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Anne Schafer, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 24895
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityB.A.History and Science
    University of California, San FranciscoM.D.Medicine
    University of California, San FranciscoInternship and ResidencyInternal Medicine
    University of California, San FranciscoFellowshipEndocrinology and Metabolism
    San Francisco VA Medical CenterFellowshipWomen's Health
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Dr. Schafer is Associate Professor of Medicine and of Epidemiology & Biostatistics at UCSF and Chief of Endocrinology and Metabolism at the San Francisco VA Health Care System. She is board-certified by the American Board of Internal Medicine in the subspecialty of Endocrinology, Diabetes and Metabolism. Her research focus is osteoporosis and bone metabolism. One of her research emphases is osteoporosis treatment and the assessment of response to osteoporosis therapy. She also studies the relationships between bone, fat, and glucose metabolism, including the effects of obesity and diabetes on bone, and the skeletal regulation of energy metabolism. Currently, she is investigating the effects of bariatric surgery (weight loss surgery) on calcium metabolism and skeletal health. Dr. Schafer's research has been funded by the NIH (National Institute of Diabetes and Digestive and Kidney Diseases), the US Department of Veterans Affairs, and the American Society for Bone and Mineral Research.

    Collapse Research 
    Collapse Research Activities and Funding
    Skeletal Health in Type 1 Diabetes and the Role of Diabetic Kidney Disease
    NIH/NIDDK R01DK125646Sep 10, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Prebiotic Intervention to Improve Calcium Absorption After Gastric Bypass Surgery
    NIH/NIDDK R21DK112126Jul 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Effects of Sleeve Gastrectomy on Calcium Metabolism and the Skeleton
    NIH R01DK107629Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    NIH IK2CX000549Apr 1, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner. Bone. 2020 Sep; 138:115505. Wu PH, Gupta T, Chang H, Petrenko D, Schafer A, Kazakia G. PMID: 32599223.
      View in: PubMed   Mentions:    Fields:    
    2. Increases in PYY and uncoupling of bone turnover are associated with loss of bone mass after gastric bypass surgery. Bone. 2020 02; 131:115115. Kim TY, Shoback DM, Black DM, Rogers SJ, Stewart L, Carter JT, Posselt AM, King NJ, Schafer AL. PMID: 31689523.
      View in: PubMed   Mentions:    Fields:    
    3. Commercial Laboratory Reproducibility of Serum CTX in Clinical Practice. JBMR Plus. 2019 Oct; 3(10):e10225. Hindi SM, Vittinghoff E, Schafer AL, Silverman S, Bauer DC. PMID: 31687653.
      View in: PubMed   Mentions:
    4. Roux-en-Y gastric bypass is a safe and effective option that improves major Co-Morbidities associated with obesity in an older, veteran population. Am J Surg. 2019 10; 218(4):684-688. Lyo V, Schafer AL, Stewart L. PMID: 31399194.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Bone Quality Sleuths: Uncovering Tissue-Level Mechanisms of Bone Fragility in Human Type 2 Diabetes. J Bone Miner Res. 2019 07; 34(7):1189-1190. Alliston T, Schafer A. PMID: 31225923.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. High dose vitamin D supplementation does not rescue bone loss following Roux-en-Y gastric bypass in female rats. Bone. 2019 10; 127:172-180. Niu A, Carpenter TO, Grams JM, Bozorgmehri S, Tommasini SM, Schafer AL, Canales BK. PMID: 31226531.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery. J Clin Endocrinol Metab. 2019 03 01; 104(3):711-720. Alba DL, Wu L, Cawthon PM, Mulligan K, Lang T, Patel S, King NJ, Carter JT, Rogers SJ, Posselt AM, Stewart L, Shoback DM, Schafer AL. PMID: 30657952.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Leptinemia is Associated With Peripheral Artery Disease. J Surg Res. 2019 06; 238:48-56. Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM. PMID: 30738358.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Comparison of BMD Changes and Bone Formation Marker Levels 3 Years After Bisphosphonate Discontinuation: FLEX and HORIZON-PFT Extension I Trials. J Bone Miner Res. 2019 05; 34(5):810-816. Kim TY, Bauer DC, McNabb BL, Schafer AL, Cosman F, Black DM, Eastell R. PMID: 30536713.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    10. Trunk Muscle Composition 2 Months After Hip Fracture: Findings From the Baltimore Hip Studies. Arch Phys Med Rehabil. 2019 09; 100(9):1663-1671. Hicks GE, Shardell MD, Miller RR, Eastlack M, Orwig DL, Goodpaster BH, Chomentowski PJ, Hochberg MC, Rathbun AM, Cauley JA, Harris T, Satterfield S, Schafer AL, Magaziner J. PMID: 30578772.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease. J Vasc Surg. 2019 02; 69(2):497-506. Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM. PMID: 30292618.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans. J Clin Endocrinol Metab. 2018 09 01; 103(9):3194-3204. Alba DL, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK. PMID: 29846621.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. PC128. Serum Resistin Is Associated With Impaired Endothelial Function and Poor Outcomes in Patients With Peripheral Artery Disease. Journal of Vascular Surgery. 2018 Jun 1; 67(6):e208-e209. Joel L. Ramirez, Sukaynah A. Khetani, Greg J. Zahner, Melinda S. Schaller, Warren J. Gasper, Nancy K. Hills, Anne L. Schafer, S. Marlene Grenon. .
      View in: Publisher Site   Mentions:
    14. Bone Health After Bariatric Surgery. JBMR Plus. 2018 May; 2(3):121-133. Gagnon C, Schafer AL. PMID: 30283897.
      View in: PubMed   Mentions:
    15. Fibroblast Growth Factor 23 is Associated With Adiposity in Patients Receiving Hemodialysis: Possible Cross Talk Between Bone and Adipose Tissue. J Ren Nutr. 2018 07; 28(4):278-282. Chiang JM, Kaysen GA, Schafer AL, Delgado C, Johansen KL. PMID: 29606304.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. J Bone Miner Res. 2018 06; 33(6):975-986. Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. PMID: 29281126.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Chapter 64 Bariatric Surgery, Vitamin D, and Bone Loss. Vitamin D. 2018 Jan 1; 129-150. Kim Tiffany Y, Anne L. Schafer. .
      View in: Publisher Site   Mentions:
    18. Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study. J Bone Miner Res. 2018 01; 33(1):63-69. Napoli N, Schwartz AV, Schafer AL, Vittinghoff E, Cawthon PM, Parimi N, Orwoll E, Strotmeyer ES, Hoffman AR, Barrett-Connor E, Black DM. PMID: 28861910.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Sex differences in response to targeted kyphosis specific exercise and posture training in community-dwelling older adults: a randomized controlled trial. BMC Musculoskelet Disord. 2017 Dec 04; 18(1):509. Katzman WB, Parimi N, Gladin A, Poltavskiy EA, Schafer AL, Long RK, Fan B, Wong SS, Lane NE. PMID: 29202732.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass. J Bone Miner Res. 2017 Nov; 32(11):2239-2247. Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL. PMID: 28791737.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Targeted spine strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial. Osteoporos Int. 2017 10; 28(10):2831-2841. Katzman WB, Vittinghoff E, Lin F, Schafer A, Long RK, Wong S, Gladin A, Fan B, Allaire B, Kado DM, Lane NE. PMID: 28689306.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. SEX DIFFERENCES IN RESPONSE TO A TARGETED KYPHOSIS SPECIFIC EXERCISE PROGRAM. Innovation in Aging. 2017 Jul 1; 1(suppl_1):589-590. W.B. Katzman, N. Parimi, A. Schafer, R. Long, S. Wong, N. Lane. .
      View in: Publisher Site   Mentions:
    23. Vitamin D and intestinal calcium transport after bariatric surgery. J Steroid Biochem Mol Biol. 2017 10; 173:202-210. Schafer AL. PMID: 28027914.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    24. Diabetes and Bone Marrow Adiposity. Curr Osteoporos Rep. 2016 12; 14(6):337-344. Kim TY, Schafer AL. PMID: 27714580.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec; 5:312-319. Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S. PMID: 28580402.
      View in: PubMed   Mentions:
    26. Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study. Bone. 2016 09; 90:181-4. Napoli N, Schafer AL, Lui LY, Cauley JA, Strotmeyer ES, Le Blanc ES, Hoffman AR, Lee CG, Black DM, Schwartz AV. PMID: 27393241.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. Variability in DXA Reporting and Other Challenges in Osteoporosis Evaluation. JAMA Intern Med. 2016 Mar; 176(3):393-5. Kim TY, Schafer AL. PMID: 26746871.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Decline in Bone Mass During Weight Loss: A Cause for Concern? J Bone Miner Res. 2016 Jan; 31(1):36-9. Schafer AL. PMID: 26595270.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    29. Intestinal Calcium Absorption and Skeletal Health After Bariatric Surgery. Nutritional Influences on Bone Health. 2016 Jan 1; 271-278. Anne L. Schafer. .
      View in: Publisher Site   Mentions:
    30. Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis. Phys Ther. 2016 Mar; 96(3):371-81. Katzman WB, Vittinghoff E, Kado DM, Schafer AL, Wong SS, Gladin A, Lane NE. PMID: 26251480.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status. J Bone Miner Res. 2015 Aug; 30(8):1377-85. Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. PMID: 25640580.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCTClinical Trials
    32. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Bone. 2015 May; 74:140-5. Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. PMID: 25603463.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    33. Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review. AIDS. 2015 Jan 14; 29(2):245-6. Wheeler AL, Tien PC, Grunfeld C, Schafer AL. PMID: 25532609.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Importance of nutrition visits after gastric bypass surgery for American veterans, San Francisco, 2004-2010. Prev Chronic Dis. 2014 Dec 24; 11:E226. Win AZ, Ceresa C, Schafer AL, Mak P, Stewart L. PMID: 25539130.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Income, food insecurity, and osteoporosis among older adults in the 2007-2008 National Health and Nutrition Examination Survey (NHANES). J Health Care Poor Underserved. 2014 Nov; 25(4):1530-41. Lyles CR, Schafer AL, Seligman HK. PMID: 25418225.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. J Bone Miner Res. 2014 Apr; 29(4):911-21. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. PMID: 24014458.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Surg Obes Relat Dis. 2014 Sep-Oct; 10(5):878-84. Canales BK, Schafer AL, Shoback DM, Carpenter TO. PMID: 24969093.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    38. Serum 25-hydroxyvitamin D concentration does not independently predict incident diabetes in older women. Diabet Med. 2014 May; 31(5):564-9. Schafer AL, Napoli N, Lui L, Schwartz AV, Black DM. PMID: 24299116.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    39. The search for the optimal anabolic osteoporosis therapy. J Bone Miner Res. 2013 Nov; 28(11):2263-5. Black DM, Schafer AL. PMID: 24115189.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 2013 Jul 19; 572-578. Anne L. Schafer, Dolores Shoback. .
      View in: Publisher Site   Mentions:
    41. Effects of antiresorptive therapies on glucose metabolism: results from the FIT, HORIZON-PFT, and FREEDOM trials. J Bone Miner Res. 2013 Jun; 28(6):1348-54. Schwartz AV, Schafer AL, Grey A, Vittinghoff E, Palermo L, Lui LY, Wallace RB, Cummings SR, Black DM, Bauer DC, Reid IR. PMID: 23322676.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    42. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Osteoporos Int. 2013 Oct; 24(10):2591-601. Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. PMID: 23589163.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    43. Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study). Am J Cardiol. 2012 Dec 15; 110(12):1729-34. Welles CC, Schafer AL, Vittinghoff E, Shlipak MG, Whooley MA, Ix JH. PMID: 22975467.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    44. Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial. J Clin Endocrinol Metab. 2012 Oct; 97(10):3522-9. Schafer AL, Sellmeyer DE, Palermo L, Hietpas J, Eastell R, Shoback DM, Black DM. PMID: 22791766.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    45. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). J Clin Endocrinol Metab. 2011 Dec; 96(12):E1982-9. Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM. PMID: 21994958.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    46. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging. 2011 Apr; 33(4):974-9. Li X, Kuo D, Schafer AL, Porzig A, Link TM, Black D, Schwartz AV. PMID: 21448966.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    47. Consistency of bone turnover marker and calcium responses to parathyroid hormone (1-84) therapy in postmenopausal osteoporosis. J Clin Densitom. 2011 Jan-Mar; 14(1):68-73. Schafer AL, Palermo L, Bauer DC, Bilezikian JP, Sellmeyer DE, Black DM. PMID: 21095149.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010 Nov; 95(11):E368-72. Schafer AL, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV. PMID: 20668037.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    49. Mild positive hCG in a perimenopausal female: normal, malignancy, or phantom?. Lab Medicine. 2009; 40:463-5. Wu AHB, Branch J, Schafer A, Murphy E .
    50. Laboratory reproducibility of biochemical markers of bone turnover in clinical practice. Osteoporos Int. 2010 Mar; 21(3):439-45. Schafer AL, Vittinghoff E, Ramachandran R, Mahmoudi N, Bauer DC. PMID: 19506793.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    51. Interventions to improve treatment of osteoporosis following fracture. J Clin Outcomes Manag. 2008; 15:587-94. Schafer AL, Sellmeyer DS.
    52. High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: correlation with severity and activity of disease. Acta Neurol Scand. 1999 Sep; 100(3):139-47. Agius MA, Kirvan CA, Schafer AL, Gudipati E, Zhu S. PMID: 10478576.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    53. Rapsyn antibodies in myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:516-21. Agius MA, Zhu S, Kirvan CA, Schafer AL, Lin MY, Fairclough RH, Oger JJ, Aziz T, Aarli JA. PMID: 9668284.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
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