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Sanjeev Datar, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-9283
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoFellowship, Pediatric Critical Care Medicine2008School of Medicine
    University of California, San FranciscoResidency, Pediatrics2004School of Medicine
    University of WashingtonM.D.2001School of Medicine
    University of Washington/Fred Hutchinson Cancer Research CenterPh.D.2000Molecular and Cellular Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Altered Lymphatic Function and Development in Congenital Heart Disease
    NIH/NHLBI R01HL133034Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Altered Lymphatics in an Ovine Cardiac Model of Increased Pulmonary Blood Flow
    NIH/NHLBI K08HL116763Aug 1, 2013 - May 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Black SM, Field-Ridley A, Sharma S, Kumar S, Keller RL, Kameny R, Maltepe E, Datar S, Fineman JR. Altered Carnitine Homeostasis in Children With Increased Pulmonary Blood Flow Due to Ventricular Septal Defects. Pediatr Crit Care Med. 2017 Jul 18. PMID: 28723882.
      View in: PubMed
    2. Boehme J, Sun X, Tormos K, Gong W, Kellner M, Datar S, Johnson Kameny R, Yuan JX, Raff GW, Fineman JR, Black SM, Maltepe E, et al. Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. Am J Physiol Heart Circ Physiol. 2016 Sep 2; ajpheart.00040.2016. PMID: 27591215.
      View in: PubMed
    3. Datar S, Gong W, He Y, Johengen M, Kameny RJ, Raff GW, Maltepe E, Oishi PE, Fineman JR. Disrupted NOS signaling in lymphatic endothelial cells exposed to chronically increased pulmonary lymph flow. Am J Physiol Heart Circ Physiol. 2016 Jul 1; 311(1):H137-45. PMID: 27199125.
      View in: PubMed
    4. Kameny RJ, He Y, Morris C, Sun C, Johengen M, Gong W, Raff GW, Datar S, Oishi PE, Fineman JR. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Am J Physiol Heart Circ Physiol. 2015 Jul 1; 309(1):H157-65. PMID: 25934095; PMCID: PMC4491525 [Available on 07/01/16].
    5. Gross CM, Aggarwal S, Kumar S, Tian J, Kasa A, Bogatcheva N, Datar S, Verin AD, Fineman JR, Black SM. Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress. J Cell Physiol. 2014 Nov; 229(11):1802-16. PMID: 24677020; PMCID: PMC4117725.
    6. Johnson RC, Datar S, Oishi PE, Bennett S, Maki J, Sun C, Johengen M, He Y, Raff GW, Redington AN, Fineman JR. Adaptive right ventricular performance in response to acutely increased afterload in a lamb model of congenital heart disease: evidence for enhanced Anrep effect. Am J Physiol Heart Circ Physiol. 2014 Apr 15; 306(8):H1222-30. PMID: 24561861; PMCID: PMC3989751.
    7. Datar S, Oishi PE, Gong W, Bennett SH, Sun CE, Johengen M, Maki J, Johnson RC, Raff GW, Fineman JR. Altered reactivity and nitric oxide signaling in the isolated thoracic duct from an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2014 Apr 1; 306(7):H954-62. PMID: 24531811; PMCID: PMC4116402.
    8. Radman M, Keller RL, Oishi P, Datar S, Wellnitz K, Azakie A, Hanley F, Char D, Hsu JH, Amrinovin R, Adatia I, Fineman JR. Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan). J Thorac Cardiovasc Surg. 2014 Jul; 148(1):212-9. PMID: 24079880; PMCID: PMC3968237.
    9. Sharma S, Aramburo A, Rafikov R, Sun X, Kumar S, Oishi PE, Datar S, Raff G, Xoinis K, Kalkan G, Fratz S, Fineman JR, Black SM. L-carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow. Pediatr Res. 2013 Jul; 74(1):39-47. PMID: 23628882; PMCID: PMC3709010.
    10. Radman M, Mack R, Barnoya J, Castañeda A, Rosales M, Azakie A, Mehta N, Keller R, Datar S, Oishi P, Fineman J. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50. PMID: 23583172; PMCID: PMC3787941.
    11. Kumar S, Oishi PE, Rafikov R, Aggarwal S, Hou Y, Datar S, Sharma S, Azakie A, Fineman JR, Black SM. Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. J Cell Biochem. 2013 Feb; 114(2):435-47. PMID: 22961736; PMCID: PMC3906673.
    12. Sharma S, Barton J, Rafikov R, Aggarwal S, Kuo HC, Oishi PE, Datar S, Fineman JR, Black SM. Chronic inhibition of PPAR-? signaling induces endothelial dysfunction in the juvenile lamb. Pulm Pharmacol Ther. 2013 Apr; 26(2):271-80. PMID: 23257346; PMCID: PMC3872991.
    13. Oishi PE, Sharma S, Datar S, Kumar S, Aggarwal S, Lu Q, Raff G, Azakie A, Hsu JH, Sajti E, Fratz S, Black SM, Fineman JR. Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow. Pediatr Res. 2013 Jan; 73(1):54-61. PMID: 23128423; PMCID: PMC3977665.
    14. Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol. 2013 Feb; 34(2):291-5. PMID: 22961274; PMCID: PMC3574568.
    15. Sharma S, Sun X, Rafikov R, Kumar S, Hou Y, Oishi PE, Datar S, Raff G, Fineman JR, Black SM. PPAR-? regulates carnitine homeostasis and mitochondrial function in a lamb model of increased pulmonary blood flow. PLoS One. 2012; 7(9):e41555. PMID: 22962578; PMCID: PMC3433474.
    16. Amirnovin R, Keller RL, Herrera C, Hsu JH, Datar S, Karl TR, Adatia I, Oishi P, Fineman JR. B-type natriuretic peptide levels predict outcomes in infants undergoing cardiac surgery in a lesion-dependent fashion. J Thorac Cardiovasc Surg. 2013 May; 145(5):1279-87. PMID: 22914252.
      View in: PubMed
    17. Radman MR, Goldhoff P, Jones KD, Azakie A, Datar S, Adatia I, Oishi PE, Fineman JR. Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease? Pediatr Cardiol. 2013 Jun; 34(5):1254-7. PMID: 22614905; PMCID: PMC3651824.
    18. Datar S, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay MA, Fineman JR. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L530-40. PMID: 22207591; PMCID: PMC3311527.
    19. Aggarwal S, Gross CM, Kumar S, Datar S, Oishi P, Kalkan G, Schreiber C, Fratz S, Fineman JR, Black SM. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011 Dec; 226(12):3104-13. PMID: 21351102; PMCID: PMC3527072.
    20. Oishi P, Datar S, Fineman JR. Advances in the management of pediatric pulmonary hypertension. Respir Care. 2011 Sep; 56(9):1314-39; discussion 1339-40. PMID: 21944683.
      View in: PubMed
    21. Oishi P, Datar S, Fineman JR. Pediatric pulmonary arterial hypertension: current and emerging therapeutic options. Expert Opin Pharmacother. 2011 Aug; 12(12):1845-64. PMID: 21609302.
      View in: PubMed
    22. Tian J, Fratz S, Hou Y, Lu Q, Görlach A, Hess J, Schreiber C, Datar S, Oishi P, Nechtman J, Podolsky R, She JX, Fineman JR, Black SM. Delineating the angiogenic gene expression profile before pulmonary vascular remodeling in a lamb model of congenital heart disease. Physiol Genomics. 2011 Jan 1; 43(2):87-98. PMID: 20978110; PMCID: PMC3026563.
    23. Hsu JH, Oishi P, Wiseman DA, Hou Y, Chikovani O, Datar S, Sajti E, Johengen MJ, Harmon C, Black SM, Fineman JR. Nitric oxide alterations following acute ductal constriction in the fetal lamb: a role for superoxide. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L880-7. PMID: 20363848; PMCID: PMC2886608.
    24. Sharma S, Kumar S, Sud N, Wiseman DA, Tian J, Rehmani I, Datar S, Oishi P, Fratz S, Venema RC, Fineman JR, Black SM. Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow. Vascul Pharmacol. 2009 Nov-Dec; 51(5-6):359-64. PMID: 19818875; PMCID: PMC2879580.
    25. Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar S, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L756-66. PMID: 18757524; PMCID: PMC2584884.
    26. Datar S, Galloni M, de la Cruz A, Marti M, Edgar BA, Frei C. Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila. Cell Cycle. 2006 Mar; 5(6):647-52. PMID: 16582602.
      View in: PubMed
    27. Datar S, Jacobs HW, de la Cruz AF, Lehner CF, Edgar BA. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 2000 Sep 1; 19(17):4543-54. PMID: 10970848; PMCID: PMC302080.
    28. Meyer CA, Jacobs HW, Datar S, Du W, Edgar BA, Lehner CF. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 2000 Sep 1; 19(17):4533-42. PMID: 10970847; PMCID: PMC302073.
    29. Venezian R, Shenker BJ, Datar S, Leboy PS. Modulation of chondrocyte proliferation by ascorbic acid and BMP-2. J Cell Physiol. 1998 Mar; 174(3):331-41. PMID: 9462695.
      View in: PubMed
    30. InSug O, Datar S, Koch CJ, Shapiro IM, Shenker BJ. Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve. Toxicology. 1997 Dec 31; 124(3):211-24. PMID: 9482123.
      View in: PubMed
    31. Edgar BA, Datar S. Zygotic degradation of two maternal Cdc25 mRNAs terminates Drosophila's early cell cycle program. Genes Dev. 1996 Aug 1; 10(15):1966-77. PMID: 8756353.
      View in: PubMed
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