Anne Schafer, MD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 24895
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityB.A.History and Science
    University of California, San FranciscoM.D.Medicine
    University of California, San FranciscoInternship and ResidencyInternal Medicine
    University of California, San FranciscoFellowshipEndocrinology and Metabolism
    San Francisco VA Medical CenterFellowshipWomen's Health

    Collapse Overview 
    Collapse Overview
    Dr. Schafer is Associate Professor of Medicine and of Epidemiology & Biostatistics at UCSF and a practicing endocrinologist at the San Francisco VA Medical Center. She is board-certified by the American Board of Internal Medicine in the subspecialty of Endocrinology, Diabetes and Metabolism. Her research focus is osteoporosis and bone metabolism. One of her research emphases is osteoporosis treatment and the assessment of response to osteoporosis therapy. She also studies the relationships between bone, fat, and glucose metabolism, including the effects of obesity and diabetes on bone, and the skeletal regulation of energy metabolism. Currently, she is investigating the effects of bariatric surgery (weight loss surgery) on calcium metabolism and skeletal health. Dr. Schafer's research has been funded by the NIH (National Institute of Diabetes and Digestive and Kidney Diseases), the US Department of Veterans Affairs, and the American Society for Bone and Mineral Research.

    Collapse Research 
    Collapse Research Activities and Funding
    Prebiotic Intervention to Improve Calcium Absorption After Gastric Bypass Surgery
    NIH/NIDDK R21DK112126Jul 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Effects of Sleeve Gastrectomy on Calcium Metabolism and the Skeleton
    NIH R01DK107629Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    NIH IK2CX000549Apr 1, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM. Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease. J Vasc Surg. 2018 Oct 03. PMID: 30292618.
      View in: PubMed
    2. Alba DL, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK. Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese-Americans. J Clin Endocrinol Metab. 2018 May 28. PMID: 29846621.
      View in: PubMed
    3. Gagnon C, Schafer AL. Bone Health After Bariatric Surgery. JBMR Plus. 2018 May; 2(3):121-133. PMID: 30283897.
      View in: PubMed
    4. Chiang JM, Kaysen GA, Schafer AL, Delgado C, Johansen KL. Fibroblast Growth Factor 23 is Associated With Adiposity in Patients Receiving Hemodialysis: Possible Cross Talk Between Bone and Adipose Tissue. J Ren Nutr. 2018 Mar 29. PMID: 29606304.
      View in: PubMed
    5. Napoli N, Schwartz AV, Schafer AL, Vittinghoff E, Cawthon PM, Parimi N, Orwoll E, Strotmeyer ES, Hoffman AR, Barrett-Connor E, Black DM. Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study. J Bone Miner Res. 2018 Jan; 33(1):63-69. PMID: 28861910.
      View in: PubMed
    6. Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women. J Bone Miner Res. 2017 Dec 27. PMID: 29281126.
      View in: PubMed
    7. Katzman WB, Parimi N, Gladin A, Poltavskiy EA, Schafer AL, Long RK, Fan B, Wong SS, Lane NE. Sex differences in response to targeted kyphosis specific exercise and posture training in community-dwelling older adults: a randomized controlled trial. BMC Musculoskelet Disord. 2017 Dec 04; 18(1):509. PMID: 29202732.
      View in: PubMed
    8. Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL. Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass. J Bone Miner Res. 2017 Nov; 32(11):2239-2247. PMID: 28791737.
      View in: PubMed
    9. Katzman WB, Vittinghoff E, Lin F, Schafer A, Long RK, Wong S, Gladin A, Fan B, Allaire B, Kado DM, Lane NE. Targeted spine strengthening exercise and posture training program to reduce hyperkyphosis in older adults: results from the study of hyperkyphosis, exercise, and function (SHEAF) randomized controlled trial. Osteoporos Int. 2017 Oct; 28(10):2831-2841. PMID: 28689306.
      View in: PubMed
    10. Schafer AL. Vitamin D and intestinal calcium transport after bariatric surgery. J Steroid Biochem Mol Biol. 2017 10; 173:202-210. PMID: 28027914.
      View in: PubMed
    11. Kim TY, Schafer AL. Diabetes and Bone Marrow Adiposity. Curr Osteoporos Rep. 2016 Dec; 14(6):337-344. PMID: 27714580.
      View in: PubMed
    12. Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S. Bone microstructure in men assessed by HR-pQCT: Associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec; 5:312-319. PMID: 28580402.
      View in: PubMed
    13. Napoli N, Schafer AL, Lui LY, Cauley JA, Strotmeyer ES, Le Blanc ES, Hoffman AR, Lee CG, Black DM, Schwartz AV. Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study. Bone. 2016 09; 90:181-4. PMID: 27393241.
      View in: PubMed
    14. Kim TY, Schafer AL. Variability in DXA Reporting and Other Challenges in Osteoporosis Evaluation. JAMA Intern Med. 2016 Mar; 176(3):393-5. PMID: 26746871.
      View in: PubMed
    15. Schafer AL. Decline in Bone Mass During Weight Loss: A Cause for Concern? J Bone Miner Res. 2016 Jan; 31(1):36-9. PMID: 26595270.
      View in: PubMed
    16. Katzman WB, Vittinghoff E, Kado DM, Schafer AL, Wong SS, Gladin A, Lane NE. Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis. Phys Ther. 2016 Mar; 96(3):371-81. PMID: 26251480; PMCID: PMC4774389.
    17. Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status. J Bone Miner Res. 2015 Aug; 30(8):1377-85. PMID: 25640580; PMCID: PMC4593653.
    18. Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study. Bone. 2015 May; 74:140-5. PMID: 25603463; PMCID: PMC4355193.
    19. Wheeler AL, Tien PC, Grunfeld C, Schafer AL. Teriparatide treatment of osteoporosis in an HIV-infected man: a case report and literature review. AIDS. 2015 Jan 14; 29(2):245-6. PMID: 25532609; PMCID: PMC4438749.
    20. Win AZ, Ceresa C, Schafer AL, Mak P, Stewart L. Importance of nutrition visits after gastric bypass surgery for American veterans, San Francisco, 2004-2010. Prev Chronic Dis. 2014 Dec 24; 11:E226. PMID: 25539130; PMCID: PMC4279866.
    21. Lyles CR, Schafer AL, Seligman HK. Income, food insecurity, and osteoporosis among older adults in the 2007-2008 National Health and Nutrition Examination Survey (NHANES). J Health Care Poor Underserved. 2014 Nov; 25(4):1530-41. PMID: 25418225.
      View in: PubMed
    22. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. J Bone Miner Res. 2014 Apr; 29(4):911-21. PMID: 24014458; PMCID: PMC4419358.
    23. Canales BK, Schafer AL, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Surg Obes Relat Dis. 2014 Sep-Oct; 10(5):878-84. PMID: 24969093; PMCID: PMC4113565.
    24. Schafer AL, Napoli N, Lui L, Schwartz AV, Black DM. Serum 25-hydroxyvitamin D concentration does not independently predict incident diabetes in older women. Diabet Med. 2014 May; 31(5):564-9. PMID: 24299116; PMCID: PMC3988213.
    25. Black DM, Schafer AL. The search for the optimal anabolic osteoporosis therapy. J Bone Miner Res. 2013 Nov; 28(11):2263-5. PMID: 24115189.
      View in: PubMed
    26. Schwartz AV, Schafer AL, Grey A, Vittinghoff E, Palermo L, Lui LY, Wallace RB, Cummings SR, Black DM, Bauer DC, Reid IR. Effects of antiresorptive therapies on glucose metabolism: results from the FIT, HORIZON-PFT, and FREEDOM trials. J Bone Miner Res. 2013 Jun; 28(6):1348-54. PMID: 23322676.
      View in: PubMed
    27. Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM. Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS). Osteoporos Int. 2013 Oct; 24(10):2591-601. PMID: 23589163.
      View in: PubMed
    28. Welles CC, Schafer AL, Vittinghoff E, Shlipak MG, Whooley MA, Ix JH. Urine calcium excretion, cardiovascular events, and mortality in outpatients with stable coronary artery disease (from the Heart and Soul study). Am J Cardiol. 2012 Dec 15; 110(12):1729-34. PMID: 22975467; PMCID: PMC3511634.
    29. Schafer AL, Sellmeyer DE, Palermo L, Hietpas J, Eastell R, Shoback DM, Black DM. Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial. J Clin Endocrinol Metab. 2012 Oct; 97(10):3522-9. PMID: 22791766; PMCID: PMC3674294.
    30. Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). J Clin Endocrinol Metab. 2011 Dec; 96(12):E1982-9. PMID: 21994958; PMCID: PMC3232610.
    31. Li X, Kuo D, Schafer AL, Porzig A, Link TM, Black D, Schwartz AV. Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging. 2011 Apr; 33(4):974-9. PMID: 21448966; PMCID: PMC3072841.
    32. Schafer AL, Palermo L, Bauer DC, Bilezikian JP, Sellmeyer DE, Black DM. Consistency of bone turnover marker and calcium responses to parathyroid hormone (1-84) therapy in postmenopausal osteoporosis. J Clin Densitom. 2011 Jan-Mar; 14(1):68-73. PMID: 21095149.
      View in: PubMed
    33. Schafer AL, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. J Clin Endocrinol Metab. 2010 Nov; 95(11):E368-72. PMID: 20668037; PMCID: PMC2968723.
    34. Wu AHB, Branch J, Schafer A, Murphy E .Mild positive hCG in a perimenopausal female: normal, malignancy, or phantom?. Lab Medicine. 2009; 40:463-5.
    35. Schafer AL, Vittinghoff E, Ramachandran R, Mahmoudi N, Bauer DC. Laboratory reproducibility of biochemical markers of bone turnover in clinical practice. Osteoporos Int. 2010 Mar; 21(3):439-45. PMID: 19506793; PMCID: PMC2817087.
    36. Schafer AL, Sellmeyer DS.Interventions to improve treatment of osteoporosis following fracture. J Clin Outcomes Manag. 2008; 15:587-94.
    37. Agius MA, Kirvan CA, Schafer AL, Gudipati E, Zhu S. High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: correlation with severity and activity of disease. Acta Neurol Scand. 1999 Sep; 100(3):139-47. PMID: 10478576.
      View in: PubMed
    38. Agius MA, Zhu S, Kirvan CA, Schafer AL, Lin MY, Fairclough RH, Oger JJ, Aziz T, Aarli JA. Rapsyn antibodies in myasthenia gravis. Ann N Y Acad Sci. 1998 May 13; 841:516-21. PMID: 9668284.
      View in: PubMed