Steven Altschuler, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th Street, #408C
San Francisco CA 94158
Phone415-502-3196
PronounsHe/Him/His
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    Collapse Overview
    Dr. Steven Altschuler is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. Dr. Altschuler also applies high-throughput technology developed by his laboratory to diverse problems, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Altschuler worked at UT Southwestern, Harvard, Rosetta Informatics, Microsoft, Princeton, and the Institute for Advanced Studies.

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    Scalable Image-Based Approach for Profiling and Annotating Very Large Compound Libraries”
    NIH/NCI 2R01 CA184984-06A1Apr 1, 2020 - Mar 31, 2025
    Role: co-PI
    Description: We will develop a cost-effective, image-based platform for assigning large numbers of compounds to their biological functions
    A drug discovery paradigm for fast-tracking adaptations to high altitude
    DARPA PanaceaSep 1, 2019 - Aug 31, 2024
    Role: co-PI
    Description: The goal of this proposal is to identify novel compounds that promote adaptive responses to hypoxia and/or that block maladaptive responses to hypoxia, thereby accelerating acclimatization to hypoxia and prolonging physiologic endurance under oxygen-limited conditions or environments
    Reverse-engineering mechanisms of neural circuit wiring in the fly visual system
    NIH R01EY028205Sep 1, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Systems-level role of GSK3 in colonic epithelium homeostasis and drug resistance
    NIH R01GM112690Feb 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Lung cancer heterogeneity and its impact on drug resistance.
    NIH R01CA133253Aug 1, 2010 - May 31, 2016
    Role: Principal Investigator
    Turnkey solution for image phenotype classification
    NIH R01GM085442Sep 19, 2008 - Aug 31, 2014
    Role: Principal Investigator
    On the emergence of polarization and motility responses from chemotactic networks
    NIH R01GM071794Jul 1, 2004 - May 31, 2015
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting PRMT1 reduces cancer persistence and tumor relapse in EGFR- and KRAS-mutant lung cancer. Cancer Res Commun. 2024 Dec 19. Sun X, Kumbier K, Gayathri S, Steri V, Wu LF, Altschuler SJ. PMID: 39699269.
      View in: PubMed   Mentions:
    2. Targeting therapy-persistent residual disease. Nat Cancer. 2024 Sep; 5(9):1298-1304. Sun X, Wu LF, Altschuler SJ, Hata AN. PMID: 39289594.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Small molecule in situ resin capture provides a compound first approach to natural product discovery. Nat Commun. 2024 Jun 19; 15(1):5230. Bogdanov A, Salib MN, Chase AB, Hammerlindl H, Muskat MN, Luedtke S, da Silva EB, O'Donoghue AJ, Wu LF, Altschuler SJ, Molinski TF, Jensen PR. PMID: 38898025; PMCID: PMC11187115.
      View in: PubMed   Mentions: 1     Fields:    
    4. Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts. Dev Cell. 2024 Aug 19; 59(16):2134-2142.e6. Kumbier K, Roth M, Li Z, Lazzari-Dean J, Waters C, Hammerlindl S, Rinaldi C, Huang P, Korobeynikov VA, New York Genome Center ALS Consortium, Phatnani H, Shneider N, Jacobson MP, Wu LF, Altschuler SJ. PMID: 38878774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit. Cell Rep. 2023 10 31; 42(10):113260. Waters CS, Angenent SB, Altschuler SJ, Wu LF. PMID: 37851575; PMCID: PMC10668033.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Searching for molecular hypoxia sensors among oxygen-dependent enzymes. Elife. 2023 07 26; 12. Li L, Shen S, Bickler P, Jacobson MP, Wu LF, Altschuler SJ. PMID: 37494095; PMCID: PMC10371230.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. Small Molecule in situ Resin Capture - A Compound First Approach to Natural Product Discovery. bioRxiv. 2023 May 30. Bogdanov A, Salib MN, Chase AB, Hammerlindl H, Muskat MN, Luedtke S, Barbosa da Silva E, O'Donoghue AJ, Wu LF, Altschuler SJ, Molinski TF, Jensen PR. PMID: 37398257; PMCID: PMC10312467.
      View in: PubMed   Mentions:
    8. Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity. Cell Rep. 2023 05 30; 42(5):112447. Rinaldi C, Waters CS, Li Z, Kumbier K, Rao L, Nichols RJ, Jacobson MP, Wu LF, Altschuler SJ. PMID: 37141099.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Selection of Optimal Cell Lines for High-Content Phenotypic Screening. ACS Chem Biol. 2023 04 21; 18(4):679-685. Heinrich L, Kumbier K, Li L, Altschuler SJ, Wu LF. PMID: 36920184; PMCID: PMC10127200.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Biallelic TET2 mutations confer sensitivity to 5'-azacitidine in acute myeloid leukemia. JCI Insight. 2023 Jan 24; 8(2). Stölzel F, Fordham SE, Nandana D, Lin WY, Blair H, Elstob C, Bell HL, Mohr B, Ruhnke L, Kunadt D, Dill C, Allsop D, Piddock R, Soura EN, Park C, Fadly M, Rahman T, Alharbi A, Wobus M, Altmann H, Röllig C, Wagenführ L, Jones GL, Menne T, Jackson GH, Marr HJ, Fitzgibbon J, Onel K, Meggendorfer M, Robinson A, Bziuk Z, Bowes E, Heidenreich O, Haferlach T, Villar S, Ariceta B, Diaz RA, Altschuler SJ, Wu LF, Prosper F, Montesinos P, Martinez-Lopez J, Bornhäuser M, Allan JM. PMID: 36480300; PMCID: PMC9977313.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Publisher Correction: Integrative spatial analysis of cell morphologies and transcriptional states with MUSE. Nat Biotechnol. 2022 Aug; 40(8):1295. Bao F, Deng Y, Wan S, Shen SQ, Wang B, Dai Q, Altschuler SJ, Wu LF. PMID: 35505109.
      View in: PubMed   Mentions:    Fields:    
    12. Integrative spatial analysis of cell morphologies and transcriptional states with MUSE. Nat Biotechnol. 2022 08; 40(8):1200-1209. Bao F, Deng Y, Wan S, Shen SQ, Wang B, Dai Q, Altschuler SJ, Wu LF. PMID: 35347329.
      View in: PubMed   Mentions: 40     Fields:    
    13. Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters. Sci Adv. 2022 01 28; 8(4):eabi7711. Sun X, Bieber JM, Hammerlindl H, Chalkley RJ, Li KH, Burlingame AL, Jacobson MP, Wu LF, Altschuler SJ. PMID: 35089788; PMCID: PMC8797778.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs. Commun Biol. 2022 01 27; 5(1):99. Bieber JM, Sanman LE, Sun X, Hammerlindl H, Bao F, Roth MA, Koleske ML, Huang L, Aweeka F, Wu LF, Altschuler SJ. PMID: 35087225; PMCID: PMC8795448.
      View in: PubMed   Mentions: 1  Translation:AnimalsCells
    15. Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system. PLoS Genet. 2021 11; 17(11):e1009857. Ji W, Wu LF, Altschuler SJ. PMID: 34731164; PMCID: PMC8565740.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition. Dev Cell. 2021 02 08; 56(3):356-365.e9. Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ. PMID: 33484640; PMCID: PMC7917018.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    17. Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes. Cell Rep. 2021 01 19; 34(3):108647. Kochanowski K, Sander T, Link H, Chang J, Altschuler SJ, Wu LF. PMID: 33472066; PMCID: PMC7877896.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Cell Syst. 2020 07 22; 11(1):86-94.e5. Morinishi L, Kochanowski K, Levine RL, Wu LF, Altschuler SJ. PMID: 32619551; PMCID: PMC7428059.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    19. Generation and Quantitative Imaging of Enteroid Monolayers. Methods Mol Biol. 2020; 2171:99-113. Sanman LE, Chen IW, Bieber JM, Thorne CA, Wu LF, Altschuler SJ. PMID: 32705637.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors. Sci Data. 2019 10 31; 6(1):253. Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF. PMID: 31672976; PMCID: PMC6823477.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019 07 11; 178(2):361-373.e12. Hsu CH, Altschuler SJ, Wu LF. PMID: 31204100; PMCID: PMC6688629.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    22. Scalable analysis of cell-type composition from single-cell transcriptomics using deep recurrent learning. Nat Methods. 2019 04; 16(4):311-314. Deng Y, Bao F, Dai Q, Wu LF, Altschuler SJ. PMID: 30886411; PMCID: PMC6774994.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    23. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia. 2018 08; 20(8):826-837. Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW. PMID: 30015158; PMCID: PMC6037876.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    24. Planar Enteroids Reveal an Autonomous WNT And BMP Circuit Controlling Intestinal Epithelial Growth and Organization. The FASEB Journal. 2018 Apr 1; 32:659.14-659.14. Thorne TC, Chen CI, Sanman SL, Cobb CM, Wu WL, Altschuler AS. .
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    25. Drug persistence - from antibiotics to cancer therapies. Curr Opin Syst Biol. 2018 Aug; 10:1-8. Kochanowski K, Morinishi L, Altschuler S, Wu L. PMID: 30740553; PMCID: PMC6366840.
      View in: PubMed   Mentions: 15  
    26. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Syst. 2018 Mar 28; 6(3):355-367.e5. Thurley K, Wu LF, Altschuler SJ. PMID: 29525203; PMCID: PMC5913757.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    27. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Dev Cell. 2018 03 12; 44(5):624-633.e4. Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. PMID: 29503158; PMCID: PMC5849535.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    28. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970. Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ. PMID: 28869755; PMCID: PMC5658002.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    29. Abstract 3950: A novel combination therapy targeting BCL6 and phospho-STAT3 defeats intratumor heterogeneity in a subset of non-small cell lung cancers. Tumor Biology. 2017 Jul 1; 3950-3950. Deb DD, Rajaram RS, Larsen LJ, Dospoy DP, Marullo MR, Li LL, Avila AK, Cerchietti CL, Minna MJ, Wu WL, Altschuler AS. .
      View in: Publisher Site   Mentions:
    30. Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 06 01; 77(11):3070-3081. Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler SJ, Wu LF. PMID: 28377453; PMCID: PMC5489259.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    31. Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 12 13; 9(458):ra122. Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH. PMID: 27965424; PMCID: PMC5479306.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    32. Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways. J Biol Chem. 2017 Jan 06; 292(1):244-250. Coster AD, Thorne CA, Wu LF, Altschuler SJ. PMID: 27895117; PMCID: PMC5217683.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    33. PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 06 15; 32(12):i44-i51. Deng Y, Altschuler SJ, Wu LF. PMID: 27307643; PMCID: PMC4908335.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    34. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. PMID: 27280401; PMCID: PMC4900667.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    35. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19; 7:10690. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. PMID: 26891683; PMCID: PMC4762880.
      View in: PubMed   Mentions: 266     Fields:    Translation:HumansAnimalsCells
    36. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol. 2016 Jan; 34(1):70-77. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF. PMID: 26655497; PMCID: PMC4844861.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    37. Abstract 760: On the evolution of erlotinib-resistant NSCLC subpopulations. Experimental and Molecular Therapeutics. 2015 Aug 1; 760-760. Ramirez RM, Steininger SR, Wu WL, Altschuler AS. .
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    38. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 02; 162(1):120-33. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. PMID: 26119341; PMCID: PMC4646663.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    39. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. PMID: 25739453; PMCID: PMC4436775.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    40. On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67. Steininger RJ, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ. PMID: 25425168; PMCID: PMC4442742.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015 Jan; 11(1):58-63. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ. PMID: 25402767; PMCID: PMC4270937.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    42. The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32. Agi E, Langen M, Altschuler SJ, Wu LF, Zimmermann T, Hiesinger PR. PMID: 24912630; PMCID: PMC4245170.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    43. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF. PMID: 24874571; PMCID: PMC4277860.
      View in: PubMed   Mentions: 6     Fields:    
    44. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014 Mar 19; (85). Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler SJ. PMID: 24686220; PMCID: PMC4390293.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    45. Rapid Analysis and Exploration of Fluorescence Microscopy Images. Journal of Visualized Experiments. 2014 Mar 19; (85). Pavie PB, Rajaram RS, Ouyang OA, Altschuler AJ, Steininger III SR, Wu WL, Altschuler AS. .
      View in: Publisher Site   Mentions:
    46. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. PMID: 23665220; PMCID: PMC3674638.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    47. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. Zhang ER, Wu LF, Altschuler SJ. PMID: 23660413; PMCID: PMC3758422.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    48. The zoo of solitons for curve shortening in On the occasion of Richard Hamilton's nth birthday. Nonlinearity. 2013 May 1; 26(5):1189. Altschuler AD, Altschuler AS, Angenent AS, Wu WL. .
      View in: Publisher Site   Mentions:
    49. The Zoo of Solitons for Curve Shortening in ℝn. Nonlinearity. 2013; 26(5):1189-1226. Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F.
    50. Abstract 5226: Understanding single cell variability in oncogene induced pathway aberration in lung cancer. Molecular and Cellular Biology. 2013 Apr 15; 5226-5226. Deb DD, Rajaram RS, Larsen LJ, Minna MJ, Wu WL, Altschuler AS. .
      View in: Publisher Site   Mentions:
    51. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jun 28; 9(7):634-5. Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu LF. PMID: 22743763; PMCID: PMC3842427.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    52. PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jun 28; 9(7):635-7. Rajaram S, Pavie B, Wu LF, Altschuler SJ. PMID: 22743764; PMCID: PMC3842428.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    53. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. PMID: 22632971; PMCID: PMC3614011.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    54. Denial, acceptance, and loss of cell polarization for a stochastic model of positive feedback. The FASEB Journal. 2012 Apr 1; 26:468.2-468.2. Altschuler AS, Angenent AS, Jilkine JS, Wu WL. .
      View in: Publisher Site   Mentions:
    55. Dynamic information flow during neutrophil polarization. The FASEB Journal. 2012 Apr 1; 26:345.1-345.1. Wu WL, Ku KC, Wang WY, Weiner WO, Altschuler AS. .
      View in: Publisher Site   Mentions:
    56. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15. Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM. PMID: 22341450; PMCID: PMC3368334.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    57. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. PMID: 22265410; PMCID: PMC3308728.
      View in: PubMed   Mentions: 280     Fields:    Translation:HumansCells
    58. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271. Jilkine A, Angenent SB, Wu LF, Altschuler SJ. PMID: 22102805; PMCID: PMC3213192.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    59. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. Altschuler SJ, Wu LF. PMID: 20478246; PMCID: PMC2918286.
      View in: PubMed   Mentions: 456     Fields:    Translation:AnimalsCells
    60. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. PMID: 20461076; PMCID: PMC2890326.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    61. ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 01; 14-17:1029-1032. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. PMID: 20725643; PMCID: PMC2921656.
      View in: PubMed   Mentions: 5  
    62. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 02; 187(3):375-84. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. PMID: 19948481; PMCID: PMC2779244.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    63. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. PMID: 19767759; PMCID: PMC2818727.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    64. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. Artyukhin AB, Wu LF, Altschuler SJ. PMID: 19703388.
      View in: PubMed   Mentions: 1     Fields:    
    65. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19306-11. Slack MD, Martinez ED, Wu LF, Altschuler SJ. PMID: 19052231; PMCID: PMC2614757.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    66. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9. Altschuler SJ, Angenent SB, Wang Y, Wu LF. PMID: 18704086; PMCID: PMC2562338.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    67. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. PMID: 17696648; PMCID: PMC1945041.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansCells
    68. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. PMID: 17448998; PMCID: PMC2000346.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    69. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. Loo LH, Wu LF, Altschuler SJ. PMID: 17401369.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansCells
    70. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. PMID: 16738550; PMCID: PMC1681477.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    71. Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254. Loo, L.H., Wu, L., Altschuler, S.J., 2006; 251-54.
    72. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. PMID: 15961632.
      View in: PubMed   Mentions: 623     Fields:    Translation:AnimalsCells
    73. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. Dion MF, Altschuler SJ, Wu LF, Rando OJ. PMID: 15795371; PMCID: PMC555684.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    74. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. PMID: 15539606.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansCells
    75. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. PMID: 12837249.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    76. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. Wedlich-Soldner R, Altschuler S, Wu L, Li R. PMID: 12560471.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    77. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. PMID: 12089522.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    78. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. PMID: 11237012.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    79. On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97. Altschuler, S.J., Wu, L.F.
    80. Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000. Acero, A., Altschuler S.J., Wu L.F.
    81. On deforming confoliations. Journal of Differential Geometry. 2000 Jan 1; 54(1):75-97. Altschuler AS, Wu WL. .
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    82. Proceedings of the Section on Physical and Engineering Sciences. Clustering finite discrete markov chains. 1998; 228-229. Ridgeway, G., Altschuler, S.J.
    83. Proceedings of the ICSR5. Generating Signal Processing Software. 1998. Altschuler, S.J., Kim, W.
    84. Mean curvature flow through singularities for surfaces of rotation. The Journal of Geometric Analysis. 1995 Sep 1; 5(3):293-358. Altschuler AS, Angenent AS, Giga GY. .
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    85. A geometric heat flow for one-forms on three dimensional manifolds. Illinois Journal of Mathematics. 1995 Mar 1; 39(1). Altschuler AS. .
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    86. Mean curvature flow through singularities for surfaces of rotation. Journal of Geometric Analysis. 1995; 5(3):293-358. Altschuler, S.J., Angenet, S., Giga, Y.
    87. A geometric heat flow for one-forms on three dimensional manifolds. Illinois Journal of Mathematics. 1995; 39(1):98-118. Altschuler, S.J.
    88. Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111. Altschuler, S.J., Wu, L.F.
    89. Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765. Altschuler, S.J., Wu, L.F.
    90. Shortening space curves and flow through singularities. Journal of Differential Geometry. 1992; 35(2):283-298. Altschuler, S.J., Grayson, M.
    91. Singularities for the curve shortening flow for space curves. Journal of Differential Geometry. 1991; 34(2):491-514. Altschuler, S.J.
    92. Mean curvature flow through singularities for surfaces of rotation. Hokkaido University Preprint Series in Mathematics. 1991 Jan 1; 130:1-62. Altschuler AS, Angenent AS, Giga GY. .
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