Jennifer Rosenbluth, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address10 Koret Way, #231
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    Princeton UniversityAB
    Vanderbilt University School of MedicineMD
    Vanderbilt University School of MedicinePhD
    Massachusetts General HospitalInternal Medicine
    Dana-Farber Cancer InstituteMedical Oncology
    Collapse Awards and Honors
    Chan Zuckerberg Biohub2022Investigator Award
    UCSF2021Sulochana Pradhan, MD Endowed Professorship in Breast Cancer
    Doris Duke Charitable Foundation2021Clinical Scientist Development Award
    Breast Cancer Alliance2021Young Investigator Grant
    Terri Brodeur Breast Cancer Foundation2021Fellowship Award
    Dana-Farber Cancer Institute2020  - 2021Sidney Farber Scholar
    Susan G. Komen Foundation2019Career Catalyst Research Grant
    Dana-Farber Cancer Institute2019  - 2020Eleanor and Miles Shore Award
    American Cancer Society2017  - 2019Postdoctoral Fellowship
    American Society of Clinical Oncology2017  - 2018Young Investigator Award
    Dana-Farber Cancer Institute2014Leadership Council Fellow
    Vanderbilt University2011Dean's Award for Research
    Vanderbilt University2011John G. Coniglio Prize for Excellence in Biochemistry

    Collapse Overview 
    Collapse Overview
    Jennifer Rosenbluth, MD, PhD, is a medical oncologist who specializes in breast cancer, an Assistant Professor in the Department of Medicine, and a member of the Breast Oncology Program in the Helen Diller Family Comprehensive Cancer Center. The research in her laboratory utilizes three-dimensional organoid cultures of premalignant and tumorigenic breast tissues to identify heterogeneous populations of cells that promote cancer development and progression.
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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation. Cancer Immunol Res. 2024 Oct 15. Cho NW, Guldberg SM, Nabet BY, Yu JZ, Kim EJ, Hiam-Galvez KJ, Yee JL, DeBarge R, Tenvooren I, Ashitey NA, Lynce F, Dillon DA, Rosenbluth JM, Spitzer MH. PMID: 39404741.
      View in: PubMed   Mentions:    Fields:    
    2. MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis. bioRxiv. 2024 Oct 09. Graham AJ, Khoo MWL, Srivastava V, Viragova S, Kim H, Parekh K, Hennick KM, Bird M, Goldhammer N, Yu JZ, Morley CD, Lebel P, Kumar S, Rosenbluth JM, Nowakowski TJ, Klein O, Gómez-Sjöberg R, Gartner ZJ. PMID: 38370663; PMCID: PMC10871257.
      View in: PubMed   Mentions:
    3. Magnetic resonance imaging insights from active surveillance of women with ductal carcinoma in situ. NPJ Breast Cancer. 2024 Aug 04; 10(1):71. Greenwood HI, Maldonado Rodas CK, Freimanis RI, Glencer AC, Miller PN, Mukhtar RA, Brabham C, Yau C, Rosenbluth JM, Hirst GL, Campbell MJ, Campbell MJ, Borowsky A, Hylton N, Esserman LJ, Basu A. PMID: 39098868; PMCID: PMC11298531.
      View in: PubMed   Mentions:
    4. Clinical outcomes of de novo metastatic HER2-positive inflammatory breast cancer. NPJ Breast Cancer. 2023 Jun 02; 9(1):50. Garrido-Castro AC, Regan MM, Niman SM, Nakhlis F, Remolano C, Rosenbluth JM, Block C, Warren LE, Bellon JR, Yeh E, Harrison BT, Troll E, Lin NU, Tolaney SM, Overmoyer B, Lynce F. PMID: 37268625; PMCID: PMC10238481.
      View in: PubMed   Mentions: 1  
    5. Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression. bioRxiv. 2023 Mar 29. Nguyen HP, Sheng R, Murray E, Ito Y, Bruck M, Biellak C, An K, Lynce F, Dillon DA, Magbanua MJM, Huppert LA, Hammerlindl H, Esserman L, Rosenbluth JM, Ahituv N. PMID: 37034710; PMCID: PMC10081280.
      View in: PubMed   Mentions:
    6. Identifying Good Candidates for Active Surveillance of Ductal Carcinoma In Situ: Insights from a Large Neoadjuvant Endocrine Therapy Cohort. Cancer Res Commun. 2022 12; 2(12):1579-1589. Glencer AC, Miller PN, Greenwood H, Maldonado Rodas CK, Freimanis R, Basu A, Mukhtar RA, Brabham C, Kim P, Hwang ES, Rosenbluth JM, Hirst GL, Campbell MJ, Borowsky AD, Esserman LJ. PMID: 36970720; PMCID: PMC10035518.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. A human breast atlas integrating single-cell proteomics and transcriptomics. Dev Cell. 2022 06 06; 57(11):1400-1420.e7. Gray GK, Li CM, Rosenbluth JM, Selfors LM, Girnius N, Lin JR, Schackmann RCJ, Goh WL, Moore K, Shapiro HK, Mei S, D'Andrea K, Nathanson KL, Sorger PK, Santagata S, Regev A, Garber JE, Dillon DA, Brugge JS. PMID: 35617956; PMCID: PMC9202341.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    8. Dermal Lymphatic Invasion, Survival, and Time to Recurrence or Progression in Inflammatory Breast Cancer. Am J Clin Oncol. 2021 09 01; 44(9):449-455. Hirko KA, Regan MM, Remolano MC, Schlossman J, Harrison B, Yeh E, Jacene H, Nakhlis F, Block C, Rosenbluth JM, Garrido-Castro AC, Overmoyer BA. PMID: 34149037.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids. Nat Protoc. 2021 04; 16(4):1936-1965. Dekkers JF, van Vliet EJ, Sachs N, Rosenbluth JM, Kopper O, Rebel HG, Wehrens EJ, Piani C, Visvader JE, Verissimo CS, Boj SF, Brugge JS, Clevers H, Rios AC. PMID: 33692550; PMCID: PMC8221035.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    10. Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing. Cell Rep. 2020 12 29; 33(13):108566. Li CM, Shapiro H, Tsiobikas C, Selfors LM, Chen H, Rosenbluth J, Moore K, Gupta KP, Gray GK, Oren Y, Steinbaugh MJ, Guerriero JL, Pinello L, Regev A, Brugge JS. PMID: 33378681; PMCID: PMC7898263.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    11. Characteristics associated with inflammatory breast cancer (IBC): An epidemiologic study from a dedicated IBC program. Breast J. 2020 09; 26(9):1688-1694. White RE, Warren L, Nakhlis F, Rosenbluth J, Bellon J, Block C, Overmoyer B. PMID: 32875655.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Discrepancy between FDG-PET/CT and contrast-enhanced CT in the staging of patients with inflammatory breast cancer: implications for treatment planning. Breast Cancer Res Treat. 2020 Jun; 181(2):383-390. Jacene HA, DiPiro PJ, Bellon J, Hu J, Cheng SC, Warren L, Schlosnagle E, Nakhlis F, Rosenbluth JM, Yeh E, Overmoyer B. PMID: 32318957.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nat Commun. 2020 04 06; 11(1):1711. Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS. PMID: 32249764; PMCID: PMC7136203.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    14. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 2020 02; 38(2):199-209. Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CR, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justesen S, Stevens J, Lane WJ, Eisenhaure T, Lan Zhang G, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB. PMID: 31844290; PMCID: PMC7008090.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansCells
    15. Inflammatory Breast Cancer: a Separate Entity. Curr Oncol Rep. 2019 08 15; 21(10):86. Rosenbluth JM, Overmoyer BA. PMID: 31414257.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    16. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 05 07; 29(5):1166-1181.e6. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. PMID: 30799286; PMCID: PMC6506399.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    17. Metabolic Characterization of Inflammatory Breast Cancer With Baseline FDG-PET/CT: Relationship With Pathologic Response After Neoadjuvant Chemotherapy, Receptor Status, and Tumor Grade. Clin Breast Cancer. 2019 04; 19(2):146-155. Jacene HA, Youn T, DiPiro PJ, Hu J, Cheng SC, Franchetti Y, Shah H, Bellon JR, Warren L, Schlosnagle E, Nakhlis F, Rosenbluth J, Yeh E, Overmoyer B, Dana-Farber Cancer Institute Inflammatory Breast Cancer Program. PMID: 30584057.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67. Clin Cancer Res. 2017 Aug 01; 23(15):4035-4045. Jovanovic B, Mayer IA, Mayer EL, Abramson VG, Bardia A, Sanders ME, Kuba MG, Estrada MV, Beeler JS, Shaver TM, Johnson KC, Sanchez V, Rosenbluth JM, Dillon PM, Forero-Torres A, Chang JC, Meszoely IM, Grau AM, Lehmann BD, Shyr Y, Sheng Q, Chen SC, Arteaga CL, Pietenpol JA. PMID: 28270498; PMCID: PMC5540799.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCellsCTClinical Trials
    19. p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network. Cell Rep. 2016 Mar 15; 14(10):2289-300. Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA. PMID: 26947080; PMCID: PMC4794398.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    20. Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2076-81. Rosenbluth JM, Mays DJ, Jiang A, Shyr Y, Pietenpol JA. PMID: 21245298; PMCID: PMC3033306.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    21. ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. Mol Cancer. 2010 Apr 29; 9:95. Eby KG, Rosenbluth JM, Mays DJ, Marshall CB, Barton CE, Sinha S, Johnson KN, Tang L, Pietenpol JA. PMID: 20429933; PMCID: PMC2873442.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    22. Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Clin Cancer Res. 2010 Jan 15; 16(2):681-90. Bauer JA, Chakravarthy AB, Rosenbluth JM, Mi D, Seeley EH, De Matos Granja-Ingram N, Olivares MG, Kelley MC, Mayer IA, Meszoely IM, Means-Powell JA, Johnson KN, Tsai CJ, Ayers GD, Sanders ME, Schneider RJ, Formenti SC, Caprioli RM, Pietenpol JA. PMID: 20068102; PMCID: PMC2892225.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    23. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle. 2009 Nov 15; 8(22):3702-6. Rosenbluth JM, Johnson K, Tang L, Triplett T, Pietenpol JA. PMID: 19855172.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    24. mTOR regulates autophagy-associated genes downstream of p73. Autophagy. 2009 Jan; 5(1):114-6. Rosenbluth JM, Pietenpol JA. PMID: 19001857; PMCID: PMC2792737.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    25. The jury is in: p73 is a tumor suppressor after all. Genes Dev. 2008 Oct 01; 22(19):2591-5. Rosenbluth JM, Pietenpol JA. PMID: 18832062.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    26. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol. 2008 Oct; 28(19):5951-64. Rosenbluth JM, Mays DJ, Pino MF, Tang LJ, Pietenpol JA. PMID: 18678646; PMCID: PMC2547001.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    27. Xenotransplantation of transgenic oligodendrocyte-lineage cells into spinal cord-injured adult rats. Exp Neurol. 1997 Sep; 147(1):172-82. Rosenbluth J, Schiff R, Liang WL, Menna G, Young W. PMID: 9294414.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Extracellular potassium activity and axonal conduction in spinal cord of the myelin-deficient mutant rat. Exp Neurol. 1989 Oct; 106(1):41-51. Young W, Rosenbluth J, Wojak JC, Sakatani K, Kim H. PMID: 2551718.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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