Loading...

Lynn Pulliam, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
Address4150 Clement St, Blg 2, Rm 259
San Francisco CA 94121
Phone415-221-4810
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1983 Graduate Division (Experimental Pathology)
    California State University, Long BeachM.S.1977Microbiology
    Collapse Awards and Honors
    San Francisco Business Times2012Most Influential Women in Business
    Society for Neurovirology2010  - 2013President
    International Society for Neurovirology2009Outstanding Women in Neuroscience
    Northern California Institute for Research and Development2008Research and Leadership

    Collapse Overview 
    Collapse Overview
    Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.


    Collapse Research 
    Collapse Research Activities and Funding
    Brain-derived exosomes as blood markers of HIV cognitive impairment
    NIH/NIMH R21MH112483Dec 20, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Exosomes from HIV-activated monocytes induce endothelial cell activation
    NIH/NHLBI R21HL129853Sep 2, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Interferon-a drives peripheral activation and brain injury in chronic HIV
    NIH/NIMH R01MH096673Jul 18, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Hepatitis C Drives Neuropathogenesis in HIV/HCV Coinfection Patients
    NIH/NIMH R01MH085538Dec 1, 2008 - Jun 30, 2018
    Role: Principal Investigator
    Predicting HAD using Monocyte Profiling and Neuroimaging
    NIH/NIMH R01MH073478Feb 14, 2005 - Jan 31, 2010
    Role: Principal Investigator
    HIV-1 Infection Increases Brain Amyloid Beta
    NIH/NIMH R01MH068213Jul 1, 2003 - Oct 31, 2008
    Role: Principal Investigator
    Role of Inflammation in HIV Dementia
    NIH/NIMH R21MH064406Dec 1, 2002 - May 31, 2006
    Role: Principal Investigator
    MONOCYTE SUBSETS AND AIDS DEMENTIA
    NIH/NIMH R01MH056840Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    APOPTOSIS INHIBITORS--THERAPY FOR NEUROTOXICITY
    NIH/NIMH R41MH056311Aug 1, 1996 - Jul 31, 1997
    Role: Principal Investigator
    Role of PreS2 Mutants in Pathogenesis of Chronic Hepatitis B
    NIH/NCI R01CA055578Mar 5, 1992 - Jan 31, 2012
    Role: Principal Investigator
    HIV-ASSOCIATED NEUROTOXIN AND AIDS DEMENTIA
    NIH/NINDS R01NS030311Dec 23, 1991 - Nov 30, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-?B in endothelial cells. FASEB J. 2016 Sep; 30(9):3097-106. PMID: 27226520; PMCID: PMC5001509 [Available on 09/01/17].
      View in: PubMed, PubMed Central
    2. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 May; 30(5):2058-63. PMID: 26873936.
      View in: PubMed
    3. Pulliam L, Gupta A. Modulation of cellular function through immune-activated exosomes. DNA Cell Biol. 2015 Jul; 34(7):459-63. PMID: 25945690; PMCID: PMC4504252 [Available on 07/01/16].
      View in: PubMed, PubMed Central
    4. Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. Monocyte activation from interferon-a in HIV infection increases acetylated LDL uptake and ROS production. J Interferon Cytokine Res. 2014 Oct; 34(10):822-8. PMID: 24731171; PMCID: PMC4186262.
      View in: PubMed, PubMed Central
    5. Pulliam L. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Curr HIV Res. 2014; 12(2):77-84. PMID: 24862334; PMCID: PMC4175740.
      View in: PubMed, PubMed Central
    6. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. PMID: 23437063; PMCID: PMC3578833.
      View in: PubMed, PubMed Central
    7. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 1; 62(2):190-6. PMID: 23187938; PMCID: PMC3587125.
      View in: PubMed, PubMed Central
    8. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. Global NeuroAIDS roundtable. J Neurovirol. 2013 Feb; 19(1):1-9. PMID: 23354550; PMCID: PMC3713197.
      View in: PubMed, PubMed Central
    9. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. PMID: 22606292; PMCID: PMC3350475.
      View in: PubMed, PubMed Central
    10. Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. AIDS. 2011 Sep 10; 25(14):1721-6. PMID: 21750421; PMCID: PMC4120827.
      View in: PubMed, PubMed Central
    11. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32. PMID: 21508516; PMCID: PMC3825251.
      View in: PubMed, PubMed Central
    12. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31. PMID: 21145962; PMCID: PMC3039086.
      View in: PubMed, PubMed Central
    13. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. PMID: 20495440; PMCID: PMC2991092.
      View in: PubMed, PubMed Central
    14. Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. J Neurovirol. 2010 Mar; 16(2):115-24. PMID: 20307252.
      View in: PubMed
    15. Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam. Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection. 2010; 24:1415-1423.
    16. Pulliam L. HIV regulation of amyloid beta production. J Neuroimmune Pharmacol. 2009 Jun; 4(2):213-7. PMID: 19288202.
      View in: PubMed
    17. Rempel H, Calosing C, Sun B, Pulliam L. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. PLoS One. 2008; 3(4):e1967. PMID: 18414664; PMCID: PMC2288672.
      View in: PubMed, PubMed Central
    18. Price RW, Epstein LG, Becker JT, Cinque P, Gisslen M, Pulliam L, McArthur JC. Biomarkers of HIV-1 CNS infection and injury. Neurology. 2007 Oct 30; 69(18):1781-8. PMID: 17967994.
      View in: PubMed
    19. Rempel HC, Pulliam L. HIV-1 Tat inhibits neprilysin and elevates amyloid beta. AIDS. 2005 Jan 28; 19(2):127-35. PMID: 15668537.
      View in: PubMed
    20. Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol. 2004 Dec; 157(1-2):93-8. PMID: 15579285.
      View in: PubMed
    21. Sun B, Rempel HC, Pulliam L. Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometry. AIDS. 2004 Apr 30; 18(7):1009-12. PMID: 15096803.
      View in: PubMed
    22. Kusdra L, McGuire D, Pulliam L. Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia. AIDS. 2002 Jan 4; 16(1):31-8. PMID: 11741160.
      View in: PubMed
    23. Rempel H, Kusdra L, Pulliam L. Interleukin-1beta up-regulates expression of neurofilament light in human neuronal cells. J Neurochem. 2001 Aug; 78(3):640-5. PMID: 11483667.
      View in: PubMed
    24. Pulliam L, Irwin I, Kusdra L, Rempel H, Flitter WD, Garland WA. CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation. Brain Res. 2001 Mar 2; 893(1-2):95-103. PMID: 11222997.
      View in: PubMed
    25. Kusdra L, Rempel H, Yaffe K, Pulliam L. Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease. Immunobiology. 2000 May; 202(1):26-33. PMID: 10879686.
      View in: PubMed
    26. Pulliam L, Zhou M, Stubblebine M, Bitler CM. Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. J Neurosci Res. 1998 Nov 15; 54(4):530-8. PMID: 9822163.
      View in: PubMed
    27. Pulliam L, Stubblebine M, Hyun W. Quantification of neurotoxicity and identification of cellular subsets in a three-dimensional brain model. Cytometry. 1998 May 1; 32(1):66-9. PMID: 9581626.
      View in: PubMed
    28. Pulliam L, Gascon R, Stubblebine M, McGuire D, McGrath MS. Unique monocyte subset in patients with AIDS dementia. Lancet. 1997 Mar 8; 349(9053):692-5. PMID: 9078201.
      View in: PubMed
    29. Pulliam L, Clarke JA, McGrath MS, Moore D, McGuire D. Monokine products as predictors of AIDS dementia. AIDS. 1996 Nov; 10(13):1495-500. PMID: 8931783.
      View in: PubMed
    30. Pulliam L, Moore D, West DC. Human cytomegalovirus induces IL-6 and TNF alpha from macrophages and microglial cells: possible role in neurotoxicity. J Neurovirol. 1995 Jun; 1(2):219-27. PMID: 9222360.
      View in: PubMed
    31. Yeung MC, Pulliam L, Lau AS. The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-alpha. AIDS. 1995 Feb; 9(2):137-43. PMID: 7536422.
      View in: PubMed
    32. Pulliam L, Clarke JA, McGuire D, McGrath MS. Investigation of HIV-infected macrophage neurotoxin production from patients with AIDS dementia. Adv Neuroimmunol. 1994; 4(3):195-8. PMID: 7874387.
      View in: PubMed
    33. Pulliam L, West D, Haigwood N, Swanson RA. HIV-1 envelope gp120 alters astrocytes in human brain cultures. AIDS Res Hum Retroviruses. 1993 May; 9(5):439-44. PMID: 8318270.
      View in: PubMed
    34. Hughes-Fulford M, McGrath MS, Hanks D, Erickson S, Pulliam L. Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication. Antimicrob Agents Chemother. 1992 Oct; 36(10):2253-8. PMID: 1332592; PMCID: PMC245485.
      View in: PubMed, PubMed Central
    35. Pulliam L, Herndier BG, McGrath MS. Purified trichosanthin (GLQ223) exacerbation of indirect HIV-associated neurotoxicity in vitro. AIDS. 1991 Oct; 5(10):1237-42. PMID: 1786150.
      View in: PubMed
    36. Pulliam L. Cytomegalovirus preferentially infects a monocyte derived macrophage/microglial cell in human brain cultures: neuropathology differs between strains. J Neuropathol Exp Neurol. 1991 Jul; 50(4):432-40. PMID: 1648122.
      View in: PubMed
    37. Pulliam L, Herndier BG, Tang NM, McGrath MS. Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest. 1991 Feb; 87(2):503-12. PMID: 1671392; PMCID: PMC296337.
      View in: PubMed, PubMed Central
    38. Cregan P, Yamamoto A, Lum A, VanDerHeide T, MacDonald M, Pulliam L. Comparison of four methods for rapid detection of Pneumocystis carinii in respiratory specimens. J Clin Microbiol. 1990 Nov; 28(11):2432-6. PMID: 1701444; PMCID: PMC268201.
      View in: PubMed, PubMed Central
    39. Pulliam L, Berens ME, Rosenblum ML. A normal human brain cell aggregate model for neurobiological studies. J Neurosci Res. 1988 Oct-Dec; 21(2-4):521-30. PMID: 3216435.
      View in: PubMed
    Lynn's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (216) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (14) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    Back to TOP