Orion Weiner, PhD
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Title(s) | Professor, Cardiovascular Research Inst |
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School | School of Medicine |
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Address | 555 Mission Bay Blvd South San Francisco CA 94158
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Phone | 415-514-4352 |
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ORCID
.gif) | 0000-0002-1778-6543  |
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vCard | Download vCard |
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Biography University of California, San Francisco | Ph.D. | 2001 | Graduate Division (Biochemistry & Molecular Biology) |
| 1995
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| 2000 | HHMI Predoctoral Fellowship | | 2001
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| 2004 | Damon Runyon CRF Postdoctoral Fellowship | | 2007
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| 2010 | Searle Scholar | | 2010 | | Kavli Fellow, National Academy of Sciences | | 2017 | | UCSF Outstanding Faculty Mentorship Award |
Overview Our lab seeks to define the molecular logic of complex cell behaviors— how cells go from sets of interacting molecules to the emergent properties of living systems. We currently focus on three questions: 1. How do cells control their shape and movement? 2. How lymphocytes detect rare foreign peptides in a sea of self-peptides? 3. How do cells regulate transcriptional activation?
We study a diversity of cell types and behaviors. We believe that this makes it easier to identify the general principles of cellular decision-making. We often pair biosensors to visualize a quantitative dynamic of choice inside living cells with precision tools to control the regulators of these behaviors. This approach reveals the molecular logic of these complex cell decisions. Transformative science often happens at interfaces. So we seek to borrow tools and concepts from other fields to address open questions in cell biology and frequently develop new tools when they are needed to accelerate progress. Our approach opens up opportunities for cross pollination between different projects in the lab.
Research ORNG Applications Bibliographic
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Cell confinement reveals a branched-actin independent circuit for neutrophil polarity. PLoS Biol. 2019 10; 17(10):e3000457.
Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnaric M, Penic S, Iglic A, Kralj-Iglic V, Gov NS, Diz-Muñoz A, Weiner OD. PMID: 31600188.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity. Elife. 2019 05 24; 8.
Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y, Huang B, Lomvardas S, Weiner OD. PMID: 31124784.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell. 2019 06 15; 30(13):1610-1620.
Mclaurin JD, Weiner OD. PMID: 31042097.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling. Elife. 2019 04 05; 8.
Tischer DK, Weiner OD. PMID: 30947808.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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A size-invariant bud-duration timer enables robustness in yeast cell size control. PLoS One. 2018; 13(12):e0209301.
Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR. PMID: 30576342.
View in: PubMed Mentions: 2 Fields: Translation: Animals
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Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish. Development. 2018 09 14; 145(17).
Liu Z, Woo S, Weiner OD. PMID: 30111654.
View in: PubMed Mentions: Fields: Translation: Animals
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In pursuit of the mechanics that shape cell surfaces. Nat Phys. 2018 Jul; 14(7):648-652.
Diz-Muñoz A, Weiner OD, Fletcher DA. PMID: 31007706.
View in: PubMed Mentions:
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Joining forces: crosstalk between biochemical signalling and physical forces orchestrates cellular polarity and dynamics. Philos Trans R Soc Lond B Biol Sci. 2018 05 26; 373(1747).
Saha S, Nagy TL, Weiner OD. PMID: 29632270.
View in: PubMed Mentions: 8 Fields: Translation: Cells
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Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol. 2018 12 01; 444 Suppl 1:S252-S261.
Genuth MA, Allen CDC, Mikawa T, Weiner OD. PMID: 29501457.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev Cell. 2017 11 20; 43(4):507-521.e4.
Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. PMID: 29161594.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol. 2017 08 07; 216(8):2515-2531.
Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD. PMID: 28687663.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development. 2017 01 15; 144(2):345-355.
Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S. PMID: 27993986.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Positioning the cleavage furrow: All you need is Rho. J Cell Biol. 2016 06 20; 213(6):605-7.
Liu Z, Weiner OD. PMID: 27325786.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 06; 14(6):e1002474.
Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. PMID: 27280401.
View in: PubMed Mentions: 40 Fields: Translation: HumansCells
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Gß Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol. 2016 Feb; 14(2):e1002381.
Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. PMID: 26890004.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo. Dev Cell. 2016 Jan 11; 36(1):117-126.
Buckley CE, Moore RE, Reade A, Goldberg AR, Weiner OD, Clarke JDW. PMID: 26766447.
View in: PubMed Mentions: 33 Fields: Translation: AnimalsCells
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Cell Migration: Recoiling from an Embrace. Curr Biol. 2015 Jun 29; 25(13):R566-8.
Genuth MA, Weiner OD. PMID: 26126284.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods. 2015 Aug; 12(8):763-5.
Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. PMID: 26098020.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function. ACS Synth Biol. 2015 Oct 16; 4(10):1077-85.
Jost AP, Weiner OD. PMID: 26035630.
View in: PubMed Mentions: 13 Fields: Translation: Animals
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Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. J Cell Biol. 2015 Apr 27; 209(2):275-88.
Lou SS, Diz-Muñoz A, Weiner OD, Fletcher DA, Theriot JA. PMID: 25918227.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 01; 26(9):1629-39.
Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. PMID: 25739453.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol. 2014 08; 15(8):551-8.
Tischer D, Weiner OD. PMID: 25027655.
View in: PubMed Mentions: 83 Fields: Translation: HumansAnimalsCells
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Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol. 2014 Oct; 30:60-7.
Graziano BR, Weiner OD. PMID: 24998184.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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Response to Bell et al. Mol Biol Cell. 2014 Jul 01; 25(13):1945.
Weiner O. PMID: 24970486.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901.
Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. PMID: 24711398.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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How to understand and outwit adaptation. Dev Cell. 2014 Mar 31; 28(6):607-616.
Hoeller O, Gong D, Weiner OD. PMID: 24697896.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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How should we be selecting our graduate students? Mol Biol Cell. 2014 Feb; 25(4):429-30.
Weiner OD. PMID: 24525948.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol. 2014 Mar; 10(3):196-202.
Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH. PMID: 24413462.
View in: PubMed Mentions: 83 Fields: Translation: AnimalsCells
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Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 05; 155(6):1422-34.
Toettcher JE, Weiner OD, Lim WA. PMID: 24315106.
View in: PubMed Mentions: 163 Fields: Translation: AnimalsCells
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Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008.
Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. PMID: 24062580.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration. Curr Opin Cell Biol. 2013 Oct; 25(5):523-5.
Parent CA, Weiner OD. PMID: 23927870.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci. 2013 Sep 15; 126(Pt 18):4296-307.
Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR. PMID: 23843627.
View in: PubMed Mentions: 30 Fields: Translation: HumansCells
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A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Mol Biol Cell. 2013 Aug; 24(15):2419-30.
Yang X, Jost AP, Weiner OD, Tang C. PMID: 23761071.
View in: PubMed Mentions: 36 Fields: Translation: AnimalsCells
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Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16.
Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. PMID: 23665220.
View in: PubMed Mentions: 17 Fields: Translation: HumansCells
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Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol. 2013 Feb; 23(2):47-53.
Diz-Muñoz A, Fletcher DA, Weiner OD. PMID: 23122885.
View in: PubMed Mentions: 124 Fields: Translation: AnimalsCells
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Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. J Cell Biol. 2012 Sep 03; 198(5):941-52.
Woo S, Housley MP, Weiner OD, Stainier DY. PMID: 22945937.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83.
Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. PMID: 22632971.
View in: PubMed Mentions: 28 Fields: Translation: HumansCells
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Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging. J Cell Sci. 2012 Mar 01; 125(Pt 5):1165-76.
Millius A, Watanabe N, Weiner OD. PMID: 22349699.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88.
Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. PMID: 22265410.
View in: PubMed Mentions: 173 Fields: Translation: HumansCells
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Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011 Sep 11; 8(10):837-9.
Toettcher JE, Gong D, Lim WA, Weiner OD. PMID: 21909100.
View in: PubMed Mentions: 72 Fields: Translation: HumansAnimalsCells
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A pharmacological cocktail for arresting actin dynamics in living cells. Mol Biol Cell. 2011 Nov; 22(21):3986-94.
Peng GE, Wilson SR, Weiner OD. PMID: 21880897.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol. 2011; 497:409-23.
Toettcher JE, Gong D, Lim WA, Weiner OD. PMID: 21601096.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods. 2011 Jan; 8(1):35-8.
Toettcher JE, Voigt CA, Weiner OD, Lim WA. PMID: 21191370.
View in: PubMed Mentions: 79 Fields: Translation: Cells
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Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73.
Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. PMID: 21111236.
View in: PubMed Mentions: 132 Fields: Translation: HumansCells
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Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration. Methods Mol Biol. 2010; 591:147-58.
Millius A, Weiner OD. PMID: 19957129.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Cell stimulation with optically manipulated microsources. Nat Methods. 2009 Dec; 6(12):905-9.
Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER. PMID: 19915561.
View in: PubMed Mentions: 25 Fields: Translation: HumansCells
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Compete globally, bud locally. Cell. 2009 Nov 13; 139(4):656-8.
Houk AR, Millius A, Weiner OD. PMID: 19914160.
View in: PubMed Mentions: Fields: Translation: Animals
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Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15; 461(7266):997-1001.
Levskaya A, Weiner OD, Lim WA, Voigt CA. PMID: 19749742.
View in: PubMed Mentions: 331 Fields: Translation: AnimalsCells
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Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr Biol. 2009 Feb 10; 19(3):253-9.
Millius A, Dandekar SN, Houk AR, Weiner OD. PMID: 19200726.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Chemotaxis in neutrophil-like HL-60 cells. Methods Mol Biol. 2009; 571:167-77.
Millius A, Weiner OD. PMID: 19763966.
View in: PubMed Mentions: 19 Fields: Translation: HumansCells
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An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221.
Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. PMID: 17696648.
View in: PubMed Mentions: 162 Fields: Translation: HumansCells
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Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood. 2006 Oct 15; 108(8):2814-20.
Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M. PMID: 16809619.
View in: PubMed Mentions: 44 Fields: Translation: HumansAnimalsCells
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Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38.
Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. PMID: 16417406.
View in: PubMed Mentions: 77 Fields: Translation: HumansAnimalsCells
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A chemical compass. Nature. 2002 Sep 05; 419(6902):21.
Bourne HR, Weiner O. PMID: 12214215.
View in: PubMed Mentions: 58 Fields: Translation: AnimalsCells
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Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol. 2002 Jul; 4(7):513-8.
Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. PMID: 12080345.
View in: PubMed Mentions: 172 Fields: Translation: HumansAnimalsCells
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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol. 2002 Jul; 4(7):509-13.
Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. PMID: 12080346.
View in: PubMed Mentions: 197 Fields: Translation: HumansAnimalsCells
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Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma? Curr Biol. 2002 Jun 25; 12(12):R429-31.
Weiner OD. PMID: 12123595.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr Opin Cell Biol. 2002 Apr; 14(2):196-202.
Weiner OD. PMID: 11891119.
View in: PubMed Mentions: 90 Fields: Translation: HumansAnimalsCells
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PIP3, PIP2, and cell movement--similar messages, different meanings? Dev Cell. 2001 Dec; 1(6):743-7.
Insall RH, Weiner OD. PMID: 11740936.
View in: PubMed Mentions: 73 Fields: Translation: Cells
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Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol. 2000 Nov; 10(11):466-73.
Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. PMID: 11050418.
View in: PubMed Mentions: 79 Fields: Translation: HumansAnimalsCells
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Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science. 2000 Feb 11; 287(5455):1037-40.
Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. PMID: 10669415.
View in: PubMed Mentions: 287 Fields: Translation: HumansCells
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Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nat Cell Biol. 1999 Oct; 1(6):389-91.
Kalman D, Weiner OD, Goosney DL, Sedat JW, Finlay BB, Abo A, Bishop JM. PMID: 10559969.
View in: PubMed Mentions: 61 Fields: Translation: HumansCells
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Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol. 1999 Jun; 1(2):75-81.
Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. PMID: 10559877.
View in: PubMed Mentions: 78 Fields: Translation: HumansAnimalsCells
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Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell. 1999 Apr; 10(4):1163-78.
Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR. PMID: 10198064.
View in: PubMed Mentions: 72 Fields: Translation: HumansCells
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Medium weight neurofilament mRNA in goldfish Mauthner axoplasm. Neurosci Lett. 1996 Aug 02; 213(2):83-6.
Weiner OD, Zorn AM, Krieg PA, Bittner GD. PMID: 8858614.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Year | Publications |
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1996 | 1 | 1999 | 3 | 2000 | 2 | 2001 | 1 | 2002 | 5 | 2006 | 2 | 2007 | 1 | 2009 | 5 | 2010 | 3 | 2011 | 3 | 2012 | 5 | 2013 | 6 | 2014 | 7 | 2015 | 5 | 2016 | 5 | 2017 | 2 | 2018 | 5 | 2019 | 4 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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