Lani Wu, PhD
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Title(s) | Professor, Pharmaceutical Chemistry |
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School | School of Pharmacy |
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Address | 1700 4th St San Francisco CA 94158
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Phone | 415-502-3196 |
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vCard | Download vCard |
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Overview Dr. Lani Wu is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. She also applies the high-throughput technology developed by her laboratory to diverse applications, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Wu has worked at the UT Southwestern, Harvard University, Rosetta Informatics, Microsoft, and Princeton University.
Research ORNG Applications Bibliographic
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(Note that publications are often cited in additional ways that are not shown here.)
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Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes. Cell Rep. 2021 Jan 19; 34(3):108647.
Kochanowski K, Sander T, Link H, Chang J, Altschuler SJ, Wu LF. PMID: 33472066.
View in: PubMed Mentions: Fields:
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Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Dev Cell. 2021 Jan 15.
Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ. PMID: 33484640.
View in: PubMed Mentions: Fields:
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Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Cell Syst. 2020 07 22; 11(1):86-94.e5.
Morinishi L, Kochanowski K, Levine RL, Wu LF, Altschuler SJ. PMID: 32619551.
View in: PubMed Mentions: 1 Fields:
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Generation and Quantitative Imaging of Enteroid Monolayers. Methods Mol Biol. 2020; 2171:99-113.
Sanman LE, Chen IW, Bieber JM, Thorne CA, Wu LF, Altschuler SJ. PMID: 32705637.
View in: PubMed Mentions: Fields:
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A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. Sci Data. 2019 10 31; 6(1):253.
Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF. PMID: 31672976.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019 07 11; 178(2):361-373.e12.
Hsu CH, Altschuler SJ, Wu LF. PMID: 31204100.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Scalable analysis of cell-type composition from single-cell transcriptomics using deep recurrent learning. Nat Methods. 2019 04; 16(4):311-314.
Deng Y, Bao F, Dai Q, Wu LF, Altschuler SJ. PMID: 30886411.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia. 2018 08; 20(8):826-837.
Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW. PMID: 30015158.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Planar Enteroids Reveal an Autonomous WNT And BMP Circuit Controlling Intestinal Epithelial Growth and Organization. The FASEB Journal. 2018 Apr 1; 32:659.14-659.14.
Curtis A. Thorne, Ina W. Chen, Laura E. Sanman, Melanie H. Cobb, Lani F. Wu, Steven J. Altschuler. .
View in: Publisher Site Mentions:
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Drug persistence - from antibiotics to cancer therapies. Curr Opin Syst Biol. 2018 Aug; 10:1-8.
Kochanowski K, Morinishi L, Altschuler S, Wu L. PMID: 30740553.
View in: PubMed Mentions:
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Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Syst. 2018 Mar 28; 6(3):355-367.e5.
Thurley K, Wu LF, Altschuler SJ. PMID: 29525203.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Dev Cell. 2018 03 12; 44(5):624-633.e4.
Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. PMID: 29503158.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
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Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970.
PMID: 28869755.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 06 01; 77(11):3070-3081.
PMID: 28377453.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 12 13; 9(458):ra122.
PMID: 27965424.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Examining Crosstalk among Transforming Growth Factor ß, Bone Morphogenetic Protein, and Wnt Pathways. J Biol Chem. 2017 Jan 06; 292(1):244-250.
PMID: 27895117.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 06 15; 32(12):i44-i51.
PMID: 27307643.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474.
PMID: 27280401.
View in: PubMed Mentions: 40 Fields: Translation: HumansCells
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Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19; 7:10690.
PMID: 26891683.
View in: PubMed Mentions: 80 Fields: Translation: HumansAnimalsCells
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Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol. 2016 Jan; 34(1):70-77.
PMID: 26655497.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimalsCells
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The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 02; 162(1):120-33.
PMID: 26119341.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39.
PMID: 25739453.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67.
PMID: 25425168.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015 Jan; 11(1):58-63.
PMID: 25402767.
View in: PubMed Mentions: 11 Fields: Translation: HumansCells
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The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32.
PMID: 24912630.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602.
PMID: 24874571.
View in: PubMed Mentions: 5 Fields:
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Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014 Mar 19; (85).
PMID: 24686220.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16.
PMID: 23665220.
View in: PubMed Mentions: 17 Fields: Translation: HumansCells
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Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42.
PMID: 23660413.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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The Zoo of Solitons for Curve Shortening in ℝn. Nonlinearity. 2013; 26(5):1189-1226.
Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F. .
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The zoo of solitons for curve shortening in On the occasion of Richard Hamilton's nth birthday. Nonlinearity. 2013 May 1; 26(5):1189.
Dylan J Altschuler, Steven J Altschuler, Sigurd B Angenent, Lani F Wu. .
View in: Publisher Site Mentions:
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SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jun 28; 9(7):634-5.
PMID: 22743763.
View in: PubMed Mentions: 9 Fields: Translation: Cells
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PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jun 28; 9(7):635-7.
PMID: 22743764.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83.
PMID: 22632971.
View in: PubMed Mentions: 28 Fields: Translation: HumansCells
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Dynamic information flow during neutrophil polarization. The FASEB Journal. 2012 Apr 1; 26:345.1-345.1.
Lani Wu, Chin-Jen Ku, Yanqin Wang, Orion Weiner, Steven Altschuler. .
View in: Publisher Site Mentions:
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Denial, acceptance, and loss of cell polarization for a stochastic model of positive feedback. The FASEB Journal. 2012 Apr 1; 26:468.2-468.2.
Steven Altschuler, Sigurd Angenent, Sasha Jilkine, Lani Wu. .
View in: Publisher Site Mentions:
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Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15.
PMID: 22341450.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88.
PMID: 22265410.
View in: PubMed Mentions: 173 Fields: Translation: HumansCells
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A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271.
PMID: 22102805.
View in: PubMed Mentions: 16 Fields: Translation: Cells
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Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63.
Altschuler SJ, Wu LF. PMID: 20478246.
View in: PubMed Mentions: 247 Fields: Translation: AnimalsCells
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Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369.
Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. PMID: 20461076.
View in: PubMed Mentions: 60 Fields: Translation: HumansCells
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ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 01; 14-17:1029-1032.
Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. PMID: 20725643.
View in: PubMed Mentions:
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Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 02; 187(3):375-84.
Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. PMID: 19948481.
View in: PubMed Mentions: 39 Fields: Translation: AnimalsCells
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An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65.
Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. PMID: 19767759.
View in: PubMed Mentions: 23 Fields: Translation: Cells
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Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21.
Artyukhin AB, Wu LF, Altschuler SJ. PMID: 19703388.
View in: PubMed Mentions: 1 Fields:
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Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19306-11.
Slack MD, Martinez ED, Wu LF, Altschuler SJ. PMID: 19052231.
View in: PubMed Mentions: 57 Fields: Translation: HumansCells
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On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9.
Altschuler SJ, Angenent SB, Wang Y, Wu LF. PMID: 18704086.
View in: PubMed Mentions: 89 Fields: Translation: AnimalsCells
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An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221.
Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. PMID: 17696648.
View in: PubMed Mentions: 162 Fields: Translation: HumansCells
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Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22.
Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. PMID: 17448998.
View in: PubMed Mentions: 112 Fields: Translation: AnimalsCells
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Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53.
Loo LH, Wu LF, Altschuler SJ. PMID: 17401369.
View in: PubMed Mentions: 119 Fields: Translation: HumansCells
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Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003.
Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. PMID: 16738550.
View in: PubMed Mentions: 10 Fields: Translation: Animals
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Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
Loo, L.H., Wu, L., Altschuler, S.J.
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Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30.
Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. PMID: 15961632.
View in: PubMed Mentions: 541 Fields: Translation: AnimalsCells
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Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6.
Dion MF, Altschuler SJ, Wu LF, Rando OJ. PMID: 15795371.
View in: PubMed Mentions: 158 Fields: Translation: AnimalsCells
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Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8.
Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. PMID: 15539606.
View in: PubMed Mentions: 184 Fields: Translation: HumansCells
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A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33.
Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. PMID: 12837249.
View in: PubMed Mentions: 117 Fields: Translation: AnimalsCells
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Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5.
Wedlich-Soldner R, Altschuler S, Wu L, Li R. PMID: 12560471.
View in: PubMed Mentions: 170 Fields: Translation: AnimalsCells
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Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65.
Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. PMID: 12089522.
View in: PubMed Mentions: 109 Fields: Translation: AnimalsCells
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Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7.
Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. PMID: 11237012.
View in: PubMed Mentions: 106 Fields: Translation: HumansCells
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On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
Altschuler, S.J., Wu, L.F.
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Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000.
Acero, A., Altschuler S.J., Wu L.F . .
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On deforming confoliations. Journal of Differential Geometry. 2000 Jan 1; 54(1):75-97.
Steven J. Altschuler, Lani F. Wu. .
View in: Publisher Site Mentions:
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Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
Altschuler, S.J., Wu, L.F.
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A new result for the porous medium equation on R2 derived from the Ricci flow. Bulletin of the American Mathematical Society. 1993; 28:90-94.
Wu, L.F.
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The Ricci Flow on complete R2. Comm. in Analysis and Geometry. 1993; 1:439-472.
Wu, L.F.
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Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
Altschuler, S.J., Wu, L.F.
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The Ricci Flow on 2-orbifolds with positive curvature. Journal of Differential Geometry. 1991; 33:575-596.
Wu, L.F.
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The Ricci Flow on compact 2-orbifolds with curvature negative somewhere. Communications on Pure and Applied Mathematics. 1991; 44:275-286.
Chow, B., Wu, L.F.
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Year | Publications |
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1991 | 2 | 1993 | 3 | 1994 | 1 | 2000 | 3 | 2001 | 1 | 2002 | 1 | 2003 | 2 | 2004 | 1 | 2005 | 2 | 2006 | 2 | 2007 | 3 | 2008 | 2 | 2009 | 3 | 2010 | 3 | 2011 | 1 | 2012 | 7 | 2013 | 4 | 2014 | 5 | 2015 | 3 | 2016 | 5 | 2017 | 2 | 2018 | 5 | 2019 | 3 | 2020 | 2 | 2021 | 2 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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