Sabra Inslicht, PhD

Title(s)Associate Professor, Psychiatry
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 3341
Emailsabra.inslicht@ucsf.edu
ORCID ORCID Icon0000-0002-2456-1625 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, San Francisco, CAPostdoctoral Studies2008Graduate Division
    Rutgers University, New Brunswick, NJBA1994Psychology
    University of Haifa, Haifa, Israel1993Psychology Honors Program
    University of Pittsburgh, Pittsburgh, PAMS1998Clinical and Health Psychology
    University of Pittsburgh, Pittsburgh, PAPh.D.1998Clinical and Health Psychology
    VA Palo Alto Healthcare System, Palo Alto, CAInternship2002Clinical Psychology
    Stanford University Medical Center, Stanford, CAPostdoctoral Studies2003Child and Adolescent Clinical Psychology

    Collapse Overview 
    Collapse Overview
    My research goals include: 1) identifying psychobiological causes and consequences of traumatic stress symptoms; 2) utilizing fear conditioning and extinction models to better understand PTSD; 3) characterizing sex differences in the biology of PTSD; 4) improving measurement techniques in the laboratory and the field such as with mobile health devices; and 5) conducting research that will inform novel interventions for ameliorating prolonged PTSD responses.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Sex differences in stress-related cardiometabolic risk in PTSD
    pendingApr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance inPosttraumatic Stress
    NIH I01CX001814Jan 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    Individual Variation in Effects of Traumatic Stress on Gray Matter Myelin
    NIH 1 R01 MH115020-01A1Sep 1, 2018 - Aug 31, 2023
    Role: Co-Investigator
    Improving Health Care for Women Veterans: Addressing Menopause and Mental Health
    1 IK2 HX002402-01A1Jul 1, 2018 - Jun 30, 2023
    Role: Co-mentor
    Metabolomics: A window for understanding long-term physical consequences of disturbed sleep and hypothalamic-pituitary-adrenal function in posttraumatic stress.
    Department of Defense, Peer Reviewed Medical Research Program (PRMRP), Discovery Award W81XWH-15-PRMRP-DASep 30, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Mobile Technology-Based Examination of Biomarkers of Treatment Response in Exposure-Based Psychotherapy for PTSD
    UCSF: Department of Psychiatry’s Digital Health Core MPSP20DHCPJun 1, 2016 - Nov 30, 2019
    Role: Principal Investigator
    Sex Differences in Fear Conditioning: Mechanisms of Risk and Resilience for PTSD
    NIH I01CX000720Jan 1, 2014 - Dec 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ventromedial and insular cortical volume moderates the relationship between BDNF Val66Met and threat sensitivity. J Psychiatr Res. 2021 Oct; 142:337-344. Young DA, Chao LL, Zhang H, Metzler T, Ross J, Richards A, O'Donovan A, Inslicht SS, Neylan TC. PMID: 34425486.
      View in: PubMed   Mentions:    Fields:    
    2. COVID-19 related moral injury: Associations with pandemic-related perceived threat and risky and protective behaviors. J Psychiatr Res. 2021 10; 142:80-88. Khan AJ, Nishimi K, Tripp P, Maven D, Jiha A, Woodward E, Inslicht S, Richards A, Neylan TC, Maguen S, O'Donovan A. PMID: 34330024.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    3. Examining the Effect of Sleep Disruption on the Neural Correlates of Fear Extinction. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 03; 6(3):251-252. Straus LD, Richards A, Inslicht SS, Dolsen MR, Neylan TC. PMID: 33685648.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial. Sleep. 2020 10 13; 43(10). Neylan TC, Richards A, Metzler TJ, Ruoff LM, Varbel J, O'Donovan A, Sivasubramanian M, Motraghi T, Hlavin J, Batki SL, Inslicht SS, Samuelson K, Morairty SR, Kilduff TS. PMID: 32303763.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. Impulsivity as a multifactorial construct and its relationship to PTSD severity and threat sensitivity. Psychiatry Res. 2020 11; 293:113468. Young DA, Neylan TC, Zhang H, O'Donovan A, Inslicht SS. PMID: 32977054.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Validation of sleep measurement in a multisensor consumer grade wearable device in healthy young adults. J Clin Sleep Med. 2020 06 15; 16(6):917-924. Kanady JC, Ruoff L, Straus LD, Varbel J, Metzler T, Richards A, Inslicht SS, O'Donovan A, Hlavin J, Neylan TC. PMID: 32048595.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Work by day and sleep by night, do not sleep too little or too much: Effects of sleep duration, time of day and circadian synchrony on flanker-task performance in internet brain-game users from teens to advanced age. J Sleep Res. 2020 12; 29(6):e12919. Richards A, Kanady JC, Huie JR, Straus LD, Inslicht SS, Levihn-Coon A, Metzler TJ, Neylan TC. PMID: 31631467.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Gender Differences in Threat Biases: Trauma Type Matters in Posttraumatic Stress Disorder. J Trauma Stress. 2019 10; 32(5):701-711. Cowden Hindash AH, Lujan C, Howard M, O'Donovan A, Richards A, Neylan TC, Inslicht SS. PMID: 31590206.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Psychophysiological treatment outcomes: Corticotropin-releasing factor type 1 receptor antagonist increases inhibition of fear-potentiated startle in PTSD patients. Psychophysiology. 2020 01; 57(1):e13356. Jovanovic T, Duncan EJ, Kaye J, Garza K, Norrholm SD, Inslicht SS, Neylan TC, Mathew SJ, Iosifescu D, Rothbaum BO, Mayberg HS, Dunlop BW. PMID: 30807663.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. Child abuse interacts with hippocampal and corpus callosum volume on psychophysiological response to startling auditory stimuli in a sample of veterans. J Psychiatr Res. 2019 04; 111:16-23. Young DA, Neylan TC, Chao LL, O'Donovan A, Metzler TJ, Inslicht SS. PMID: 30660809.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Altered overnight levels of pro-inflammatory cytokines in men and women with posttraumatic stress disorder. Psychoneuroendocrinology. 2019 04; 102:114-120. Küffer A, Straus LD, Prather AA, Inslicht SS, Richards A, Shigenaga JK, Madden E, Metzler TJ, Neylan TC, O'Donovan A. PMID: 30544002.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Gender Differences in Cardiovascular Risk Related to Diabetes and Posttraumatic Stress Disorder. Am J Geriatr Psychiatry. 2018 12; 26(12):1268-1272. Gibson CJ, Li Y, Inslicht SS, Seal KH, Byers AL. PMID: 30314941.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Association among anterior cingulate cortex volume, psychophysiological response, and PTSD diagnosis in a Veteran sample. Neurobiol Learn Mem. 2018 11; 155:189-196. Young DA, Chao L, Neylan TC, O'Donovan A, Metzler TJ, Inslicht SS. PMID: 30086395.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Effects of Threat Context, Trauma History, and Posttraumatic Stress Disorder Status on Physiological Startle Reactivity in Gulf War Veterans. J Trauma Stress. 2018 08; 31(4):579-590. Niles AN, Luxenberg A, Neylan TC, Inslicht SS, Richards A, Metzler TJ, Hlavin J, Deng J, O'Donovan A. PMID: 30058728.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Patterns of Zolpidem Use in Male and Female Veterans Following Revised FDA Dosing Guidelines. J Clin Sleep Med. 2018 07 15; 14(7):1093-1094. Inslicht SS, Neylan TC. PMID: 29991413.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans. J Affect Disord. 2018 08 01; 235:52-60. Young DA, Neylan TC, O'Donovan A, Metzler T, Richards A, Ross JA, Inslicht SS. PMID: 29649711.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans. Psychiatry Res. 2018 12; 270:961-966. Young DA, Inslicht SS, Metzler TJ, Neylan TC, Ross JA. PMID: 29576410.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Deployment Anxiety Reduction Training: A Pilot Study of Acceptability and Feasibility in Current or Recent Active Duty Service Members. Mil Med. 2018 03 01; 183(suppl_1):371-378. McCaslin SE, Herbst ED, Armitage NH, Allen I, Neylan T, Becket-Davenport C, Choucroun G, Best S, Inslicht SS. PMID: 29635621.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. An Open-Label Study of Doxazosin Extended-Release for PTSD: Findings and Recommendations for Future Research on Doxazosin. Focus (Am Psychiatr Publ). 2018 Jan; 16(1):67-73. Richards A, Inslicht S, Ruoff LM, Metzler TJ, Goldstein LA, Chapman CM, Hubachek SQ, Neylan TC. PMID: 31975904.
      View in: PubMed   Mentions:
    20. Subjective Sleep Related to Post Traumatic Stress Disorder Symptoms among Trauma-Exposed Men and Women. Behav Sleep Med. 2019 Jul-Aug; 17(4):492-501. Gibson CJ, Richards A, Villanueva C, Barrientos M, Neylan TC, Inslicht SS. PMID: 29172723.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Sleep and hypothalamic pituitary adrenal axis responses to metyrapone in posttraumatic stress disorder. Psychoneuroendocrinology. 2018 02; 88:136-143. Inslicht SS, Rao MN, Richards A, O'Donovan A, Gibson CJ, Baum T, Metzler TJ, Neylan TC. PMID: 29268182.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Repeated Exposure to Experimental Pain Differentiates Combat Traumatic Brain Injury with and without Post-Traumatic Stress Disorder. J Neurotrauma. 2018 01 15; 35(2):297-307. Strigo IA, Spadoni AD, Inslicht SS, Simmons AN. PMID: 28931334.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Assessment of skin conductance in African American and Non-African American participants in studies of conditioned fear. Psychophysiology. 2017 Nov; 54(11):1741-1754. Alexandra Kredlow M, Pineles SL, Inslicht SS, Marin MF, Milad MR, Otto MW, Orr SP. PMID: 28675471.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. Sleep and Cognitive Performance From Teens To Old Age: More Is Not Better. Sleep. 2017 Jan 01; 40(1). Richards A, Inslicht SS, Metzler TJ, Mohlenhoff BS, Rao MN, O'Donovan A, Neylan TC. PMID: 28364476.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Metabolic risk factors and posttraumatic stress disorder: the role of sleep in young, healthy adults. Psychosom Med. 2015 May; 77(4):383-91. Talbot LS, Rao MN, Cohen BE, Richards A, Inslicht SS, O'Donovan A, Maguen S, Metzler TJ, Neylan TC. PMID: 25886830.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Hyperinsulinemic response to oral glucose challenge in individuals with posttraumatic stress disorder. Psychoneuroendocrinology. 2014 Nov; 49:171-81. Rao MN, Chau A, Madden E, Inslicht S, Talbot L, Richards A, O'Donovan A, Ruoff L, Grunfeld C, Neylan TC. PMID: 25108160.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Prospective study of police officer spouse/partners: a new pathway to secondary trauma and relationship violence? PLoS One. 2014; 9(7):e100663. Meffert SM, Henn-Haase C, Metzler TJ, Qian M, Best S, Hirschfeld A, McCaslin S, Inslicht S, Neylan TC, Marmar CR. PMID: 24987848.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    28. Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder. Psychopharmacology (Berl). 2014 Sep; 231(17):3581-95. Inslicht SS, Richards A, Madden E, Rao MN, O'Donovan A, Talbot LS, Rucker E, Metzler TJ, Hauger RL, Neylan TC. PMID: 24952092.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Cortisol response to an experimental stress paradigm prospectively predicts long-term distress and resilience trajectories in response to active police service. J Psychiatr Res. 2014 Sep; 56:36-42. Galatzer-Levy IR, Steenkamp MM, Brown AD, Qian M, Inslicht S, Henn-Haase C, Otte C, Yehuda R, Neylan TC, Marmar CR. PMID: 24952936.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    30. Sex differences in objective measures of sleep in post-traumatic stress disorder and healthy control subjects. J Sleep Res. 2013 Dec; 22(6):679-87. Richards A, Metzler TJ, Ruoff LM, Inslicht SS, Rao M, Talbot LS, Neylan TC. PMID: 23763708.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    31. Sex differences in fear conditioning in posttraumatic stress disorder. J Psychiatr Res. 2013 Jan; 47(1):64-71. Inslicht SS, Metzler TJ, Garcia NM, Pineles SL, Milad MR, Orr SP, Marmar CR, Neylan TC. PMID: 23107307.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    32. Cortisol awakening response prospectively predicts peritraumatic and acute stress reactions in police officers. Biol Psychiatry. 2011 Dec 01; 70(11):1055-62. Inslicht SS, Otte C, McCaslin SE, Apfel BA, Henn-Haase C, Metzler T, Yehuda R, Neylan TC, Marmar CR. PMID: 21906725.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    33. Pretraumatic prolonged elevation of salivary MHPG predicts peritraumatic distress and symptoms of post-traumatic stress disorder. J Psychiatr Res. 2011 Jun; 45(6):735-41. Apfel BA, Otte C, Inslicht SS, McCaslin SE, Henn-Haase C, Metzler TJ, Makotkine I, Yehuda R, Neylan TC, Marmar CR. PMID: 21196013.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    34. Protective factors for posttraumatic stress disorder symptoms in a prospective study of police officers. Psychiatry Res. 2011 Jun 30; 188(1):45-50. Yuan C, Wang Z, Inslicht SS, McCaslin SE, Metzler TJ, Henn-Haase C, Apfel BA, Tong H, Neylan TC, Fang Y, Marmar CR. PMID: 21095622.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    35. Adaptation effects to sleep studies in participants with and without chronic posttraumatic stress disorder. Psychophysiology. 2010 Nov; 47(6):1127-33. Herbst E, Metzler TJ, Lenoci M, McCaslin SE, Inslicht S, Marmar CR, Neylan TC. PMID: 20456661.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    36. A prospective study of predictors of depression symptoms in police. Psychiatry Res. 2010 Feb 28; 175(3):211-6. Wang Z, Inslicht SS, Metzler TJ, Henn-Haase C, McCaslin SE, Tong H, Neylan TC, Marmar CR. PMID: 20044144.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    37. Routine work environment stress and PTSD symptoms in police officers. J Nerv Ment Dis. 2009 Oct; 197(10):754-60. Maguen S, Metzler TJ, McCaslin SE, Inslicht SS, Henn-Haase C, Neylan TC, Marmar CR. PMID: 19829204.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    38. Family psychiatric history, peritraumatic reactivity, and posttraumatic stress symptoms: a prospective study of police. J Psychiatr Res. 2010 Jan; 44(1):22-31. Inslicht SS, McCaslin SE, Metzler TJ, Henn-Haase C, Hart SL, Maguen S, Neylan TC, Marmar CR. PMID: 19683259.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    39. Low expression of catecholamine-O-methyl-transferase gene in obsessive-compulsive disorder. J Anxiety Disord. 2009 Jun; 23(5):660-4. Wang Z, Xiao Z, Inslicht SS, Tong H, Jiang W, Wang X, Metzler T, Marmar CR, Jiang S. PMID: 19269131.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Trait dissociation predicts posttraumatic stress disorder symptoms in a prospective study of urban police officers. J Nerv Ment Dis. 2008 Dec; 196(12):912-8. McCaslin SE, Inslicht SS, Metzler TJ, Henn-Haase C, Maguen S, Neylan TC, Choucroun G, Marmar CR. PMID: 19077859.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    41. A prospective study of trait anger and PTSD symptoms in police. J Trauma Stress. 2008 Aug; 21(4):410-6. Meffert SM, Metzler TJ, Henn-Haase C, McCaslin S, Inslicht S, Chemtob C, Neylan T, Marmar CR. PMID: 18720397.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder. Ann N Y Acad Sci. 2006 Jul; 1071:428-9. Inslicht SS, Marmar CR, Neylan TC, Metzler TJ, Hart SL, Otte C, McCaslin SE, Larkin GL, Hyman KB, Baum A. PMID: 16891591.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    43. Association between alexithymia and neuroendocrine response to psychological stress in police academy recruits. Ann N Y Acad Sci. 2006 Jul; 1071:425-7. McCaslin SE, Inslicht SS, Neylan TC, Metzler TJ, Otte C, Lenoci M, Henn-Haase C, Best S, Yehuda R, Marmar CR. PMID: 16891590.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder. Psychoneuroendocrinology. 2006 Aug; 31(7):825-38. Inslicht SS, Marmar CR, Neylan TC, Metzler TJ, Hart SL, Otte C, McCaslin SE, Larkin GL, Hyman KB, Baum A. PMID: 16716530.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    45. Posttraumatic stress associated with cancer history and BRCA1/2 genetic testing. Psychosom Med. 2005 Sep-Oct; 67(5):766-72. Hamann HA, Somers TJ, Smith AW, Inslicht SS, Baum A. PMID: 16204436.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    46. Similarity of prior trauma exposure as a determinant of chronic stress responding to an airline disaster. J Consult Clin Psychol. 2000 Apr; 68(2):290-5. Dougall AL, Herberman HB, Delahanty DL, Inslicht SS, Baum A. PMID: 10780129.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
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