Lynn Pulliam, PhD

InstitutionUniversity of California San Francisco
DepartmentLaboratory Medicine
Address4150 Clement St, Blg 2, Rm 259
San Francisco CA 94121
Phone415-221-4810 ext. 6490
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1983 Graduate Division (Experimental Pathology)
    California State University, Long BeachM.S.1977Microbiology
    Collapse Awards and Honors
    San Francisco Business Times2012Most Influential Women in Business
    Society for Neurovirology2010  - 2013President
    International Society for Neurovirology2009Outstanding Women in Neuroscience
    Northern California Institute for Research and Development2008Research and Leadership
    Drexel College of Medicine2017Prize in Neurovirology

    Collapse Overview 
    Collapse Overview
    Dr. Pulliam is Professor of Laboratory Medicine and Medicine at UCSF. Her research interests are in HIV-associated cognitive impairment, neuroinflammation and chronic monocyte activation. She has begun to study how extracellular vesicles from activated cells can influence inflammation in recipient cells. Also, isolation of blood neuron-derived exosomes can be a window into the health of brain neurons. She is former President and continuing Board of Directors Member of the Society for Neurovirology as well as a member of several journal Editorial Boards. Dr. Pulliam is Director of Microbiology at the San Francisco Veterans Affairs Medical Center where she teaches microbiology to Infectious Disease and Laboratory Medicine residents and fellows.

    Collapse Research 
    Collapse Research Activities and Funding
    Engineered exosomes target inflammation in HIV
    NIH/NIAID R21AI138923May 15, 2018 - Apr 30, 2020
    Role: Principal Investigator
    Brain-derived exosomes as blood markers of HIV cognitive impairment
    NIH/NIMH R21MH112483Dec 20, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Exosomes from HIV-activated monocytes induce endothelial cell activation
    NIH/NHLBI R21HL129853Sep 2, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Interferon-a drives peripheral activation and brain injury in chronic HIV
    NIH/NIMH R01MH096673Jul 18, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Hepatitis C Drives Neuropathogenesis in HIV/HCV Coinfection Patients
    NIH/NIMH R01MH085538Dec 1, 2008 - Jun 30, 2018
    Role: Principal Investigator
    Predicting HAD using Monocyte Profiling and Neuroimaging
    NIH/NIMH R01MH073478Feb 14, 2005 - Jan 31, 2010
    Role: Principal Investigator
    HIV-1 Infection Increases Brain Amyloid Beta
    NIH/NIMH R01MH068213Jul 1, 2003 - Oct 31, 2008
    Role: Principal Investigator
    Role of Inflammation in HIV Dementia
    NIH/NIMH R21MH064406Dec 1, 2002 - May 31, 2006
    Role: Principal Investigator
    NIH/NIMH R01MH056840Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    NIH/NIMH R41MH056311Aug 1, 1996 - Jul 31, 1997
    Role: Principal Investigator
    Role of PreS2 Mutants in Pathogenesis of Chronic Hepatitis B
    NIH/NCI R01CA055578Mar 5, 1992 - Jan 31, 2012
    Role: Principal Investigator
    NIH/NINDS R01NS030311Dec 23, 1991 - Nov 30, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sun B, Dalvi P, Abadjian L, Tang N, Pulliam L. Blood neuron-derived exosomes as biomarkers of cognitive impairment in HIV. AIDS. 2017 Sep 10; 31(14):F9-F17. PMID: 28692534.
      View in: PubMed
    2. Dalvi P, Sun B, Tang N, Pulliam L. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Sci Rep. 2017 Aug 30; 7(1):9954. PMID: 28855621.
      View in: PubMed
    3. Tang N, Sun B, Gupta A, Rempel H, Pulliam L. Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-?B in endothelial cells. FASEB J. 2016 09; 30(9):3097-106. PMID: 27226520; PMCID: PMC5001509 [Available on 09/01/17].
    4. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 05; 30(5):2058-63. PMID: 26873936; PMCID: PMC4836374 [Available on 05/01/17].
    5. Pulliam L, Gupta A. Modulation of cellular function through immune-activated exosomes. DNA Cell Biol. 2015 Jul; 34(7):459-63. PMID: 25945690; PMCID: PMC4504252.
    6. Pulliam L, Calosing C, Sun B, Grunfeld C, Rempel H. Monocyte activation from interferon-a in HIV infection increases acetylated LDL uptake and ROS production. J Interferon Cytokine Res. 2014 Oct; 34(10):822-8. PMID: 24731171; PMCID: PMC4186262.
    7. Pulliam L. Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection. Curr HIV Res. 2014; 12(2):77-84. PMID: 24862334; PMCID: PMC4175740.
    8. Rempel H, Sun B, Calosing C, Abadjian L, Monto A, Pulliam L. Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One. 2013; 8(2):e55776. PMID: 23437063; PMCID: PMC3578833.
    9. Sun B, Abadjian L, Rempel H, Monto A, Pulliam L. Differential cognitive impairment in HCV coinfected men with controlled HIV compared to HCV monoinfection. J Acquir Immune Defic Syndr. 2013 Feb 01; 62(2):190-6. PMID: 23187938; PMCID: PMC3587125.
    10. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C. Global NeuroAIDS roundtable. J Neurovirol. 2013 Feb; 19(1):1-9. PMID: 23354550; PMCID: PMC3713197.
    11. Wang Q, Na B, Ou JH, Pulliam L, Yen TS. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One. 2012; 7(5):e36818. PMID: 22606292; PMCID: PMC3350475.
    12. Pulliam L, Rempel H, Sun B, Abadjian L, Calosing C, Meyerhoff DJ. A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations. AIDS. 2011 Sep 10; 25(14):1721-6. PMID: 21750421; PMCID: PMC4120827.
    13. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32. PMID: 21508516; PMCID: PMC3825251.
    14. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31. PMID: 21145962; PMCID: PMC3039086.
    15. Rempel H, Sun B, Calosing C, Pillai SK, Pulliam L. Interferon-alpha drives monocyte gene expression in chronic unsuppressed HIV-1 infection. AIDS. 2010 Jun 19; 24(10):1415-23. PMID: 20495440; PMCID: PMC2991092.
    16. Sun B, Abadjian L, Rempel H, Calosing C, Rothlind J, Pulliam L. Peripheral biomarkers do not correlate with cognitive impairment in highly active antiretroviral therapy-treated subjects with human immunodeficiency virus type 1 infection. J Neurovirol. 2010 Mar; 16(2):115-24. PMID: 20307252.
      View in: PubMed
    17. Hans Rempel, Bing Sun, Cyrus Calosing, Satish Pillai, Lynn Pulliam.Interferon alpha drives monocyte gene expression in chronic unsuppressed HIV-i1 infection. 2010; 24:1415-1423.
    18. Pulliam L. HIV regulation of amyloid beta production. J Neuroimmune Pharmacol. 2009 Jun; 4(2):213-7. PMID: 19288202.
      View in: PubMed
    19. Rempel H, Calosing C, Sun B, Pulliam L. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. PLoS One. 2008 Apr 16; 3(4):e1967. PMID: 18414664; PMCID: PMC2288672.
    20. Rempel HC, Pulliam L. HIV-1 Tat inhibits neprilysin and elevates amyloid beta. AIDS. 2005 Jan 28; 19(2):127-35. PMID: 15668537.
      View in: PubMed
    21. Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol. 2004 Dec; 157(1-2):93-8. PMID: 15579285.
      View in: PubMed
    22. Sun B, Rempel HC, Pulliam L. Loss of macrophage-secreted lysozyme in HIV-1-associated dementia detected by SELDI-TOF mass spectrometry. AIDS. 2004 Apr 30; 18(7):1009-12. PMID: 15096803.
      View in: PubMed
    23. Kusdra L, McGuire D, Pulliam L. Changes in monocyte/macrophage neurotoxicity in the era of HAART: implications for HIV-associated dementia. AIDS. 2002 Jan 04; 16(1):31-8. PMID: 11741160.
      View in: PubMed
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