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Srinath Sanda, MD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Phone415-514-5234
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    Collapse Overview 
    Collapse Interests

    Collapse Research 
    Collapse Research Activities and Funding
    Functional Interrogation of Non-Coding Type 1 Diabetes Risk Variants in Human Immune Cells and Beta Cells
    NIH/NIDDK DP3DK111914Sep 30, 2016 - Jun 30, 2021
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James EA, French D, Lelic A, Larché M, Altman MC, Togias A, Durham SR. Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen. J Allergy Clin Immunol. 2020 Mar 10. PMID: 32169380.
      View in: PubMed
    2. Norris AW, Ode KL, Merjaneh L, Sanda S, Yi Y, Sun X, Engelhardt JF, Hull RL. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. J Endocrinol. 2019 Feb 01. PMID: 30759072.
      View in: PubMed
    3. Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL. Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control. Matrix Biol. 2019 07; 80:46-58. PMID: 30196101.
      View in: PubMed
    4. Hull RL, Gibson RL, McNamara S, Deutsch GH, Fligner CL, Frevert CW, Ramsey BW, Sanda S. Islet Interleukin-1ß Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to ß-Cell Failure. Diabetes Care. 2018 04; 41(4):823-830. PMID: 29437698.
      View in: PubMed
    5. Long SA, Thorpe J, Herold KC, Ehlers M, Sanda S, Lim N, Linsley PS, Nepom GT, Harris KM. Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes. Cell Immunol. 2017 Sep; 319:3-9. PMID: 28844471.
      View in: PubMed
    6. Sanda S. Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests. Pediatr Diabetes. 2018 03; 19(2):271-276. PMID: 28707353.
      View in: PubMed
    7. Spindler MP, Ho AM, Tridgell D, McCulloch-Olson M, Gersuk V, Ni C, Greenbaum C, Sanda S. Acute hyperglycemia impairs IL-6 expression in humans. Immun Inflamm Dis. 2016 Mar; 4(1):91-7. PMID: 27042306.
      View in: PubMed
    8. Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT. Avidity-dependent programming of autoreactive T cells in T1D. PLoS One. 2014; 9(5):e98074. PMID: 24844227.
      View in: PubMed
    9. Mauseth R, Hirsch IB, Bollyky J, Kircher R, Matheson D, Sanda S, Greenbaum C. Use of a "fuzzy logic" controller in a closed-loop artificial pancreas. Diabetes Technol Ther. 2013 Aug; 15(8):628-33. PMID: 23829285.
      View in: PubMed
    10. Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS, Pickersgill L, de Koning E, Ziegler AG, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castaño L, Wägner A, Lervang HH, Perrild H, Mandrup-Poulsen T. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet. 2013 Jun 01; 381(9881):1905-15. PMID: 23562090.
      View in: PubMed
    11. Yang J, James EA, Sanda S, Greenbaum C, Kwok WW. CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring. Immunology. 2013 Mar; 138(3):269-79. PMID: 23228173.
      View in: PubMed
    12. Chiu HK, Sanda S, Fechner PY, Pihoker C. Correlation of TSH with the risk of paediatric thyroid carcinoma. Clin Endocrinol (Oxf). 2012 Aug; 77(2):316-22. PMID: 22404106.
      View in: PubMed
    13. Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, Bluestone JA, Buckner JH, Greenbaum CJ. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs ß-cell function. Diabetes. 2012 Sep; 61(9):2340-8. PMID: 22721971.
      View in: PubMed
    14. Greenbaum CJ, Schatz DA, Haller MJ, Sanda S. Through the fog: recent clinical trials to preserve ß-cell function in type 1 diabetes. Diabetes. 2012 Jun; 61(6):1323-30. PMID: 22618767.
      View in: PubMed
    15. Sanda S, Wei S, Rue T, Shilling H, Greenbaum C. A SNP in G6PC2 predicts insulin secretion in type 1 diabetes. Acta Diabetol. 2013 Jun; 50(3):459-62. PMID: 22438186.
      View in: PubMed
    16. Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):E715-24. PMID: 22308341.
      View in: PubMed
    17. Hondowicz BD, Schwedhelm KV, Kas A, Tasch MA, Rawlings C, Ramchurren N, McIntosh M, D'Amico LA, Sanda S, Standifer NE, Shendure J, Stone B. Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries. PLoS One. 2012; 7(1):e29949. PMID: 22253836.
      View in: PubMed
    18. Habib T, Funk A, Rieck M, Brahmandam A, Dai X, Panigrahi AK, Luning Prak ET, Meyer-Bahlburg A, Sanda S, Greenbaum C, Rawlings DJ, Buckner JH. Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant. J Immunol. 2012 Jan 01; 188(1):487-96. PMID: 22105996.
      View in: PubMed
    19. Sanda S, Greenbaum CJ. Comment on: Atkinson. It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes. Diabetes 2011;60:361-363. Diabetes. 2011 Jun; 60(6):e17, author reply e18. PMID: 21617183.
      View in: PubMed
    20. Sanda S, Bollyky J, Standifer N, Nepom G, Hamerman JA, Greenbaum C. Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes. Clin Immunol. 2010 Aug; 136(2):170-3. PMID: 20483667.
      View in: PubMed
    21. S. Alice Long, Karen Cerosaletti, Heather Shilling, Paul Bollyky, David Rawlings, Srinath Sanda, Jane Buckner. A T1D-associated Variant of PTPN2 Correlates with Decreased IL-2/IL-15 Responsiveness, Reduced FOXP3 Expression and Altered CD8 T Cell Differentiation. Clinical Immunology. 2010 Jan 1; 135:s118.
      View in: Publisher Site
    22. Brian Hondowicz, Katharine Schwedhelm, Arnold Kas, Michael Tasch, Nirasha Ramchurren, Nathan Standifer, Srinath Sanda, Crystal Rawlings, Jay Shendure, Brad Stone. High-throughput Screening for CD8+ T Cell Epitopes Targeted in Type 1 Diabetes. Clinical Immunology. 2010 Jan 1; 135:s19.
      View in: Publisher Site
    23. Srinath Sanda, Jenna Bollyky, Gerald Nepom, Jessica Hamerman, Carla Greenbaum. Reduced CD11b Integrin Expression with Short-term Administration of an IL-1R Antagonist in Type 1 Diabetes Patients. Clinical Immunology. 2010 Jan 1; 135:s106-s107.
      View in: Publisher Site
    24. Long SA, Cerosaletti K, Bollyky PL, Tatum M, Shilling H, Zhang S, Zhang ZY, Pihoker C, Sanda S, Greenbaum C, Buckner JH. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes. 2010 Feb; 59(2):407-15. PMID: 19875613.
      View in: PubMed
    25. Long SA, Walker MR, Rieck M, James E, Kwok WW, Sanda S, Pihoker C, Greenbaum C, Nepom GT, Buckner JH. Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects. Eur J Immunol. 2009 Feb; 39(2):612-20. PMID: 19180473.
      View in: PubMed
    26. Srinath Sanda, Jennifer Bollyky, Emily Burwell, Nathan Standifer, Gerald Nepom, Carla Greenbaum. T.128. Short-term Administration of Anakinra does not Appear to Affect Stimulated C-peptide Responses Acutely in Patients with Type 1 Diabetes. Clinical Immunology. 2009 Jan 1; 131:s89.
      View in: Publisher Site
    27. Ivana Durinovic-Bello, Rebecca Wu, Srinath Sanda, Gerald Nepom. F.69. Selection of Antigen Specific Autoreactive T Cells is Influenced by INS-VNTR Genotype. Clinical Immunology. 2009 Jan 1; 131:s112.
      View in: Publisher Site
    28. S. Alice Long, Paul Bollyky, Karen Cerosaletti, Heather Shilling, Catherine Pihoker, Srinath Sanda, Carla Greenbaum, Jane Buckner. OR.62. Impaired IL-2 Responsiveness and Treg Persistence in T1D is Revealed by Disease-Associated Variants in PTPN2. Clinical Immunology. 2009 Jan 1; 131:s26-s27.
      View in: Publisher Site
    29. Schneider A, Rieck M, Sanda S, Pihoker C, Greenbaum C, Buckner JH. The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol. 2008 Nov 15; 181(10):7350-5. PMID: 18981158.
      View in: PubMed
    30. Bollyky J, Sanda S, Greenbaum CJ. Type 1 diabetes mellitus: primary, secondary, and tertiary prevention. Mt Sinai J Med. 2008 Aug; 75(4):385-97. PMID: 18729155.
      View in: PubMed
    31. Sanda S, Schlingmann KP, Newfield RS. Autosomal dominant hypoparathyroidism with severe hypomagnesemia and hypocalcemia, successfully treated with recombinant PTH and continuous subcutaneous magnesium infusion. J Pediatr Endocrinol Metab. 2008 Apr; 21(4):385-91. PMID: 18556971.
      View in: PubMed
    32. Sanda S, Roep BO, von Herrath M. Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. Clin Immunol. 2008 May; 127(2):138-43. PMID: 18304876.
      View in: PubMed
    33. Sanda S, Newfield RS. A child with pericardial effusion and cardiac tamponade due to previously unrecognized hypothyroidism. J Natl Med Assoc. 2007 Dec; 99(12):1411-3. PMID: 18229779.
      View in: PubMed
    34. von Herrath M, Sanda S, Herold K. Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol. 2007 Dec; 7(12):988-94. PMID: 17982429.
      View in: PubMed
    35. Srinath Sanda, Bart Roep, Matthias von Herrath. Reduced Foxp3 and Interleukin 10 Expression During the Partial Remission Phase of Type 1 Diabetes in Children. Clinical Immunology. 2007 Jan 1; 123:s16.
      View in: Publisher Site