Orion Weiner, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #352F
San Francisco CA 94158
Phone415-514-4352
ORCID ORCID Icon0000-0002-1778-6543 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.2001 Graduate Division (Biochemistry & Molecular Biology)
    Collapse Awards and Honors
    1995  - 2000HHMI Predoctoral Fellowship
    2001  - 2004Damon Runyon CRF Postdoctoral Fellowship
    2007  - 2010Searle Scholar
    2010Kavli Fellow, National Academy of Sciences
    2017UCSF Outstanding Faculty Mentorship Award

    Collapse Overview 
    Collapse Overview
    Our lab seeks to define the molecular logic of complex cell behaviors— how cells go from sets of interacting molecules to the emergent properties of living systems. We currently focus on three questions:
    1. How do cells control their shape and movement?
    2. How lymphocytes detect rare foreign peptides in a sea of self-peptides?
    3. How do cells regulate transcriptional activation?

    We study a diversity of cell types and behaviors. We believe that this makes it easier to identify the general principles of cellular decision-making. We often pair biosensors to visualize a quantitative dynamic of choice inside living cells with precision tools to control the regulators of these behaviors. This approach reveals the molecular logic of these complex cell decisions. Transformative science often happens at interfaces. So we seek to borrow tools and concepts from other fields to address open questions in cell biology and frequently develop new tools when they are needed to accelerate progress. Our approach opens up opportunities for cross pollination between different projects in the lab.

    Collapse Research 
    Collapse Research Activities and Funding
    2019 Directed Cell Migration Gordon Research Conference and Seminar
    NIH R13HD097861Dec 20, 2018 - Nov 30, 2019
    Role: Principal Investigator
    A toolkit for visualizing and manipulating chromosomal interactions in living cells.
    NIH R21EB022787Jul 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Cellular Decision Making
    NIH R35GM118167Jun 1, 2016 - May 31, 2026
    Role: Principal Investigator
    Antigen Decoding by T cells
    NIH R01GM109899Jun 5, 2014 - Feb 28, 2018
    Role: Principal Investigator
    An optogenetic method to rapidly and reversibly titrate protein levels in cells
    NIH R21EB017399Jul 1, 2013 - Jun 30, 2015
    Role: Principal Investigator
    A Toolkit for Light-Control of Molecular Processes in Living Cells
    NIH R01GM096164Mar 1, 2012 - Jan 31, 2016
    Role: Principal Investigator
    Integrative Program in Complex Biological System (ipCBS)
    NIH T32EB009383Apr 1, 2009 - Jun 30, 2023
    Role: Co-Principal Investigator
    Signal Integration in Neutrophil Chemotaxis
    NIH R01GM084040Jun 1, 2008 - May 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin. Sci Adv. 2024 Jan 26; 10(4):eadj3880. Jiang WI, De Belly H, Wang B, Wong A, Kim M, Oh F, DeGeorge J, Huang X, Guang S, Weiner OD, Ma DK. PMID: 38266092; PMCID: PMC10807809.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin. bioRxiv. 2023 Dec 17. Jiang WI, De Belly H, Wang B, Wong A, Kim M, Oh F, DeGeorge J, Huang X, Guang S, Weiner OD, Ma DK. PMID: 37546737; PMCID: PMC10402089.
      View in: PubMed   Mentions:
    3. Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation. Nat Commun. 2023 10 30; 14(1):6929. Meyer K, Lammers NC, Bugaj LJ, Garcia HG, Weiner OD. PMID: 37903793; PMCID: PMC10616176.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance. PLoS Biol. 2023 Sep; 21(9):e3002307. Town JP, Weiner OD. PMID: 37747905; PMCID: PMC10553818.
      View in: PubMed   Mentions:    Fields:    
    5. Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells. bioRxiv. 2023 Sep 13. Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Wong YY, Perry JSA, Geissmann F, Cross J, Zhou T, Kam LC, Pasoli HA, Hohl T, Cyster JG, Weiner OD, Huse M. PMID: 37745515; PMCID: PMC10515848.
      View in: PubMed   Mentions:
    6. Molecular mechanism of GPCR spatial organization at the plasma membrane. Nat Chem Biol. 2023 Jul 17. Kockelkoren G, Lauritsen L, Shuttle CG, Kazepidou E, Vonkova I, Zhang Y, Breuer A, Kennard C, Brunetti RM, D'Este E, Weiner OD, Uline M, Stamou D. PMID: 37460675; PMCID: PMC10792125.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Neutrophils actively swell to potentiate rapid migration. bioRxiv. 2023 Jul 05. Nagy TL, Strickland J, Weiner OD. PMID: 37292824; PMCID: PMC10245588.
      View in: PubMed   Mentions:
    8. Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming. bioRxiv. 2023 Jun 28. Strickland J, Pan D, Godfrey C, Kim JS, Hopke A, Degrange M, Villavicencio B, Mansour MK, Zerbe CS, Irimia D, Amir A, Weiner OD. PMID: 37425711; PMCID: PMC10327146.
      View in: PubMed   Mentions:
    9. Cell protrusions and contractions generate long-range membrane tension propagation. Cell. 2023 07 06; 186(14):3049-3061.e15. De Belly H, Yan S, Borja da Rocha H, Ichbiah S, Town JP, Zager PJ, Estrada DC, Meyer K, Turlier H, Bustamante C, Weiner OD. PMID: 37311454; PMCID: PMC10330871.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration. Mol Biol Cell. 2023 05 01; 34(5):ar35. Saha S, Town JP, Weiner OD. PMID: 36857159; PMCID: PMC10162419.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    11. From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles. Chem Sci. 2022 Oct 05; 13(38):11330-11340. Naudin EA, Albanese KI, Smith AJ, Mylemans B, Baker EG, Weiner OD, Andrews DM, Tigue N, Savery NJ, Woolfson DN. PMID: 36320580; PMCID: PMC9533478.
      View in: PubMed   Mentions: 4  
    12. Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation. Elife. 2022 09 20; 11. Britain DM, Town JP, Weiner OD. PMID: 36125261; PMCID: PMC9536835.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    13. WASP integrates substrate topology and cell polarity to guide neutrophil migration. J Cell Biol. 2022 02 07; 221(2). Brunetti RM, Kockelkoren G, Raghavan P, Bell GRR, Britain D, Puri N, Collins SR, Leonetti MD, Stamou D, Weiner OD. PMID: 34964841; PMCID: PMC8719638.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    14. The WAVE complex associates with sites of saddle membrane curvature. J Cell Biol. 2021 08 02; 220(8). Pipathsouk A, Brunetti RM, Town JP, Graziano BR, Breuer A, Pellett PA, Marchuk K, Tran NT, Krummel MF, Stamou D, Weiner OD. PMID: 34096975; PMCID: PMC8185649.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. Optogenetic Tuning of Protein-protein Binding in Bilayers Using LOVTRAP. Bio Protoc. 2020 Sep 05; 10(17):e3745. Tischer D, Weiner OD. PMID: 33659405; PMCID: PMC7842827.
      View in: PubMed   Mentions:
    16. Cell confinement reveals a branched-actin independent circuit for neutrophil polarity. PLoS Biol. 2019 10; 17(10):e3000457. Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnaric M, Penic S, Iglic A, Kralj-Iglic V, Gov NS, Diz-Muñoz A, Weiner OD. PMID: 31600188; PMCID: PMC6805013.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    17. Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity. Elife. 2019 05 24; 8. Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y, Huang B, Lomvardas S, Weiner OD. PMID: 31124784; PMCID: PMC6534382.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    18. Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell. 2019 06 15; 30(13):1610-1620. Mclaurin JD, Weiner OD. PMID: 31042097; PMCID: PMC6727637.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling. Elife. 2019 04 05; 8. Tischer DK, Weiner OD. PMID: 30947808; PMCID: PMC6488292.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    20. A size-invariant bud-duration timer enables robustness in yeast cell size control. PLoS One. 2018; 13(12):e0209301. Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR. PMID: 30576342; PMCID: PMC6303054.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    21. Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish. Development. 2018 09 14; 145(17). Liu Z, Woo S, Weiner OD. PMID: 30111654; PMCID: PMC6141772.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    22. In pursuit of the mechanics that shape cell surfaces. Nat Phys. 2018 Jul; 14(7):648-652. Diz-Muñoz A, Weiner OD, Fletcher DA. PMID: 31007706; PMCID: PMC6469718.
      View in: PubMed   Mentions: 23  
    23. Joining forces: crosstalk between biochemical signalling and physical forces orchestrates cellular polarity and dynamics. Philos Trans R Soc Lond B Biol Sci. 2018 05 26; 373(1747). Saha S, Nagy TL, Weiner OD. PMID: 29632270; PMCID: PMC5904304.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    24. Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol. 2018 12 01; 444 Suppl 1:S252-S261. Genuth MA, Allen CDC, Mikawa T, Weiner OD. PMID: 29501457; PMCID: PMC6126999.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev Cell. 2017 11 20; 43(4):507-521.e4. Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. PMID: 29161594; PMCID: PMC5826602.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol. 2017 08 07; 216(8):2515-2531. Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD. PMID: 28687663; PMCID: PMC5551696.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    27. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development. 2017 01 15; 144(2):345-355. Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S. PMID: 27993986; PMCID: PMC5394756.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    28. Positioning the cleavage furrow: All you need is Rho. J Cell Biol. 2016 06 20; 213(6):605-7. Liu Z, Weiner OD. PMID: 27325786; PMCID: PMC4915198.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. PMID: 27280401; PMCID: PMC4900667.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    30. Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol. 2016 Feb; 14(2):e1002381. Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. PMID: 26890004; PMCID: PMC4758609.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo. Dev Cell. 2016 Jan 11; 36(1):117-126. Buckley CE, Moore RE, Reade A, Goldberg AR, Weiner OD, Clarke JDW. PMID: 26766447; PMCID: PMC4712025.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    32. Cell Migration: Recoiling from an Embrace. Curr Biol. 2015 Jun 29; 25(13):R566-8. Genuth MA, Weiner OD. PMID: 26126284; PMCID: PMC4504735.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5. Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. PMID: 26098020; PMCID: PMC4521985.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    34. Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function. ACS Synth Biol. 2015 Oct 16; 4(10):1077-85. Jost AP, Weiner OD. PMID: 26035630; PMCID: PMC4609243.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    35. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. J Cell Biol. 2015 Apr 27; 209(2):275-88. Lou SS, Diz-Muñoz A, Weiner OD, Fletcher DA, Theriot JA. PMID: 25918227; PMCID: PMC4411279.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. PMID: 25739453; PMCID: PMC4436775.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    37. Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol. 2014 08; 15(8):551-8. Tischer D, Weiner OD. PMID: 25027655; PMCID: PMC4145075.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    38. Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol. 2014 Oct; 30:60-7. Graziano BR, Weiner OD. PMID: 24998184; PMCID: PMC4177965.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    39. Response to Bell et al. Mol Biol Cell. 2014 Jul 01; 25(13):1945. Weiner O. PMID: 24970486; PMCID: PMC4072568.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. PMID: 24711398; PMCID: PMC4000811.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    41. How to understand and outwit adaptation. Dev Cell. 2014 Mar 31; 28(6):607-616. Hoeller O, Gong D, Weiner OD. PMID: 24697896; PMCID: PMC4012857.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    42. How should we be selecting our graduate students? Mol Biol Cell. 2014 Feb; 25(4):429-30. Weiner OD. PMID: 24525948; PMCID: PMC3923635.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    43. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol. 2014 Mar; 10(3):196-202. Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH. PMID: 24413462; PMCID: PMC3944926.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    44. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 05; 155(6):1422-34. Toettcher JE, Weiner OD, Lim WA. PMID: 24315106; PMCID: PMC3925772.
      View in: PubMed   Mentions: 277     Fields:    Translation:AnimalsCells
    45. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008. Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. PMID: 24062580; PMCID: PMC3785960.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    46. The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration. Curr Opin Cell Biol. 2013 Oct; 25(5):523-5. Parent CA, Weiner OD. PMID: 23927870.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    47. Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci. 2013 Sep 15; 126(Pt 18):4296-307. Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR. PMID: 23843627; PMCID: PMC3772393.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    48. A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Mol Biol Cell. 2013 Aug; 24(15):2419-30. Yang X, Jost AP, Weiner OD, Tang C. PMID: 23761071; PMCID: PMC3727934.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    49. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. PMID: 23665220; PMCID: PMC3674638.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    50. Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol. 2013 Feb; 23(2):47-53. Diz-Muñoz A, Fletcher DA, Weiner OD. PMID: 23122885; PMCID: PMC3558607.
      View in: PubMed   Mentions: 219     Fields:    Translation:AnimalsCells
    51. Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. J Cell Biol. 2012 Sep 03; 198(5):941-52. Woo S, Housley MP, Weiner OD, Stainier DY. PMID: 22945937; PMCID: PMC3432772.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    52. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. PMID: 22632971; PMCID: PMC3614011.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    53. Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging. J Cell Sci. 2012 Mar 01; 125(Pt 5):1165-76. Millius A, Watanabe N, Weiner OD. PMID: 22349699; PMCID: PMC3324580.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    54. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. PMID: 22265410; PMCID: PMC3308728.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansCells
    55. Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011 Sep 11; 8(10):837-9. Toettcher JE, Gong D, Lim WA, Weiner OD. PMID: 21909100; PMCID: PMC3184382.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    56. A pharmacological cocktail for arresting actin dynamics in living cells. Mol Biol Cell. 2011 Nov; 22(21):3986-94. Peng GE, Wilson SR, Weiner OD. PMID: 21880897; PMCID: PMC3204061.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    57. Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol. 2011; 497:409-23. Toettcher JE, Gong D, Lim WA, Weiner OD. PMID: 21601096; PMCID: PMC3121701.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    58. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods. 2011 Jan; 8(1):35-8. Toettcher JE, Voigt CA, Weiner OD, Lim WA. PMID: 21191370; PMCID: PMC3024327.
      View in: PubMed   Mentions: 116     Fields:    Translation:Cells
    59. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. PMID: 21111236; PMCID: PMC3058345.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    60. Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration. Methods Mol Biol. 2010; 591:147-58. Millius A, Weiner OD. PMID: 19957129; PMCID: PMC3128798.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    61. Cell stimulation with optically manipulated microsources. Nat Methods. 2009 Dec; 6(12):905-9. Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER. PMID: 19915561; PMCID: PMC2813772.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    62. Compete globally, bud locally. Cell. 2009 Nov 13; 139(4):656-8. Houk AR, Millius A, Weiner OD. PMID: 19914160; PMCID: PMC2812431.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    63. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15; 461(7266):997-1001. Levskaya A, Weiner OD, Lim WA, Voigt CA. PMID: 19749742; PMCID: PMC2989900.
      View in: PubMed   Mentions: 456     Fields:    Translation:AnimalsCells
    64. Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr Biol. 2009 Feb 10; 19(3):253-9. Millius A, Dandekar SN, Houk AR, Weiner OD. PMID: 19200726; PMCID: PMC2705202.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    65. Chemotaxis in neutrophil-like HL-60 cells. Methods Mol Biol. 2009; 571:167-77. Millius A, Weiner OD. PMID: 19763966; PMCID: PMC2812563.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    66. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. PMID: 17696648; PMCID: PMC1945041.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansCells
    67. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood. 2006 Oct 15; 108(8):2814-20. Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M. PMID: 16809619; PMCID: PMC1895589.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    68. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38. Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. PMID: 16417406; PMCID: PMC1334198.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    69. A chemical compass. Nature. 2002 Sep 05; 419(6902):21. Bourne HR, Weiner O. PMID: 12214215.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    70. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol. 2002 Jul; 4(7):513-8. Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. PMID: 12080345.
      View in: PubMed   Mentions: 199     Fields:    Translation:HumansAnimalsCells
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