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Linda Chao, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentRadiology
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-221-4810 ext. 24386
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    Collapse Biography 
    Collapse Awards and Honors
    National Institute of Mental Health1999Fellows Award for Research Excellence
    National Institute of Mental Health1994Pre-Doctoral Fellowship
    University of California, Davis1994Graduate Research Award

    Collapse Overview 
    Collapse Overview
    Linda Chao, PhD, is an Associate Adjunct Professor in the Department of Radiology and Biomedical Imaging and in the Department of Psychiatry at the University of California, San Francisco. Dr. Chao obtained her BS in Biological Science from the University of California, Davis in 1991, and she completed her PhD studies in Neuroscience from UCD in 1996. For the past 11-years, she has served as leader for the Psychiatry Block of the Interdepartmental Studies course 104, Brain, Mind and Behavior for first-year medical students.

    Dr. Chao’s professional activities primarily consist of conducting basic research using neuropsychological and imaging techniques to characterize how normal aging, neurodegenerative processes, stress, and exposure to neurotoxins affect the brain and cognition. She has an ongoing project, funded by the Department of Veterans Affairs, that seeks to use cognitive tests, structural, and diffusion tensor imaging to examine the effects of low-level exposure to sarin on brain structure and brain function in Gulf War Veterans. Dr. Chao has another project that is funded by the US Army Military Operational Medicine Research Program. The purpose of this project is to investigate the links between post-traumatic stress disorder (PTSD) and dementia.

    Dr. Chao serves as an Academic Editor for PlosOne and she has previously served as a reviewer for 26 scientific journals. Dr. Chao has 25 published articles and she has written 58 abstracts, 44 peer-reviewed articles, and 5 significant publications resulting from her research.

    Expertise:
    Neuroscience

    Specialty:
    Brain, neurodegenerative process, neuropsychological and imaging techniques

    Professional Interests:
    Cognitive neuroscience, memory, attention, aging, neurodegenerative disorders, post-traumatic stress disorder, magnetic resonance imaging, spectroscopic imaging, functional magnetic resonance imaging

    Education and Training:
    • Bachelor of Science: University of California, Davis - Biological Science
    • Doctor of Philosophy: University of California, Davis - Neuroscience


    Collapse Research 
    Collapse Research Activities and Funding
    Pilot Test of Telephone-Delivered Cognitive Behavioral Therapy for Insomnia for Veterans with Gulf War Illness
    VA I21CX001428Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Longitudinal assessment of Gulf War veterans with suspected Sarin exposure
    VA I01CX000798Oct 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    CORTICAL AND LIMBIC CONTRIBUTIONS TO AUDITORY MEMORY
    NIH/NIMH F31MH010958Mar 23, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chao L, Raymond MR, Leo CK, Abadjian LR. Evidence of Hippocampal Structural Alterations in Gulf War Veterans With Predicted Exposure to the Khamisiyah Plume. J Occup Environ Med. 2017 Oct; 59(10):923-929. PMID: 28692012.
      View in: PubMed
    2. Chao L. Evidence of Objective Memory Impairments in Deployed Gulf War Veterans With Subjective Memory Complaints. Mil Med. 2017 May; 182(5):e1625-e1631. PMID: 29087904.
      View in: PubMed
    3. Chao L. Associations Between the Self-Reported Frequency of Hearing Chemical Alarms in Theater and Visuospatial Function in Gulf War Veterans. J Occup Environ Med. 2016 Oct; 58(10):1014-1020. PMID: 27513172.
      View in: PubMed
    4. Chao L, Abadjian LR, Esparza IL, Reeb R. Insomnia Severity, Subjective Sleep Quality, and Risk for Obstructive Sleep Apnea in Veterans With Gulf War Illness. Mil Med. 2016 09; 181(9):1127-34. PMID: 27612364.
      View in: PubMed
    5. Chao L, Reeb R, Esparza IL, Abadjian LR. Associations between the self-reported frequency of hearing chemical alarms in theater and regional brain volume in Gulf War Veterans. Neurotoxicology. 2016 Mar; 53:246-256. PMID: 26920621.
      View in: PubMed
    6. Chao L, Tosun D, Woodward SH, Kaufer D, Neylan TC. Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. Front Behav Neurosci. 2015; 9:333. PMID: 26696852; PMCID: PMC4667092.
      View in: PubMed, PubMed Central
    7. Chao L, Zhang Y, Buckley S. Effects of low-level sarin and cyclosarin exposure on white matter integrity in Gulf War Veterans. Neurotoxicology. 2015 May; 48:239-48. PMID: 25929683.
      View in: PubMed
    8. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Stud Health Technol Inform. 2015; 216:736-40. PMID: 26262149.
      View in: PubMed
    9. Frazier DT, Seider T, Bettcher BM, Mack WJ, Jastrzab L, Chao L, Weiner MW, DeCarli C, Reed BR, Mungas D, Chui HC, Kramer JH. The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort. Cerebrovasc Dis. 2014; 38(6):441-7. PMID: 25502351; PMCID: PMC4303029.
      View in: PubMed, PubMed Central
    10. O'Donovan A, Chao L, Paulson J, Samuelson KW, Shigenaga JK, Grunfeld C, Weiner MW, Neylan TC. Altered inflammatory activity associated with reduced hippocampal volume and more severe posttraumatic stress symptoms in Gulf War veterans. Psychoneuroendocrinology. 2015 Jan; 51:557-66. PMID: 25465168; PMCID: PMC4374733.
      View in: PubMed, PubMed Central
    11. Chao L, Kriger S, Buckley S, Ng P, Mueller SG. Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans. Neurotoxicology. 2014 Sep; 44:263-9. PMID: 25058901.
      View in: PubMed
    12. Mohlenhoff BS, Chao L, Buckley ST, Weiner MW, Neylan TC. Are hippocampal size differences in posttraumatic stress disorder mediated by sleep pathology? Alzheimers Dement. 2014 Jun; 10(3 Suppl):S146-54. PMID: 24924666; PMCID: PMC4111235.
      View in: PubMed, PubMed Central
    13. Chao L, Yaffe K, Samuelson K, Neylan TC. Hippocampal volume is inversely related to PTSD duration. Psychiatry Res. 2014 Jun 30; 222(3):119-23. PMID: 24742925.
      View in: PubMed
    14. Chao L, Mohlenhoff BS, Weiner MW, Neylan TC. Associations between subjective sleep quality and brain volume in Gulf War veterans. Sleep. 2014 Mar 01; 37(3):445-52. PMID: 24587566; PMCID: PMC3920309.
      View in: PubMed, PubMed Central
    15. Chao L, Weiner M, Neylan T. Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Res. 2013 Sep 30; 213(3):193-201. PMID: 23816189.
      View in: PubMed
    16. Chao L, Decarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack WJ, Chui HC, Weiner MW. Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One. 2013; 8(6):e65175. PMID: 23762308.
      View in: PubMed
    17. Zhang Y, Schuff N, Camacho M, Chao L, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW. MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS One. 2013; 8(6):e66367. PMID: 23762488; PMCID: PMC3675142.
      View in: PubMed, PubMed Central
    18. Cardenas VA, Tosun D, Chao L, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43. PMID: 23421601; PMCID: PMC3951683.
      View in: PubMed, PubMed Central
    19. Cardenas VA, Reed B, Chao L, Chui H, Sanossian N, DeCarli CC, Mack W, Kramer J, Hodis HN, Yan M, Buonocore MH, Carmichael O, Jagust WJ, Weiner MW. Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults. Stroke. 2012 Nov; 43(11):2865-70. PMID: 22984010; PMCID: PMC3732460.
      View in: PubMed, PubMed Central
    20. Chao L, Lenoci M, Neylan TC. Effects of post-traumatic stress disorder on occipital lobe function and structure. Neuroreport. 2012 May 09; 23(7):412-9. PMID: 22453299.
      View in: PubMed
    21. Chao L, Abadjian L, Hlavin J, Meyerhoff DJ, Weiner MW. Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T. Neurotoxicology. 2011 Dec; 32(6):814-22. PMID: 21741405.
      View in: PubMed
    22. Mueller SG, Chao L, Berman B, Weiner MW. Evidence for functional specialization of hippocampal subfields detected by MR subfield volumetry on high resolution images at 4 T. Neuroimage. 2011 Jun 01; 56(3):851-7. PMID: 21419225; PMCID: PMC3085574.
      View in: PubMed, PubMed Central
    23. Chao L, Rothlind JC, Cardenas VA, Meyerhoff DJ, Weiner MW. Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans. Neurotoxicology. 2010 Sep; 31(5):493-501. PMID: 20580739; PMCID: PMC2934883.
      View in: PubMed, PubMed Central
    24. Chao L, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):19-27. PMID: 20220321; PMCID: PMC2865220.
      View in: PubMed, PubMed Central
    25. Cardenas VA, Meyerhoff DJ, Studholme C, Kornak J, Rothlind J, Lampiris H, Neuhaus J, Grant RM, Chao L, Truran D, Weiner MW. Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. J Neurovirol. 2009 Jul; 15(4):324-33. PMID: 19499454; PMCID: PMC2889153.
      View in: PubMed, PubMed Central
    26. Chao L, Pa J, Duarte A, Schuff N, Weiner MW, Kramer JH, Miller BL, Freeman KM, Johnson JK. Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):245-52. PMID: 19812467; PMCID: PMC2760039.
      View in: PubMed, PubMed Central
    27. Cardenas VA, Chao L, Studholme C, Yaffe K, Miller BL, Madison C, Buckley ST, Mungas D, Schuff N, Weiner MW. Brain atrophy associated with baseline and longitudinal measures of cognition. Neurobiol Aging. 2011 Apr; 32(4):572-80. PMID: 19446370; PMCID: PMC2891686.
      View in: PubMed, PubMed Central
    28. Pa J, Boxer A, Chao L, Gazzaley A, Freeman K, Kramer J, Miller BL, Weiner MW, Neuhaus J, Johnson JK. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Ann Neurol. 2009 Apr; 65(4):414-23. PMID: 19399879; PMCID: PMC2680500.
      View in: PubMed, PubMed Central
    29. Chao L, Mueller SG, Buckley ST, Peek K, Raptentsetseng S, Elman J, Yaffe K, Miller BL, Kramer JH, Madison C, Mungas D, Schuff N, Weiner MW. Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria. Neurobiol Aging. 2010 Mar; 31(3):368-77. PMID: 18550226; PMCID: PMC2814904.
      View in: PubMed, PubMed Central
    30. Chao L, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW. Patterns of white matter atrophy in frontotemporal lobar degeneration. Arch Neurol. 2007 Nov; 64(11):1619-24. PMID: 17998444; PMCID: PMC2443735.
      View in: PubMed, PubMed Central
    31. Cardenas VA, Boxer AL, Chao L, Gorno-Tempini ML, Miller BL, Weiner MW, Studholme C. Deformation-based morphometry reveals brain atrophy in frontotemporal dementia. Arch Neurol. 2007 Jun; 64(6):873-7. PMID: 17562936; PMCID: PMC2733361.
      View in: PubMed, PubMed Central
    32. Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv Exp Med Biol. 2006; 576:241-62; discussion 361-3. PMID: 16802717; PMCID: PMC1779762.
      View in: PubMed, PubMed Central
    33. Cardenas VA, Chao L, Blumenfeld R, Song E, Meyerhoff DJ, Weiner MW, Studholme C. Using automated morphometry to detect associations between ERP latency and structural brain MRI in normal adults. Hum Brain Mapp. 2005 Jul; 25(3):317-27. PMID: 15834860; PMCID: PMC2443725.
      View in: PubMed, PubMed Central
    34. Du AT, Schuff N, Chao L, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40. PMID: 15961190; PMCID: PMC1779763.
      View in: PubMed, PubMed Central
    35. Du AT, Schuff N, Chao L, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9. PMID: 15653183.
      View in: PubMed
    36. Chao L, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, Wolkowitz OM, Jagust WJ, Chui HC, Miller BL, Yaffe K, Weiner MW. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients. Neurology. 2005 Jan 25; 64(2):282-9. PMID: 15668426; PMCID: PMC1851679.
      View in: PubMed, PubMed Central
    37. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. PMID: 15592130; PMCID: PMC1820853.
      View in: PubMed, PubMed Central
    38. Chao L, Lindgren JA, Flenniken DL, Weiner MW. ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy. Clin Neurophysiol. 2004 Jul; 115(7):1583-91. PMID: 15203059; PMCID: PMC2367143.
      View in: PubMed, PubMed Central
    39. Meyerhoff DJ, Blumenfeld R, Truran D, Lindgren J, Flenniken D, Cardenas V, Chao L, Rothlind J, Studholme C, Weiner MW. Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites. Alcohol Clin Exp Res. 2004 Apr; 28(4):650-61. PMID: 15100618; PMCID: PMC2365749.
      View in: PubMed, PubMed Central
    40. Chao L, Cardenas VA, Meyerhoff DJ, Rothlind JC, Flenniken DL, Lindgren JA, Weiner MW. Abnormal contingent negative variation in HIV patients receiving antiretroviral therapy. Neuroreport. 2003 Nov 14; 14(16):2111-5. PMID: 14600507; PMCID: PMC2733942.
      View in: PubMed, PubMed Central
    41. Chao L, Meyerhoff DJ, Cardenas VA, Rothlind JC, Weiner MW. Abnormal CNV in chronic heavy drinkers. Clin Neurophysiol. 2003 Nov; 114(11):2081-95. PMID: 14580606.
      View in: PubMed
    42. Chao L, Weisberg J, Martin A. Experience-dependent modulation of category-related cortical activity. Cereb Cortex. 2002 May; 12(5):545-51. PMID: 11950772.
      View in: PubMed
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