-
Therapeutic Trial of anle138b in Mouse Models of Genetic Prion Disease. J Virol. 2023 02 28; 97(2):e0167222.
Vallabh SM, Zou D, Pitstick R, O'Moore J, Peters J, Silvius D, Kriz J, Jackson WS, Carlson GA, Minikel EV, Cabin DE. PMID: 36651748; PMCID: PMC9973041.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Fibril treatment changes protein interactions of tau and α-synuclein in human neurons. J Biol Chem. 2023 03; 299(3):102888.
Griffin TA, Schnier PD, Cleveland EM, Newberry RW, Becker J, Carlson GA. PMID: 36634849; PMCID: PMC9978635.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders. Int J Mol Sci. 2021 May 04; 22(9).
Carlson GA, Prusiner SB. PMID: 34064393; PMCID: PMC8125442.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021 05 19; 109(10):1675-1691.e9.
Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R. PMID: 33848474; PMCID: PMC8141031.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
-
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints. Nucleic Acids Res. 2020 11 04; 48(19):10615-10631.
Minikel EV, Zhao HT, Le J, O'Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-Ura K, Beck M, O'Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. PMID: 32776089; PMCID: PMC7641729.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
-
Core transcriptional regulatory circuits in prion diseases. Mol Brain. 2020 01 20; 13(1):10.
Kim TK, Lee I, Cho JH, Canine B, Keller A, Price ND, Hwang D, Carlson G, Hood L. PMID: 31959236; PMCID: PMC6972013.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein. Acta Neuropathol Commun. 2019 05 20; 7(1):81.
Krejciova Z, Carlson GA, Giles K, Prusiner SB. PMID: 31109379; PMCID: PMC6526619.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
-
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nat Neurosci. 2019 01; 22(1):57-64.
Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. PMID: 30559471; PMCID: PMC6560629.
View in:
PubMed Mentions:
150 Fields:
Translation:
AnimalsCells
-
Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212.
DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BT. PMID: 29733334; PMCID: PMC6022692.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proc Natl Acad Sci U S A. 2017 12 19; 114(51):E11029-E11036.
Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB. PMID: 29203673; PMCID: PMC5754811.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Neurodegenerative Disease Transmission and Transgenesis in Mice. Cold Spring Harb Perspect Biol. 2017 Nov 01; 9(11).
Dugger BN, Perl DP, Carlson GA. PMID: 28193724; PMCID: PMC5666636.
View in:
PubMed Mentions:
8 Fields:
Translation:
Animals
-
Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding. Prog Mol Biol Transl Sci. 2017; 150:123-145.
Carlson GA. PMID: 28838658.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circ Res. 2017 Jul 21; 121(3):258-269.
Park L, Uekawa K, Garcia-Bonilla L, Koizumi K, Murphy M, Pistik R, Younkin L, Younkin S, Zhou P, Carlson G, Anrather J, Iadecola C. PMID: 28515043; PMCID: PMC5522360.
View in:
PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
-
Enhanced Tau Aggregation in the Presence of Amyloid β. Am J Pathol. 2017 Jul; 187(7):1601-1612.
Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. PMID: 28500862; PMCID: PMC5500829.
View in:
PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
-
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017 Jun; 187(6):1399-1412.
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S. PMID: 28408124; PMCID: PMC5455060.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
-
Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse. 2017 06; 71(6).
Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL. PMID: 28196395; PMCID: PMC5516127.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds. Hum Mol Genet. 2017 03 01; 26(5):913-922.
Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE. PMID: 28334820; PMCID: PMC6075528.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
-
The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system. Dis Model Mech. 2017 05 01; 10(5):605-618.
Chaverra M, George L, Mergy M, Waller H, Kujawa K, Murnion C, Sharples E, Thorne J, Podgajny N, Grindeland A, Ueki Y, Eiger S, Cusick C, Babcock AM, Carlson GA, Lefcort F. PMID: 28167615; PMCID: PMC5451171.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. Eur J Neurosci. 2016 12; 44(12):3056-3066.
Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. PMID: 27748574; PMCID: PMC5215483.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 08 18; 23(8):992-1001.
Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. PMID: 27499529; PMCID: PMC4992411.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016 09; 80(3):355-67.
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. PMID: 27351289; PMCID: PMC5016222.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
-
Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice. PLoS One. 2016; 11(7):e0159377.
Gallego-Llamas J, Timms AE, Pitstick R, Peters J, Carlson GA, Beier DR. PMID: 27441645; PMCID: PMC4956170.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis. Hum Mol Genet. 2016 06 01; 25(11):2245-2255.
Husson H, Moreno S, Smith LA, Smith MM, Russo RJ, Pitstick R, Sergeev M, Ledbetter SR, Bukanov NO, Lane M, Zhang K, Billot K, Carlson G, Shah J, Meijer L, Beier DR, Ibraghimov-Beskrovnaya O. PMID: 27053712; PMCID: PMC5081056.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
-
A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone. PLoS One. 2016; 11(2):e0149410.
Daude N, Lee I, Kim TK, Janus C, Glaves JP, Gapeshina H, Yang J, Sykes BD, Carlson GA, Hood LE, Westaway D. PMID: 26894278; PMCID: PMC4760942.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2016 Mar; 75(3):256-62.
Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond SJ. PMID: 26851378; PMCID: PMC4902861.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J. 2015 Dec 14; 34(24):3028-41.
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. PMID: 26538322; PMCID: PMC4687785.
View in:
PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
-
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490.
Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. PMID: 26458742; PMCID: PMC4608380.
View in:
PubMed Mentions:
171 Fields:
Translation:
HumansAnimalsCells
-
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathol Commun. 2015 Mar 24; 3:14.
Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. PMID: 25853174; PMCID: PMC4371800.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansAnimalsCells
-
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice. Mamm Genome. 2015 Feb; 26(1-2):80-93.
Anderson SR, Lee I, Ebeling C, Stephenson DA, Schweitzer KM, Baxter D, Moon TM, LaPierre S, Jaques B, Silvius D, Wegner M, Hood LE, Carlson G, Gunn TM. PMID: 25399070; PMCID: PMC4305468.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Lipids Health Dis. 2014 Oct 31; 13:167.
Helmering J, Juan T, Li CM, Chhoa M, Baron W, Gyuris T, Richards WG, Turk JR, Lawrence J, Cosgrove PA, Busby J, Kim KW, Kaufman SA, Cummings C, Carlson G, Véniant MM, Lloyd DJ. PMID: 25361754; PMCID: PMC4232700.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke. 2014 Jun; 45(6):1815-21.
Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. PMID: 24781082; PMCID: PMC4284427.
View in:
PubMed Mentions:
65 Fields:
Translation:
Animals
-
Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain. Springerplus. 2014; 3:161.
Ghate PS, Sidhar H, Carlson GA, Giri RK. PMID: 25140287; PMCID: PMC4137416.
View in:
PubMed Mentions:
9
-
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol. 2014 Feb 03; 204(3):423-41.
Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, Carlson GA, Godsave SF, Peters PJ, Luhr K, Kristensson K, Taraboulos A. PMID: 24493590; PMCID: PMC3912534.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neurosci Lett. 2014 Mar 06; 562:63-8.
Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. PMID: 24462887; PMCID: PMC3992382.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. J Comp Neurol. 2013 Dec 15; 521(18):4236-48.
Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. PMID: 23839581; PMCID: PMC3797265.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy. Neuropharmacology. 2014 Apr; 79:307-13.
Graham DL, Gray AJ, Joyce JA, Yu D, O'Moore J, Carlson GA, Shearman MS, Dellovade TL, Hering H. PMID: 24326295.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathol. 2014 Feb; 127(2):257-70.
Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. PMID: 24271788; PMCID: PMC3946978.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
-
Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One. 2013; 8(11):e80834.
Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. PMID: 24278327; PMCID: PMC3835324.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
-
Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18698-703.
George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F. PMID: 24173031; PMCID: PMC3831979.
View in:
PubMed Mentions:
42 Fields:
Translation:
Animals
-
Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400. FEBS Lett. 2013 Nov 15; 587(22):3722-8.
Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, Neny M, Beher D, Carlson G, O'Moore J, Shearman M, Hering H. PMID: 24113653.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. J Neurosci. 2013 Aug 14; 33(33):13300-11.
Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT. PMID: 23946388; PMCID: PMC3742920.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
-
RML prions act through Mahogunin and Attractin-independent pathways. Prion. 2013 Jul-Aug; 7(4):267-71.
Gunn TM, Carlson GA. PMID: 23787699; PMCID: PMC3904309.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013 Apr 15; 521(6):1334-53.
Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. PMID: 23047530; PMCID: PMC3725804.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
-
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3089-94.
Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, Iadecola C. PMID: 23382216; PMCID: PMC3581946.
View in:
PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
-
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLoS One. 2013; 8(1):e55575.
Silvius D, Pitstick R, Ahn M, Meishery D, Oehler A, Barsh GS, DeArmond SJ, Carlson GA, Gunn TM. PMID: 23383230; PMCID: PMC3559536.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
-
Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke. 2013 Jan; 44(1):198-204.
Park L, Zhou P, Koizumi K, El Jamal S, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. PMID: 23204056; PMCID: PMC3530010.
View in:
PubMed Mentions:
28 Fields:
Translation:
Animals
-
Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 2012; 7(6):e39328.
Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. PMID: 22723997; PMCID: PMC3377636.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. J Mol Biol. 2012 Sep 28; 422(4):556-574.
Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G. PMID: 22687393; PMCID: PMC5006934.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):9035-40.
Daude N, Wohlgemuth S, Brown R, Pitstick R, Gapeshina H, Yang J, Carlson GA, Westaway D. PMID: 22619325; PMCID: PMC3384183.
View in:
PubMed Mentions:
40 Fields:
Translation:
AnimalsCells
-
A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases. J Neuropathol Exp Neurol. 2012 May; 71(5):449-66.
Bajsarowicz K, Ahn M, Ackerman L, Dearmond BN, Carlson G, DeArmond SJ. PMID: 22507918.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Front Pharmacol. 2012; 3:42.
Spires-Jones TL, Fox LM, Rozkalne A, Pitstick R, Carlson GA, Kazantsev AG. PMID: 22416232; PMCID: PMC3298895.
View in:
PubMed Mentions:
22
-
Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 2012 Feb 23; 73(4):685-97.
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. PMID: 22365544; PMCID: PMC3292759.
View in:
PubMed Mentions:
716 Fields:
Translation:
HumansAnimalsCells
-
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation. PLoS Pathog. 2011 Nov; 7(11):e1002391.
Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. PMID: 22114562; PMCID: PMC3219720.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 2011 Oct; 179(4):2071-82.
Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. PMID: 21854751; PMCID: PMC3181340.
View in:
PubMed Mentions:
146 Fields:
Translation:
HumansAnimalsCells
-
The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model. J Neuroimmune Pharmacol. 2012 Jun; 7(2):412-23.
Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. PMID: 21826404; PMCID: PMC3223330.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. J Neuropathol Exp Neurol. 2011 Jul; 70(7):588-95.
Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT. PMID: 21666499; PMCID: PMC3118928.
View in:
PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
-
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):5063-8.
Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C. PMID: 21383152; PMCID: PMC3064396.
View in:
PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
-
Principal network analysis: identification of subnetworks representing major dynamics using gene expression data. Bioinformatics. 2011 Feb 01; 27(3):391-8.
Kim Y, Kim TK, Kim Y, Yoo J, You S, Lee I, Carlson G, Hood L, Choi S, Hwang D. PMID: 21193522; PMCID: PMC3031040.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
-
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010 Dec 22; 68(6):1067-81.
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D. PMID: 21172610; PMCID: PMC3026458.
View in:
PubMed Mentions:
517 Fields:
Translation:
AnimalsCells
-
Generation of antisera to purified prions in lipid rafts. Prion. 2010 Apr-Jun; 4(2):94-104.
Hnasko R, Serban AV, Carlson G, Prusiner SB, Stanker LH. PMID: 20647769; PMCID: PMC2933057.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Caspase activation precedes and leads to tangles. Nature. 2010 Apr 22; 464(7292):1201-4.
de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. PMID: 20357768; PMCID: PMC3091360.
View in:
PubMed Mentions:
281 Fields:
Translation:
HumansAnimalsCells
-
Systems biology and the discovery of diagnostic biomarkers. Dis Markers. 2010; 28(4):199-207.
Wang K, Lee I, Carlson G, Hood L, Galas D. PMID: 20534905; PMCID: PMC3021550.
View in:
PubMed Mentions:
18 Fields:
Translation:
Humans
-
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. PLoS Pathog. 2009 Oct; 5(10):e1000608.
Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. PMID: 19798432; PMCID: PMC2749441.
View in:
PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
-
The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database (Oxford). 2009; 2009:bap011.
Gehlenborg N, Hwang D, Lee IY, Yoo H, Baxter D, Petritis B, Pitstick R, Marzolf B, Dearmond SJ, Carlson GA, Hood L. PMID: 20157484; PMCID: PMC2790306.
View in:
PubMed Mentions:
14 Fields:
-
New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification. J Bone Miner Res. 2009 Sep; 24(9):1552-64.
Babij P, Roudier M, Graves T, Han CY, Chhoa M, Li CM, Juan T, Morony S, Grisanti M, Li X, Yu L, Dwyer D, Lloyd DJ, Bass MB, Richards WG, Ebeling C, Amato J, Carlson G. PMID: 19419305.
View in:
PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
-
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. J Neuropathol Exp Neurol. 2009 Jul; 68(7):757-61.
de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT. PMID: 19535996; PMCID: PMC2756569.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
A systems approach to prion disease. Mol Syst Biol. 2009; 5:252.
Hwang D, Lee IY, Yoo H, Gehlenborg N, Cho JH, Petritis B, Baxter D, Pitstick R, Young R, Spicer D, Price ND, Hohmann JG, Dearmond SJ, Carlson GA, Hood LE. PMID: 19308092; PMCID: PMC2671916.
View in:
PubMed Mentions:
147 Fields:
Translation:
HumansAnimalsCells
-
Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice. J Lipid Res. 2009 Mar; 50(3):534-545.
Juan T, Véniant MM, Helmering J, Babij P, Baker DM, Damore MA, Bass MB, Gyuris T, Chhoa M, Li CM, Ebeling C, Amato J, Carlson GA, Lloyd DJ. PMID: 18974039.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-1788.
Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. PMID: 18559949; PMCID: PMC2828448.
View in:
PubMed Mentions:
67 Fields:
Translation:
HumansAnimals
-
Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells. J Gen Virol. 2008 Jun; 89(Pt 6):1525-1532.
Kumar R, McClain D, Young R, Carlson GA. PMID: 18474570; PMCID: PMC2706533.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 2008 Jan 23; 28(4):862-7.
Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. PMID: 18216194; PMCID: PMC6670992.
View in:
PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
-
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1347-52.
Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C. PMID: 18202172; PMCID: PMC2234141.
View in:
PubMed Mentions:
193 Fields:
Translation:
HumansAnimalsCells
-
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. EMBO J. 2007 Sep 05; 26(17):4038-50.
Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D. PMID: 17703189; PMCID: PMC1950727.
View in:
PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
-
Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation. Am J Pathol. 2006 Oct; 169(4):1365-75.
Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti MA, Janus C, Matsubara E, Sasaki A, Kawarai T, Phinney AL, Harigaya Y, Horne P, Egashira N, Mishima K, Hanna A, Yang J, Iwasaki K, Takahashi M, Fujiwara M, Ishiguro K, Bergeron C, Carlson GA, Abe K, Westaway D, St George-Hyslop P, Shoji M. PMID: 17003492; PMCID: PMC1698843.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. Am J Pathol. 2006 May; 168(5):1598-607.
Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. PMID: 16651626; PMCID: PMC1606598.
View in:
PubMed Mentions:
194 Fields:
Translation:
AnimalsCells
-
Prion infection of mouse neurospheres. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3875-80.
Giri RK, Young R, Pitstick R, DeArmond SJ, Prusiner SB, Carlson GA. PMID: 16495413; PMCID: PMC1533787.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci. 2005 Nov 16; 25(46):10637-47.
Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. PMID: 16291936; PMCID: PMC6725849.
View in:
PubMed Mentions:
335 Fields:
Translation:
HumansAnimalsCells
-
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8972-7.
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. PMID: 15951428; PMCID: PMC1149500.
View in:
PubMed Mentions:
30 Fields:
Translation:
Animals
-
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 2005 Feb 16; 25(7):1769-77.
Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C. PMID: 15716413; PMCID: PMC6725936.
View in:
PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
-
Implementing large-scale ENU mutagenesis screens in North America. Genetica. 2004 Sep; 122(1):51-64.
Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepka SM, Peters LL, Frankel WN, Carlson GA, Rossant J, Nadeau JH, Justice MJ. PMID: 15619961; PMCID: PMC3774779.
View in:
PubMed Mentions:
40 Fields:
Translation:
Animals
-
Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Hum Mol Genet. 2004 Sep 15; 13(18):1989-97.
Krezowski J, Knudson D, Ebeling C, Pitstick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA. PMID: 15254013.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J Neurochem. 2004 Jun; 89(5):1308-12.
Li F, Calingasan NY, Yu F, Mauck WM, Toidze M, Almeida CG, Takahashi RH, Carlson GA, Flint Beal M, Lin MT, Gouras GK. PMID: 15147524.
View in:
PubMed Mentions:
129 Fields:
Translation:
HumansAnimals
-
Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. J Cereb Blood Flow Metab. 2004 Mar; 24(3):334-42.
Park L, Anrather J, Forster C, Kazama K, Carlson GA, Iadecola C. PMID: 15091114.
View in:
PubMed Mentions:
69 Fields:
Translation:
HumansAnimals
-
In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14193-8.
Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. PMID: 14617772; PMCID: PMC283568.
View in:
PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
-
A welcoming environment for amyloid plaques. Nat Neurosci. 2003 Apr; 6(4):328-30.
Carlson GA. PMID: 12658277.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
Postexposure prophylaxis against transmissible spongiform encephalopathies: CpG oligodeoxynucleotides in mice. Lancet. 2002 Jul 20; 360(9328):184.
Carlson GA. PMID: 12133649.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimals
-
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002 Mar 01; 22(5):1858-67.
Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. PMID: 11880515; PMCID: PMC6758862.
View in:
PubMed Mentions:
281 Fields:
Translation:
HumansAnimals