Anne Schafer, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
Address4150 Clement St
San Francisco CA 94121
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    Collapse Education and Training
    University of California, San FranciscoM.D. School of Medicine
    University of California, San Francisco Residency - Internal MedicineSchool of Medicine
    University of California, San FranciscoFellowship - Endocrinology & MetabolismSchool of Medicine
    San Francisco VA Medical CenterFellowship - Women's Health

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    Dr. Schafer is Assistant Professor of Medicine and of Epidemiology & Biostatistics at UCSF and a practicing endocrinologist at the San Francisco VA Medical Center. She is board-certified by the American Board of Internal Medicine in Internal Medicine and by the American Board of Internal Medicine in Endocrinology, Diabetes and Metabolism Subspecialty. Her research focus is on osteoporosis and metabolic bone disease. One of her specific research emphases is osteoporosis treatment and the assessment of response to osteoporosis therapy. Pharmacologic treatment for osteoporosis may involve the use of an antiresorptive agent (one that decreases bone resorption) or an anabolic agent (one that stimulates bone formation). Dr. Schafer and colleagues conducted a randomized, placebo-controlled trial testing two innovative combinations of concurrent and sequential anabolic and anti-resorptive therapy in postmenopausal women with low bone mass. Findings from the trial may help to expand treatment options for osteoporosis. Additionally, Dr. Schafer is actively engaged in research involving the relationship between bone and fat. Bone-fat interplay—including the effects of fat on bone metabolism and the skeletal regulation of energy metabolism—is an area of increasing investigation. Currently, she is studying the effects of bariatric surgery (surgical weight loss) on calcium metabolism and skeletal health. Her research is funded by the U.S. Department of Veterans Affairs, the National Institutes of Health (National Institute on Diabetes and Digestive and Kidney Diseases), and the American Society for Bone and Mineral Research.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schafer A. Vitamin D and Intestinal Calcium Transport After Bariatric Surgery. J Steroid Biochem Mol Biol. 2016 Dec 24. PMID: 28027914.
      View in: PubMed
    2. Kim TY, Schafer A. Diabetes and Bone Marrow Adiposity. Curr Osteoporos Rep. 2016 Dec; 14(6):337-344. PMID: 27714580.
      View in: PubMed
    3. Okazaki N, Burghardt AJ, Chiba K, Schafer A, Majumdar S. Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec; 5:312-319. PMID: 28580402.
      View in: PubMed
    4. Napoli N, Schafer A, Lui LY, Cauley JA, Strotmeyer ES, Le Blanc ES, Hoffman AR, Lee CG, Black DM, Schwartz AV. Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study. Bone. 2016 Sep; 90:181-4. PMID: 27393241.
      View in: PubMed
    5. Kim TY, Schafer A. Variability in DXA Reporting and Other Challenges in Osteoporosis Evaluation. JAMA Intern Med. 2016 Mar 1; 176(3):393-5. PMID: 26746871.
      View in: PubMed
    6. Schafer A. Decline in Bone Mass During Weight Loss: A Cause for Concern? J Bone Miner Res. 2016 Jan; 31(1):36-9. PMID: 26595270.
      View in: PubMed
    7. Katzman WB, Vittinghoff E, Kado DM, Schafer A, Wong SS, Gladin A, Lane NE. Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis. Phys Ther. 2016 Mar; 96(3):371-81. PMID: 26251480.
      View in: PubMed
    8. Schafer A, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status. J Bone Miner Res. 2015 Aug; 30(8):1377-85. PMID: 25640580; PMCID: PMC4593653 [Available on 08/01/16].
    9. Schafer A, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Bone. 2015 May; 74:140-5. PMID: 25603463; PMCID: PMC4355193 [Available on 05/01/16].
    10. Wheeler AL, Tien PC, Grunfeld C, Schafer A. Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review. AIDS. 2015 Jan 14; 29(2):245-6. PMID: 25532609; PMCID: PMC4438749 [Available on 01/14/16].
    11. Win AZ, Ceresa C, Schafer A, Mak P, Stewart L. Importance of nutrition visits after gastric bypass surgery for American veterans, San Francisco, 2004-2010. Prev Chronic Dis. 2014; 11:E226. PMID: 25539130; PMCID: PMC4279866.
    12. Lyles CR, Schafer A, Seligman HK. Income, food insecurity, and osteoporosis among older adults in the 2007-2008 National Health and Nutrition Examination Survey (NHANES). J Health Care Poor Underserved. 2014 Nov; 25(4):1530-41. PMID: 25418225.
      View in: PubMed
    13. Schafer A, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. J Bone Miner Res. 2014 Apr; 29(4):911-21. PMID: 24014458; PMCID: PMC4419358.
    14. Canales BK, Schafer A, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Surg Obes Relat Dis. 2014 Sep-Oct; 10(5):878-84. PMID: 24969093; PMCID: PMC4113565.
    15. Schafer A, Napoli N, Lui L, Schwartz AV, Black DM. Serum 25-hydroxyvitamin D concentration does not independently predict incident diabetes in older women. Diabet Med. 2014 May; 31(5):564-9. PMID: 24299116; PMCID: PMC3988213.
    16. Black DM, Schafer A. The search for the optimal anabolic osteoporosis therapy. J Bone Miner Res. 2013 Nov; 28(11):2263-5. PMID: 24115189.
      View in: PubMed
    17. Schwartz AV, Schafer A, Grey A, Vittinghoff E, Palermo L, Lui LY, Wallace RB, Cummings SR, Black DM, Bauer DC, Reid IR. Effects of antiresorptive therapies on glucose metabolism: results from the FIT, HORIZON-PFT, and FREEDOM trials. J Bone Miner Res. 2013 Jun; 28(6):1348-54. PMID: 23322676.
      View in: PubMed
    18. Schafer A, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Osteoporos Int. 2013 Oct; 24(10):2591-601. PMID: 23589163.
      View in: PubMed
    19. Welles CC, Schafer A, Vittinghoff E, Shlipak MG, Whooley MA, Ix JH. Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study). Am J Cardiol. 2012 Dec 15; 110(12):1729-34. PMID: 22975467; PMCID: PMC3511634.
    20. Schafer A, Sellmeyer DE, Palermo L, Hietpas J, Eastell R, Shoback DM, Black DM. Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial. J Clin Endocrinol Metab. 2012 Oct; 97(10):3522-9. PMID: 22791766; PMCID: PMC3674294.
    21. Schafer A, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). J Clin Endocrinol Metab. 2011 Dec; 96(12):E1982-9. PMID: 21994958; PMCID: PMC3232610.
    22. Li X, Kuo D, Schafer A, Porzig A, Link TM, Black D, Schwartz AV. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging. 2011 Apr; 33(4):974-9. PMID: 21448966; PMCID: PMC3072841.
    23. Schafer A, Palermo L, Bauer DC, Bilezikian JP, Sellmeyer DE, Black DM. Consistency of bone turnover marker and calcium responses to parathyroid hormone (1-84) therapy in postmenopausal osteoporosis. J Clin Densitom. 2011 Jan-Mar; 14(1):68-73. PMID: 21095149.
      View in: PubMed
    24. Schafer A, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010 Nov; 95(11):E368-72. PMID: 20668037; PMCID: PMC2968723.
    25. Wu AHB, Branch J, Schafer A, Murphy E . Mild positive hCG in a perimenopausal female: normal, malignancy, or phantom?. Lab Medicine. 2009; 40:463-5.
    26. Schafer A, Vittinghoff E, Ramachandran R, Mahmoudi N, Bauer DC. Laboratory reproducibility of biochemical markers of bone turnover in clinical practice. Osteoporos Int. 2010 Mar; 21(3):439-45. PMID: 19506793; PMCID: PMC2817087.
    27. Schafer A, Sellmeyer DS. Interventions to improve treatment of osteoporosis following fracture. J Clin Outcomes Manag. 2008; 15:587-94.
    28. Agius MA, Kirvan CA, Schafer A, Gudipati E, Zhu S. High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: correlation with severity and activity of disease. Acta Neurol Scand. 1999 Sep; 100(3):139-47. PMID: 10478576.
      View in: PubMed
    29. Agius MA, Zhu S, Kirvan CA, Schafer A, Lin MY, Fairclough RH, Oger JJ, Aziz T, Aarli JA. Rapsyn antibodies in myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:516-21. PMID: 9668284.
      View in: PubMed
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