Steven Altschuler, PhD

InstitutionUniversity of California San Francisco
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
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    Collapse Overview
    Dr. Steven Altschuler is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. Dr. Altschuler also applies high-throughput technology developed by his laboratory to diverse problems, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Altschuler worked at UT Southwestern, Harvard, Rosetta Informatics, Microsoft, Princeton, and the Institute for Advanced Studies.

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    Reverse-engineering mechanisms of neural circuit wiring in the fly visual system
    NIH/NEI R01EY028205Sep 1, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Systems-level role of GSK3 in colonic epithelium homeostasis and drug resistance
    NIH/NIGMS R01GM112690Feb 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    Lung cancer heterogeneity and its impact on drug resistance.
    NIH/NCI R01CA133253Aug 1, 2010 - May 31, 2016
    Role: Principal Investigator
    Turnkey solution for image phenotype classification
    NIH/NIGMS R01GM085442Sep 19, 2008 - Aug 31, 2014
    Role: Principal Investigator
    On the emergence of polarization and motility responses from chemotactic networks
    NIH/NIGMS R01GM071794Jul 1, 2004 - May 31, 2015
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Thurley K, Wu LF, Altschuler S. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Syst. 2018 Mar 28; 6(3):355-367.e5. PMID: 29525203.
      View in: PubMed
    2. Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler S. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Dev Cell. 2018 Mar 12; 44(5):624-633.e4. PMID: 29503158.
      View in: PubMed
    3. Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler S. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct; 14(10):967-970. PMID: 28869755.
      View in: PubMed
    4. Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler S, Wu LF. Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers. Cancer Res. 2017 06 01; 77(11):3070-3081. PMID: 28377453.
      View in: PubMed
    5. Zhang ER, Liu S, Wu LF, Altschuler S, Cobb MH. Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 12 13; 9(458):ra122. PMID: 27965424.
      View in: PubMed
    6. Coster AD, Thorne CA, Wu LF, Altschuler S. Examining Crosstalk among Transforming Growth Factor ß, Bone Morphogenetic Protein, and Wnt Pathways. J Biol Chem. 2017 Jan 06; 292(1):244-250. PMID: 27895117.
      View in: PubMed
    7. Deng Y, Altschuler S, Wu LF. PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 06 15; 32(12):i44-i51. PMID: 27307643; PMCID: PMC4908335.
    8. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler S, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 Jun; 14(6):e1002474. PMID: 27280401; PMCID: PMC4900667.
    9. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler S. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016 Feb 19; 7:10690. PMID: 26891683; PMCID: PMC4762880.
    10. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler S, Wu LF. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol. 2016 Jan; 34(1):70-77. PMID: 26655497; PMCID: PMC4844861.
    11. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler S, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 02; 162(1):120-33. PMID: 26119341; PMCID: PMC4646663.
    12. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39. PMID: 25739453; PMCID: PMC4436775.
    13. Steininger RJ, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler S. On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67. PMID: 25425168; PMCID: PMC4442742.
    14. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler S. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015 Jan; 11(1):58-63. PMID: 25402767; PMCID: PMC4270937.
    15. Agi E, Langen M, Altschuler S, Wu LF, Zimmermann T, Hiesinger PR. The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32. PMID: 24912630; PMCID: PMC4245170.
    16. Coster AD, Wichaidit C, Rajaram S, Altschuler S, Wu LF. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602. PMID: 24874571; PMCID: PMC4277860.
    17. Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler S. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014 Mar 19; (85). PMID: 24686220; PMCID: PMC4390293.
    18. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler S. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220; PMCID: PMC3674638.
    19. Zhang ER, Wu LF, Altschuler S. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. PMID: 23660413; PMCID: PMC3758422.
    20. Altschuler D.J., Altschuler S, Angenent S.B., Wu L.F.The Zoo of Solitons for Curve Shortening in Rn. Nonlinearity. 2013; 26(5):1189-1226.
    21. Rajaram S, Pavie B, Wu LF, Altschuler S. PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jun 28; 9(7):635-7. PMID: 22743764; PMCID: PMC3842428.
    22. Rajaram S, Pavie B, Hac NE, Altschuler S, Wu LF. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jun 28; 9(7):634-5. PMID: 22743763; PMCID: PMC3842427.
    23. Ku CJ, Wang Y, Weiner OD, Altschuler S, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971; PMCID: PMC3614011.
    24. Orchard RC, Kittisopikul M, Altschuler S, Wu LF, Süel GM, Alto NM. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15. PMID: 22341450; PMCID: PMC3368334.
    25. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler S, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410; PMCID: PMC3308728.
    26. Jilkine A, Angenent SB, Wu LF, Altschuler S. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271. PMID: 22102805; PMCID: PMC3213192.
    27. Altschuler S, Wu LF. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. PMID: 20478246; PMCID: PMC2918286.
    28. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler S. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. PMID: 20461076; PMCID: PMC2890326.
    29. Ku CJ, Wang Y, Pavie B, Altschuler S, Wu LF. ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 01; 14-17:1029-1032. PMID: 20725643.
      View in: PubMed
    30. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler S, Wu LF. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 02; 187(3):375-84. PMID: 19948481; PMCID: PMC2779244.
    31. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler S. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. PMID: 19767759; PMCID: PMC2818727.
    32. Artyukhin AB, Wu LF, Altschuler S. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. PMID: 19703388.
      View in: PubMed
    33. Slack MD, Martinez ED, Wu LF, Altschuler S. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19306-11. PMID: 19052231; PMCID: PMC2614757.
    34. Altschuler S, Angenent SB, Wang Y, Wu LF. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9. PMID: 18704086; PMCID: PMC2562338.
    35. Weiner OD, Marganski WA, Wu LF, Altschuler S, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648; PMCID: PMC1945041.
    36. Marco E, Wedlich-Soldner R, Li R, Altschuler S, Wu LF. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. PMID: 17448998; PMCID: PMC2000346.
    37. Loo LH, Wu LF, Altschuler S. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. PMID: 17401369.
      View in: PubMed
    38. Maciag K, Altschuler S, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. PMID: 16738550; PMCID: PMC1681477.
    39. Loo, L.H., Wu, L., Altschuler, S.J., 2006; 251-54.Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
    40. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler S, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. PMID: 15961632.
      View in: PubMed
    41. Dion MF, Altschuler S, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. PMID: 15795371; PMCID: PMC555684.
    42. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler S. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. PMID: 15539606.
      View in: PubMed
    43. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler S, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. PMID: 12837249.
      View in: PubMed
    44. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. PMID: 12560471.
      View in: PubMed
    45. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler S. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. PMID: 12089522.
      View in: PubMed
    46. Altschuler, S.J., Wu, L.F. .On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
    47. Acero, A., Altschuler S, Wu L.F. .Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000.
    48. Ridgeway, G., Altschuler, S.J. .Proceedings of the Section on Physical and Engineering Sciences. Clustering finite discrete markov chains. 1998; 228-229.
    49. Altschuler, S.J., Kim, W. .Proceedings of the ICSR5. Generating Signal Processing Software. 1998.
    50. Altschuler, S.J., Angenet, S., Giga, Y. .Mean curvature flow through singularities for surfaces of rotation. Journal of Geometric Analysis. 1995; 5(3):293-358.
    51. Altschuler, S.J. .A geometric heat flow for one-forms on three dimensional manifolds. Illinois Journal of Mathematics. 1995; 39(1):98-118.
    52. Altschuler, S.J., Wu, L.F. .Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
    53. Altschuler, S.J., Wu, L.F.Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
    54. Altschuler, S.J., Grayson, M. .Shortening space curves and flow through singularities. Journal of Differential Geometry. 1992; 35(2):283-298.
    55. Altschuler, S.J. .Singularities for the curve shortening flow for space curves. Journal of Differential Geometry. 1991; 34(2):491-514.