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Sharon Chung, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-514-1673
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.A.S. in Clinical Research2008 Graduate Division (Advance Training in Clinical Research)
    University of California, San FranciscoCert2006 Medicine (Advance Training in Clinical Research)
    Johns Hopkins UniversityM.D.2001School of Medicine
    Collapse Awards and Honors
    University of California, San Francisco2011Ephraim Engleman Award for Excellence in Arthritis Research
    American College of Rheumatology2007Distinguished Fellow Award

    Collapse Overview 
    Collapse Overview
    Dr. Chung completed her MD (2001) at Johns Hopkins University where she was also an intern and resident (2001-04) in Internal Medicine. She was a Rheumatology Clinical Fellow at UCSF (2004-07), and joined the UCSF faculty in 2007. Dr. Chung completed a Master’s Degree in Advanced Studies in Clinical Research at UCSF (2008).

    The central goal of Dr. Chung's research program is to discover genetic and epigenetic factors that influence autoimmune disease susceptibility and its manifestations, in order to identify biologic pathways involved in disease pathogenesis and potential targets for therapeutic intervention. Current projects focused on systemic lupus erythematosus (SLE) include genome-wide association studies, more focused investigations of the major histocompatilibity complex, and DNA methylation studies of specific disease manifestations. Her clinical interest is systemic vasculitis, and she directs the UCSF Vasculitis Clinic. Her research activities in vasculitis include genetic, epigenetic, and transcriptional studies of small vessel vasculitides. The UCSF Vasculitis Clinic is a member of the Vasculitis Clinical Research Consortium (VCRC), and the clinic participates in ongoing VCRC studies.

    Collapse Research 
    Collapse Research Activities and Funding
    Using genomics to elucidate the pathogenesis of granulomatosis with polyangiitis
    NIH/NIAMS K23AR063126Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. Nat Commun. 2020 02 27; 11(1):1164. Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Rhead B, Barcellos LF, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Criswell LA. PMID: 32109229.
      View in: PubMed   Mentions:    Fields:    
    2. A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. Nat Commun. 2019 08 29; 10(1):3902. Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Rhead B, Barcellos LF, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Criswell LA. PMID: 31467281.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. The Right Frame. J Hosp Med. 2019 04; 14(4):246-250. Minter DJ, Geha RM, Boslett BA, Chung SA, Ramani B, Manesh R. PMID: 30933677.
      View in: PubMed   Mentions:    Fields:    
    4. DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity. Lupus Sci Med. 2018; 5(1):e000285. Lanata CM, Chung SA, Criswell LA. PMID: 30094041.
      View in: PubMed   Mentions:
    5. Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients. PLoS One. 2018; 13(6):e0199003. Lanata CM, Nititham J, Taylor KE, Chung SA, Torgerson DG, Seldin MF, Pons-Estel BA, Tusié-Luna T, Tsao BP, Morand EF, Alarcón-Riquelme ME, Criswell LA. PMID: 29953444.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    6. Analysis of pulmonary features and treatment approaches in the COPA syndrome. ERJ Open Res. 2018 Apr; 4(2). Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK. PMID: 29977900.
      View in: PubMed   Mentions:
    7. Primary Angiitis of the Central Nervous System. Rheum Dis Clin North Am. 2017 11; 43(4):503-518. Mandal J, Chung SA. PMID: 29061238.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses. Lupus Sci Med. 2016; 3(1):e000183. Mok A, Solomon O, Nayak RR, Coit P, Quach HL, Nititham J, Sawalha AH, Barcellos LF, Criswell LA, Chung SA. PMID: 28074145.
      View in: PubMed   Mentions:
    9. Rare variants, autoimmune disease, and arthritis. Curr Opin Rheumatol. 2016 Jul; 28(4):346-51. Chung SA, Shum AK. PMID: 27224741.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Current Treatment of Cryoglobulinemic Vasculitis. Current Treatment Options in Rheumatology. 2016 Jun 1; 2(2):213-224. Sarah Goglin, Sharon A. Chung. .
      View in: Publisher Site   Mentions:
    11. Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. PLoS One. 2015; 10(7):e0129813. Chung SA, Nititham J, Elboudwarej E, Quach HL, Taylor KE, Barcellos LF, Criswell LA. PMID: 26192630.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Differential methylation of interferon-related genes is associated with autoantibody production in systemic lupus erythematosus. Arthritis Research & Therapy. 2014 Dec 1; 16(Suppl 1):a9. Sharon A Chung, Joanne Nititham, Emon Elboudwarej, Hong L Quach, Kimberly E Taylor, Lisa F Barcellos, Lindsey A Criswell. .
      View in: Publisher Site   Mentions:
    13. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol. 2014 Dec; 25(12):2859-70. Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kretzler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD. PMID: 24925725.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    14. MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun. 2014 Apr; 15(4):210-7. Morris DL, Fernando MM, Taylor KE, Chung SA, Nititham J, Alarcón-Riquelme ME, Barcellos LF, Behrens TW, Cotsapas C, Gaffney PM, Graham RR, Pons-Estel BA, Gregersen PK, Harley JB, Hauser SL, Hom G, Langefeld CD, Noble JA, Rioux JD, Seldin MF, Vyse TJ, Criswell LA. PMID: 24598797.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    15. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013; 8(8):e69404. Namjou B, Kim-Howard X, Sun C, Adler A, Chung SA, Kaufman KM, Kelly JA, Glenn SB, Guthridge JM, Scofield RH, Kimberly RP, Brown EE, Alarcón GS, Edberg JC, Kim JH, Choi J, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Boackle SA, Freedman BI, Tsao BP, Langefeld CD, Vyse TJ, Jacob CO, Pons-Estel B, Niewold TB, Moser Sivils KL, Merrill JT, Anaya JM, Gilkeson GS, Gaffney PM, Bae SC, Alarcón-Riquelme ME, Harley JB, Criswell LA, James JA, Nath SK. PMID: 23950893.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    16. CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat Genet. 2012 Nov; 44(11):1227-30. Manjarrez-Orduño N, Marasco E, Chung SA, Katz MS, Kiridly JF, Simpfendorfer KR, Freudenberg J, Ballard DH, Nashi E, Hopkins TJ, Cunninghame Graham DS, Lee AT, Coenen MJ, Franke B, Swinkels DW, Graham RR, Kimberly RP, Gaffney PM, Vyse TJ, Behrens TW, Criswell LA, Diamond B, Gregersen PK. PMID: 23042117.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    17. Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. Arthritis Rheum. 2012 Oct; 64(10):3463-71. Chung SA, Xie G, Roshandel D, Sherva R, Edberg JC, Kravitz M, Dellaripa PF, Hoffman GS, Mahr AD, Seo P, Specks U, Spiera RF, St Clair EW, Stone JH, Plenge RM, Siminovitch KA, Merkel PA, Monach PA. PMID: 22508400.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    18. European genetic ancestry is associated with a decreased risk of lupus nephritis. Arthritis Rheum. 2012 Oct; 64(10):3374-82. Richman IB, Taylor KE, Chung SA, Trupin L, Petri M, Yelin E, Graham RR, Lee A, Behrens TW, Gregersen PK, Seldin MF, Criswell LA. PMID: 23023776.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    19. Differential DNA methylation associated with anti-dsDNA autoantibody production in systemic lupus erythematosus. Arthritis Research & Therapy. 2012 Sep 1; 14(Suppl 3):a6. SA Chung, J French, KE Taylor, E Elboudwarej, HL Quach, LF Barcellos, LA Criswell. .
      View in: Publisher Site   Mentions:
    20. A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011 Dec; 7(12):e1002406. Ramos PS, Criswell LA, Moser KL, Comeau ME, Williams AH, Pajewski NM, Chung SA, Graham RR, Zidovetzki R, Kelly JA, Kaufman KM, Jacob CO, Vyse TJ, Tsao BP, Kimberly RP, Gaffney PM, Alarcón-Riquelme ME, Harley JB, Langefeld CD. PMID: 22174698.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    21. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet. 2011 Mar; 7(3):e1001323. Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA, Jacob CO, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, Petri M, Demirci FY, Kamboh MI, Manzi S, Gregersen PK, Langefeld CD, Behrens TW, Criswell LA. PMID: 21408207.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    22. Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet. 2011 Feb; 7(2):e1001311. Taylor KE, Chung SA, Graham RR, Ortmann WA, Lee AT, Langefeld CD, Jacob CO, Kamboh MI, Alarcón-Riquelme ME, Tsao BP, Moser KL, Gaffney PM, Harley JB, Petri M, Manzi S, Gregersen PK, Behrens TW, Criswell LA. PMID: 21379322.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    23. Microscopic polyangiitis. Rheum Dis Clin North Am. 2010 Aug; 36(3):545-58. Chung SA, Seo P. PMID: 20688249.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    24. Association of CSK Variants with Systemic Lupus Erythematosus. Clinical Immunology. 2010 Jan 1; 135:s48-s49. Nataly Manjarrez Orduño, Sharon Chung, Monica Chang, Ann Begovich, Joseph Catanese, Lindsey Criswell, Betty Diamond, Peter Gregersen. .
      View in: Publisher Site   Mentions:
    25. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet. 2009 Oct; 5(10):e1000696. Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. PMID: 19851445.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    26. European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent. Genes Immun. 2010 Sep; 11(6):515-21. Richman IB, Chung SA, Taylor KE, Kosoy R, Tian C, Ortmann WA, Nititham J, Lee AT, Rutman S, Petri M, Manzi S, Behrens TW, Gregersen PK, Seldin MF, Criswell LA. PMID: 19847193.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    27. A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet. 2009 Nov; 41(11):1228-33. Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, Ortmann W, Kosoy R, Ferreira RC, Nordmark G, Gunnarsson I, Svenungsson E, Padyukov L, Sturfelt G, Jönsen A, Bengtsson AA, Rantapää-Dahlqvist S, Baechler EC, Brown EE, Alarcón GS, Edberg JC, Ramsey-Goldman R, McGwin G, Reveille JD, Vilá LM, Kimberly RP, Manzi S, Petri MA, Lee A, Gregersen PK, Seldin MF, Rönnblom L, Criswell LA, Syvänen AC, Behrens TW, Graham RR. PMID: 19838195.
      View in: PubMed   Mentions: 324     Fields:    Translation:HumansCells
    28. European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis Rheum. 2009 Aug; 60(8):2448-56. Chung SA, Tian C, Taylor KE, Lee AT, Ortmann WA, Hom G, Graham RR, Nititham J, Kelly JA, Morrisey J, Wu H, Yin H, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, Manzi S, Petri M, Gregersen PK, Langefeld CD, Behrens TW, Seldin MF, Criswell LA. PMID: 19644962.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    29. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J Clin Invest. 2009 Apr; 119(4):911-23. Liu K, Li QZ, Delgado-Vega AM, Abelson AK, Sánchez E, Kelly JA, Li L, Liu Y, Zhou J, Yan M, Ye Q, Liu S, Xie C, Zhou XJ, Chung SA, Pons-Estel B, Witte T, de Ramón E, Bae SC, Barizzone N, Sebastiani GD, Merrill JT, Gregersen PK, Gilkeson GG, Kimberly RP, Vyse TJ, Kim I, D'Alfonso S, Martin J, Harley JB, Criswell LA, Wakeland EK, Alarcón-Riquelme ME, Mohan C. PMID: 19307730.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    30. Advances in the use of biologic agents for the treatment of systemic vasculitis. Curr Opin Rheumatol. 2009 Jan; 21(1):3-9. Chung SA, Seo P. PMID: 19077713.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus. PLoS Genet. 2008 May 30; 4(5):e1000084. Taylor KE, Remmers EF, Lee AT, Ortmann WA, Plenge RM, Tian C, Chung SA, Nititham J, Hom G, Kao AH, Demirci FY, Kamboh MI, Petri M, Manzi S, Kastner DL, Seldin MF, Gregersen PK, Behrens TW, Criswell LA. PMID: 18516230.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    32. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008 Feb 28; 358(9):900-9. Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW. PMID: 18204098.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansCells
    33. PTPN22: its role in SLE and autoimmunity. Autoimmunity. 2007 Dec; 40(8):582-90. Chung SA, Criswell LA. PMID: 18075792.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
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