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Lynn Pulliam, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address4150 Clement St, Blg 2, Rm 259
San Francisco CA 94121
Phone415-221-4810 ext. 6490
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1983 Graduate Division (Experimental Pathology)
    California State University, Long BeachM.S.1977Microbiology
    Collapse Awards and Honors
    San Francisco Business Times2012Most Influential Women in Business
    Society for Neurovirology2010  - 2013President
    International Society for Neurovirology2009Outstanding Women in Neuroscience
    Drexel College of Medicine2017Prize in Neurovirology
    International Society for Neurovirology2019Pioneer in Neurovirology

    Collapse Overview 
    Collapse Overview
    Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She has begun to study how extracellular vesicles from activated cells can influence inflammation in recipient cells. Also, isolation of blood neuron-derived exosomes can be a window into the health of brain neurons. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.

    Collapse Research 
    Collapse Research Activities and Funding
    Plasma neuronal-derived exosomes are biomarkers of HIV cognitive impairment
    NIH/NIMH R01MH121121May 15, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Engineered exosomes target inflammation in HIV
    NIH/NIAID R21AI138923May 15, 2018 - Apr 30, 2020
    Role: Principal Investigator
    Brain-derived exosomes as blood markers of HIV cognitive impairment
    NIH/NIMH R21MH112483Dec 20, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Exosomes from HIV-activated monocytes induce endothelial cell activation
    NIH/NHLBI R21HL129853Sep 2, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Interferon-a drives peripheral activation and brain injury in chronic HIV
    NIH/NIMH R01MH096673Jul 18, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Hepatitis C Drives Neuropathogenesis in HIV/HCV Coinfection Patients
    NIH/NIMH R01MH085538Dec 1, 2008 - Oct 31, 2012
    Role: Principal Investigator
    Predicting HAD using Monocyte Profiling and Neuroimaging
    NIH/NIMH R01MH073478Feb 14, 2005 - Jan 31, 2010
    Role: Principal Investigator
    HIV-1 Infection Increases Brain Amyloid Beta
    NIH/NIMH R01MH068213Jul 1, 2003 - Oct 31, 2008
    Role: Principal Investigator
    Role of Inflammation in HIV Dementia
    NIH/NIMH R21MH064406Dec 1, 2002 - Nov 30, 2005
    Role: Principal Investigator
    MONOCYTE SUBSETS AND AIDS DEMENTIA
    NIH/NIMH R01MH056840Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    APOPTOSIS INHIBITORS--THERAPY FOR NEUROTOXICITY
    NIH/NIMH R41MH056311Aug 1, 1996 - Jul 31, 1997
    Role: Principal Investigator
    Role of PreS2 Mutants in Pathogenesis of Chronic Hepatitis B
    NIH/NCI R01CA055578Mar 5, 1992 - Sep 29, 2011
    Role: Principal Investigator
    HIV-ASSOCIATED NEUROTOXIN AND AIDS DEMENTIA
    NIH/NINDS R01NS030311Dec 23, 1991 - Oct 31, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Using neuronal extracellular vesicles and machine learning to predict cognitive deficits in HIV. J Neurovirol. 2020 Jul 17. Pulliam L, Liston M, Sun B, Narvid J. PMID: 32681213.
      View in: PubMed   Mentions:    Fields:    
    2. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. J Neurovirol. 2019 10; 25(5):702-709. Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D. PMID: 30610738.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    3. Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV. AIDS. 2017 09 10; 31(14):F9-F17. Sun B, Dalvi P, Abadjian L, Tang N, Pulliam L. PMID: 28692534.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    4. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Sci Rep. 2017 08 30; 7(1):9954. Dalvi P, Sun B, Tang N, Pulliam L. PMID: 28855621.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    5. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-?B in endothelial cells. FASEB J. 2016 09; 30(9):3097-106. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. PMID: 27226520.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    6. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 05; 30(5):2058-63. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. PMID: 26873936.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    7. Modulation of cellular function through immune-activated exosomes. DNA Cell Biol. 2015 Jul; 34(7):459-63. Pulliam L, Gupta A. PMID: 25945690.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. Monocyte activation from interferon-a in HIV infection increases acetylated LDL uptake and ROS production. J Interferon Cytokine Res. 2014 Oct; 34(10):822-8. Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. PMID: 24731171.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Exosomes as mediators of neuroinflammation. J Neuroinflammation. 2014 Apr 03; 11:68. Gupta A, Pulliam L. PMID: 24694258.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    10. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Curr HIV Res. 2014; 12(2):77-84. Pulliam L. PMID: 24862334.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. PMID: 23437063.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 01; 62(2):190-6. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. PMID: 23187938.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    13. Global NeuroAIDS roundtable. J Neurovirol. 2013 Feb; 19(1):1-9. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. PMID: 23354550.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    14. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. PMID: 22606292.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. AIDS. 2011 Sep 10; 25(14):1721-6. Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. PMID: 21750421.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    16. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. PMID: 21508516.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    17. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. PMID: 21145962.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    18. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. PMID: 20495440.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    19. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. J Neurovirol. 2010 Mar; 16(2):115-24. Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. PMID: 20307252.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    20. Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection. 2010; 24:1415-1423. Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam..
    21. HIV regulation of amyloid beta production. J Neuroimmune Pharmacol. 2009 Jun; 4(2):213-7. Pulliam L. PMID: 19288202.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
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