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    Linda Noble, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address513 Parnassus Ave, HSE-722
    San Francisco CA 94143
    Phone415-476-4850

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11; 490(7419):187-91.
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      2. Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ. Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury. Dev Neurosci. 2010; 32(5-6):454-65.
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      3. Mao H, Jin X, Zhang L, Yang KH, Igarashi T, Noble-Haeusslein LJ, King AI. Finite element analysis of controlled cortical impact-induced cell loss. J Neurotrauma. 2010 May; 27(5):877-88.
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      4. Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist. 2010 Apr; 16(2):156-70.
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      5. Yoneyama-Sarnecky T, Olivas AD, Azari S, Ferriero DM, Manvelyan HM, Noble-Haeusslein LJ. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Dev Neurosci. 2010 Mar; 32(1):81-90.
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      6. Bazarian JJ, Cernak I, Noble-Haeusslein L, Potolicchio S, Temkin N. Long-term neurologic outcomes after traumatic brain injury. J Head Trauma Rehabil. 2009 Nov-Dec; 24(6):439-51.
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      7. Cernak I, Noble-Haeusslein LJ. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J Cereb Blood Flow Metab. 2010 Feb; 30(2):255-66.
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      8. Potts MB, Adwanikar H, Noble-Haeusslein LJ. Models of traumatic cerebellar injury. Cerebellum. 2009 Sep; 8(3):211-21.
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      9. Margulies S, Hicks R. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma. 2009 Jun; 26(6):925-39.
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      10. Potts MB, Rola R, Claus CP, Ferriero DM, Fike JR, Noble-Haeusslein LJ. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. J Neurosci Res. 2009 Jun; 87(8):1848-57.
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      11. Tsuru-Aoyagi K, Potts MB, Trivedi A, Pfankuch T, Raber J, Wendland M, Claus CP, Koh SE, Ferriero D, Noble-Haeusslein LJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol. 2009 May; 65(5):540-9.
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      12. Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci. 2008 Dec 10; 28(50):13467-77.
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      13. Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res. 2007 Aug 1; 85(10):2272-83.
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      14. Trivedi A, Olivas AD, Noble-Haeusslein LJ. Inflammation and Spinal Cord Injury: Infiltrating Leukocytes as Determinants of Injury and Repair Processes. Clin Neurosci Res. 2006 Dec; 6(5):283-292.
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      15. Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ. Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. J Cereb Blood Flow Metab. 2007 May; 27(5):1010-21.
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      16. Igarashi T, Potts MB, Noble-Haeusslein LJ. Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury. Exp Neurol. 2007 Jan; 203(1):258-68.
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      17. Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 2006 Sep 27; 26(39):9841-50.
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      18. Rola R, Mizumatsu S, Otsuka S, Morhardt DR, Noble-Haeusslein LJ, Fishman K, Potts MB, Fike JR. Alterations in hippocampal neurogenesis following traumatic brain injury in mice. Exp Neurol. 2006 Nov; 202(1):189-99.
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      19. Olivas AD, Noble-Haeusslein LJ. Phospholipase A2 and spinal cord injury: a novel target for therapeutic intervention. Ann Neurol. 2006 Apr; 59(4):577-9.
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      20. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx. 2006 Apr; 3(2):143-53.
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      21. Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol. 2006 Mar; 198(1):88-100.
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      22. Pullela R, Raber J, Pfankuch T, Ferriero DM, Claus CP, Koh SE, Yamauchi T, Rola R, Fike JR, Noble-Haeusslein LJ. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Dev Neurosci. 2006; 28(4-5):396-409.
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      23. Chang EF, Claus CP, Vreman HJ, Wong RJ, Noble-Haeusslein LJ. Heme regulation in traumatic brain injury: relevance to the adult and developing brain. J Cereb Blood Flow Metab. 2005 Nov; 25(11):1401-17.
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      24. McLean CW, Mirochnitchenko O, Claus CP, Noble-Haeusslein LJ, Ferriero DM. Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress. Dev Neurosci. 2005 Mar-Aug; 27(2-4):169-75.
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      25. Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ. Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase. Brain Res. 2004 Dec 24; 1030(1):125-32.
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      26. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 2004 Aug; 21(8):1017-30.
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      27. Fiore C, Inman DM, Hirose S, Noble LJ, Igarashi T, Compagnone NA. Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse. J Neurosci Res. 2004 Feb 1; 75(3):391-400.
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      28. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003 Oct 15; 74(2):227-39.
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      29. Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 2003 Oct 15; 129(1):49-59.
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      30. Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. J Neurosurg. 2003 Sep; 99(2 Suppl):188-97.
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      31. Luk HW, Noble LJ, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J Neurosci Res. 2003 Sep 1; 73(5):644-58.
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      32. Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci. 2003 May 1; 23(9):3689-96.
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      33. Fan P, Yamauchi T, Noble LJ, Ferriero DM. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma. 2003 May; 20(5):437-45.
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      34. Weinzierl M, Mautes AE, Lin Y, Noble LJ. Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase. Neurosci Lett. 2003 Jan 9; 336(1):13-6.
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      35. Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci. 2002 Sep 1; 22(17):7526-35.
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      36. Tong W, Igarashi T, Ferriero DM, Noble LJ. Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability. Exp Neurol. 2002 Jul; 176(1):105-16.
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      37. Igarashi T, Huang TT, Noble LJ. Regional vulnerability after traumatic brain injury: gender differences in mice that overexpress human copper, zinc superoxide dismutase. Exp Neurol. 2001 Dec; 172(2):332-41.
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      38. Sato M, Chang E, Igarashi T, Noble LJ. Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res. 2001 Oct 26; 917(1):45-54.
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      39. Sheldon RA, Hall JJ, Noble LJ, Ferriero DM. Delayed cell death in neonatal mouse hippocampus from hypoxia-ischemia is neither apoptotic nor necrotic. Neurosci Lett. 2001 May 25; 304(3):165-8.
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      40. Mautes AE, Bergeron M, Sharp FR, Panter SS, Weinzierl M, Guenther K, Noble LJ. Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurol. 2000 Dec; 166(2):254-65.
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      41. Mautes AE, Noble LJ. Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat. Brain Res. 2000 Nov 17; 883(2):233-7.
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      42. Mautes AE, Weinzierl MR, Donovan F, Noble LJ. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys Ther. 2000 Jul; 80(7):673-87.
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      43. Sato M, Noble LJ. Involvement of the endothelin receptor subtype A in neuronal pathogenesis after traumatic brain injury. Brain Res. 1998 Oct 26; 809(1):39-49.
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      44. Mautes AE, Kim DH, Sharp FR, Panter S, Sato M, Maida N, Bergeron M, Guenther K, Noble LJ. Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat. Brain Res. 1998 Jun 8; 795(1-2):17-24.
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      45. Turner CP, Bergeron M, Matz P, Zegna A, Noble LJ, Panter SS, Sharp FR. Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J Cereb Blood Flow Metab. 1998 Mar; 18(3):257-73.
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      46. Richmon JD, Fukuda K, Maida N, Sato M, Bergeron M, Sharp FR, Panter SS, Noble LJ. Induction of heme oxygenase-1 after hyperosmotic opening of the blood-brain barrier. Brain Res. 1998 Jan 5; 780(1):108-18.
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      47. Beattie MS, Bresnahan JC, Komon J, Tovar CA, Van Meter M, Anderson DK, Faden AI, Hsu CY, Noble LJ, Salzman S, Young W. Endogenous repair after spinal cord contusion injuries in the rat. Exp Neurol. 1997 Dec; 148(2):453-63.
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      48. Cobbs CS, Fenoy A, Bredt DS, Noble LJ. Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat. Brain Res. 1997 Mar 21; 751(2):336-8.
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      49. Noble LJ, Mautes AE, Hall JJ. Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J Comp Neurol. 1996 Dec 23; 376(4):542-56.
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      50. Fukuda K, Richmon JD, Sato M, Sharp FR, Panter SS, Noble LJ. Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury. Brain Res. 1996 Oct 14; 736(1-2):68-75.
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      51. Kim DH, Gutin PH, Noble LJ, Nathan D, Yu JS, Nockels RP. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. Neuroreport. 1996 Sep 2; 7(13):2221-5.
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      52. Mautes AE, Fukuda K, Noble LJ. Cellular response in the cerebellum after midline traumatic brain injury in the rat. Neurosci Lett. 1996 Aug 23; 214(2-3):95-8.
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      53. Basso DM, Beattie MS, Bresnahan JC, Anderson DK, Faden AI, Gruner JA, Holford TR, Hsu CY, Noble LJ, Nockels R, Perot PL, Salzman SK, Young W. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma. 1996 Jul; 13(7):343-59.
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      54. Fukuda K, Aihara N, Sagar SM, Sharp FR, Pitts LH, Honkaniemi J, Noble LJ. Purkinje cell vulnerability to mild traumatic brain injury. J Neurotrauma. 1996 May; 13(5):255-66.
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      55. Richmon JD, Fukuda K, Sharp FR, Noble LJ. Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. Neurosci Lett. 1995 Dec 29; 202(1-2):1-4.
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      56. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. 1995 Dec; 11(4):376-81.
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      57. Fukuda K, Panter SS, Sharp FR, Noble LJ. Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat. Neurosci Lett. 1995 Oct 20; 199(2):127-30.
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      58. Westmark R, Noble LJ, Fukuda K, Aihara N, McKenzie AL. Intrathecal administration of endothelin-1 in the rat: impact on spinal cord blood flow and the blood-spinal cord barrier. Neurosci Lett. 1995 Jun 16; 192(3):173-6.
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      59. McKenzie AL, Hall JJ, Aihara N, Fukuda K, Noble LJ. Immunolocalization of endothelin in the traumatized spinal cord: relationship to blood-spinal cord barrier breakdown. J Neurotrauma. 1995 Jun; 12(3):257-68.
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      60. Aihara N, Hall JJ, Pitts LH, Fukuda K, Noble LJ. Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma. 1995 Feb; 12(1):53-63.
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      61. Noble LJ, Kalinyak JE, Pitts LH, Hall JJ. Fluid-phase endocytosis of horseradish peroxidase by cerebral endothelial cells in primary culture: characterization and kinetic analysis. J Neurosci Res. 1994 Aug 15; 38(6):654-63.
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      62. Aihara N, Tanno H, Hall JJ, Pitts LH, Noble LJ. Immunocytochemical localization of immunoglobulins in the rat brain: relationship to the blood-brain barrier. J Comp Neurol. 1994 Apr 22; 342(4):481-96.
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      63. Tanno H, Nockels RP, Pitts LH, Noble LJ. Immunolocalization of heat shock protein after fluid percussive brain injury and relationship to breakdown of the blood-brain barrier. J Cereb Blood Flow Metab. 1993 Jan; 13(1):116-24.
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      64. Tanno H, Nockels RP, Pitts LH, Noble LJ. Breakdown of the blood-brain barrier after fluid percussive brain injury in the rat. Part 1: Distribution and time course of protein extravasation. J Neurotrauma. 1992; 9(1):21-32.
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      65. Noble LJ, Hall JJ, Chen S, Chan PH. Morphologic changes in cultured astrocytes after exposure to glutamate. J Neurotrauma. 1992; 9(3):255-67.
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      66. Tanno H, Nockels RP, Pitts LH, Noble LJ. Breakdown of the blood-brain barrier after fluid percussion brain injury in the rat: Part 2: Effect of hypoxia on permeability to plasma proteins. J Neurotrauma. 1992; 9(4):335-47.
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      67. Noble LJ, Cortez SC, Ellison JA. Endogenous peroxidatic activity in astrocytes after spinal cord injury. J Comp Neurol. 1990 Jun 22; 296(4):674-85.
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      68. Faden AI, Ellison JA, Noble LJ. Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury. Eur J Pharmacol. 1990 Jan 10; 175(2):165-74.
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      69. Noble LJ, Ellison JA. Effect of transection on the blood-spinal cord barrier of the rat after isolation from descending sources. Brain Res. 1989 May 22; 487(2):299-310.
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      70. Cortez SC, McIntosh TK, Noble LJ. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res. 1989 Mar 20; 482(2):271-82.
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      71. Noble LJ, Wrathall JR. Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Res. 1989 Mar 13; 482(1):57-66.
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      72. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL. Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience. 1989; 28(1):233-44.
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      73. Vink R, Noble LJ, Knoblach SM, Bendall MR, Faden AI. Metabolic changes in rabbit spinal cord after trauma: magnetic resonance spectroscopy studies. Ann Neurol. 1989 Jan; 25(1):26-31.
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      74. Noble LJ, Wrathall JR. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp Neurol. 1989 Jan; 103(1):34-40.
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      75. Faden AI, Sacksen I, Noble LJ. Structure-activity relationships of TRH analogs in rat spinal cord injury. Brain Res. 1988 May 17; 448(2):287-93.
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      76. Faden AI, Sacksen I, Noble LJ. Opiate-receptor antagonist nalmefene improves neurological recovery after traumatic spinal cord injury in rats through a central mechanism. J Pharmacol Exp Ther. 1988 May; 245(2):742-8.
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      77. Noble LJ, Wrathall JR. Blood-spinal cord barrier disruption proximal to a spinal cord transection in the rat: time course and pathways associated with protein leakage. Exp Neurol. 1988 Mar; 99(3):567-78.
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      78. Faden AI, Lemke M, Simon RP, Noble LJ. N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies. J Neurotrauma. 1988; 5(1):33-45.
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      79. Noble LJ, Wrathall JR. The blood-spinal cord barrier after injury: pattern of vascular events proximal and distal to a transection in the rat. Brain Res. 1987 Oct 20; 424(1):177-88.
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      80. Noble LJ, Wrathall JR. An inexpensive apparatus for producing graded spinal cord contusive injury in the rat. Exp Neurol. 1987 Feb; 95(2):530-3.
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      81. Noble LJ, Wrathall JR. Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp Neurol. 1985 Apr; 88(1):135-49.
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      82. Noble LJ, Maxwell DS. Morphometric analysis of effects of spinal cord transection. Exp Neurol. 1983 Jan; 79(1):200-11.
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      83. Noble LJ, Maxwell DS. Blood-spinal cord barrier response to transection. Exp Neurol. 1983 Jan; 79(1):188-99.
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