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William Whetstone, MD

Title(s)Professor, Emergency Medicine
SchoolSchool of Medicine
Phone415-353-1238
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    Collapse Biography 
    Collapse Education and Training
    University of ColoradoBS1990Aerospace Engineering
    University of ColoradoM.D.1994M.D.
    University of MichiganResidency1997Department of Emergency Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Thrombin and PAR-1 in Spinal Cord Injury
    NIH/NINDS K08NS043302Jul 25, 2002 - Jun 30, 2008
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yue JK, Hemmerle DP, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS. Clinical implementation of a novel spinal cord perfusion pressure protocol in acute traumatic spinal cord injury at a U.S. Level I trauma center: A TRACK-SCI study. World Neurosurg. 2019 Sep 14. PMID: 31526882.
      View in: PubMed
    2. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS. In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2019 Aug 01; 85(2):E401-E402. PMID: 31173137.
      View in: PubMed
    3. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS. Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2019 Aug 01; 85(2):199-203. PMID: 30496474.
      View in: PubMed
    4. McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF. Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury. AJNR Am J Neuroradiol. 2019 Apr; 40(4):737-744. PMID: 30923086.
      View in: PubMed
    5. Lau D, Dalle Ore CL, Tarapore PE, Huang M, Manley G, Singh V, Mummaneni PV, Beattie M, Bresnahan J, Ferguson AR, Talbott JF, Whetstone W, Dhall SS. Value of aggressive surgical and intensive care unit in elderly patients with traumatic spinal cord injury. Neurosurg Focus. 2019 Mar 01; 46(3):E3. PMID: 30835676.
      View in: PubMed
    6. William D. Whetstone. Neurotrauma and Critical Care of the Spine. By Jack Jallo, MD, PhD, and Alexander R. Vaccaro, MD, PhD, MBA. New York: Thieme Medical Publishers, 2018; 225 pp; $179.99 (hardcover). Academic Emergency Medicine. 2019 Feb 5; 26(6):708-709.
      View in: Publisher Site
    7. Whetstone WD. Neurotrauma and Critical Care of the Spine. By Jack Jallo, MD, PhD, and Alexander R. Vaccaro, MD, PhD, MBA. New York: Thieme Medical Publishers, 2018; 225 pp; $179.99 (hardcover). Acad Emerg Med. 2019 Feb 05. PMID: 30843337.
      View in: PubMed
    8. Kvam KA, Douglas VC, Whetstone WD, Josephson SA, Betjemann JP. Yield of Emergent CT in Patients With Epilepsy Presenting With a Seizure. Neurohospitalist. 2019 Apr; 9(2):71-78. PMID: 30915184.
      View in: PubMed
    9. Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD. Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury. Neurosurgery. 2018 06 01; 82(6):870-876. PMID: 28973360.
      View in: PubMed
    10. Graterol J, Beylin M, Whetstone WD, Matzoll A, Burke R, Talbott J, Rodriguez RM. Low Yield of Paired Head and Cervical Spine Computed Tomography in Blunt Trauma Evaluation. J Emerg Med. 2018 06; 54(6):749-756. PMID: 29685476.
      View in: PubMed
    11. Vineeta Singh, J. Russell Huie, Dolores Torres, Adam Ferguson, Michael Beattie, Jacqueline Bresnahan, Jonathan Pan, Lisa Pascual, Jason Talbott, Rachel Tsolinas, Xuan Fernandez, William Whetstone, Sanjay Dhall, Phil Weinstein. 141. Critical Care Medicine. 2018 Jan 1; 46(1):53.
      View in: Publisher Site
    12. DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley GT, Whetstone WD, Mummaneni PV, Dhall SS. Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data. Neurosurg Focus. 2017 Nov; 43(5):E21. PMID: 29088948.
      View in: PubMed
    13. Lisa U. Pascual, J. Russell Huie, William D. Whetstone, Sanjay S. Dhall, Geoffrey T. Manley, Jacqueline C. Bresnahan, Michael S. Beattie, Vineeta Singh, Adam R. Ferguson, Rachel E. Tsolinas, Jason F. Talbott. Poster 466: Prospective Determination of Clinical Neurologic Level of Injury with Early MRI Following Blunt Traumatic Spinal Cord Injury. PM&R. 2017 Sep 1; 9(9):s280-s281.
      View in: Publisher Site
    14. Whetstone WD, Walker B, Trivedi A, Lee S, Noble-Haeusslein LJ, Hsu JC. Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury. PLoS One. 2017; 12(1):e0170512. PMID: 28122028.
      View in: PubMed
    15. Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF. Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury. AJNR Am J Neuroradiol. 2017 Mar; 38(3):648-655. PMID: 28007771.
      View in: PubMed
    16. Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 Nov; 79(5):708-714. PMID: 27759678.
      View in: PubMed
    17. Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries. World Neurosurg. 2016 Dec; 96:72-79. PMID: 27565460.
      View in: PubMed
    18. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J, Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley GT, Tarapore PE, Dhall SS. 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression. Neurosurgery. 2016 Aug; 63 Suppl 1:172. PMID: 27399461.
      View in: PubMed
    19. John Frederick Burke, John K. Yue, Laura Benjamin Ngwenya, Ethan A. Winkler, Jason Talbott, Jonathan Pan, Adam Ferguson, Michael Beattie, Jacqueline Bresnahan, Jenny Haefeli, William Whetstone, Catherine Suen, Michael C. Huang, Geoffrey T. Manley, Phiroz E. Tarapore, Sanjay S. Dhall. 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression. Neurosurgery. 2016 Aug 1; 63:172.
      View in: Publisher Site
    20. Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 May 03. PMID: 27145343.
      View in: PubMed
    21. Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR. Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury. J Neurotrauma. 2016 05 15; 33(10):954-62. PMID: 26414451.
      View in: PubMed
    22. Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma. 2015 Dec 15; 32(24):1958-67. PMID: 25669633.
      View in: PubMed
    23. Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J Neurosurg Spine. 2015 Nov; 23(5):574-580. PMID: 26230417.
      View in: PubMed
    24. Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS. The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings. J Neurosurg Spine. 2015 Oct; 23(4):495-504. PMID: 26161519.
      View in: PubMed
    25. Burnett MM, Zimmermann L, Coralic Z, Quon T, Whetstone W, Kim AS. Simple text-messaging intervention is associated with improved door-to-needle times for acute ischemic stroke. Stroke. 2014 Dec; 45(12):3714-6. PMID: 25352486.
      View in: PubMed
    26. Sanjay S. Dhall, Geoffrey T. Manley, Tomoo S. Inoue, William Whetstone. 161 Complications and Duration of Vasopressor Usage for Acute Traumatic Central Cord Syndrome. Neurosurgery. 2014 Aug 1; 61(CN_suppl_1):213-213.
      View in: Publisher Site
    27. Gregory W.J. Hawryluk, William Whetstone, Rajiv Saigal, Adam Ferguson, Jason Talbott, Jacqueline Bresnahan, Jonathan Pan, Michael Beattie, Sanjay S. Dhall, Geoffrey T. Manley. 162 Higher Mean Arterial Blood Pressures Following Spinal Cord Injury are Associated With Greater Neurological Recovery. Neurosurgery. 2014 Aug 1; 61(CN_suppl_1):213-213.
      View in: Publisher Site
    28. Inoue T, Manley GT, Patel N, Whetstone WD. Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications. J Neurotrauma. 2014 Feb 01; 31(3):284-91. PMID: 24020382.
      View in: PubMed
    29. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. The use of neuroimaging studies and neurological consultation to evaluate dizzy patients in the emergency department. Neurohospitalist. 2013 Jan; 3(1):7-14. PMID: 23983882.
      View in: PubMed
    30. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. Rate and predictors of serious neurologic causes of dizziness in the emergency department. Mayo Clin Proc. 2012 Nov; 87(11):1080-8. PMID: 23063099.
      View in: PubMed
    31. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke. 2012 Jun; 43(6):1484-9. PMID: 22442167.
      View in: PubMed
    32. Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ. Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury. Dev Neurosci. 2010; 32(5-6):454-65. PMID: 20847543.
      View in: PubMed
    33. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx. 2006 Apr; 3(2):143-53. PMID: 16554253.
      View in: PubMed
    34. William Whetstone.. Prehospital Management of SCI Individuals with Extremity Fractures. Topics in Spinal Cord Injury Rehabilitation. 2005; 11(1):11-17.
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    35. Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ. Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase. Brain Res. 2004 Dec 24; 1030(1):125-32. PMID: 15567344.
      View in: PubMed
    36. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003 Oct 15; 74(2):227-39. PMID: 14515352.
      View in: PubMed
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