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    David Morgan, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPhysiology
    Address600 16th Street 94158 2517
    Phone415-476-6695

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201.
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      2. Foster SA, Morgan DO. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32.
        View in: PubMed
      3. Yaakov G, Thorn K, Morgan DO. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36.
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      4. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7.
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      5. Schaefer JB, Morgan DO. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96.
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      6. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Dec 1; 480(7375):128-31.
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      7. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23.
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      8. Lyons NA, Morgan DO. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 6; 42(3):378-89.
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      9. Rodrigo-Brenni MC, Foster SA, Morgan DO. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59.
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      10. Morgan DO. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6.
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      11. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6.
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      12. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6.
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      13. Matyskiela ME, Morgan DO. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80.
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      14. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90.
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      15. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO. Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol. 2009; 8(10):92.
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      16. Tully GH, Nishihama R, Pringle JR, Morgan DO. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell. 2009 Feb; 20(4):1201-12.
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      17. Morgan DO. SnapShot: Cell-cycle regulators II. Cell. 2008 Nov 28; 135(5):974-974.e1.
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      18. Morgan DO. SnapShot: cell-cycle regulators I. Cell. 2008 Nov 14; 135(4):764-764.e1.
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      19. Sullivan M, Holt L, Morgan DO. Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol. 2008 Sep; 28(17):5328-36.
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      20. Holt LJ, Krutchinsky AN, Morgan DO. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17; 454(7202):353-7.
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      21. Enquist-Newman M, Sullivan M, Morgan DO. Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell. 2008 May 23; 30(4):437-46.
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      22. Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1442-7.
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      23. Sullivan M, Morgan DO. Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol. 2007 Nov; 8(11):894-903.
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      24. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72.
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      25. Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell. 2007 Dec; 18(12):5139-53.
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      26. Woodbury EL, Morgan DO. The role of self-association in Fin1 function on the mitotic spindle. J Biol Chem. 2007 Nov 2; 282(44):32138-43.
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      27. Rodrigo-Brenni MC, Morgan DO. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell. 2007 Jul 13; 130(1):127-39.
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      28. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7.
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      29. Sullivan M, Morgan DO. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem. 2007 Jul 6; 282(27):19710-5.
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      30. Holt LJ, Hutti JE, Cantley LC, Morgan DO. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell. 2007 Mar 9; 25(5):689-702.
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      31. Woodbury EL, Morgan DO. Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol. 2007 Jan; 9(1):106-12.
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      32. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60.
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      33. Loog M, Morgan DO. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature. 2005 Mar 3; 434(7029):104-8.
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      34. Carroll CW, Enquist-Newman M, Morgan DO. The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol. 2005 Jan 11; 15(1):11-8.
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      35. Carroll CW, Morgan DO. Enzymology of the anaphase-promoting complex. Methods Enzymol. 2005; 398:219-30.
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      36. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64.
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      37. Carroll CW, Morgan DO. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol. 2002 Nov; 4(11):880-7.
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      38. Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc. 2002 Oct 16; 124(41):12118-28.
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      39. Morgan DO, Roberts JM. Oscillation sensation. Nature. 2002 Aug 1; 418(6897):495-6.
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      40. Polson AG, Huang L, Lukac DM, Blethrow JD, Morgan DO, Burlingame AL, Ganem D. Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. J Virol. 2001 Apr; 75(7):3175-84.
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      41. Takizawa CG, Morgan DO. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol. 2000 Dec; 12(6):658-65.
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      42. Jaspersen SL, Morgan DO. Cdc14 activates cdc15 to promote mitotic exit in budding yeast. Curr Biol. 2000 May 18; 10(10):615-8.
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      43. Farrell A, Morgan DO. Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol Cell Biol. 2000 Feb; 20(3):749-54.
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      44. Tinker-Kulberg RL, Morgan DO. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev. 1999 Aug 1; 13(15):1936-49.
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      45. Takizawa CG, Weis K, Morgan DO. Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta. Proc Natl Acad Sci U S A. 1999 Jul 6; 96(14):7938-43.
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      46. Morgan DO. Regulation of the APC and the exit from mitosis. Nat Cell Biol. 1999 Jun; 1(2):E47-53.
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      47. Jaspersen SL, Charles JF, Morgan DO. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol. 1999 Mar 11; 9(5):227-36.
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      48. Espinoza FH, Farrell A, Nourse JL, Chamberlin HM, Gileadi O, Morgan DO. Cak1 is required for Kin28 phosphorylation and activation in vivo. Mol Cell Biol. 1998 Nov; 18(11):6365-73.
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      49. Jaspersen SL, Charles JF, Tinker-Kulberg RL, Morgan DO. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 1998 Oct; 9(10):2803-17.
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      50. Jin P, Hardy S, Morgan DO. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998 May 18; 141(4):875-85.
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      51. Morgan DO, Fisher RP, Espinoza FH, Farrell A, Nourse J, Chamberlin H, Jin P. Control of eukaryotic cell cycle progression by phosphorylation of cyclin-dependent kinases. Cancer J Sci Am. 1998 May; 4 Suppl 1:S77-83.
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      52. Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 1998 Apr 23; 8(9):497-507.
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      53. Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM. The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997 Oct 15; 11(20):2645-57.
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      54. Morgan DO. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol. 1997; 13:261-91.
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      55. Morgan DO. The dynamics of cyclin dependent kinase structure. Curr Opin Cell Biol. 1996 Dec; 8(6):767-72.
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      56. Espinoza FH, Farrell A, Erdjument-Bromage H, Tempst P, Morgan DO. A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science. 1996 Sep 20; 273(5282):1714-7.
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      57. Fisher RP, Morgan DO. CAK in TFIIH: crucial connection or confounding coincidence? Biochim Biophys Acta. 1996 Aug 8; 1288(1):O7-10.
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      58. Jin P, Gu Y, Morgan DO. Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J Cell Biol. 1996 Aug; 134(4):963-70.
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      59. Fisher RP, Jin P, Chamberlin HM, Morgan DO. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell. 1995 Oct 6; 83(1):47-57.
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      60. Kaplan KB, Swedlow JR, Morgan DO, Varmus HE. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 1995 Jun 15; 9(12):1505-17.
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      61. Gerber MR, Farrell A, Deshaies RJ, Herskowitz I, Morgan DO. Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Proc Natl Acad Sci U S A. 1995 May 9; 92(10):4651-5.
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      62. Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9; 374(6518):131-4.
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      63. Desai D, Wessling HC, Fisher RP, Morgan DO. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol. 1995 Jan; 15(1):345-50.
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      64. Espinoza FH, Ogas J, Herskowitz I, Morgan DO. Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science. 1994 Nov 25; 266(5189):1388-91.
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      65. Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J. 1994 Oct 17; 13(20):4745-56.
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      66. Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell. 1994 Aug 26; 78(4):713-24.
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      67. Morgan DO, De Bondt HL. Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol. 1994 Apr; 6(2):239-46.
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      68. Gu Y, Turck CW, Morgan DO. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 1993 Dec 16; 366(6456):707-10.
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      69. Murphy SM, Bergman M, Morgan DO. Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae. Mol Cell Biol. 1993 Sep; 13(9):5290-300.
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      70. Rosenblatt J, De Bondt H, Jancarik J, Morgan DO, Kim SH. Purification and crystallization of human cyclin-dependent kinase 2. J Mol Biol. 1993 Apr 20; 230(4):1317-9.
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      71. Gu Y, Rosenblatt J, Morgan DO. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 1992 Nov; 11(11):3995-4005.
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      72. Kaplan KB, Swedlow JR, Varmus HE, Morgan DO. Association of p60c-src with endosomal membranes in mammalian fibroblasts. J Cell Biol. 1992 Jul; 118(2):321-33.
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      73. Desai D, Gu Y, Morgan DO. Activation of human cyclin-dependent kinases in vitro. Mol Biol Cell. 1992 May; 3(5):571-82.
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      74. Rosenblatt J, Gu Y, Morgan DO. Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2824-8.
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      75. Morgan DO. Cell cycle control in normal and neoplastic cells. Curr Opin Genet Dev. 1992 Feb; 2(1):33-7.
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      76. Morgan DO, Kaplan JM, Bishop JM, Varmus HE. Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Cell. 1989 Jun 2; 57(5):775-86.
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      77. Ellis L, Morgan DO, Clauser E, Roth RA, Rutter WJ. A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose. Mol Endocrinol. 1987 Jan; 1(1):15-24.
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