Our lab seeks to define the molecular logic of complex cell behaviors— how cells go from sets of interacting molecules to the emergent properties of living systems. We currently focus on three questions:

1. How do individual cells control their shape and movement?
2. How do groups of cells share information to make collective decisions?
3. How are signaling and mechanics integrated to guide cell fate decisions during pre-implantation mammalian development?

We study a diversity of cell types and behaviors. We believe that this makes it easier to identify the general principles of cellular decision-making. We often pair biosensors to visualize a quantitative dynamic of choice inside living cells with precision tools to control the regulators of these behaviors. We also leverage synthetic approaches like optogenetics and de novo protein design to sharpen our understanding of cellular self-organization. This approach reveals the molecular logic of these complex cell decisions. Transformative science often happens at interfaces. We seek to borrow tools and concepts from other fields to address open questions in cell biology and frequently develop new tools when they are needed to accelerate progress. Our approach opens up opportunities for cross pollination between different projects in the lab and frequently leverages collaborations with other labs in the field.