Chloe Atreya, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-353-9888
ORCID ORCID Icon0000-0003-2954-1727 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Yale UniversityMD, PhD2005School of Medicine
    Princeton UniversityBA1998
    University of California, San Francisco, CA11/2019Diversity, Equity, and Inclusion Champion Training
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    2011American Cancer Society Postdoctoral Fellowship 11-183-01-TBG
    2011Conquer Cancer Foundation of the American Society of Clinical Oncology Young Investigator Award
    2012Alliance for Clinical Trials in Oncology Foundation Investigator Award
    2014The Ernest H. Rosenbaum MD Commitment to Patient Care Award, UCSF Symptom Management Service
    2017The Marcus Program in Precision Medicine Innovation Seeding Bold Ideas Award
    2017Clinical Innovation Center Inside Out Accelerator Award

    Collapse Overview 
    Collapse Overview
    Dr. Chloe E. Atreya specializes in gastrointestinal cancer, particularly colorectal cancer, at the UCSF Helen Diller Comprehensive Cancer Center. Her research focuses on the interplay of tumor genetics and response to therapies for colorectal cancer, with the goal of improving patient outcomes and quality of life by personalizing treatment.

    Collapse Research 
    Collapse Research Activities and Funding
    Kinome-guided Targeting of Cooperative Dependencies in BRAF and KRAS Mutated Colorectal Cancer
    NIH R01CA229447Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator
    (PQ10) Harnessing the human gut microbiome to predict chemotherapy outcomes
    NIH R21CA227232Jun 21, 2018 - May 31, 2021
    Role: Co-Principal Investigator
    Targeting of Aberrant Signaling in Patient-Derived Colorectal Cancer Models
    NIH K08CA175153Sep 15, 2013 - Apr 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Student Projects

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy. Anticancer Res. 2021 Jun; 41(6):2985-2992. Keenan BP, VAN Loon K, Khilnani AD, Fidelman N, Behr SC, Atreya CE, Oh DY. PMID: 34083289.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406). J Clin Oncol. 2021 02 01; 39(4):285-294. Kopetz S, Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, Hochster HS. PMID: 33356422.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    3. Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients. J Natl Compr Canc Netw. 2020 11; 18(11):1446-1452. Atreya CE, Collisson EA, Park M, Grenert JP, Behr SC, Gonzalez A, Chou J, Maisel S, Friedlander TW, Freise CE, Shoji J, Semrad TJ, Van Ziffle J, Chin-Hong P. PMID: 33152701.
      View in: PubMed   Mentions:    Fields:    
    4. Association of Diet Quality With Survival Among People With Metastatic Colorectal Cancer in the Cancer and Leukemia B and Southwest Oncology Group 80405 Trial. JAMA Netw Open. 2020 10 01; 3(10):e2023500. Van Blarigan EL, Zhang S, Ou FS, Venlo A, Ng K, Atreya C, Van Loon K, Niedzwiecki D, Giovannucci E, Wolfe EG, Lenz HJ, Innocenti F, O'Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Mayer RJ, Blanke CD, O'Reilly EM, Fuchs CS, Meyerhardt JA. PMID: 33125497.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    5. ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. Nat Rev Clin Oncol. 2020 12; 17(12):757-770. Dasari A, Morris VK, Allegra CJ, Atreya C, Benson AB, Boland P, Chung K, Copur MS, Corcoran RB, Deming DA, Dwyer A, Diehn M, Eng C, George TJ, Gollub MJ, Goodwin RA, Hamilton SR, Hechtman JF, Hochster H, Hong TS, Innocenti F, Iqbal A, Jacobs SA, Kennecke HF, Lee JJ, Lieu CH, Lenz HJ, Lindwasser OW, Montagut C, Odisio B, Ou FS, Porter L, Raghav K, Schrag D, Scott AJ, Shi Q, Strickler JH, Venook A, Yaeger R, Yothers G, You YN, Zell JA, Kopetz S. PMID: 32632268.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    6. Factors Impacting Differential Outcomes in the Definitive Radiation Treatment of Anal Cancer Between HIV-Positive and HIV-Negative Patients. Oncologist. 2020 09; 25(9):772-779. Susko M, Wang CJ, Lazar AA, Kim S, Laffan A, Feng M, Ko A, Venook AP, Atreya CE, Van Loon K, Anwar M. PMID: 32390297.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Probing the tumor micro(b)environment. Science. 2020 05 29; 368(6494):938-939. Atreya CE, Turnbaugh PJ. PMID: 32467376.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Embedded palliative care for patients with metastatic colorectal cancer: a mixed-methods pilot study. Support Care Cancer. 2020 Dec; 28(12):5995-6010. Bischoff KE, Zapata C, Sedki S, Ursem C, O'Riordan DL, England AE, Thompson N, Alfaro A, Rabow MW, Atreya CE. PMID: 32285263.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. BRAF-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer. Clin Cancer Res. 2020 06 01; 26(11):2466-2476. Middleton G, Yang Y, Campbell CD, André T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, De Vos F, Van Cutsem E, Millholland JM, Brase JC, Rangwala F, Gasal E, Corcoran RB. PMID: 32047001.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Clinicopathologic Characteristics and Impact of Oophorectomy for Ovarian Metastases from Colorectal Cancer. Oncologist. 2020 07; 25(7):564-571. Ursem C, Zhou M, Paciorek A, Atreya CE, Ko AH, Venook A, Zhang L, Van Loon K. PMID: 32031306.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Postoperative Exacerbation of Oxaliplatin-induced Neurotoxicity in Gastrointestinal Cancers: A Case Series. Anticancer Res. 2020 02; 40(2):865-871. Gonzalez A, Walker EJ, Van Loon K, Cinar P, Atreya CE. PMID: 32014930.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Feasibility and Acceptability of a Web-Based Dietary Intervention with Text Messages for Colorectal Cancer: A Randomized Pilot Trial. Cancer Epidemiol Biomarkers Prev. 2020 04; 29(4):752-760. Van Blarigan EL, Kenfield SA, Chan JM, Van Loon K, Paciorek A, Zhang L, Chan H, Savoie MB, Bocobo AG, Liu VN, Wong LX, Laffan A, Atreya CE, Miaskowski C, Fukuoka Y, Meyerhardt JA, Venook AP. PMID: 31941707.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation. J Gastrointest Cancer. 2019 Dec; 50(4):769-779. Savoie MB, Paciorek A, Zhang L, Van Blarigan EL, Sommovilla N, Abrams D, Atreya CE, Bergsland EK, Chern H, Kelley RK, Ko A, Laffan A, Sarin A, Varma MG, Venook AP, Van Loon K. PMID: 30058032.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164. J Clin Oncol. 2020 01 01; 38(1):11-19. Le DT, Kim TW, Van Cutsem E, Geva R, Jäger D, Hara H, Burge M, O'Neil B, Kavan P, Yoshino T, Guimbaud R, Taniguchi H, Elez E, Al-Batran SE, Boland PM, Crocenzi T, Atreya CE, Cui Y, Dai T, Marinello P, Diaz LA, André T. PMID: 31725351.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCellsCTClinical Trials
    15. A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. Sci Data. 2019 10 31; 6(1):253. Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF. PMID: 31672976.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Hormone receptor expression of colorectal cancer diagnosed during the peri-partum period. Endocr Connect. 2019 Aug; 8(8):1149-1158. Silverstein J, Kidder W, Fisher S, Hope TA, Maisel S, Ng D, Van Ziffle J, Atreya CE, Van Loon K. PMID: 31370007.
      View in: PubMed   Mentions:
    17. Improving Access to Integrative Oncology Through Group Medical Visits: A Pilot Implementation Project. J Altern Complement Med. 2019 Jul; 25(7):733-739. Thompson-Lastad A, Atreya CE, Chao MT, Pollak C, Dhruva A, Santana T, Abrams DI. PMID: 31314561.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial. BMC Cancer. 2019 Mar 11; 19(1):218. Van Blarigan EL, Chan H, Van Loon K, Kenfield SA, Chan JM, Mitchell E, Zhang L, Paciorek A, Joseph G, Laffan A, Atreya CE, Fukuoka Y, Miaskowski C, Meyerhardt JA, Venook AP. PMID: 30866859.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    19. Of Microbes and Microsatellites. Cancer Immunol Res. 2018 11; 6(11):1290-1291. Atreya CE, Venook AP. PMID: 30389718.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Applying New Models of Care to Meet Patient Needs in Integrative Oncology. J Altern Complement Med. 2018 Sep/Oct; 24(9-10):1010-1011. Dhruva A, Atreya CE, Chao MT. PMID: 30247958.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Being Present: A single-arm feasibility study of audio-based mindfulness meditation for colorectal cancer patients and caregivers. PLoS One. 2018; 13(7):e0199423. Atreya CE, Kubo A, Borno HT, Rosenthal B, Campanella M, Rettger JP, Joseph G, Allen IE, Venook AP, Altschuler A, Dhruva A. PMID: 30036361.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Emerging treatment options for BRAF-mutant colorectal cancer. Gastrointest Cancer. 2018; 8:13-23. Ursem C, Atreya CE, Van Loon K. PMID: 29628780.
      View in: PubMed   Mentions:
    23. Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer. Cancer Discov. 2018 04; 8(4):428-443. Corcoran RB, André T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Middleton G, Muro K, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, Humblet Y, De Vos F, Jung AS, Brase JC, Jaeger S, Bettinger S, Mookerjee B, Rangwala F, Van Cutsem E. PMID: 29431699.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCellsCTClinical Trials
    24. Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer. Cancer Discov. 2018 02; 8(2):164-173. Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, Corcoran RB, Kopetz S. PMID: 29196463.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    25. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970. Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ. PMID: 28869755.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Prolonged Response to HER2-Directed Therapy in a Patient With HER2-Amplified, Rapidly Progressive Metastatic Colorectal Cancer. J Natl Compr Canc Netw. 2017 01; 15(1):3-8. Parikh A, Atreya C, Korn WM, Venook AP. PMID: 28040715.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Systemic Therapy for Metastatic Colorectal Cancer: From Current Standards to Future Molecular Targeted Approaches. Am Soc Clin Oncol Educ Book. 2017; 37:246-256. Atreya CE, Yaeger R, Chu E. PMID: 28561718.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. Differential Radiographic Appearance of BRAF V600E-Mutant Metastatic Colorectal Cancer in Patients Matched by Primary Tumor Location. J Natl Compr Canc Netw. 2016 12; 14(12):1536-1543. Atreya CE, Greene C, McWhirter RM, Ikram NS, Allen IE, Van Loon K, Venook AP, Yeh BM, Behr SC. PMID: 27956538.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Radioembolization with 90Y glass microspheres for the treatment of unresectable metastatic liver disease from chemotherapy-refractory gastrointestinal cancers: final report of a prospective pilot study. J Gastrointest Oncol. 2016 Dec; 7(6):860-874. Fidelman N, Kerlan RK, Hawkins RA, Pampaloni M, Taylor AG, Kohi MP, Kolli KP, Atreya CE, Bergsland EK, Kelley RK, Ko AH, Korn WM, Van Loon K, McWhirter RM, Luan J, Johanson C, Venook AP. PMID: 28078110.
      View in: PubMed   Mentions:
    30. Role of Biologics in Colon Cancer: Still Not Clear. J Oncol Pract. 2016 12; 12(12):1229-1230. Atreya CE, Venook AP. PMID: 27943687.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. A phase II study of axitinib in advanced neuroendocrine tumors. Endocr Relat Cancer. 2016 05; 23(5):411-8. Strosberg JR, Cives M, Hwang J, Weber T, Nickerson M, Atreya CE, Venook A, Kelley RK, Valone T, Morse B, Coppola D, Bergsland EK. PMID: 27080472.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    32. Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer. J Clin Oncol. 2015 Dec 01; 33(34):4023-31. Corcoran RB, Atreya CE, Falchook GS, Kwak EL, Ryan DP, Bendell JC, Hamid O, Messersmith WA, Daud A, Kurzrock R, Pierobon M, Sun P, Cunningham E, Little S, Orford K, Motwani M, Bai Y, Patel K, Venook AP, Kopetz S. PMID: 26392102.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCTClinical Trials
    33. Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas. Cancer Discov. 2015 Oct; 5(10):1040-8. Zill OA, Greene C, Sebisanovic D, Siew LM, Leng J, Vu M, Hendifar AE, Wang Z, Atreya CE, Kelley RK, Van Loon K, Ko AH, Tempero MA, Bivona TG, Munster PN, Talasaz A, Collisson EA. PMID: 26109333.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    34. Expanded RAS: refining the patient population. J Clin Oncol. 2015 Mar 01; 33(7):682-5. Atreya CE, Corcoran RB, Kopetz S. PMID: 25584005.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    35. Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model. Int J Cancer. 2015 Apr 15; 136(8):1967-75. Song EK, Tai WM, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Pitts TM, Wang G, Blatchford P, Yahn R, Kaplan J, Tan AC, Atreya CE, Eckhardt G, Kelley RK, Venook A, Kwak EL, Ryan D, Arcaroli JJ. PMID: 25242168.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    36. Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803. Clin Cancer Res. 2013 Oct 15; 19(20):5777-87. Warren RS, Atreya CE, Niedzwiecki D, Weinberg VK, Donner DB, Mayer RJ, Goldberg RM, Compton CC, Zuraek MB, Ye C, Saltz LB, Bertagnolli MM. PMID: 23983256.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    37. Cancer Medicine. PTEN Expression is Consistent in Colorectal Cancer Primaries and Metastases and Associates with Patient Survival. 2013. Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, and Warren RS. View Publication.
    38. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med. 2013 Aug; 2(4):496-506. Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS. PMID: 24156022.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    39. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene. 2014 Mar 20; 33(12):1590-600. Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS. PMID: 23542178.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    40. Personalized Medicine in Oncology. KRAS and Colorectal Cancer: Shades of Gray. 2012; 6(1). Atreya CE, Ostrem JM, and Kelley RK.
    41. Predictive biomarkers in advance of a companion drug: ahead of their time? J Natl Compr Canc Netw. 2012 Mar; 10(3):303-9. Kelley RK, Atreya C, Venook AP, Febbo PG. PMID: 22393192.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Invest New Drugs. 2012 Dec; 30(6):2219-25. Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM. PMID: 22270257.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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