Loading...

UCSF Coronavirus Response: UCSF is partnering with public agencies to address the rapidly evolving outbreak and protect our communities. The UCSF COVID-19 Resources Website provides guidance and information for our patients, faculty, staff, trainees and learners.

Orion Weiner, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Phone415-514-4508
ORCID ORCID Icon0000-0002-1778-6543 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.2001 Graduate Division (Biochemistry & Molecular Biology)

    Collapse Overview 
    Collapse Overview
    Signal transduction networks enable cells to respond to the world around them. To uncover how these signaling networks generate proper responses, we need not only a parts list but also an understanding of how their constituent molecular components work together to process information. I have devoted my lab to developing technologies that will enable us to answer signaling questions that have not been possible to address before. My primary interest is to understand the signaling circuits that organize cell polarity. We take advantage of advanced microscopy techniques in conjunction with techniques to rewire cell signaling or to activate and inhibit signaling on a subcellular level. We aim to move beyond a parts list of components involved in migration to a systems level understanding of cell polarity.

    Collapse Research 
    Collapse Research Activities and Funding
    2019 Directed Cell Migration Gordon Research Conference and Seminar
    NIH/NICHD R13HD097861Dec 20, 2018 - Nov 30, 2019
    Role: Principal Investigator
    A toolkit for visualizing and manipulating chromosomal interactions in living cells.
    NIH/NIBIB R21EB022787Jul 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Cellular Decision Making
    NIH/NIGMS R35GM118167Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Antigen Decoding by T cells
    NIH/NIGMS R01GM109899Jun 5, 2014 - Feb 28, 2018
    Role: Principal Investigator
    An optogenetic method to rapidly and reversibly titrate protein levels in cells
    NIH/NIBIB R21EB017399Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator
    A Toolkit for Light-Control of Molecular Processes in Living Cells
    NIH/NIGMS R01GM096164Mar 1, 2012 - Jan 31, 2016
    Role: Principal Investigator
    Integrative Program in Complex Biological System (ipCBS)
    NIH/NIBIB T32EB009383Apr 1, 2009 - Mar 31, 2014
    Role: Co-Principal Investigator
    Signal Integration in Neutrophil Chemotaxis
    NIH/NIGMS R01GM084040Jun 1, 2008 - May 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnaric M, Penic S, Iglic A, Kralj-Iglic V, Gov NS, Diz-Muñoz A, Weiner OD. Cell confinement reveals a branched-actin independent circuit for neutrophil polarity. PLoS Biol. 2019 10; 17(10):e3000457. PMID: 31600188.
      View in: PubMed
    2. Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y, Huang B, Lomvardas S, Weiner OD. Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity. Elife. 2019 05 24; 8. PMID: 31124784.
      View in: PubMed
    3. Mclaurin JD, Weiner OD. Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell. 2019 06 15; 30(13):1610-1620. PMID: 31042097.
      View in: PubMed
    4. Tischer DK, Weiner OD. Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling. Elife. 2019 04 05; 8. PMID: 30947808.
      View in: PubMed
    5. Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR. A size-invariant bud-duration timer enables robustness in yeast cell size control. PLoS One. 2018; 13(12):e0209301. PMID: 30576342.
      View in: PubMed
    6. Liu Z, Woo S, Weiner OD. Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish. Development. 2018 09 14; 145(17). PMID: 30111654.
      View in: PubMed
    7. Saha S, Nagy TL, Weiner OD. Joining forces: crosstalk between biochemical signalling and physical forces orchestrates cellular polarity and dynamics. Philos Trans R Soc Lond B Biol Sci. 2018 05 26; 373(1747). PMID: 29632270.
      View in: PubMed
    8. Genuth MA, Allen CDC, Mikawa T, Weiner OD. Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol. 2018 12 01; 444 Suppl 1:S252-S261. PMID: 29501457.
      View in: PubMed
    9. Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev Cell. 2017 11 20; 43(4):507-521.e4. PMID: 29161594.
      View in: PubMed
    10. Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD. A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol. 2017 08 07; 216(8):2515-2531. PMID: 28687663.
      View in: PubMed
    11. Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development. 2017 01 15; 144(2):345-355. PMID: 27993986.
      View in: PubMed
    12. Liu Z, Weiner OD. Positioning the cleavage furrow: All you need is Rho. J Cell Biol. 2016 06 20; 213(6):605-7. PMID: 27325786.
      View in: PubMed
    13. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474. PMID: 27280401.
      View in: PubMed
    14. Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. Gß Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol. 2016 Feb; 14(2):e1002381. PMID: 26890004.
      View in: PubMed
    15. Genuth MA, Weiner OD. Cell Migration: Recoiling from an Embrace. Curr Biol. 2015 Jun 29; 25(13):R566-8. PMID: 26126284.
      View in: PubMed
    16. Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5. PMID: 26098020.
      View in: PubMed
    17. Jost AP, Weiner OD. Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function. ACS Synth Biol. 2015 Oct 16; 4(10):1077-85. PMID: 26035630.
      View in: PubMed
    18. Lou SS, Diz-Muñoz A, Weiner OD, Fletcher DA, Theriot JA. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. J Cell Biol. 2015 Apr 27; 209(2):275-88. PMID: 25918227.
      View in: PubMed
    19. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39. PMID: 25739453.
      View in: PubMed
    20. Tischer D, Weiner OD. Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol. 2014 08; 15(8):551-8. PMID: 25027655.
      View in: PubMed
    21. Graziano BR, Weiner OD. Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol. 2014 Oct; 30:60-7. PMID: 24998184.
      View in: PubMed
    22. Weiner O. Response to Bell et al. Mol Biol Cell. 2014 Jul 01; 25(13):1945. PMID: 24970486.
      View in: PubMed
    23. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901. PMID: 24711398.
      View in: PubMed
    24. Hoeller O, Gong D, Weiner OD. How to understand and outwit adaptation. Dev Cell. 2014 Mar 31; 28(6):607-616. PMID: 24697896.
      View in: PubMed
    25. Weiner OD. How should we be selecting our graduate students? Mol Biol Cell. 2014 Feb; 25(4):429-30. PMID: 24525948.
      View in: PubMed
    26. Toettcher JE, Weiner OD, Lim WA. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 05; 155(6):1422-34. PMID: 24315106.
      View in: PubMed
    27. Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008. PMID: 24062580.
      View in: PubMed
    28. Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR. Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci. 2013 Sep 15; 126(Pt 18):4296-307. PMID: 23843627.
      View in: PubMed
    29. Yang X, Jost AP, Weiner OD, Tang C. A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Mol Biol Cell. 2013 Aug; 24(15):2419-30. PMID: 23761071.
      View in: PubMed
    30. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220.
      View in: PubMed
    31. Diz-Muñoz A, Fletcher DA, Weiner OD. Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol. 2013 Feb; 23(2):47-53. PMID: 23122885.
      View in: PubMed
    32. Woo S, Housley MP, Weiner OD, Stainier DY. Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. J Cell Biol. 2012 Sep 03; 198(5):941-52. PMID: 22945937.
      View in: PubMed
    33. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971.
      View in: PubMed
    34. Millius A, Watanabe N, Weiner OD. Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging. J Cell Sci. 2012 Mar 01; 125(Pt 5):1165-76. PMID: 22349699.
      View in: PubMed
    35. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410.
      View in: PubMed
    36. Toettcher JE, Gong D, Lim WA, Weiner OD. Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011 Sep 11; 8(10):837-9. PMID: 21909100.
      View in: PubMed
    37. Peng GE, Wilson SR, Weiner OD. A pharmacological cocktail for arresting actin dynamics in living cells. Mol Biol Cell. 2011 Nov; 22(21):3986-94. PMID: 21880897.
      View in: PubMed
    38. Toettcher JE, Gong D, Lim WA, Weiner OD. Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol. 2011; 497:409-23. PMID: 21601096.
      View in: PubMed
    39. Toettcher JE, Voigt CA, Weiner OD, Lim WA. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods. 2011 Jan; 8(1):35-8. PMID: 21191370.
      View in: PubMed
    40. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. PMID: 21111236.
      View in: PubMed
    41. Millius A, Weiner OD. Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration. Methods Mol Biol. 2010; 591:147-58. PMID: 19957129.
      View in: PubMed
    42. Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER. Cell stimulation with optically manipulated microsources. Nat Methods. 2009 Dec; 6(12):905-9. PMID: 19915561.
      View in: PubMed
    43. Houk AR, Millius A, Weiner OD. Compete globally, bud locally. Cell. 2009 Nov 13; 139(4):656-8. PMID: 19914160.
      View in: PubMed
    44. Levskaya A, Weiner OD, Lim WA, Voigt CA. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15; 461(7266):997-1001. PMID: 19749742.
      View in: PubMed
    45. Millius A, Dandekar SN, Houk AR, Weiner OD. Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr Biol. 2009 Feb 10; 19(3):253-9. PMID: 19200726.
      View in: PubMed
    46. Millius A, Weiner OD. Chemotaxis in neutrophil-like HL-60 cells. Methods Mol Biol. 2009; 571:167-77. PMID: 19763966.
      View in: PubMed
    47. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648.
      View in: PubMed
    48. Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood. 2006 Oct 15; 108(8):2814-20. PMID: 16809619.
      View in: PubMed
    49. Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38. PMID: 16417406.
      View in: PubMed
    50. Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol. 2002 Jul; 4(7):513-8. PMID: 12080345.
      View in: PubMed
    51. Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol. 2002 Jul; 4(7):509-13. PMID: 12080346.
      View in: PubMed
    52. Weiner OD. Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma? Curr Biol. 2002 Jun 25; 12(12):R429-31. PMID: 12123595.
      View in: PubMed
    Orion's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (247) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (17) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑