William Whetstone, MD

Title(s)Professor, Emergency Medicine
SchoolSchool of Medicine
Address521 Parnassus Avenue
San Francisco CA 94117
Phone415-353-1634
ORCID ORCID Icon0002-8568-6640 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of ColoradoBS1990Aerospace Engineering
    University of ColoradoM.D.1994M.D.
    University of MichiganResidency1997Department of Emergency Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Thrombin and PAR-1 in Spinal Cord Injury
    NIH K08NS043302Jul 25, 2002 - Jun 30, 2008
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome. PLoS One. 2022; 17(4):e0265254. Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone WD, Ferguson AR, TRACK-SCI Investigators. PMID: 35390006; PMCID: PMC8989303.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury. Neurosurg Focus. 2022 04; 52(4):E9. Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone WD, Bresnahan JC, Manley GT, Beattie MS, DiGiorgio AM. PMID: 35364586.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study. J Neurotrauma. 2022 08; 39(15-16):1030-1038. Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR, Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) Investigators. PMID: 35255740; PMCID: PMC9536347.
      View in: PubMed   Mentions:    Fields:    
    4. Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury. Elife. 2021 11 16; 10. Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, Whetstone WD, Bresnahan JC, Beattie MS, McKenna SL, Pan JZ, Ferguson AR, TRACK-SCI Investigators. PMID: 34783309; PMCID: PMC8639149.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Diagnostic blood RNA profiles for human acute spinal cord injury. J Exp Med. 2021 03 01; 218(3). Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein PR, Manley GT, Dhall SS, Ferguson AR, Oldham MC, Bresnahan JC, Beattie MS. PMID: 33512429; PMCID: PMC7852457.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research. J Neurotrauma. 2021 05 01; 38(9):1251-1266. Morse LR, Field-Fote EC, Contreras-Vidal J, Noble-Haeusslein LJ, Rodreick M, Shields RK, Sofroniew M, Wudlick R, Zanca JM, SCI 2020 Working Group. PMID: 33353467.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Atlas-based Volumetric Analysis of Blunt Spinal Cord Contusion Injury. Neurosurgery. 2020 Dec 1; 67(Supplement_1). Burke BJ, Mummaneni MN, Ferguson FA, Huie HJ, Thomas TL, Pascual PL, DiGiorgio DA, Hemmerle HD, Singh SV, Torres TA, Kyritsis KN, Weinstein WP, Whetstone WW, Dhall DS, Fernandez FX, Beattie BM, Bresnahan BJ, Talbott TJ. .
      View in: Publisher Site   Mentions:
    8. Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study. J Clin Neurosci. 2020 Dec; 82(Pt B):231-236. Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Cohen-Adad J, Dhall SS, Talbott JF. PMID: 33248950.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. XGBoost, a Machine Learning Method, Predicts Neurological Recovery in Patients with Cervical Spinal Cord Injury. Neurotrauma Rep. 2020; 1(1):8-16. Inoue T, Ichikawa D, Ueno T, Cheong M, Inoue T, Whetstone WD, Endo T, Nizuma K, Tominaga T. PMID: 34223526; PMCID: PMC8240917.
      View in: PubMed   Mentions: 4  
    10. Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics. Neurosurg Focus. 2020 05 01; 48(5):E6. Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Haefeli J, Weinstein PR, de Almeida Neto CA, Kuo YH, Taggard D, Talbott JF, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Dhall SS. PMID: 32357323.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study. World Neurosurg. 2020 Jan; 133:e391-e396. Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS. PMID: 31526882.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Initial Experience of Spinal Cord Perfusion Pressure Goals in Lieu of Mean Arterial Pressure Goals in Acute Traumatic Spinal Cord Injury at a United States Level I Trauma Center: A Transforming Research and Clinical Knowledge-Spinal Cord Injury Study. Neurosurgery. 2019 Sep 1; 66(Supplement_1). Yue YJ, Hemmerle HD, Deng DH, Winkler WE, Thomas TL, Fernandez FX, Upadhyayula UP, Kyritsis KN, Pascual PL, Singh SV, Weinstein WP, Talbott TJ, Huie HJ, Ferguson FA, Whetstone WW, Manley MG, Beattie BM, Bresnahan BJ, Mummaneni MP, Dhall DS. .
      View in: Publisher Site   Mentions:
    13. In Reply: Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2019 08 01; 85(2):E401-E402. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS. PMID: 31173137.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Ultra-Early (<12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury. Neurosurgery. 2019 08 01; 85(2):199-203. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott JF, Pan JZ, Ferguson AR, Beattie MS, Bresnahan JC, Haefeli J, Whetstone WD, Suen CG, Huang MC, Manley GT, Tarapore PE, Dhall SS. PMID: 30496474.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    15. Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury. AJNR Am J Neuroradiol. 2019 04; 40(4):737-744. McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF, TRACK-SCI Investigators. PMID: 30923086; PMCID: PMC7048524.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. Value of aggressive surgical and intensive care unit in elderly patients with traumatic spinal cord injury. Neurosurg Focus. 2019 03 01; 46(3):E3. Lau D, Dalle Ore CL, Tarapore PE, Huang M, Manley G, Singh V, Mummaneni PV, Beattie M, Bresnahan J, Ferguson AR, Talbott JF, Whetstone W, Dhall SS. PMID: 30835676.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Neurotrauma and Critical Care of the Spine. By Jack Jallo, MD, PhD, and Alexander R. Vaccaro, MD, PhD, MBA. New York: Thieme Medical Publishers, 2018; 225 pp; $179.99 (hardcover). Acad Emerg Med. 2019 Feb 05. Whetstone WD. PMID: 30843337.
      View in: PubMed   Mentions:
    18. Yield of Emergent CT in Patients With Epilepsy Presenting With a Seizure. Neurohospitalist. 2019 Apr; 9(2):71-78. Kvam KA, Douglas VC, Whetstone WD, Josephson SA, Betjemann JP. PMID: 30915184; PMCID: PMC6429671.
      View in: PubMed   Mentions:
    19. Motor Evoked Potentials Correlate With Magnetic Resonance Imaging and Early Recovery After Acute Spinal Cord Injury. Neurosurgery. 2018 06 01; 82(6):870-876. Dhall SS, Haefeli J, Talbott JF, Ferguson AR, Readdy WJ, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Whetstone WD. PMID: 28973360.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    20. Low Yield of Paired Head and Cervical Spine Computed Tomography in Blunt Trauma Evaluation. J Emerg Med. 2018 06; 54(6):749-756. Graterol J, Beylin M, Whetstone WD, Matzoll A, Burke R, Talbott J, Rodriguez RM. PMID: 29685476.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. 141. Critical Care Medicine. 2018 Jan 1; 46(1):53. Singh SV, Huie HJ, Torres TD, Ferguson FA, Beattie BM, Bresnahan BJ, Pan PJ, Pascual PL, Talbott TJ, Tsolinas TR, Fernandez FX, Whetstone WW, Dhall DS, Weinstein WP. .
      View in: Publisher Site   Mentions:
    22. Safety and effectiveness of early chemical deep venous thrombosis prophylaxis after spinal cord injury: pilot prospective data. Neurosurg Focus. 2017 Nov; 43(5):E21. DiGiorgio AM, Tsolinas R, Alazzeh M, Haefeli J, Talbott JF, Ferguson AR, Bresnahan JC, Beattie MS, Manley GT, Whetstone WD, Mummaneni PV, Dhall SS. PMID: 29088948.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. Poster 466: Prospective Determination of Clinical Neurologic Level of Injury with Early MRI Following Blunt Traumatic Spinal Cord Injury. PM&R. 2017 Sep 1; 9(9):s280-s281. Pascual PL, Huie HJ, Whetstone WW, Dhall DS, Manley MG, Bresnahan BJ, Beattie BM, Singh SV, Ferguson FA, Tsolinas TR, Talbott TJ. .
      View in: Publisher Site   Mentions:
    24. Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury. PLoS One. 2017; 12(1):e0170512. Whetstone WD, Walker B, Trivedi A, Lee S, Noble-Haeusslein LJ, Hsu JC. PMID: 28122028; PMCID: PMC5266300.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury. AJNR Am J Neuroradiol. 2017 Mar; 38(3):648-655. Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF. PMID: 28007771; PMCID: PMC5671488.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 Nov; 79(5):708-714. Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS. PMID: 27759678.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Higher Mean Arterial Pressure Values Correlate with Neurologic Improvement in Patients with Initially Complete Spinal Cord Injuries. World Neurosurg. 2016 Dec; 96:72-79. Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. PMID: 27565460; PMCID: PMC5127746.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    28. 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression. Neurosurgery. 2016 Aug; 63 Suppl 1:172. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J, Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley GT, Tarapore PE, Dhall SS. PMID: 27399461.
      View in: PubMed   Mentions:
    29. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 May 03. Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS. PMID: 27145343.
      View in: PubMed   Mentions:
    30. Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury. J Neurotrauma. 2016 05 15; 33(10):954-62. Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley GT, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR. PMID: 26414451; PMCID: PMC4876497.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    31. Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma. 2015 Dec 15; 32(24):1958-67. Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. PMID: 25669633; PMCID: PMC4677564.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    32. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J Neurosurg Spine. 2015 Nov; 23(5):574-580. Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS. PMID: 26230417.
      View in: PubMed   Mentions: 12     Fields:    
    33. The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings. J Neurosurg Spine. 2015 Oct; 23(4):495-504. Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS. PMID: 26161519.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    34. Simple text-messaging intervention is associated with improved door-to-needle times for acute ischemic stroke. Stroke. 2014 Dec; 45(12):3714-6. Burnett MM, Zimmermann L, Coralic Z, Quon T, Whetstone W, Kim AS. PMID: 25352486.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    35. 161 Complications and Duration of Vasopressor Usage for Acute Traumatic Central Cord Syndrome. Neurosurgery. 2014 Aug 1; 61(CN_suppl_1):213-213. Dhall DS, Manley MG, Inoue IT, Whetstone WW. .
      View in: Publisher Site   Mentions:
    36. 162 Higher Mean Arterial Blood Pressures Following Spinal Cord Injury are Associated With Greater Neurological Recovery. Neurosurgery. 2014 Aug 1; 61(CN_suppl_1):213-213. Hawryluk HG, Whetstone WW, Saigal SR, Ferguson FA, Talbott TJ, Bresnahan BJ, Pan PJ, Beattie BM, Dhall DS, Manley MG. .
      View in: Publisher Site   Mentions:
    37. Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications. J Neurotrauma. 2014 Feb 01; 31(3):284-91. Inoue T, Manley GT, Patel N, Whetstone WD. PMID: 24020382.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    38. The use of neuroimaging studies and neurological consultation to evaluate dizzy patients in the emergency department. Neurohospitalist. 2013 Jan; 3(1):7-14. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. PMID: 23983882; PMCID: PMC3726125.
      View in: PubMed   Mentions: 6  
    39. Rate and predictors of serious neurologic causes of dizziness in the emergency department. Mayo Clin Proc. 2012 Nov; 87(11):1080-8. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. PMID: 23063099; PMCID: PMC3541873.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    40. Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke. 2012 Jun; 43(6):1484-9. Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. PMID: 22442167.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    41. Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury. Dev Neurosci. 2010; 32(5-6):454-65. Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ. PMID: 20847543; PMCID: PMC3073760.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    42. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx. 2006 Apr; 3(2):143-53. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ. PMID: 16554253; PMCID: PMC3593438.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
    43. Prehospital Management of SCI Individuals with Extremity Fractures. Topics in Spinal Cord Injury Rehabilitation. 2005; 11(1):11-17. William Whetstone. . View Publication.
    44. Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase. Brain Res. 2004 Dec 24; 1030(1):125-32. Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ. PMID: 15567344.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    45. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003 Oct 15; 74(2):227-39. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. PMID: 14515352; PMCID: PMC2837839.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
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