Sanjeev Datar, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #1418
San Francisco CA 94143
Phone415-502-6391
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    University of California, San FranciscoFellowship, Pediatric Critical Care Medicine2008School of Medicine
    University of California, San FranciscoResidency, Pediatrics2004School of Medicine
    University of WashingtonM.D.2001School of Medicine
    University of Washington/Fred Hutchinson Cancer Research CenterPh.D.2000Molecular and Cellular Biology
    Yale UniversityB.S.1991Molecular Biophysics & Biochemistry
    Collapse Awards and Honors
    UCSF2022RAP Pilot Grant for Established Investigators
    UCSF Benioff Children's Hospitals2022Pediatric Heart Center Catalyst Award
    UCSF2014RAP Pilot Grant for Junior Investigators
    Council of the Society for Pediatric Research2013Elected as Member of the Society for Pediatric Research
    The Pediatric Social Work Department, UCSF Benioff Children's Hospital2013Ida M. Cannon Award: The Dorothy Bradley Award for Integrity
    The Haile T. Debas Academy of Medical Educators2012Excellence in Teaching Award
    American Heart Association2012WSA Beginning Grant-in-Aid Award
    Children's Hospital & Research Center Oakland2007Charlotte Coleman Frey Pediatric Intensive Care Fellowship Award
    Science and Health Education Partnership2003ACE Partnership Award
    Achievement Rewards for College Scientists (ARCS)1998ARCS Foundation Fellow
    Fred Hutchinson Cancer Research Center1995Fred Hutchinson Scholarship Award for Outstanding Scholarship in the Field of Cancer Research
    University of Washington1992  - 2000MSTP Fellow

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Altered Lymphatic Function and Development in Congenital Heart Disease
    NIH R01HL133034Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Altered Lymphatics in an Ovine Cardiac Model of Increased Pulmonary Blood Flow
    NIH K08HL116763Aug 1, 2013 - May 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 1180: PULMONARY PULSE WAVE ANALYSIS: A NOVEL MODEL TO IDENTIFY VASCULAR INJURY IN PULMONARY HYPERTENSION. Critical Care Medicine. 2023 Dec 14; 52(1):s562-s562. Ahmed AY, Bennett BS, Boehme BJ, Teitel TD, Fineman FJ, Datar DS. .
      View in: Publisher Site   Mentions:
    2. Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation. Nitric Oxide. 2024 Jan 01; 142:58-68. Boehme JT, Sun X, Lu Q, Barton J, Wu X, Gong W, Raff GW, Datar SA, Wang T, Fineman JR, Black SM. PMID: 38061411.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure. Front Physiol. 2023; 14:1188824. Soares JHN, Raff GW, Fineman JR, Datar SA. PMID: 37362431; PMCID: PMC10288580.
      View in: PubMed   Mentions:
    4. HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Sci Rep. 2021 01 14; 11(1):1468. Boehme JT, Morris CJ, Chiacchia SR, Gong W, Wu KY, Kameny RJ, Raff GW, Fineman JR, Maltepe E, Datar SA. PMID: 33446832; PMCID: PMC7809484.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020922118. Zhu T, Chiacchia S, Kameny RJ, Garcia De Herreros A, Gong W, Raff GW, Boehme JB, Maltepe E, Lasheras JC, Black SM, Datar SA, Fineman JR. PMID: 32489641; PMCID: PMC7238833.
      View in: PubMed   Mentions: 1  
    6. Mechanical Forces Alter Endothelin-1 Signaling: Comparative Ovine Models of Congenital Heart Disease. Biophysical Journal. 2020 Feb 1; 118(3):251a-252a. Garcia-Herreros GA, Kameny KR, Zhu ZT, Boehme BJ, Raff RG, Lasheras LJ, Black BS, Maltepe ME, Datar DS, Fineman FJ. .
      View in: Publisher Site   Mentions:
    7. The Adaptive Right Ventricle in Eisenmenger Syndrome: Potential Therapeutic Targets for Pulmonary Hypertension?. . 2020 Jan 1; 183-192. Kameny KR, Datar DS, Boehme BJ, Fineman FJ. .
      View in: Publisher Site   Mentions:
    8. Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling. Am J Respir Cell Mol Biol. 2019 05; 60(5):503-514. Johnson Kameny R, Datar SA, Boehme JB, Morris C, Zhu T, Goudy BD, Johnson EG, Galambos C, Raff GW, Sun X, Wang T, Chiacchia SR, Lu Q, Black SM, Maltepe E, Fineman JR. PMID: 30620615; PMCID: PMC6503613.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. Correction: Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2019 Jan; 17(1):e3000119. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30677022; PMCID: PMC6345423.
      View in: PubMed   Mentions: 1     Fields:    
    10. Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic. PLoS Biol. 2018 10; 16(10):e2005924. Boehme J, Le Moan N, Kameny RJ, Loucks A, Johengen MJ, Lesneski AL, Gong W, Goudy BD, Davis T, Tanaka K, Davis A, He Y, Long-Boyle J, Ivaturi V, Gobburu JVS, Winger JA, Cary SP, Datar SA, Fineman JR, Krtolica A, Maltepe E. PMID: 30335746; PMCID: PMC6193608.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    11. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H847-H854. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. PMID: 29906222; PMCID: PMC6230913.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. Lymphatic dysfunction in critical illness. Curr Opin Pediatr. 2018 06; 30(3):332-337. Burke E, Datar SA. PMID: 29538048; PMCID: PMC6002844.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. KLF2-mediated disruption of PPAR-γ signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H173-H181. Morris CJ, Kameny RJ, Boehme J, Gong W, He Y, Zhu T, Maltepe E, Raff GW, Fineman JR, Datar SA. PMID: 29631374; PMCID: PMC6087778.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Oct; 18(10):931-934. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar SA, Fineman JR. PMID: 28723882; PMCID: PMC5628126.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 10 01; 311(4):H944-H957. Boehme J, Sun X, Tormos KV, Gong W, Kellner M, Datar SA, Kameny RJ, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E. PMID: 27591215; PMCID: PMC5114466.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    16. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 07 01; 311(1):H137-45. Datar SA, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. PMID: 27199125; PMCID: PMC4967199.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015 Jul 01; 309(1):H157-65. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar SA, Oishi PE, Fineman JR. PMID: 25934095; PMCID: PMC4491525.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. 220. Critical Care Medicine. 2014 Dec 1; 42(12):a1413. Kameny KR, Morris MC, He HY, Sun SC, Maki MJ, Datar DS, Oishi OP, Fineman FJ. .
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    19. 162. Critical Care Medicine. 2014 Dec 1; 42(12):a1399. Maki MJ, Johnson JR, Datar DS, Gong GW, Johengen JM, Sun SC, Oishi OP, Fineman FJ. .
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    20. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. J Cell Physiol. 2014 Nov; 229(11):1802-16. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar SA, Verin AD, Fineman JR, Black SM. PMID: 24677020; PMCID: PMC4117725.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1222-30. Johnson RC, Datar SA, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR. PMID: 24561861; PMCID: PMC3989751.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    22. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H954-62. Datar SA, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR. PMID: 24531811; PMCID: PMC4116402.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Pulmonary Hypertension. Pediatric Critical Care Medicine. 2014 Jan 1; 263-281. Oishi OP, Datar DS, Fineman FJ. .
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    24. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul; 148(1):212-9. Radman M, Keller RL, Oishi P, Datar SA, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR. PMID: 24079880; PMCID: PMC3968237.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res. 2013 Jul; 74(1):39-47. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar SA, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM. PMID: 23628882; PMCID: PMC3709010.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50. Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. PMID: 23583172; PMCID: PMC3787941.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    27. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. J Cell Biochem. 2013 Feb; 114(2):435-447. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar SA, Sharma S, Azakie A, Fineman JR, Black SM. PMID: 22961736; PMCID: PMC3906673.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther. 2013 Apr; 26(2):271-80. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar SA, Fineman JR, Black SM. PMID: 23257346; PMCID: PMC3872991.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61. Oishi PE, Sharma S, Datar SA, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. PMID: 23128423; PMCID: PMC3977665.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    30. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. PMID: 22961274; PMCID: PMC3574568.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. PPAR-γ regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PLoS One. 2012; 7(9):e41555. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar SA, Raff G, Fineman JR, Black SM. PMID: 22962578; PMCID: PMC3433474.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    32. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. PMID: 22914252.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    33. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. PMID: 22614905; PMCID: PMC3651824.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. B-Type Natriuretic Peptide (BNP) in Neonates, Infants and Children Undergoing Cardiac Surgery. Front Lines of Thoracic Surgery. 2012 Feb 3. Oishi OP, Field-Ridley FA, Datar DS, Fineman FJ. .
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    35. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L530-40. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR. PMID: 22207591; PMCID: PMC3311527.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    36. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011 Dec; 226(12):3104-13. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM. PMID: 21351102; PMCID: PMC3527072.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    37. Advances in the management of pediatric pulmonary hypertension. Respir Care. 2011 Sep; 56(9):1314-39; discussion 1339-40. Oishi P, Datar SA, Fineman JR. PMID: 21944683.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    38. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert Opin Pharmacother. 2011 Aug; 12(12):1845-64. Oishi P, Datar SA, Fineman JR. PMID: 21609302.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    39. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiol Genomics. 2011 Jan 01; 43(2):87-98. Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar SA, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM. PMID: 20978110; PMCID: PMC3026563.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L880-7. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. PMID: 20363848; PMCID: PMC2886608.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    41. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. PMID: 19818875; PMCID: PMC2879580.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. A CAUSAL DESIGN TRAJECTORY LINKS DIVERSE FORMS OF PULMONARY HYPERTENSION: EVIDENCE OF A FETAL PHENOTYPE OF ARTERIAL REMODELING UNDER THE PRINCIPLE OF MINIMUM WORK. CHEST Journal. 2009 Oct 1; 136(4):58s-a1-58s-a2. Allen AR, Raff RG, Datar DS, Moon MA, Milstein MJ, Bennett BS, Black BS, Fineman FJ, Eldridge EM. .
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    43. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L756-66. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. PMID: 18757524; PMCID: PMC2584884.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    44. Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila. Cell Cycle. 2006 Mar; 5(6):647-52. Datar SA, Galloni M, de la Cruz A, Marti M, Edgar BA, Frei C. PMID: 16582602.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    45. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 2000 Sep 01; 19(17):4533-42. Meyer CA, Jacobs HW, Datar SA, Du W, Edgar BA, Lehner CF. PMID: 10970847; PMCID: PMC302073.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    46. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 2000 Sep 01; 19(17):4543-54. Datar SA, Jacobs HW, de la Cruz AF, Lehner CF, Edgar BA. PMID: 10970848; PMCID: PMC302080.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    47. Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program. Genes Dev. 1996 Aug 01; 10(15):1966-77. Edgar BA, Datar SA. PMID: 8756353.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
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