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    David Morgan, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPhysiology
    Address600 16th Street
    San Francisco CA 94158
    Phone415-476-6695
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPh.D. Graduate Division (Endocrinology)1986

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Davey NE, Morgan DO. Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex. Mol Cell. 2016 Oct 6; 64(1):12-23. PMID: 27716480.
        View in: PubMed
      2. Morgan DO. Cell division: Mitotic regulation comes into focus. Nature. 2016 Aug 25; 536(7617):407-8. PMID: 27509855.
        View in: PubMed
      3. Galli M, Morgan DO. Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development. Dev Cell. 2016 Feb 8; 36(3):344-52. PMID: 26859356.
        View in: PubMed
      4. Girard JR, Tenthorey JL, Morgan DO. An E2 Accessory Domain Increases Affinity for the Anaphase-promoting Complex and Ensures E2 Competition. J Biol Chem. 2015 Oct 2; 290(40):24614-25. PMID: 26306044; PMCID: PMC4591839 [Available on 10/02/16].
      5. Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol. 2014 Oct 13; 207(1):23-39. PMID: 25287299; PMCID: PMC4195823.
      6. Eshleman HD, Morgan DO. Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis. J Cell Sci. 2014 Nov 15; 127(Pt 22):4974-83. PMID: 25236599; PMCID: PMC4231310.
      7. Matsusaka T, Enquist-Newman M, Morgan DO, Pines J. Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Biol Open. 2014; 3(10):904-12. PMID: 25217616; PMCID: PMC4197439.
      8. Van Voorhis VA, Morgan DO. Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr Biol. 2014 Jul 7; 24(13):1556-62. PMID: 24930963; PMCID: PMC4090254.
      9. Naylor SG, Morgan DO. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci. 2014 Mar 1; 127(Pt 5):1128-37. PMID: 24413167; PMCID: PMC3937778.
      10. Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc. 2013 Dec 4; 135(48):18153-9. PMID: 24171479; PMCID: PMC3938282.
      11. Morgan DO. The D box meets its match. Mol Cell. 2013 Jun 6; 50(5):609-10. PMID: 23746347; PMCID: PMC3702177.
      12. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201. PMID: 23314252; PMCID: PMC3565030.
      13. Foster SA, Morgan DO. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32. PMID: 22940250; PMCID: PMC3462283.
      14. Yaakov G, Thorn K, Morgan DO. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36. PMID: 22814605; PMCID: PMC3413326.
      15. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7. PMID: 22079111; PMCID: PMC3430386.
      16. Schaefer JB, Morgan DO. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96. PMID: 22072716; PMCID: PMC3247991.
      17. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Dec 1; 480(7375):128-31. PMID: 21993622; PMCID: PMC3228899.
      18. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23. PMID: 21658602; PMCID: PMC3115021.
      19. Lyons NA, Morgan DO. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 6; 42(3):378-89. PMID: 21549314; PMCID: PMC3095509.
      20. Rodrigo-Brenni MC, Foster SA, Morgan DO. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59. PMID: 20797627; PMCID: PMC2929935.
      21. Morgan DO. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6. PMID: 20403319.
        View in: PubMed
      22. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6. PMID: 19884882; PMCID: PMC2914104.
      23. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6. PMID: 19779198; PMCID: PMC2813701.
      24. Matyskiela ME, Morgan DO. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80. PMID: 19362536; PMCID: PMC2754851.
      25. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90. PMID: 19285942; PMCID: PMC2883288.
      26. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO. Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol. 2009; 8(10):92. PMID: 19874575; PMCID: PMC2790831.
      27. Tully GH, Nishihama R, Pringle JR, Morgan DO. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell. 2009 Feb; 20(4):1201-12. PMID: 19109423; PMCID: PMC2642741.
      28. Morgan DO. SnapShot: Cell-cycle regulators II. Cell. 2008 Nov 28; 135(5):974-974.e1. PMID: 19041757.
        View in: PubMed
      29. Morgan DO. SnapShot: cell-cycle regulators I. Cell. 2008 Nov 14; 135(4):764-764.e1. PMID: 19013283.
        View in: PubMed
      30. Sullivan M, Holt L, Morgan DO. Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol. 2008 Sep; 28(17):5328-36. PMID: 18591250; PMCID: PMC2519743.
      31. Holt LJ, Krutchinsky AN, Morgan DO. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17; 454(7202):353-7. PMID: 18552837; PMCID: PMC2636747.
      32. Enquist-Newman M, Sullivan M, Morgan DO. Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell. 2008 May 23; 30(4):437-46. PMID: 18498748; PMCID: PMC2494983.
      33. Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1442-7. PMID: 18234856; PMCID: PMC2234163.
      34. Sullivan M, Morgan DO. Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol. 2007 Nov; 8(11):894-903. PMID: 17912263.
        View in: PubMed
      35. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. PMID: 18022565; PMCID: PMC2215327.
      36. Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell. 2007 Dec; 18(12):5139-53. PMID: 17942599; PMCID: PMC2096582.
      37. Woodbury EL, Morgan DO. The role of self-association in Fin1 function on the mitotic spindle. J Biol Chem. 2007 Nov 2; 282(44):32138-43. PMID: 17804403.
        View in: PubMed
      38. Rodrigo-Brenni MC, Morgan DO. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell. 2007 Jul 13; 130(1):127-39. PMID: 17632060.
        View in: PubMed
      39. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7. PMID: 17589519.
        View in: PubMed
      40. Sullivan M, Morgan DO. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem. 2007 Jul 6; 282(27):19710-5. PMID: 17493939.
        View in: PubMed
      41. Holt LJ, Hutti JE, Cantley LC, Morgan DO. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell. 2007 Mar 9; 25(5):689-702. PMID: 17349956; PMCID: PMC1939968.
      42. Woodbury EL, Morgan DO. Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol. 2007 Jan; 9(1):106-12. PMID: 17173039.
        View in: PubMed
      43. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60. PMID: 16481473; PMCID: PMC1369047.
      44. Loog M, Morgan DO. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature. 2005 Mar 3; 434(7029):104-8. PMID: 15744308.
        View in: PubMed
      45. Carroll CW, Enquist-Newman M, Morgan DO. The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol. 2005 Jan 11; 15(1):11-8. PMID: 15649358.
        View in: PubMed
      46. Carroll CW, Morgan DO. Enzymology of the anaphase-promoting complex. Methods Enzymol. 2005; 398:219-30. PMID: 16275331.
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      47. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64. PMID: 14574415.
        View in: PubMed
      48. Carroll CW, Morgan DO. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol. 2002 Nov; 4(11):880-7. PMID: 12402045.
        View in: PubMed
      49. Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc. 2002 Oct 16; 124(41):12118-28. PMID: 12371851.
        View in: PubMed
      50. Polson AG, Huang L, Lukac DM, Blethrow JD, Morgan DO, Burlingame AL, Ganem D. Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. J Virol. 2001 Apr; 75(7):3175-84. PMID: 11238844; PMCID: PMC114111.
      51. Takizawa CG, Morgan DO. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol. 2000 Dec; 12(6):658-65. PMID: 11063929.
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      52. Jaspersen SL, Morgan DO. Cdc14 activates cdc15 to promote mitotic exit in budding yeast. Curr Biol. 2000 May 18; 10(10):615-8. PMID: 10837230.
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      53. Farrell A, Morgan DO. Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol Cell Biol. 2000 Feb; 20(3):749-54. PMID: 10629030; PMCID: PMC85190.
      54. Tinker-Kulberg RL, Morgan DO. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev. 1999 Aug 1; 13(15):1936-49. PMID: 10444592; PMCID: PMC316917.
      55. Takizawa CG, Weis K, Morgan DO. Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta. Proc Natl Acad Sci U S A. 1999 Jul 6; 96(14):7938-43. PMID: 10393926; PMCID: PMC22166.
      56. Morgan DO. Regulation of the APC and the exit from mitosis. Nat Cell Biol. 1999 Jun; 1(2):E47-53. PMID: 10559897.
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      57. Jaspersen SL, Charles JF, Morgan DO. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol. 1999 Mar 11; 9(5):227-36. PMID: 10074450.
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      58. Espinoza FH, Farrell A, Nourse JL, Chamberlin HM, Gileadi O, Morgan DO. Cak1 is required for Kin28 phosphorylation and activation in vivo. Mol Cell Biol. 1998 Nov; 18(11):6365-73. PMID: 9774652; PMCID: PMC109222.
      59. Jaspersen SL, Charles JF, Tinker-Kulberg RL, Morgan DO. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 1998 Oct; 9(10):2803-17. PMID: 9763445; PMCID: PMC25555.
      60. Jin P, Hardy S, Morgan DO. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998 May 18; 141(4):875-85. PMID: 9585407; PMCID: PMC2132764.
      61. Morgan DO, Fisher RP, Espinoza FH, Farrell A, Nourse J, Chamberlin H, Jin P. Control of eukaryotic cell cycle progression by phosphorylation of cyclin-dependent kinases. Cancer J Sci Am. 1998 May; 4 Suppl 1:S77-83. PMID: 9619275.
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      62. Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 1998 Apr 23; 8(9):497-507. PMID: 9560342.
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      63. Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM. The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997 Oct 15; 11(20):2645-57. PMID: 9334327; PMCID: PMC316603.
      64. Morgan DO. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol. 1997; 13:261-91. PMID: 9442875.
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      65. Morgan DO. The dynamics of cyclin dependent kinase structure. Curr Opin Cell Biol. 1996 Dec; 8(6):767-72. PMID: 8939669.
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      66. Espinoza FH, Farrell A, Erdjument-Bromage H, Tempst P, Morgan DO. A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science. 1996 Sep 20; 273(5282):1714-7. PMID: 8781234.
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      67. Fisher RP, Morgan DO. CAK in TFIIH: crucial connection or confounding coincidence? Biochim Biophys Acta. 1996 Aug 8; 1288(1):O7-10. PMID: 8764843.
        View in: PubMed
      68. Jin P, Gu Y, Morgan DO. Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J Cell Biol. 1996 Aug; 134(4):963-70. PMID: 8769420; PMCID: PMC2120957.
      69. Fisher RP, Jin P, Chamberlin HM, Morgan DO. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell. 1995 Oct 6; 83(1):47-57. PMID: 7553872.
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      70. Kaplan KB, Swedlow JR, Morgan DO, Varmus HE. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 1995 Jun 15; 9(12):1505-17. PMID: 7541382.
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      71. Gerber MR, Farrell A, Deshaies RJ, Herskowitz I, Morgan DO. Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Proc Natl Acad Sci U S A. 1995 May 9; 92(10):4651-5. PMID: 7753858; PMCID: PMC42002.
      72. Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9; 374(6518):131-4. PMID: 7877684.
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      73. Desai D, Wessling HC, Fisher RP, Morgan DO. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol. 1995 Jan; 15(1):345-50. PMID: 7799941; PMCID: PMC231966.
      74. Espinoza FH, Ogas J, Herskowitz I, Morgan DO. Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science. 1994 Nov 25; 266(5189):1388-91. PMID: 7973730.
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      75. Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J. 1994 Oct 17; 13(20):4745-56. PMID: 7525268; PMCID: PMC395413.
      76. Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell. 1994 Aug 26; 78(4):713-24. PMID: 8069918.
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      77. Morgan DO, De Bondt HL. Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol. 1994 Apr; 6(2):239-46. PMID: 7517688.
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      78. Gu Y, Turck CW, Morgan DO. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 1993 Dec 16; 366(6456):707-10. PMID: 8259216.
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      79. Murphy SM, Bergman M, Morgan DO. Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae. Mol Cell Biol. 1993 Sep; 13(9):5290-300. PMID: 7689149; PMCID: PMC360223.
      80. Rosenblatt J, De Bondt H, Jancarik J, Morgan DO, Kim SH. Purification and crystallization of human cyclin-dependent kinase 2. J Mol Biol. 1993 Apr 20; 230(4):1317-9. PMID: 8487311.
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      81. Gu Y, Rosenblatt J, Morgan DO. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 1992 Nov; 11(11):3995-4005. PMID: 1396589; PMCID: PMC556910.
      82. Kaplan KB, Swedlow JR, Varmus HE, Morgan DO. Association of p60c-src with endosomal membranes in mammalian fibroblasts. J Cell Biol. 1992 Jul; 118(2):321-33. PMID: 1378446; PMCID: PMC2290043.
      83. Desai D, Gu Y, Morgan DO. Activation of human cyclin-dependent kinases in vitro. Mol Biol Cell. 1992 May; 3(5):571-82. PMID: 1535244; PMCID: PMC275609.
      84. Rosenblatt J, Gu Y, Morgan DO. Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2824-8. PMID: 1532660; PMCID: PMC48755.
      85. Morgan DO. Cell cycle control in normal and neoplastic cells. Curr Opin Genet Dev. 1992 Feb; 2(1):33-7. PMID: 1385997.
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      86. Morgan DO, Kaplan JM, Bishop JM, Varmus HE. Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Cell. 1989 Jun 2; 57(5):775-86. PMID: 2470513.
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      87. Ellis L, Morgan DO, Clauser E, Roth RA, Rutter WJ. A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose. Mol Endocrinol. 1987 Jan; 1(1):15-24. PMID: 2842659.
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