimension. J Am Soc Nephrol. 2014 Mar; 25(3):425-7. PMID: 24503240; PMCID: PMC3935600.
    70. Kwon SH, Liu K, Mostov KE. Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth. Curr Biol. 2014 Jan 20; 24(2):199-204. PMID: 24412205; PMCID: PMC3938203.
    71. Kallet RH, Zhuo H, Liu K, Calfee CS, Matthay MA. The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Respir Care. 2014 Nov; 59(11):1611-8. PMID: 24381187; PMCID: PMC4077995.
    72. Wilson JG, Butcher BW, Liu K. Evolving practices in critical care and their influence on acute kidney injury. Curr Opin Crit Care. 2013 Dec; 19(6):523-30. PMID: 24240818.
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    73. Parikh CR, Butrymowicz I, Yu A, Chinchilli VM, Park M, Hsu CY, Reeves WB, Devarajan P, Kimmel PL, Siew ED, Liu K. Urine stability studies for novel biomarkers of acute kidney injury. Am J Kidney Dis. 2014 Apr; 63(4):567-72. PMID: 24200462; PMCID: PMC3969397.
    74. Bonventre JV, Basile D, Liu K, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA. AKI: a path forward. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1606-8. PMID: 23868899; PMCID: PMC3805072.
    75. Liu K, Yang W, Hsu CY. The authors reply. Kidney Int. 2013 Jul; 84(1):217. PMID: 23812370.
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    76. Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z, Kellum JA, Liu K, Mehta RL, Pannu N, Van Biesen W, Vanholder R. Acute kidney injury: an increasing global concern. Lancet. 2013 Jul 13; 382(9887):170-9. PMID: 23727171.
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    77. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu K, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):736-42. PMID: 23328529; PMCID: PMC3678110.
    78. Palevsky PM, Liu K, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis. 2013 May; 61(5):649-72. PMID: 23499048.
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    83. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu K. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9. PMID: 22865551; PMCID: PMC3469636.
    84. Ghannoum M, Nolin TD, Goldfarb DS, Roberts DM, Mactier R, Mowry JB, Dargan PI, Maclaren R, Hoegberg LC, Laliberté M, Calello D, Kielstein JT, Anseeuw K, Winchester JF, Burdmann EA, Bunchman TE, Li Y, Juurlink DN, Lavergne V, Megarbane B, Gosselin S, Liu K, Hoffman RS. Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup. Clin J Am Soc Nephrol. 2012 Oct; 7(10):1682-90. PMID: 22837270.
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    90. Kangelaris KN, Sapru A, Calfee CS, Liu K, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-1169. PMID: 22207676; PMCID: PMC3342784.
    91. Liu K, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec; 39(12):2665-71. PMID: 21785346; PMCID: PMC3220741.
    92. Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu K, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 01; 184(5):561-8. PMID: 21562125; PMCID: PMC3175548.
    93. Britos M, Smoot E, Liu K, Thompson BT, Checkley W, Brower RG. The value of positive end-expiratory pressure and Fio2 criteria in the definition of the acute respiratory distress syndrome. Crit Care Med. 2011 Sep; 39(9):2025-30. PMID: 21532473; PMCID: PMC3157575.
    94. Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu K. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care. 2011 Jun 14; 1(1):21. PMID: 21906363; PMCID: PMC3224491.
    95. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu K. Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Ann Intensive Care. 2011 Jun 13; 1(1):18. PMID: 21906356; PMCID: PMC3224453.
    96. Flori HR, Church G, Liu K, Gildengorin G, Matthay MA. Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract. 2011; 2011:854142. PMID: 21687578; PMCID: PMC3114079.
    97. Matthay MA, Liu K. Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med. 2011 May 01; 183(9):1127-8. PMID: 21531953; PMCID: PMC3114049.
    98. Grams ME, Estrella MM, Coresh J, Brower RG, Liu K. Fluid balance, diuretic use, and mortality in acute kidney injury. Clin J Am Soc Nephrol. 2011 May; 6(5):966-73. PMID: 21393482; PMCID: PMC3087792.
    99. Sapru A, Pawlikowska L, Liu K, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant. 2011 Feb; 30(2):211-7. PMID: 20869266; PMCID: PMC3019270.
    100. Liu K, Chertow GM. Curbing the use of ultrasonography in the diagnosis of acute kidney injury: Penny wise or pound foolish?: Comment on "Renal ultrasonography in the evaluation of acute kidney injury". Arch Intern Med. 2010 Nov 22; 170(21):1907-8. PMID: 21098349; PMCID: PMC4095784.
    101. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu K, Calfee CS, Lee JW. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest. 2010 Oct; 138(4):965-72. PMID: 20923800; PMCID: PMC2951759.
    102. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu K. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010 Sep; 38(9):1845-51. PMID: 20581666; PMCID: PMC4009623.
    103. Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu K, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB. The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol. 2010 Aug 27; 11:22. PMID: 20799966; PMCID: PMC2944247.
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    105. Johnson XD, Liu K. Acute renal syndrome/renal angina: a new paradigm for studies of acute kidney injury? Clin J Am Soc Nephrol. 2010 May; 5(5):753-5. PMID: 20378643.
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    106. Liu K, Glidden DV. Clinical trials for acute kidney injury: design challenges and possible solutions. Curr Drug Targets. 2009 Dec; 10(12):1190-5. PMID: 19715539.
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    107. Brown LM, Liu K, Matthay MA. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L547-58. PMID: 19617309; PMCID: PMC2770794.
    108. Liu K, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care. 2009; 13(4):R104. PMID: 19570208; PMCID: PMC2750143.
    109. Liu K, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935; PMCID: PMC2717421.
    110. Neyrinck AP, Liu K, Howard JP, Matthay MA. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol. 2009 Oct; 158(4):1034-47. PMID: 19466992; PMCID: PMC2785525.
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    112. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu K. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63. PMID: 19382217; PMCID: PMC2768264.
    113. Lo L, Liu K, Hsu CY. Long-term outcomes after acute kidney injury: where we stand and how we can move forward. Am J Kidney Dis. 2009 Jun; 53(6):928-31. PMID: 19303684.
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    114. Liu K. Critical care nephrology: Core Curriculum 2009. Am J Kidney Dis. 2009 May; 53(5):898-910. PMID: 19303680; PMCID: PMC2697970.
    115. Brakeman PR, Liu K, Shimizu K, Takai Y, Mostov KE. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74. PMID: 19116242; PMCID: PMC2660185.
    116. Liu K. Impact of acute kidney injury on lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L1-2. PMID: 18996900.
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    117. Liu K, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23. PMID: 18565951; PMCID: PMC2542435.
    118. Liu K, Matthay MA. Protein C as a surrogate end-point for clinical trials of sepsis. Crit Care. 2008; 12(2):139. PMID: 18492215; PMCID: PMC2447596.
    119. Liu K, Brakeman PR. Renal repair and recovery. Crit Care Med. 2008 Apr; 36(4 Suppl):S187-92. PMID: 18382192.
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    120. Waikar SS, Liu K, Chertow GM. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol. 2008 May; 3(3):844-61. PMID: 18337550.
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    121. Liu K, Matthay MA. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86. PMID: 18199848.
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    122. Liu K, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61. PMID: 18074478; PMCID: PMC3293249.
    123. Liu K, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
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    124. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu K, Matthay MA. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest. 2007 Sep; 132(3):836-42. PMID: 17573490.
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    125. Waikar SS, Liu K, Chertow GM. The incidence and prognostic significance of acute kidney injury. Curr Opin Nephrol Hypertens. 2007 May; 16(3):227-36. PMID: 17420666; PMCID: PMC3027554.
    126. Liu K, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM. Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol. 2006 Sep; 1(5):915-9. PMID: 17699307.
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    127. Liu K, Matthay MA, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73. PMID: 17699299.
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    128. Liu K. Molecular mechanisms of recovery from acute renal failure. Crit Care Med. 2003 Aug; 31(8 Suppl):S572-81. PMID: 12907887.
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