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Lani Wu, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
Phone415-502-3196
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    Collapse Overview 
    Collapse Overview
    Dr. Lani Wu is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. She also applies the high-throughput technology developed by her laboratory to diverse applications, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Wu has worked at the UT Southwestern, Harvard University, Rosetta Informatics, Microsoft, and Princeton University.


    Collapse Research 
    Collapse Research Activities and Funding
    A scalable image-based approach for profiling and annotating very large compound
    NIH/NCI R01CA184984Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    (PQD1) An Iterative Approach for Overcoming Evolving Targeted Therapy Resistance
    NIH/NCI R01CA185404Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Image based phenotypic profiling of single-cell responses to perturbations
    NIH/NIGMS R01GM081549Sep 1, 2007 - Jul 31, 2014
    Role: Principal Investigator
    Multiscale Mathematical Modeling of Cancer Progression
    NIH U54CA113007Sep 30, 2004 - Feb 28, 2015
    Role: Co-Investigator

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang ER, Liu S, Wu L, Altschuler SJ, Cobb MH. Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 Dec 13; 9(458):ra122. PMID: 27965424.
      View in: PubMed
    2. Coster AD, Thorne CA, Wu L, Altschuler SJ. Examining crosstalk among Transforming Growth Factor ß, Bone Morphogen Protein, and Wnt pathways. J Biol Chem. 2016 Nov 28. PMID: 27895117.
      View in: PubMed
    3. Deng Y, Altschuler SJ, Wu L. PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 Jun 15; 32(12):i44-i51. PMID: 27307643.
      View in: PubMed
    4. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu L, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 Jun; 14(6):e1002474. PMID: 27280401.
      View in: PubMed
    5. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu L, Altschuler SJ. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016; 7:10690. PMID: 26891683.
      View in: PubMed
    6. Langen M, Agi E, Altschuler DJ, Wu L, Altschuler SJ, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 2; 162(1):120-33. PMID: 26119341.
      View in: PubMed
    7. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 1; 26(9):1629-39. PMID: 25739453; PMCID: PMC4436775.
      View in: PubMed, PubMed Central
    8. Steininger RJ, Rajaram S, Girard L, Minna JD, Wu L, Altschuler SJ. On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67. PMID: 25425168; PMCID: PMC4442742.
      View in: PubMed, PubMed Central
    9. Agi E, Langen M, Altschuler SJ, Wu L, Zimmermann T, Hiesinger PR. The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32. PMID: 24912630; PMCID: PMC4245170.
      View in: PubMed, PubMed Central
    10. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu L. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602. PMID: 24874571; PMCID: PMC4277860.
      View in: PubMed, PubMed Central
    11. Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu L, Altschuler SJ. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014; (85). PMID: 24686220; PMCID: PMC4390293.
      View in: PubMed, PubMed Central
    12. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu L, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220; PMCID: PMC3674638.
      View in: PubMed, PubMed Central
    13. Zhang ER, Wu L, Altschuler SJ. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. PMID: 23660413; PMCID: PMC3758422.
      View in: PubMed, PubMed Central
    14. Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L . The Zoo of Solitons for Curve Shortening in Rn. Nonlinearity. 2013; 26(5):1189-1226.
    15. Rajaram S, Pavie B, Wu L, Altschuler SJ. PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jul; 9(7):635-7. PMID: 22743764; PMCID: PMC3842428.
      View in: PubMed, PubMed Central
    16. Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu L. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jul; 9(7):634-5. PMID: 22743763; PMCID: PMC3842427.
      View in: PubMed, PubMed Central
    17. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu L. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971; PMCID: PMC3614011.
      View in: PubMed, PubMed Central
    18. Orchard RC, Kittisopikul M, Altschuler SJ, Wu L, Süel GM, Alto NM. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15. PMID: 22341450; PMCID: PMC3368334.
      View in: PubMed, PubMed Central
    19. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu L, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410; PMCID: PMC3308728.
      View in: PubMed, PubMed Central
    20. Jilkine A, Angenent SB, Wu L, Altschuler SJ. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271. PMID: 22102805; PMCID: PMC3213192.
      View in: PubMed, PubMed Central
    21. Altschuler SJ, Wu L. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. PMID: 20478246; PMCID: PMC2918286.
      View in: PubMed, PubMed Central
    22. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu L, Altschuler SJ. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. PMID: 20461076; PMCID: PMC2890326.
      View in: PubMed, PubMed Central
    23. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu L. ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 1; 14-17:1029-1032. PMID: 20725643.
      View in: PubMed
    24. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu L. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 2; 187(3):375-84. PMID: 19948481; PMCID: PMC2779244.
      View in: PubMed, PubMed Central
    25. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu L, Altschuler SJ. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. PMID: 19767759; PMCID: PMC2818727.
      View in: PubMed, PubMed Central
    26. Artyukhin AB, Wu L, Altschuler SJ. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. PMID: 19703388.
      View in: PubMed
    27. Slack MD, Martinez ED, Wu L, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19306-11. PMID: 19052231; PMCID: PMC2614757.
      View in: PubMed, PubMed Central
    28. Altschuler SJ, Angenent SB, Wang Y, Wu L. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9. PMID: 18704086; PMCID: PMC2562338.
      View in: PubMed, PubMed Central
    29. Weiner OD, Marganski WA, Wu L, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648; PMCID: PMC1945041.
      View in: PubMed, PubMed Central
    30. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu L. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. PMID: 17448998; PMCID: PMC2000346.
      View in: PubMed, PubMed Central
    31. Loo LH, Wu L, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. PMID: 17401369.
      View in: PubMed
    32. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu L. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. PMID: 16738550; PMCID: PMC1681477.
      View in: PubMed, PubMed Central
    33. Loo, L.H., Wu, L., Altschuler, S.J. Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
    34. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu L, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. PMID: 15961632.
      View in: PubMed
    35. Dion MF, Altschuler SJ, Wu L, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. PMID: 15795371; PMCID: PMC555684.
      View in: PubMed, PubMed Central
    36. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu L, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. PMID: 15539606.
      View in: PubMed
    37. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu L, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. PMID: 12837249.
      View in: PubMed
    38. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. PMID: 12560471.
      View in: PubMed
    39. Wu L, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. PMID: 12089522.
      View in: PubMed
    40. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu L, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7. PMID: 11237012.
      View in: PubMed
    41. Acero, A., Altschuler S.J., Wu L . Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000.
    42. Altschuler, S.J., Wu, L.F. . On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
    43. Altschuler, S.J., Wu, L.F. . Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
    44. Wu, L.F. The Ricci Flow on complete R2. Comm. in Analysis and Geometry. 1993; 1:439-472.
    45. Wu, L.F. A new result for the porous medium equation on R2 derived from the Ricci flow. Bulletin of the American Mathematical Society. 1993; 28:90-94.
    46. Altschuler, S.J., Wu, L.F. Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
    47. Wu, L.F. The Ricci Flow on 2-orbifolds with positive curvature. Journal of Differential Geometry. 1991; 33:575-596.
    48. Chow, B., Wu, L.F. The Ricci Flow on compact 2-orbifolds with curvature negative somewhere. Communications on Pure and Applied Mathematics. 1991; 44:275-286.
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