Su Guo, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1550 4th Street, Bldg 19B, #484D
San Francisco CA 94158
ORCID ORCID Icon0000-0002-7342-0108 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Fudan University1991  - 1991Outstanding Student Award
    Cornell Graduate School1994  - 1994Liu Memorial Award
    Pharmacia Biotech and Science 1998  - 1998Finalist, Amersham Pharmacia Biotech and Science Prize for Young Scientist
    2001  - 2001Searle Scholar
    2001  - 2001Burroughs Wellcome Fund New Investigator
    UCSF2002  - 2002Sandler Award
    David and Lucile Packard Foundation2002  - 2002Science and Engineering Fellow of the David and Lucile Packard Foundation
    UCSF2005  - 2005Sandler Award
    UCSF2006  - 2006Byers Award

    Collapse Overview 
    Collapse Overview
    Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. After graduation, she became fascinated with how the brain works. As a research and postdoctoral fellow at Harvard Medical School and Genentech Inc. respectively, she carried out neurobiological studies of the development of brain neurotransmitter systems, using the vertebrate genetic model organism zebrafish. After establishing her independent research lab at the University of California, San Francisco, Dr. Guo has continued to study the molecular genetics of neural development and has expanded her research into the understanding of behavior. With her research, Dr. Guo strives to make significant contributions to our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Single-cell transcriptomic analysis of sibling progenitors with differential Notch activity
    NIH R21NS122053Sep 30, 2021 - Mar 31, 2024
    Role: Principal Investigator
    Mechanisms of renin-angiotensin signaling in programmed and insult-induced neuronal death
    NIH R01NS120219Sep 27, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Asymmetric Cell Division of Vertebrate Radial Glia Neural Progenitors
    NIH R01NS120218May 1, 2021 - Apr 30, 2026
    Role: Principal Investigator
    Mechanisms that drive the variation of aversive behavior
    NIH R01GM132500Sep 16, 2019 - Jul 31, 2023
    Role: Principal Investigator
    Explore in vivo functional connectivity at cellular resolution in drugged brains
    NIH R21DA044007Jul 1, 2017 - Sep 30, 2019
    Role: Principal Investigator
    Functional connectivity at cellular resolution in brains with mutations in ASD genes
    NIH R21MH113961Jun 16, 2017 - May 31, 2019
    Role: Principal Investigator
    Asymmetric Cell Division in Vertebrate Brain Development
    NIH R01NS095734Sep 30, 2015 - Jun 30, 2020
    Role: Principal Investigator
    A novel RNA-guided platform for dissecting cannabinoid signaling in reward circuit development
    NIH R21DA038447Apr 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Developing tools for understanding neuromodulation of hypothalamic func
    NIH R01DA035680Sep 15, 2013 - Dec 31, 2018
    Role: Principal Investigator
    Mapping neuronal circuitry for aversion in the developing vertebrate brain
    NIH R21DA034983May 1, 2013 - Apr 30, 2016
    Role: Principal Investigator
    Advancing Whole-Organism Screening for Chemical Modifiers of the Brain
    NIH R21NS082938Feb 1, 2013 - Jan 31, 2016
    Role: Principal Investigator
    Chemical Genetics to Elucidate the Development of Dopaminergic Neurons
    NIH R01DA023904Jul 1, 2008 - Jul 31, 2013
    Role: Principal Investigator
    An in vivo cellular model to study the biological effects of alcohol
    NIH R01AA016021Sep 30, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Role of conserved non-coding elements in vertebrate brain development
    NIH R21HD051835Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    Using zebrafish to study Parkinson's disease
    NIH R21NS043590Feb 1, 2002 - Jan 31, 2005
    Role: Principal Investigator
    Development of Dopaminergic Neurons in Zebrafish
    NIH R01NS042626Dec 1, 2001 - Jul 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors. J Vis Exp. 2023 01 20; (191). Zhao X, Guo S. PMID: 36744775.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Correction to: Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons. Mol Psychiatry. 2022 Sep; 27(9):3794. Wagle M, Zarei M, Lovett-Barron M, Poston KT, Xu J, Ramey V, Pollard KS, Prober DA, Schulkin J, Deisseroth K, Guo S. PMID: 35718796; PMCID: PMC9708591.
      View in: PubMed   Mentions:    Fields:    
    3. Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons. Mol Psychiatry. 2022 09; 27(9):3777-3793. Wagle M, Zarei M, Lovett-Barron M, Poston KT, Xu J, Ramey V, Pollard KS, Prober DA, Schulkin J, Deisseroth K, Guo S. PMID: 35484242; PMCID: PMC9613822.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. High activity and high functional connectivity are mutually exclusive in resting state zebrafish and human brains. BMC Biol. 2022 04 11; 20(1):84. Zarei M, Xie D, Jiang F, Bagirov A, Huang B, Raj A, Nagarajan S, Guo S. PMID: 35410342; PMCID: PMC8996543.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets. Front Pharmacol. 2022; 13:837756. Kim GJ, Mo H, Liu H, Okorie M, Chen S, Zheng J, Li H, Arkin M, Huang B, Guo S. PMID: 35370735; PMCID: PMC8971663.
      View in: PubMed   Mentions: 3  
    6. The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19. Sci Rep. 2021 12 08; 11(1):23670. Kim GJ, Melgoza A, Jiang F, Guo S. PMID: 34880395; PMCID: PMC8655050.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021 09 22; 10. Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. PMID: 34550070; PMCID: PMC8457844.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    8. THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior. Sci Rep. 2021 08 03; 11(1):15693. Dahlén A, Zarei M, Melgoza A, Wagle M, Guo S. PMID: 34344922; PMCID: PMC8333334.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    9. Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding. Learn Mem. 2021 07; 28(7):228-238. Xu J, Casanave R, Guo S. PMID: 34131054; PMCID: PMC8212779.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021 06; 7(24). Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S. PMID: 34117063; PMCID: PMC8195473.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Regulation of Neurogenesis in Mouse Brain by HMGB1. Cells. 2020 07 17; 9(7). Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H. PMID: 32708917; PMCID: PMC7407245.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish. Molecular Biology. 2020 May 1; 54(3):382-390. Pi PY, He HK, Zhang ZW, Dong DZ, Jiang JF, Jiang JK, Guo GS. .
      View in: Publisher Site   Mentions:
    13. Chapter 14 Molecular genetic approaches to dissect complex behaviors in zebrafish. . 2020 Jan 1; 223-244. Xu XJ, Guo GS. .
      View in: Publisher Site   Mentions:
    14. Heritable natural variation of light/dark preference in an outbred zebrafish population. J Neurogenet. 2019 12; 33(4):199-208. Dahlén A, Wagle M, Zarei M, Guo S. PMID: 31544554; PMCID: PMC6919307.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol. 2019 05 16; 26(5):674-685.e6. Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. PMID: 30853418; PMCID: PMC7185887.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    16. A novel PRRT2 pathogenic variant in a family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures. Cold Spring Harb Mol Case Stud. 2018 02; 4(1). Lu JG, Bishop J, Cheyette S, Zhulin IB, Guo S, Sobreira N, Brenner SE. PMID: 29167286; PMCID: PMC5793775.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    17. Chapter 16 Systematic Screens in Zebrafish Shed Light on Cellular and Molecular Mechanisms of Complex Brain Phenotypes . Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research. 2018 Jan 1; 385-400. Melgoza MA, Guo GS. .
      View in: Publisher Site   Mentions:
    18. Heritable natural variation of an anxiety-like behavior in larval zebrafish. J Neurogenet. 2017 09; 31(3):138-148. Wagle M, Nguyen J, Lee S, Zaitlen N, Guo S. PMID: 28678579; PMCID: PMC6051355.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    19. Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model. Dev Growth Differ. 2017 May; 59(4):194-210. Oltrabella F, Melgoza A, Nguyen B, Guo S. PMID: 28516445; PMCID: PMC5636690.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    20. A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery. PLoS One. 2016; 11(10):e0164645. Liu H, Chen S, Huang K, Kim J, Mo H, Iovine R, Gendre J, Pascal P, Li Q, Sun Y, Dong Z, Arkin M, Guo S, Huang B. PMID: 27732643; PMCID: PMC5061318.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016; 25(2):308-15. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X.
    22. Open-top selective plane illumination microscope for conventionally mounted specimens. Opt Express. 2015 Jun 15; 23(12):16142-53. McGorty R, Liu H, Kamiyama D, Dong Z, Guo S, Huang B. PMID: 26193587; PMCID: PMC4523553.
      View in: PubMed   Mentions: 38     Fields:    
    23. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Cell Metab. 2015 Jan 06; 21(1):95-108. Gehrke S, Wu Z, Klinkenberg M, Sun Y, Auburger G, Guo S, Lu B. PMID: 25565208; PMCID: PMC4455944.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    24. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. PMID: 25319688; PMCID: PMC4198537.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    25. Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells. Biochem Biophys Res Commun. 2014 Oct 03; 452(4):895-900. Liu C, Sun Y, Arnold J, Lu B, Guo S. PMID: 25218470; PMCID: PMC4193974.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508. Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. PMID: 24040509; PMCID: PMC3771564.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Stable gene silencing in zebrafish with spatiotemporally targetable RNA interference. Genetics. 2013 Apr; 193(4):1065-71. Dong Z, Peng J, Guo S. PMID: 23378068; PMCID: PMC3606086.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. Understanding neurotransmitter-neuropeptide regulation through neural circuits controlling innate behaviour. International Journal of Developmental Neuroscience. 2012 Dec 1; 30(8):686. Wagle WM, Guo GS. .
      View in: Publisher Site   Mentions:
    29. Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain. J Neurosci. 2012 Aug 08; 32(32):10940-8. Yang N, Dong Z, Guo S. PMID: 22875928; PMCID: PMC3478895.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. PLoS One. 2012; 7(5):e35202. Ritter DI, Dong Z, Guo S, Chuang JH. PMID: 22567096; PMCID: PMC3342275.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    31. Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides. PLoS One. 2012; 7(4):e35645. Sun Y, Dong Z, Khodabakhsh H, Chatterjee S, Guo S. PMID: 22563390; PMCID: PMC3338518.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia. Neuron. 2012 Apr 12; 74(1):65-78. Dong Z, Yang N, Yeo SY, Chitnis A, Guo S. PMID: 22500631; PMCID: PMC3466114.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    33. Toward molecular genetic dissection of neural circuits for emotional and motivational behaviors. Dev Neurobiol. 2012 Mar; 72(3):358-65. Guo S, Wagle M, Mathur P. PMID: 21634015.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    34. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet. 2011 Aug 15; 20(16):3227-40. Yu W, Sun Y, Guo S, Lu B. PMID: 21613270; PMCID: PMC3140825.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    35. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J Biol Chem. 2011 May 27; 286(21):18641-9. Chen L, Zheng J, Yang N, Li H, Guo S. PMID: 21471212; PMCID: PMC3099680.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. Time-lapse live imaging of clonally related neural progenitor cells in the developing zebrafish forebrain. J Vis Exp. 2011 Apr 06; (50). Dong Z, Wagle M, Guo S. PMID: 21505407; PMCID: PMC3169268.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    37. Conditioned place preference behavior in zebrafish. Nat Protoc. 2011 Mar; 6(3):338-45. Mathur P, Lau B, Guo S. PMID: 21372814; PMCID: PMC6233885.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    38. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2581-6. Lau BY, Mathur P, Gould GG, Guo S. PMID: 21262817; PMCID: PMC3038752.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    39. Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behav Brain Res. 2011 Jun 01; 219(2):234-9. Mathur P, Guo S. PMID: 21255611; PMCID: PMC3062742.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    40. The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain Res. 2011 Mar 24; 1381:95-105. Mueller T, Dong Z, Berberoglu MA, Guo S. PMID: 21219890; PMCID: PMC3052766.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    41. Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol. J Neurosci. 2011 Jan 05; 31(1):214-24. Wagle M, Mathur P, Guo S. PMID: 21209207; PMCID: PMC3030280.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Preference for ethanol in zebrafish following a single exposure. Behav Brain Res. 2011 Feb 02; 217(1):128-33. Mathur P, Berberoglu MA, Guo S. PMID: 20974186; PMCID: PMC3466104.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    43. The importance of being cis: evolution of orthologous fish and mammalian enhancer activity. Mol Biol Evol. 2010 Oct; 27(10):2322-32. Ritter DI, Li Q, Kostka D, Pollard KS, Guo S, Chuang JH. PMID: 20494938; PMCID: PMC3107594.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    44. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis. 2010 Oct; 40(1):66-72. Mathur P, Guo S. PMID: 20493262; PMCID: PMC3021971.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    45. Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying alcoholism. Communicative & Integrative Biology. 2009 Nov 1; 2(6):512-514. Guo GS, Peng PJ, Wagle WM, Müller MT, Mathur MP. .
      View in: Publisher Site   Mentions:
    46. The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. J Comp Neurol. 2009 Oct 20; 516(6):553-68. Mueller T, Guo S. PMID: 19673006; PMCID: PMC2828780.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    47. A systematic approach to identify functional motifs within vertebrate developmental enhancers. Dev Biol. 2010 Jan 15; 337(2):484-95. Li Q, Ritter D, Yang N, Dong Z, Li H, Chuang JH, Guo S. PMID: 19850031; PMCID: PMC3330829.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    48. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 2009 Oct; 10(10):1569-76. Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. PMID: 19842929; PMCID: PMC2923222.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 2009 Sep 09; 4(9):e6918. Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S. PMID: 19742326; PMCID: PMC2735033.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    50. Using zebrafish to assess the impact of drugs on neural development and function. Expert Opin Drug Discov. 2009 Jul 01; 4(7):715-726. Guo S. PMID: 19774094; PMCID: PMC2747263.
      View in: PubMed   Mentions: 49     Fields:    
    51. Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. J Neurosci. 2009 Jul 01; 29(26):8408-18. Peng J, Wagle M, Mueller T, Mathur P, Lockwood BL, Bretaud S, Guo S. PMID: 19571131; PMCID: PMC2722107.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    52. fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene Expr Patterns. 2009 Sep; 9(6):411-22. Berberoglu MA, Dong Z, Mueller T, Guo S. PMID: 19524703; PMCID: PMC2746713.
      View in: PubMed   Mentions: 11     Fields:    
    53. 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7798-803. Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM. PMID: 19416841; PMCID: PMC2683122.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    54. Communicative & Integrative Biology . Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying Alcoholism . 2009; 2(6):512-514. Guo, S., Peng, J., Wagle, M., Mueller, T. and Mathur, P.
    55. Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 2008; 3(11):e3621. Krishnan K, Salomonis N, Guo S. PMID: 18978947; PMCID: PMC2575381.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation. Bioinformatics. 2008 Oct 15; 24(20):2418-9. Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH. PMID: 18718943; PMCID: PMC2562007.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    57. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol. 2008 Mar 10; 507(2):1245-57. Mueller T, Wullimann MF, Guo S. PMID: 18181142.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    58. Parkinson’s Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models. Insights from zebrafish PD models, and their potential for identifying novel drug targets and therapeutic compounds. 2008. Guo, S.
    59. Biomarkers for Psychiatric Disorders. Animal models for anxiety disorders. 2008; New York, NY. Guo, S.
    60. Chapter 23 Insights from Zebrafish PD Models and Their Potentials for Identifying Novel Drug Targets and Therapeutic Compounds. Parkinson\u0027s Disease. 2008 Jan 1; 309-319. Guo GS. .
      View in: Publisher Site   Mentions:
    61. Animal Models for Anxiety Disorders. Biomarkers for Psychiatric Disorders. 2008 Jan 1; 203-216. Guo GS. .
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    62. A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish. Neuroscience. 2007 May 25; 146(3):1109-16. Bretaud S, Li Q, Lockwood BL, Kobayashi K, Lin E, Guo S. PMID: 17428610.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    63. Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development. 2007 Jan; 134(1):127-36. Jeong JY, Einhorn Z, Mathur P, Chen L, Lee S, Kawakami K, Guo S. PMID: 17164418.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    64. A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17284-9. Wang X, Yang N, Uno E, Roeder RG, Guo S. PMID: 17088561; PMCID: PMC1859923.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    65. Dissociation of food and opiate preference by a genetic mutation in zebrafish. Genes Brain Behav. 2006 Oct; 5(7):497-505. Lau B, Bretaud S, Huang Y, Lin E, Guo S. PMID: 17010096.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    66. Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5143-8. Jeong JY, Einhorn Z, Mercurio S, Lee S, Lau B, Mione M, Wilson SW, Guo S. PMID: 16549779; PMCID: PMC1458808.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    67. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol. 2006 Mar-Apr; 28(2):245-50. Giacomini NJ, Rose B, Kobayashi K, Guo S. PMID: 16527449.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    68. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol. 2004 Nov-Dec; 26(6):857-64. Bretaud S, Lee S, Guo S. PMID: 15451049.
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    69. A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol. 2004 Sep; 53(6):1677-93. Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ. PMID: 15341647.
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    70. Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? Genes Brain Behav. 2004 Apr; 3(2):63-74. Guo S. PMID: 15005714.
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    71. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol Biochem Behav. 2004 Mar; 77(3):647-54. Lockwood B, Bjerke S, Kobayashi K, Guo S. PMID: 15006478.
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    72. The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. 2004; 127(1):147-54. Rink E, Guo S. PMID: 15219677.
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    73. The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons. Development. 2003 Jun; 130(12):2669-79. Lee SA, Shen EL, Fiser A, Sali A, Guo S. PMID: 12736211.
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    74. A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination. J Neurochem. 2002 Mar; 80(5):905-16. Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS. PMID: 11948255.
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    75. Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav. 2000 Dec; 67(4):773-82. Gerlai R, Lahav M, Guo S, Rosenthal A. PMID: 11166068.
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    76. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature. 2000 Nov 16; 408(6810):366-9. Guo S, Yamaguchi Y, Schilbach S, Wada T, Lee J, Goddard A, French D, Handa H, Rosenthal A. PMID: 11099044.
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    77. Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron. 1999 Nov; 24(3):555-66. Guo S, Brush J, Teraoka H, Goddard A, Wilson SW, Mullins MC, Rosenthal A. PMID: 10595509.
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    78. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol. 1999 Apr 15; 208(2):473-87. Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A. PMID: 10191060.
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    79. Handbook of Molecular Genetic Techniques for Brain and Behavior Research. Mutagenesis in zebrafish: studying the brain dopamine systems. 1999. Guo, S., W. Driever, and A. Rosenthal .
    80. Chapter 2.1.8 Mutagenesis in zebra fish: studying the brain dopamine systems. Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. 1999 Jan 1; 13:166-176. Guo GS, Driever DW, Rosenthal RA. .
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    81. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development. 1996 Oct; 122(10):3075-84. Boyd L, Guo S, Levitan D, Stinchcomb DT, Kemphues KJ. PMID: 8898221.
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    82. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development. 1996 Oct; 122(10):3133-40. Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ. PMID: 8898226.
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    83. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo. Curr Opin Genet Dev. 1996 Aug; 6(4):408-15. Guo S, Kemphues KJ. PMID: 8791533.
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    84. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature. 1996 Aug 01; 382(6590):455-8. Guo S, Kemphues KJ. PMID: 8684486.
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    85. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell. 1995 Dec 01; 83(5):743-52. Etemad-Moghadam B, Guo S, Kemphues KJ. PMID: 8521491.
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    86. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 1995 May 19; 81(4):611-20. Guo S, Kemphues KJ. PMID: 7758115.
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