Lynn Pulliam, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #001
San Francisco CA 94143
Phone415-221-4810 ext. 6490
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1983 Graduate Division (Experimental Pathology)
    California State University, Long BeachM.S.1977Microbiology
    Northwestern University, EvanstonBA1969Biology
    Collapse Awards and Honors
    San Francisco Business Times2012Most Influential Women in Business
    Society for Neurovirology2010  - 2013President
    International Society for Neurovirology2009Outstanding Women in Neuroscience
    Drexel College of Medicine2017Prize in Neurovirology
    International Society for Neurovirology2019Pioneer in Neurovirology

    Collapse Overview 
    Collapse Overview
    Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She has begun to study how extracellular vesicles from activated cells can influence inflammation in recipient cells. Also, isolation of blood neuron-derived exosomes can be a window into the health of brain neurons and can be used as biomarkers for cognitive impairment in HIV, Alzheimer's and post COVID sequelae. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.

    Collapse Research 
    Collapse Research Activities and Funding
    Neural and cognitive consequences of COVID-19 survival
    Veterans Affairs Merit Award CX002322Sep 1, 2021 - Aug 30, 2025
    Plasma neuronal-derived exosomes are biomarkers of HIV cognitive impairment
    NIH R01MH121121May 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Engineered exosomes target inflammation in HIV
    NIH R21AI138923May 15, 2018 - Dec 31, 2020
    Role: Principal Investigator
    Brain-derived exosomes as blood markers of HIV cognitive impairment
    NIH R21MH112483Dec 20, 2016 - May 20, 2019
    Role: Principal Investigator
    Exosomes from HIV-activated monocytes induce endothelial cell activation
    NIH R21HL129853Sep 2, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Interferon-a drives peripheral activation and brain injury in chronic HIV
    NIH R01MH096673Jul 18, 2012 - Apr 30, 2017
    Role: Principal Investigator
    Hepatitis C Drives Neuropathogenesis in HIV/HCV Coinfection Patients
    NIH R01MH085538Dec 1, 2008 - May 31, 2019
    Role: Principal Investigator
    Predicting HAD using Monocyte Profiling and Neuroimaging
    NIH R01MH073478Feb 14, 2005 - Jan 31, 2010
    Role: Principal Investigator
    HIV-1 Infection Increases Brain Amyloid Beta
    NIH R01MH068213Jul 1, 2003 - Oct 31, 2008
    Role: Principal Investigator
    Role of Inflammation in HIV Dementia
    NIH R21MH064406Dec 1, 2002 - May 31, 2006
    Role: Principal Investigator
    MONOCYTE SUBSETS AND AIDS DEMENTIA
    NIH R01MH056840Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    APOPTOSIS INHIBITORS--THERAPY FOR NEUROTOXICITY
    NIH R41MH056311Aug 1, 1996 - Jul 31, 1997
    Role: Principal Investigator
    Role of PreS2 Mutants in Pathogenesis of Chronic Hepatitis B
    NIH R01CA055578Mar 5, 1992 - Jan 31, 2012
    Role: Principal Investigator
    HIV-ASSOCIATED NEUROTOXIN AND AIDS DEMENTIA
    NIH R01NS030311Dec 23, 1991 - Nov 30, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microfluidic isolation of neuronal-enriched extracellular vesicles shows distinct and common neurological proteins in LongCOVID, HIV infection and Alzheimer's disease. Int J Mol Sci. 2024; 3830(25):1-20.
    2. Blood markers show neural consequences of LongCOVID-19. cells. 2024; 4781-17(13).
    3. Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. Cells. 2021 02 13; 10(2). Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L. PMID: 33668514; PMCID: PMC7918597.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    4. Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS. Curr Top Behav Neurosci. 2021; 50:77-103. Fernandes N, Pulliam L. PMID: 31385260.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Using neuronal extracellular vesicles and machine learning to predict cognitive deficits in HIV. J Neurovirol. 2020 12; 26(6):880-887. Pulliam L, Liston M, Sun B, Narvid J. PMID: 32681213; PMCID: PMC7718328.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms. J Infect Dis. 2020 07 06; 222(3):396-406. Sun B, Abadjian L, Monto A, Freasier H, Pulliam L. PMID: 32157304; PMCID: PMC7336574.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    7. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease. J Neurovirol. 2019 10; 25(5):702-709. Pulliam L, Sun B, Mustapic M, Chawla S, Kapogiannis D. PMID: 30610738; PMCID: PMC7372698.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    8. Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV. AIDS. 2017 09 10; 31(14):F9-F17. Sun B, Dalvi P, Abadjian L, Tang N, Pulliam L. PMID: 28692534; PMCID: PMC5578870.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    9. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Sci Rep. 2017 08 30; 7(1):9954. Dalvi P, Sun B, Tang N, Pulliam L. PMID: 28855621; PMCID: PMC5577170.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    10. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells. FASEB J. 2016 09; 30(9):3097-106. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. PMID: 27226520; PMCID: PMC5001509.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    11. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 05; 30(5):2058-63. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. PMID: 26873936; PMCID: PMC4836374.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    12. Modulation of cellular function through immune-activated exosomes. DNA Cell Biol. 2015 Jul; 34(7):459-63. Pulliam L, Gupta A. PMID: 25945690; PMCID: PMC4504252.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    13. Monocyte activation from interferon-α in HIV infection increases acetylated LDL uptake and ROS production. J Interferon Cytokine Res. 2014 Oct; 34(10):822-8. Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. PMID: 24731171; PMCID: PMC4186262.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. Exosomes as mediators of neuroinflammation. J Neuroinflammation. 2014 Apr 03; 11:68. Gupta A, Pulliam L. PMID: 24694258; PMCID: PMC3994210.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    15. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Curr HIV Res. 2014; 12(2):77-84. Pulliam L. PMID: 24862334; PMCID: PMC4175740.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. PMID: 23437063; PMCID: PMC3578833.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    17. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 01; 62(2):190-6. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. PMID: 23187938; PMCID: PMC3587125.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    18. Global NeuroAIDS roundtable. J Neurovirol. 2013 Feb; 19(1):1-9. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. PMID: 23354550; PMCID: PMC3713197.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    19. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. PMID: 22606292; PMCID: PMC3350475.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. AIDS. 2011 Sep 10; 25(14):1721-6. Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. PMID: 21750421; PMCID: PMC4120827.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    21. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. PMID: 21508516; PMCID: PMC3825251.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    22. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. PMID: 21145962; PMCID: PMC3039086.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    23. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. PMID: 20495440; PMCID: PMC2991092.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    24. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. J Neurovirol. 2010 Mar; 16(2):115-24. Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. PMID: 20307252.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    25. Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection. 2010; 24:1415-1423. Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam. .
    26. HIV regulation of amyloid beta production. J Neuroimmune Pharmacol. 2009 Jun; 4(2):213-7. Pulliam L. PMID: 19288202.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    Lynn's Networks
    Concepts (142)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (23)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-6-g69de2244 on PROFILES-PWEB03.

    Copyright © The Regents of the University of California.