UCSF Alumni

Lynn Pulliam, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #001
San Francisco CA 94143
Phone415-221-4810 ext. 6490
PronounsShe/Her/Hers
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Collapse Biography 
Collapse education and training
University of California, San FranciscoPh.D.1983 Graduate Division (Experimental Pathology)
California State University, Long BeachM.S.1977Microbiology
Northwestern University, EvanstonBA1969Biology
Collapse awards and honors
San Francisco Business Times2012Most Influential Women in Business
Society for Neurovirology2010  - 2013President
International Society for Neurovirology2009Outstanding Women in Neuroscience
Drexel College of Medicine2017Prize in Neurovirology
International Society for Neurovirology2019Pioneer in Neurovirology

Collapse Overview 
Collapse overview
Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She has begun to study how extracellular vesicles from activated cells can influence inflammation in recipient cells. Also, isolation of blood neuron-derived exosomes can be a window into the health of brain neurons and can be used as biomarkers for cognitive impairment in HIV, Alzheimer's and post COVID sequelae. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.

Collapse Research 
Collapse research activities and funding
Neural and cognitive consequences of COVID-19 survival
Veterans Affairs Merit Award CX002322Sep 1, 2021 - Aug 30, 2025
Plasma neuronal-derived exosomes are biomarkers of HIV cognitive impairment
NIH R01MH121121May 15, 2020 - Feb 28, 2025
Role: Principal Investigator
Engineered exosomes target inflammation in HIV
NIH R21AI138923May 15, 2018 - Dec 31, 2020
Role: Principal Investigator
Brain-derived exosomes as blood markers of HIV cognitive impairment
NIH R21MH112483Dec 20, 2016 - May 20, 2019
Role: Principal Investigator
Exosomes from HIV-activated monocytes induce endothelial cell activation
NIH R21HL129853Sep 2, 2015 - Jun 30, 2017
Role: Principal Investigator
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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Microfluidic isolation of neuronal-enriched extracellular vesicles shows distinct and common neurological proteins in LongCOVID, HIV infection and Alzheimer's disease. Int J Mol Sci. 2024; 3830(25):1-20.
  2. Blood markers show neural consequences of LongCOVID-19. cells. 2024; 4781-17(13).
  3. Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. Cells. 2021 02 13; 10(2). Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L. PMID: 33668514; PMCID: PMC7918597.
    View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
  4. Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS. Curr Top Behav Neurosci. 2021; 50:77-103. Fernandes N, Pulliam L. PMID: 31385260.
    View in: PubMed   Mentions: 4     Fields:    Translation:Humans
  5. Using neuronal extracellular vesicles and machine learning to predict cognitive deficits in HIV. J Neurovirol. 2020 12; 26(6):880-887. Pulliam L, Liston M, Sun B, Narvid J. PMID: 32681213; PMCID: PMC7718328.
    View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
  6. Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms. J Infect Dis. 2020 07 06; 222(3):396-406. Sun B, Abadjian L, Monto A, Freasier H, Pulliam L. PMID: 32157304; PMCID: PMC7336574.
    View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
  7. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. J Neurovirol. 2019 10; 25(5):702-709. Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D. PMID: 30610738; PMCID: PMC7372698.
    View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
  8. Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV. AIDS. 2017 09 10; 31(14):F9-F17. Sun B, Dalvi P, Abadjian L, Tang N, Pulliam L. PMID: 28692534; PMCID: PMC5578870.
    View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
  9. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Sci Rep. 2017 08 30; 7(1):9954. Dalvi P, Sun B, Tang N, Pulliam L. PMID: 28855621; PMCID: PMC5577170.
    View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
  10. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells. FASEB J. 2016 09; 30(9):3097-106. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. PMID: 27226520; PMCID: PMC5001509.
    View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
  11. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 05; 30(5):2058-63. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. PMID: 26873936; PMCID: PMC4836374.
    View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
  12. Modulation of cellular function through immune-activated exosomes. DNA Cell Biol. 2015 Jul; 34(7):459-63. Pulliam L, Gupta A. PMID: 25945690; PMCID: PMC4504252.
    View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
  13. Monocyte activation from interferon-α in HIV infection increases acetylated LDL uptake and ROS production. J Interferon Cytokine Res. 2014 Oct; 34(10):822-8. Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. PMID: 24731171; PMCID: PMC4186262.
    View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
  14. Exosomes as mediators of neuroinflammation. J Neuroinflammation. 2014 Apr 03; 11:68. Gupta A, Pulliam L. PMID: 24694258; PMCID: PMC3994210.
    View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
  15. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Curr HIV Res. 2014; 12(2):77-84. Pulliam L. PMID: 24862334; PMCID: PMC4175740.
    View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
  16. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. PMID: 23437063; PMCID: PMC3578833.
    View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
  17. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 01; 62(2):190-6. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. PMID: 23187938; PMCID: PMC3587125.
    View in: PubMed   Mentions: 25     Fields:    Translation:Humans
  18. Global NeuroAIDS roundtable. J Neurovirol. 2013 Feb; 19(1):1-9. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. PMID: 23354550; PMCID: PMC3713197.
    View in: PubMed   Mentions: 15     Fields:    Translation:Humans
  19. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. PMID: 22606292; PMCID: PMC3350475.
    View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
  20. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. AIDS. 2011 Sep 10; 25(14):1721-6. Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. PMID: 21750421; PMCID: PMC4120827.
    View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
  21. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. PMID: 21508516; PMCID: PMC3825251.
    View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
  22. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. PMID: 21145962; PMCID: PMC3039086.
    View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
  23. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. PMID: 20495440; PMCID: PMC2991092.
    View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
  24. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. J Neurovirol. 2010 Mar; 16(2):115-24. Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. PMID: 20307252.
    View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
  25. Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection. 2010; 24:1415-1423. Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam. .
  26. HIV regulation of amyloid beta production. J Neuroimmune Pharmacol. 2009 Jun; 4(2):213-7. Pulliam L. PMID: 19288202.
    View in: PubMed   Mentions: 40     Fields:    Translation:Humans
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