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Lani Wu, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Phone415-502-3196
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    Collapse Overview
    Dr. Lani Wu is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. She also applies the high-throughput technology developed by her laboratory to diverse applications, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Wu has worked at the UT Southwestern, Harvard University, Rosetta Informatics, Microsoft, and Princeton University.

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    Collapse Research Activities and Funding
    A scalable image-based approach for profiling and annotating very large compound
    NIH/NCI R01CA184984Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    (PQD1) An Iterative Approach for Overcoming Evolving Targeted Therapy Resistance
    NIH/NCI R01CA185404Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Image based phenotypic profiling of single-cell responses to perturbations
    NIH/NIGMS R01GM081549Sep 1, 2007 - Jul 31, 2014
    Role: Principal Investigator
    Multiscale Mathematical Modeling of Cancer Progression
    NIH U54CA113007Sep 30, 2004 - Feb 28, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hsu CH, Altschuler SJ, Wu LF. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019 Jun 07. PMID: 31204100.
      View in: PubMed
    2. Deng Y, Bao F, Dai Q, Wu LF, Altschuler SJ. Scalable analysis of cell-type composition from single-cell transcriptomics using deep recurrent learning. Nat Methods. 2019 04; 16(4):311-314. PMID: 30886411.
      View in: PubMed
    3. Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia. 2018 08; 20(8):826-837. PMID: 30015158.
      View in: PubMed
    4. Kochanowski K, Morinishi L, Altschuler S, Wu L. Drug persistence - from antibiotics to cancer therapies. Curr Opin Syst Biol. 2018 Aug; 10:1-8. PMID: 30740553.
      View in: PubMed
    5. Thurley K, Wu LF, Altschuler SJ. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Syst. 2018 Mar 28; 6(3):355-367.e5. PMID: 29525203.
      View in: PubMed
    6. Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Dev Cell. 2018 03 12; 44(5):624-633.e4. PMID: 29503158.
      View in: PubMed
    7. Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970. PMID: 28869755.
      View in: PubMed
    8. Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler SJ, Wu LF. Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 06 01; 77(11):3070-3081. PMID: 28377453.
      View in: PubMed
    9. Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH. Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 12 13; 9(458):ra122. PMID: 27965424.
      View in: PubMed
    10. Coster AD, Thorne CA, Wu LF, Altschuler SJ. Examining Crosstalk among Transforming Growth Factor ß, Bone Morphogenetic Protein, and Wnt Pathways. J Biol Chem. 2017 Jan 06; 292(1):244-250. PMID: 27895117.
      View in: PubMed
    11. Deng Y, Altschuler SJ, Wu LF. PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 06 15; 32(12):i44-i51. PMID: 27307643; PMCID: PMC4908335.
      View in: PubMed, PubMed Central
    12. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474. PMID: 27280401.
      View in: PubMed
    13. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19; 7:10690. PMID: 26891683; PMCID: PMC4762880.
      View in: PubMed, PubMed Central
    14. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol. 2016 Jan; 34(1):70-77. PMID: 26655497; PMCID: PMC4844861.
      View in: PubMed, PubMed Central
    15. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 02; 162(1):120-33. PMID: 26119341; PMCID: PMC4646663.
      View in: PubMed, PubMed Central
    16. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39. PMID: 25739453; PMCID: PMC4436775.
      View in: PubMed, PubMed Central
    17. Steininger RJ, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ. On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67. PMID: 25425168; PMCID: PMC4442742.
      View in: PubMed, PubMed Central
    18. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015 Jan; 11(1):58-63. PMID: 25402767; PMCID: PMC4270937.
      View in: PubMed, PubMed Central
    19. Agi E, Langen M, Altschuler SJ, Wu LF, Zimmermann T, Hiesinger PR. The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32. PMID: 24912630; PMCID: PMC4245170.
      View in: PubMed, PubMed Central
    20. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602. PMID: 24874571; PMCID: PMC4277860.
      View in: PubMed, PubMed Central
    21. Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler SJ. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014 Mar 19; (85). PMID: 24686220; PMCID: PMC4390293.
      View in: PubMed, PubMed Central
    22. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220; PMCID: PMC3674638.
      View in: PubMed, PubMed Central
    23. Zhang ER, Wu LF, Altschuler SJ. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. PMID: 23660413; PMCID: PMC3758422.
      View in: PubMed, PubMed Central
    24. Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F. .The Zoo of Solitons for Curve Shortening in Rn. Nonlinearity. 2013; 26(5):1189-1226.
    25. Rajaram S, Pavie B, Wu LF, Altschuler SJ. PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jun 28; 9(7):635-7. PMID: 22743764; PMCID: PMC3842428.
      View in: PubMed, PubMed Central
    26. Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu LF. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jun 28; 9(7):634-5. PMID: 22743763; PMCID: PMC3842427.
      View in: PubMed, PubMed Central
    27. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971; PMCID: PMC3614011.
      View in: PubMed, PubMed Central
    28. Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15. PMID: 22341450; PMCID: PMC3368334.
      View in: PubMed, PubMed Central
    29. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410; PMCID: PMC3308728.
      View in: PubMed, PubMed Central
    30. Jilkine A, Angenent SB, Wu LF, Altschuler SJ. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271. PMID: 22102805; PMCID: PMC3213192.
      View in: PubMed, PubMed Central
    31. Altschuler SJ, Wu LF. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. PMID: 20478246; PMCID: PMC2918286.
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    32. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. PMID: 20461076; PMCID: PMC2890326.
      View in: PubMed, PubMed Central
    33. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 01; 14-17:1029-1032. PMID: 20725643.
      View in: PubMed
    34. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 02; 187(3):375-84. PMID: 19948481; PMCID: PMC2779244.
      View in: PubMed, PubMed Central
    35. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. PMID: 19767759; PMCID: PMC2818727.
      View in: PubMed, PubMed Central
    36. Artyukhin AB, Wu LF, Altschuler SJ. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. PMID: 19703388.
      View in: PubMed
    37. Slack MD, Martinez ED, Wu LF, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19306-11. PMID: 19052231; PMCID: PMC2614757.
      View in: PubMed, PubMed Central
    38. Altschuler SJ, Angenent SB, Wang Y, Wu LF. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9. PMID: 18704086; PMCID: PMC2562338.
      View in: PubMed, PubMed Central
    39. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648; PMCID: PMC1945041.
      View in: PubMed, PubMed Central
    40. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. PMID: 17448998; PMCID: PMC2000346.
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    41. Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. PMID: 17401369.
      View in: PubMed
    42. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. PMID: 16738550; PMCID: PMC1681477.
      View in: PubMed, PubMed Central
    43. Loo, L.H., Wu, L., Altschuler, S.J.Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
    44. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. PMID: 15961632.
      View in: PubMed
    45. Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. PMID: 15795371; PMCID: PMC555684.
      View in: PubMed, PubMed Central
    46. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. PMID: 15539606.
      View in: PubMed
    47. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. PMID: 12837249.
      View in: PubMed
    48. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. PMID: 12560471.
      View in: PubMed
    49. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. PMID: 12089522.
      View in: PubMed
    50. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7. PMID: 11237012.
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    51. Altschuler, S.J., Wu, L.F. .On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
    52. Acero, A., Altschuler S.J., Wu L.F .Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000.
    53. Altschuler, S.J., Wu, L.F. .Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
    54. Altschuler, S.J., Wu, L.F.Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
    55. Wu, L.F.The Ricci Flow on complete R2. Comm. in Analysis and Geometry. 1993; 1:439-472.
    56. Wu, L.F.A new result for the porous medium equation on R2 derived from the Ricci flow. Bulletin of the American Mathematical Society. 1993; 28:90-94.
    57. Chow, B., Wu, L.F.The Ricci Flow on compact 2-orbifolds with curvature negative somewhere. Communications on Pure and Applied Mathematics. 1991; 44:275-286.
    58. Wu, L.F.The Ricci Flow on 2-orbifolds with positive curvature. Journal of Differential Geometry. 1991; 33:575-596.
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