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Linda Noble, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-4850
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    Collapse Research 
    Collapse Research Activities and Funding
    Determinants of vulnerability and recovery after trauma to the developing brain
    NIH/NINDS R01NS077767Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Spinal cord injury: Targeting local inhibition to improve outcome
    NIH/NINDS RC1NS068200Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Trauma to developing brain: model refinement and therapeutic intervention
    NIH/NINDS R21NS065937Aug 5, 2009 - Apr 30, 2012
    Role: Co-Principal Investigator
    Trauma to developing brain-injury and repair mechanisms
    NIH/NINDS R01NS050159Dec 1, 2004 - Mar 31, 2014
    Role: Principal Investigator
    Trauma to Developing Brain-Oxidative Events and Recovery
    NIH/NINDS R21NS041256Dec 1, 2001 - May 31, 2005
    Role: Principal Investigator
    Heme Oxygenase and Spinal Cord Injury
    NIH/NINDS R01NS039847Aug 15, 2001 - Jul 31, 2005
    Role: Principal Investigator
    Matrix Metalloproteinases and Spinal Cord Injury
    NIH/NINDS R01NS039278Sep 30, 1999 - Jun 30, 2012
    Role: Principal Investigator
    SPINAL CORD INJURY--ALTERATIONS IN BARRIER PERMEABILITY
    NIH/NINDS R01NS023324Aug 1, 1985 - Nov 30, 2000
    Role: Principal Investigator
    CNS Injury and Edema Research Center
    NIH/NINDS P50NS014543Jul 1, 1978 - Jul 31, 2012
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Faber J, Wilde EA, Hanten G, Ewing-Cobbs L, Aitken ME, Yallampalli R, MacLeod MC, Mullins SH, Chu ZD, Li X, Hunter JV, Noble-Haeusslein L, Levin HS. Ten-year outcome of early childhood traumatic brain injury: Diffusion tensor imaging of the ventral striatum in relation to executive functioning. Brain Inj. 2016; 30(13-14):1635-1641. PMID: 27680309.
      View in: PubMed
    2. Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR. Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury. Cell Stem Cell. 2016 Oct 06; 19(4):544-557. PMID: 27666009.
      View in: PubMed
    3. Neumann M, Liu W, Sun C, Yang SY, Noble-Haeusslein LJ, Liu J. Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum. Behav Brain Res. 2016 Sep 08. PMID: 27614007.
      View in: PubMed
    4. Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M, et al. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury. ACS Chem Neurosci. 2016 Nov 16; 7(11):1482-1487. PMID: 27551907.
      View in: PubMed
    5. Semple BD, Sadjadi R, Carlson J, Chen Y, Xu D, Ferriero DM, Noble-Haeusslein LJ, et al. Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice. Dev Neurosci. 2016; 38(3):220-238. PMID: 27548472.
      View in: PubMed
    6. Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ, et al. Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Exp Neurol. 2016 Oct; 284(Pt A):50-62. PMID: 27468657.
      View in: PubMed
    7. Ryan NP, Catroppa C, Godfrey C, Noble-Haeusslein LJ, Shultz SR, O'Brien TJ, Anderson V, Semple BD. Social dysfunction after pediatric traumatic brain injury: A translational perspective. Neurosci Biobehav Rev. 2016 May; 64:196-214. PMID: 26949224.
      View in: PubMed
    8. Bajwa NM, Halavi S, Hamer M, Semple BD, Noble-Haeusslein LJ, Baghchechi M, Hiroto A, Hartman RE, Obenaus A. Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice. PLoS One. 2016; 11(1):e0146886. PMID: 26796696; PMCID: PMC4721654.
    9. Semple BD, Carlson J, Noble-Haeusslein LJ. Pediatric Rodent Models of Traumatic Brain Injury. Methods Mol Biol. 2016; 1462:325-43. PMID: 27604726.
      View in: PubMed
    10. Semple BD, Noble-Haeusslein LJ, Gooyit M, Tercovich KG, Peng Z, Nguyen TT, Schroeder VA, Suckow MA, Chang M, Raber J, Trivedi A. Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse. PLoS One. 2015; 10(11):e0143386. PMID: 26588471; PMCID: PMC4654502.
    11. Smith DH, Hicks RR, Johnson VE, Bergstrom DA, Cummings DM, Noble L, Hovda D, Whalen M, Ahlers ST, LaPlaca M, Tortella FC, Duhaime AC, Dixon CE. Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories. J Neurotrauma. 2015 Nov 15; 32(22):1725-35. PMID: 26058402; PMCID: PMC4651035 [Available on 11/15/16].
    12. Semple BD, Lee S, Sadjadi R, Fritz N, Carlson J, Griep C, Ho V, Jang P, Lamb A, Popolizio B, Saini S, Bazarian JJ, Prins ML, Ferriero DM, Basso DM, Noble-Haeusslein LJ. Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies. Front Neurol. 2015; 6:69. PMID: 25883586; PMCID: PMC4382966.
    13. Bondi CO, Semple BD, Noble-Haeusslein LJ, Osier ND, Carlson SW, Dixon CE, Giza CC, Kline AE. Found in translation: Understanding the biology and behavior of experimental traumatic brain injury. Neurosci Biobehav Rev. 2015 Nov; 58:123-46. PMID: 25496906.
      View in: PubMed
    14. Semple BD, Trivedi A, Gimlin K, Noble-Haeusslein LJ. Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain. Neurobiol Dis. 2015 Feb; 74:263-80. PMID: 25497734; PMCID: PMC4323771.
    15. Semple BD, Noble-Haeusslein LJ, Jun Kwon Y, Sam PN, Gibson AM, Grissom S, Brown S, Adahman Z, Hollingsworth CA, Kwakye A, Gimlin K, Wilde EA, Hanten G, Levin HS, Schenk AK. Sociosexual and communication deficits after traumatic injury to the developing murine brain. PLoS One. 2014; 9(8):e103386. PMID: 25106033; PMCID: PMC4126664.
    16. Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One. 2014; 9(5):e96408. PMID: 24788791; PMCID: PMC4006832.
    17. Chen CY, Noble-Haeusslein LJ, Ferriero D, Semple BD. Traumatic injury to the immature frontal lobe: a new murine model of long-term motor impairment in the absence of psychosocial or cognitive deficits. Dev Neurosci. 2013; 35(6):474-90. PMID: 24247103; PMCID: PMC3923401.
    18. Hansen CN, Fisher LC, Deibert RJ, Jakeman LB, Zhang H, Noble-Haeusslein L, White S, Basso DM. Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice. J Neurosci. 2013 Aug 07; 33(32):13101-11. PMID: 23926264; PMCID: PMC3735886.
    19. Semple BD, Blomgren K, Gimlin K, Ferriero DM, Noble-Haeusslein LJ. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol. 2013 Jul-Aug; 106-107:1-16. PMID: 23583307; PMCID: PMC3737272.
    20. Semple BD, Canchola SA, Noble-Haeusslein LJ. Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice. J Neurotrauma. 2012 Nov 20; 29(17):2672-83. PMID: 22888909; PMCID: PMC3510450.
    21. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble L, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11; 490(7419):187-91. PMID: 23060188; PMCID: PMC3511845.
    22. Lapchak PA, Zhang JH, Noble-Haeusslein LJ. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl Stroke Res. 2013 Jun; 4(3):279-85. PMID: 23658596; PMCID: PMC3644408.
    23. Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J Neurosci. 2011 Nov 02; 31(44):15894-903. PMID: 22049432; PMCID: PMC3265932.
    24. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907. PMID: 21657851; PMCID: PMC3172879.
    25. Zhang H, Chang M, Hansen CN, Basso DM, Noble-Haeusslein LJ. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics. 2011 Apr; 8(2):206-20. PMID: 21455784; PMCID: PMC3077748.
    26. Levine JM, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ. Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J Neurotrauma. 2011 Apr; 28(4):675-88. PMID: 21438715; PMCID: PMC3070145.
    27. Semple BD, Noble-Haeusslein LJ. Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors. Exp Neurol. 2011 Jun; 229(2):195-7. PMID: 21316363; PMCID: PMC4430724.
    28. Wang Y, Neumann M, Hansen K, Hong SM, Kim S, Noble-Haeusslein LJ, Liu J. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma. 2011 Feb; 28(2):259-68. PMID: 21175261.
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    29. McKenna MC, Noble-Haeusslein LJ, Robertson CL. Pediatric traumatic brain injury. Preface. Dev Neurosci. 2010; 32(5-6):333-4. PMID: 21212657.
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    30. Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh AL, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM. Characterization and functionality of proliferative human Sertoli cells. Cell Transplant. 2011; 20(5):619-35. PMID: 21054948; PMCID: PMC4096632.
    31. Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ. Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury. Dev Neurosci. 2010; 32(5-6):454-65. PMID: 20847543; PMCID: PMC3073760.
    32. Mao H, Jin X, Zhang L, Yang KH, Igarashi T, Noble-Haeusslein LJ, King AI. Finite element analysis of controlled cortical impact-induced cell loss. J Neurotrauma. 2010 May; 27(5):877-88. PMID: 20199194; PMCID: PMC2943943.
    33. Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist. 2010 Apr; 16(2):156-70. PMID: 20400713; PMCID: PMC2858362.
    34. Yoneyama-Sarnecky T, Olivas AD, Azari S, Ferriero DM, Manvelyan HM, Noble-Haeusslein LJ. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Dev Neurosci. 2010 Mar; 32(1):81-90. PMID: 20389079; PMCID: PMC2866583.
    35. Bazarian JJ, Cernak I, Noble-Haeusslein L, Potolicchio S, Temkin N. Long-term neurologic outcomes after traumatic brain injury. J Head Trauma Rehabil. 2009 Nov-Dec; 24(6):439-51. PMID: 19940677.
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    36. Cernak I, Noble-Haeusslein LJ. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J Cereb Blood Flow Metab. 2010 Feb; 30(2):255-66. PMID: 19809467; PMCID: PMC2855235.
    37. Potts MB, Adwanikar H, Noble-Haeusslein LJ. Models of traumatic cerebellar injury. Cerebellum. 2009 Sep; 8(3):211-21. PMID: 19495901; PMCID: PMC2734258.
    38. Margulies S, Hicks R. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma. 2009 Jun; 26(6):925-39. PMID: 19331514; PMCID: PMC2857809.
    39. Potts MB, Rola R, Claus CP, Ferriero DM, Fike JR, Noble-Haeusslein LJ. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. J Neurosci Res. 2009 Jun; 87(8):1848-57. PMID: 19170177; PMCID: PMC3306805.
    40. Tsuru-Aoyagi K, Potts MB, Trivedi A, Pfankuch T, Raber J, Wendland M, Claus CP, Koh SE, Ferriero D, Noble-Haeusslein LJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol. 2009 May; 65(5):540-9. PMID: 19475669; PMCID: PMC2690612.
    41. Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci. 2008 Dec 10; 28(50):13467-77. PMID: 19074020; PMCID: PMC2712293.
    42. Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res. 2007 Aug 01; 85(10):2272-83. PMID: 17539027.
      View in: PubMed
    43. Trivedi A, Olivas AD, Noble-Haeusslein LJ. Inflammation and Spinal Cord Injury: Infiltrating Leukocytes as Determinants of Injury and Repair Processes. Clin Neurosci Res. 2006 Dec; 6(5):283-292. PMID: 18059979.
      View in: PubMed
    44. Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ. Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. J Cereb Blood Flow Metab. 2007 May; 27(5):1010-21. PMID: 17047682.
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    45. Igarashi T, Potts MB, Noble-Haeusslein LJ. Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury. Exp Neurol. 2007 Jan; 203(1):258-68. PMID: 17045589.
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    46. Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 2006 Sep 27; 26(39):9841-50. PMID: 17005848; PMCID: PMC2659718.
    47. Rola R, Mizumatsu S, Otsuka S, Morhardt DR, Noble-Haeusslein LJ, Fishman K, Potts MB, Fike JR. Alterations in hippocampal neurogenesis following traumatic brain injury in mice. Exp Neurol. 2006 Nov; 202(1):189-99. PMID: 16876159.
      View in: PubMed
    48. Olivas AD, Noble-Haeusslein LJ. Phospholipase A2 and spinal cord injury: a novel target for therapeutic intervention. Ann Neurol. 2006 Apr; 59(4):577-9. PMID: 16566026.
      View in: PubMed
    49. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx. 2006 Apr; 3(2):143-53. PMID: 16554253; PMCID: PMC3593438.
    50. Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol. 2006 Mar; 198(1):88-100. PMID: 16387298.
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    51. Pullela R, Raber J, Pfankuch T, Ferriero DM, Claus CP, Koh SE, Yamauchi T, Rola R, Fike JR, Noble-Haeusslein LJ. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Dev Neurosci. 2006; 28(4-5):396-409. PMID: 16943663.
      View in: PubMed
    52. Chang EF, Claus CP, Vreman HJ, Wong RJ, Noble-Haeusslein LJ. Heme regulation in traumatic brain injury: relevance to the adult and developing brain. J Cereb Blood Flow Metab. 2005 Nov; 25(11):1401-17. PMID: 15917748.
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    53. McLean CW, Mirochnitchenko O, Claus CP, Noble-Haeusslein LJ, Ferriero DM. Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress. Dev Neurosci. 2005 Mar-Aug; 27(2-4):169-75. PMID: 16046851.
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    54. Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ. Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase. Brain Res. 2004 Dec 24; 1030(1):125-32. PMID: 15567344.
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    55. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 2004 Aug; 21(8):1017-30. PMID: 15319001.
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    56. Fiore C, Inman DM, Hirose S, Noble L, Igarashi T, Compagnone NA. Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse. J Neurosci Res. 2004 Feb 01; 75(3):391-400. PMID: 14743452.
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    57. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003 Oct 15; 74(2):227-39. PMID: 14515352; PMCID: PMC2837839.
    58. Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 2003 Oct 15; 129(1):49-59. PMID: 12951232.
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    59. Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. J Neurosurg. 2003 Sep; 99(2 Suppl):188-97. PMID: 12956462; PMCID: PMC2792200.
    60. Luk HW, Noble L, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J Neurosci Res. 2003 Sep 01; 73(5):644-58. PMID: 12929132; PMCID: PMC2792202.
    61. Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci. 2003 May 01; 23(9):3689-96. PMID: 12736340.
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    62. Fan P, Yamauchi T, Noble L, Ferriero DM. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma. 2003 May; 20(5):437-45. PMID: 12803976.
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    63. Weinzierl M, Mautes AE, Lin Y, Noble L. Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase. Neurosci Lett. 2003 Jan 09; 336(1):13-6. PMID: 12493591.
      View in: PubMed
    64. Noble L, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci. 2002 Sep 01; 22(17):7526-35. PMID: 12196576; PMCID: PMC2792199.
    65. Tong W, Igarashi T, Ferriero DM, Noble L. Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability. Exp Neurol. 2002 Jul; 176(1):105-16. PMID: 12093087.
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    66. Igarashi T, Huang TT, Noble L. Regional vulnerability after traumatic brain injury: gender differences in mice that overexpress human copper, zinc superoxide dismutase. Exp Neurol. 2001 Dec; 172(2):332-41. PMID: 11716557.
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    67. Sato M, Chang E, Igarashi T, Noble L. Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res. 2001 Oct 26; 917(1):45-54. PMID: 11602228.
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    68. Sheldon RA, Hall JJ, Noble L, Ferriero DM. Delayed cell death in neonatal mouse hippocampus from hypoxia-ischemia is neither apoptotic nor necrotic. Neurosci Lett. 2001 May 25; 304(3):165-8. PMID: 11343828.
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    69. Mautes AE, Bergeron M, Sharp FR, Panter SS, Weinzierl M, Guenther K, Noble L. Sustained induction of heme oxygenase-1 in the traumatized spinal cord. Exp Neurol. 2000 Dec; 166(2):254-65. PMID: 11085891.
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    70. Mautes AE, Noble L. Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat. Brain Res. 2000 Nov 17; 883(2):233-7. PMID: 11074053.
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    71. Mautes AE, Weinzierl MR, Donovan F, Noble L. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys Ther. 2000 Jul; 80(7):673-87. PMID: 10869130.
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    72. Sato M, Noble L. Involvement of the endothelin receptor subtype A in neuronal pathogenesis after traumatic brain injury. Brain Res. 1998 Oct 26; 809(1):39-49. PMID: 9795123.
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    73. Mautes AE, Kim DH, Sharp FR, Panter S, Sato M, Maida N, Bergeron M, Guenther K, Noble L. Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat. Brain Res. 1998 Jun 08; 795(1-2):17-24. PMID: 9622586.
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    74. Turner CP, Bergeron M, Matz P, Zegna A, Noble L, Panter SS, Sharp FR. Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J Cereb Blood Flow Metab. 1998 Mar; 18(3):257-73. PMID: 9498842.
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    75. Richmon JD, Fukuda K, Maida N, Sato M, Bergeron M, Sharp FR, Panter SS, Noble L. Induction of heme oxygenase-1 after hyperosmotic opening of the blood-brain barrier. Brain Res. 1998 Jan 05; 780(1):108-18. PMID: 9473615.
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    76. Beattie MS, Bresnahan JC, Komon J, Tovar CA, Van Meter M, Anderson DK, Faden AI, Hsu CY, Noble L, Salzman S, Young W. Endogenous repair after spinal cord contusion injuries in the rat. Exp Neurol. 1997 Dec; 148(2):453-63. PMID: 9417825.
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    77. Cobbs CS, Fenoy A, Bredt DS, Noble L. Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat. Brain Res. 1997 Mar 21; 751(2):336-8. PMID: 9099824.
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    78. Noble L, Mautes AE, Hall JJ. Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J Comp Neurol. 1996 Dec 23; 376(4):542-56. PMID: 8978469.
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    79. Fukuda K, Richmon JD, Sato M, Sharp FR, Panter SS, Noble L. Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury. Brain Res. 1996 Oct 14; 736(1-2):68-75. PMID: 8930310.
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    80. Kim DH, Gutin PH, Noble L, Nathan D, Yu JS, Nockels RP. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. Neuroreport. 1996 Sep 02; 7(13):2221-5. PMID: 8930993.
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    81. Mautes AE, Fukuda K, Noble L. Cellular response in the cerebellum after midline traumatic brain injury in the rat. Neurosci Lett. 1996 Aug 23; 214(2-3):95-8. PMID: 8878092.
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    82. Basso DM, Beattie MS, Bresnahan JC, Anderson DK, Faden AI, Gruner JA, Holford TR, Hsu CY, Noble L, Nockels R, Perot PL, Salzman SK, Young W. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma. 1996 Jul; 13(7):343-59. PMID: 8863191.
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    83. Fukuda K, Aihara N, Sagar SM, Sharp FR, Pitts LH, Honkaniemi J, Noble L. Purkinje cell vulnerability to mild traumatic brain injury. J Neurotrauma. 1996 May; 13(5):255-66. PMID: 8797175.
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    84. Richmon JD, Fukuda K, Sharp FR, Noble L. Induction of HSP-70 after hyperosmotic opening of the blood-brain barrier in the rat. Neurosci Lett. 1995 Dec 29; 202(1-2):1-4. PMID: 8787816.
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    85. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble L, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. 1995 Dec; 11(4):376-81. PMID: 7493016.
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    86. Fukuda K, Panter SS, Sharp FR, Noble L. Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat. Neurosci Lett. 1995 Oct 20; 199(2):127-30. PMID: 8584240.
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    87. Westmark R, Noble L, Fukuda K, Aihara N, McKenzie AL. Intrathecal administration of endothelin-1 in the rat: impact on spinal cord blood flow and the blood-spinal cord barrier. Neurosci Lett. 1995 Jun 16; 192(3):173-6. PMID: 7566643.
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    88. McKenzie AL, Hall JJ, Aihara N, Fukuda K, Noble L. Immunolocalization of endothelin in the traumatized spinal cord: relationship to blood-spinal cord barrier breakdown. J Neurotrauma. 1995 Jun; 12(3):257-68. PMID: 7473800.
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    89. Aihara N, Hall JJ, Pitts LH, Fukuda K, Noble L. Altered immunoexpression of microglia and macrophages after mild head injury. J Neurotrauma. 1995 Feb; 12(1):53-63. PMID: 7783232.
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    90. Noble L, Kalinyak JE, Pitts LH, Hall JJ. Fluid-phase endocytosis of horseradish peroxidase by cerebral endothelial cells in primary culture: characterization and kinetic analysis. J Neurosci Res. 1994 Aug 15; 38(6):654-63. PMID: 7807581.
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    91. Aihara N, Tanno H, Hall JJ, Pitts LH, Noble L. Immunocytochemical localization of immunoglobulins in the rat brain: relationship to the blood-brain barrier. J Comp Neurol. 1994 Apr 22; 342(4):481-96. PMID: 8040362.
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    92. Tanno H, Nockels RP, Pitts LH, Noble L. Immunolocalization of heat shock protein after fluid percussive brain injury and relationship to breakdown of the blood-brain barrier. J Cereb Blood Flow Metab. 1993 Jan; 13(1):116-24. PMID: 8417000.
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    93. Tanno H, Nockels RP, Pitts LH, Noble L. Breakdown of the blood-brain barrier after fluid percussive brain injury in the rat. Part 1: Distribution and time course of protein extravasation. J Neurotrauma. 1992; 9(1):21-32. PMID: 1619673.
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    94. Noble L, Hall JJ, Chen S, Chan PH. Morphologic changes in cultured astrocytes after exposure to glutamate. J Neurotrauma. 1992; 9(3):255-67. PMID: 1361950.
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    95. Tanno H, Nockels RP, Pitts LH, Noble L. Breakdown of the blood-brain barrier after fluid percussion brain injury in the rat: Part 2: Effect of hypoxia on permeability to plasma proteins. J Neurotrauma. 1992; 9(4):335-47. PMID: 1291693.
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    96. Noble L, Cortez SC, Ellison JA. Endogenous peroxidatic activity in astrocytes after spinal cord injury. J Comp Neurol. 1990 Jun 22; 296(4):674-85. PMID: 2358556.
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    97. Faden AI, Ellison JA, Noble L. Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury. Eur J Pharmacol. 1990 Jan 10; 175(2):165-74. PMID: 2155794.
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    98. Noble L, Ellison JA. Effect of transection on the blood-spinal cord barrier of the rat after isolation from descending sources. Brain Res. 1989 May 22; 487(2):299-310. PMID: 2731047.
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    99. Cortez SC, McIntosh TK, Noble L. Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterations. Brain Res. 1989 Mar 20; 482(2):271-82. PMID: 2706487.
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    100. Noble L, Wrathall JR. Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Res. 1989 Mar 13; 482(1):57-66. PMID: 2706482.
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    101. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL. Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience. 1989; 28(1):233-44. PMID: 2761692.
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    102. Vink R, Noble L, Knoblach SM, Bendall MR, Faden AI. Metabolic changes in rabbit spinal cord after trauma: magnetic resonance spectroscopy studies. Ann Neurol. 1989 Jan; 25(1):26-31. PMID: 2913925.
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    103. Noble L, Wrathall JR. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp Neurol. 1989 Jan; 103(1):34-40. PMID: 2912748.
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    104. Faden AI, Sacksen I, Noble L. Structure-activity relationships of TRH analogs in rat spinal cord injury. Brain Res. 1988 May 17; 448(2):287-93. PMID: 3132308.
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    105. Faden AI, Sacksen I, Noble L. Opiate-receptor antagonist nalmefene improves neurological recovery after traumatic spinal cord injury in rats through a central mechanism. J Pharmacol Exp Ther. 1988 May; 245(2):742-8. PMID: 3367315.
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    106. Noble L, Wrathall JR. Blood-spinal cord barrier disruption proximal to a spinal cord transection in the rat: time course and pathways associated with protein leakage. Exp Neurol. 1988 Mar; 99(3):567-78. PMID: 3342839.
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    107. Faden AI, Lemke M, Simon RP, Noble L. N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies. J Neurotrauma. 1988; 5(1):33-45. PMID: 3057216.
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    108. Noble L, Wrathall JR. The blood-spinal cord barrier after injury: pattern of vascular events proximal and distal to a transection in the rat. Brain Res. 1987 Oct 20; 424(1):177-88. PMID: 3690298.
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    109. Noble L, Wrathall JR. An inexpensive apparatus for producing graded spinal cord contusive injury in the rat. Exp Neurol. 1987 Feb; 95(2):530-3. PMID: 3803530.
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    110. Noble L, Wrathall JR. Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp Neurol. 1985 Apr; 88(1):135-49. PMID: 3979507.
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    111. Noble L, Maxwell DS. Morphometric analysis of effects of spinal cord transection. Exp Neurol. 1983 Jan; 79(1):200-11. PMID: 6822255.
      View in: PubMed
    112. Noble L, Maxwell DS. Blood-spinal cord barrier response to transection. Exp Neurol. 1983 Jan; 79(1):188-99. PMID: 6822254.
      View in: PubMed
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