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Lani Wu, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
Phone415-502-3196
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    Dr. Lani Wu is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. She also applies the high-throughput technology developed by her laboratory to diverse applications, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Wu has worked at the UT Southwestern, Harvard University, Rosetta Informatics, Microsoft, and Princeton University.

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    Scalable Image-Based Approach for Profiling and Annotating Very Large Compound Libraries
    NIH/NCI 2R01 CA184984-06A1Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Role Description: We will develop a cost-effective, image-based platform for assigning large numbers of compounds to their biological functions.
    A drug discovery paradigm for fast-tracking adaptations to high altitude
    DARPA PanaceaSep 1, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Role Description: The goal of this proposal is to identify novel compounds that promote adaptive responses to hypoxia and/or that block maladaptive responses to hypoxia, thereby accelerating acclimatization to hypoxia and prolonging physiologic endurance under oxygen-limited conditions or environments.
    A scalable image-based approach for profiling and annotating very large compound
    NIH R01CA184984Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    (PQD1) An Iterative Approach for Overcoming Evolving Targeted Therapy Resistance
    NIH R01CA185404Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Image based phenotypic profiling of single-cell responses to perturbations
    NIH R01GM081549Sep 1, 2007 - Jul 31, 2014
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes. Cell Rep. 2021 Jan 19; 34(3):108647. Kochanowski K, Sander T, Link H, Chang J, Altschuler SJ, Wu LF. PMID: 33472066.
      View in: PubMed   Mentions:    Fields:    
    2. Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Dev Cell. 2021 Jan 15. Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ. PMID: 33484640.
      View in: PubMed   Mentions:    Fields:    
    3. Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Cell Syst. 2020 07 22; 11(1):86-94.e5. Morinishi L, Kochanowski K, Levine RL, Wu LF, Altschuler SJ. PMID: 32619551.
      View in: PubMed   Mentions: 1     Fields:    
    4. Generation and Quantitative Imaging of Enteroid Monolayers. Methods Mol Biol. 2020; 2171:99-113. Sanman LE, Chen IW, Bieber JM, Thorne CA, Wu LF, Altschuler SJ. PMID: 32705637.
      View in: PubMed   Mentions:    Fields:    
    5. A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. Sci Data. 2019 10 31; 6(1):253. Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF. PMID: 31672976.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019 07 11; 178(2):361-373.e12. Hsu CH, Altschuler SJ, Wu LF. PMID: 31204100.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    7. Scalable analysis of cell-type composition from single-cell transcriptomics using deep recurrent learning. Nat Methods. 2019 04; 16(4):311-314. Deng Y, Bao F, Dai Q, Wu LF, Altschuler SJ. PMID: 30886411.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    8. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia. 2018 08; 20(8):826-837. Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW. PMID: 30015158.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Planar Enteroids Reveal an Autonomous WNT And BMP Circuit Controlling Intestinal Epithelial Growth and Organization. The FASEB Journal. 2018 Apr 1; 32:659.14-659.14. Curtis A. Thorne, Ina W. Chen, Laura E. Sanman, Melanie H. Cobb, Lani F. Wu, Steven J. Altschuler. .
      View in: Publisher Site   Mentions:
    10. Drug persistence - from antibiotics to cancer therapies. Curr Opin Syst Biol. 2018 Aug; 10:1-8. Kochanowski K, Morinishi L, Altschuler S, Wu L. PMID: 30740553.
      View in: PubMed   Mentions:
    11. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Syst. 2018 Mar 28; 6(3):355-367.e5. Thurley K, Wu LF, Altschuler SJ. PMID: 29525203.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Dev Cell. 2018 03 12; 44(5):624-633.e4. Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. PMID: 29503158.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    13. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970. PMID: 28869755.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 06 01; 77(11):3070-3081. PMID: 28377453.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 12 13; 9(458):ra122. PMID: 27965424.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Examining Crosstalk among Transforming Growth Factor ß, Bone Morphogenetic Protein, and Wnt Pathways. J Biol Chem. 2017 Jan 06; 292(1):244-250. PMID: 27895117.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 06 15; 32(12):i44-i51. PMID: 27307643.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474. PMID: 27280401.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    19. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19; 7:10690. PMID: 26891683.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    20. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol. 2016 Jan; 34(1):70-77. PMID: 26655497.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    21. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 02; 162(1):120-33. PMID: 26119341.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    22. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39. PMID: 25739453.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67. PMID: 25425168.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015 Jan; 11(1):58-63. PMID: 25402767.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    25. The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32. PMID: 24912630.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602. PMID: 24874571.
      View in: PubMed   Mentions: 5     Fields:    
    27. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014 Mar 19; (85). PMID: 24686220.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    28. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. PMID: 23660413.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    30. The Zoo of Solitons for Curve Shortening in ℝn. Nonlinearity. 2013; 26(5):1189-1226. Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F. .
    31. The zoo of solitons for curve shortening in On the occasion of Richard Hamilton's nth birthday. Nonlinearity. 2013 May 1; 26(5):1189. Dylan J Altschuler, Steven J Altschuler, Sigurd B Angenent, Lani F Wu. .
      View in: Publisher Site   Mentions:
    32. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jun 28; 9(7):634-5. PMID: 22743763.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    33. PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jun 28; 9(7):635-7. PMID: 22743764.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    34. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    35. Dynamic information flow during neutrophil polarization. The FASEB Journal. 2012 Apr 1; 26:345.1-345.1. Lani Wu, Chin-Jen Ku, Yanqin Wang, Orion Weiner, Steven Altschuler. .
      View in: Publisher Site   Mentions:
    36. Denial, acceptance, and loss of cell polarization for a stochastic model of positive feedback. The FASEB Journal. 2012 Apr 1; 26:468.2-468.2. Steven Altschuler, Sigurd Angenent, Sasha Jilkine, Lani Wu. .
      View in: Publisher Site   Mentions:
    37. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15. PMID: 22341450.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    38. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansCells
    39. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271. PMID: 22102805.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    40. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. Altschuler SJ, Wu LF. PMID: 20478246.
      View in: PubMed   Mentions: 247     Fields:    Translation:AnimalsCells
    41. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. PMID: 20461076.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    42. ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 01; 14-17:1029-1032. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. PMID: 20725643.
      View in: PubMed   Mentions:
    43. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 02; 187(3):375-84. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. PMID: 19948481.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    44. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. PMID: 19767759.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    45. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. Artyukhin AB, Wu LF, Altschuler SJ. PMID: 19703388.
      View in: PubMed   Mentions: 1     Fields:    
    46. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19306-11. Slack MD, Martinez ED, Wu LF, Altschuler SJ. PMID: 19052231.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    47. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9. Altschuler SJ, Angenent SB, Wang Y, Wu LF. PMID: 18704086.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    48. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. PMID: 17696648.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    49. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. PMID: 17448998.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    50. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. Loo LH, Wu LF, Altschuler SJ. PMID: 17401369.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    51. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. PMID: 16738550.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    52. Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254. Loo, L.H., Wu, L., Altschuler, S.J.
    53. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. PMID: 15961632.
      View in: PubMed   Mentions: 541     Fields:    Translation:AnimalsCells
    54. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. Dion MF, Altschuler SJ, Wu LF, Rando OJ. PMID: 15795371.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    55. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. PMID: 15539606.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    56. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. PMID: 12837249.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    57. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. Wedlich-Soldner R, Altschuler S, Wu L, Li R. PMID: 12560471.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    58. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. PMID: 12089522.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    59. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. PMID: 11237012.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    60. On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97. Altschuler, S.J., Wu, L.F.
    61. Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000. Acero, A., Altschuler S.J., Wu L.F . .
    62. On deforming confoliations. Journal of Differential Geometry. 2000 Jan 1; 54(1):75-97. Steven J. Altschuler, Lani F. Wu. .
      View in: Publisher Site   Mentions:
    63. Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111. Altschuler, S.J., Wu, L.F.
    64. A new result for the porous medium equation on R2 derived from the Ricci flow. Bulletin of the American Mathematical Society. 1993; 28:90-94. Wu, L.F.
    65. The Ricci Flow on complete R2. Comm. in Analysis and Geometry. 1993; 1:439-472. Wu, L.F.
    66. Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765. Altschuler, S.J., Wu, L.F.
    67. The Ricci Flow on 2-orbifolds with positive curvature. Journal of Differential Geometry. 1991; 33:575-596. Wu, L.F.
    68. The Ricci Flow on compact 2-orbifolds with curvature negative somewhere. Communications on Pure and Applied Mathematics. 1991; 44:275-286. Chow, B., Wu, L.F.
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