Linda Noble, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentNeurological Surgery
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Determinants of vulnerability and recovery after trauma to the developing brain
    NIH/NINDS R01NS077767Jul 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Spinal cord injury: Targeting local inhibition to improve outcome
    NIH/NINDS RC1NS068200Sep 30, 2009 - Aug 31, 2012
    Role: Co-Principal Investigator
    Trauma to developing brain: model refinement and therapeutic intervention
    NIH/NINDS R21NS065937Aug 5, 2009 - Apr 30, 2012
    Role: Co-Principal Investigator
    Trauma to developing brain-injury and repair mechanisms
    NIH/NINDS R01NS050159Dec 1, 2004 - Mar 31, 2014
    Role: Principal Investigator
    Trauma to Developing Brain-Oxidative Events and Recovery
    NIH/NINDS R21NS041256Dec 1, 2001 - May 31, 2005
    Role: Principal Investigator
    Heme Oxygenase and Spinal Cord Injury
    NIH/NINDS R01NS039847Aug 15, 2001 - Jul 31, 2005
    Role: Principal Investigator
    Matrix Metalloproteinases and Spinal Cord Injury
    NIH/NINDS R01NS039278Sep 30, 1999 - Jun 30, 2012
    Role: Principal Investigator
    NIH/NINDS R01NS023324Aug 1, 1985 - Nov 30, 2000
    Role: Principal Investigator
    CNS Injury and Edema Research Center
    NIH/NINDS P50NS014543Jul 1, 1978 - Jul 31, 2012
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Faber J, Wilde EA, Hanten G, Ewing-Cobbs L, Aitken ME, Yallampalli R, MacLeod MC, Mullins SH, Chu ZD, Li X, Hunter JV, Noble-Haeusslein L, Levin HS. Ten-year outcome of early childhood traumatic brain injury: Diffusion tensor imaging of the ventral striatum in relation to executive functioning. Brain Inj. 2016; 30(13-14):1635-1641. PMID: 27680309.
      View in: PubMed
    2. Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR. Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury. Cell Stem Cell. 2016 10 06; 19(4):544-557. PMID: 27666009.
      View in: PubMed
    3. Neumann M, Liu W, Sun C, Yang SY, Noble-Haeusslein LJ, Liu J. Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum. Behav Brain Res. 2018 03 15; 340:165-171. PMID: 27614007.
      View in: PubMed
    4. Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury. ACS Chem Neurosci. 2016 11 16; 7(11):1482-1487. PMID: 27551907.
      View in: PubMed
    5. Semple BD, Sadjadi R, Carlson J, Chen Y, Xu D, Ferriero DM, Noble-Haeusslein LJ. Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice. Dev Neurosci. 2016; 38(3):220-238. PMID: 27548472.
      View in: PubMed
    6. Trivedi A, Zhang H, Ekeledo A, Lee S, Werb Z, Plant GW, Noble-Haeusslein LJ. Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord. Exp Neurol. 2016 Oct; 284(Pt A):50-62. PMID: 27468657.
      View in: PubMed
    7. Ryan NP, Catroppa C, Godfrey C, Noble-Haeusslein LJ, Shultz SR, O'Brien TJ, Anderson V, Semple BD. Social dysfunction after pediatric traumatic brain injury: A translational perspective. Neurosci Biobehav Rev. 2016 May; 64:196-214. PMID: 26949224.
      View in: PubMed
    8. Bajwa NM, Halavi S, Hamer M, Semple BD, Noble-Haeusslein LJ, Baghchechi M, Hiroto A, Hartman RE, Obenaus A. Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice. PLoS One. 2016; 11(1):e0146886. PMID: 26796696; PMCID: PMC4721654.
    9. Semple BD, Carlson J, Noble-Haeusslein LJ. Pediatric Rodent Models of Traumatic Brain Injury. Methods Mol Biol. 2016; 1462:325-43. PMID: 27604726.
      View in: PubMed
    10. Semple BD, Noble-Haeusslein LJ, Gooyit M, Tercovich KG, Peng Z, Nguyen TT, Schroeder VA, Suckow MA, Chang M, Raber J, Trivedi A. Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse. PLoS One. 2015; 10(11):e0143386. PMID: 26588471; PMCID: PMC4654502.
    11. Smith DH, Hicks RR, Johnson VE, Bergstrom DA, Cummings DM, Noble LJ, Hovda D, Whalen M, Ahlers ST, LaPlaca M, Tortella FC, Duhaime AC, Dixon CE. Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories. J Neurotrauma. 2015 Nov 15; 32(22):1725-35. PMID: 26058402; PMCID: PMC4651035 [Available on 11/15/16].
    12. Semple BD, Lee S, Sadjadi R, Fritz N, Carlson J, Griep C, Ho V, Jang P, Lamb A, Popolizio B, Saini S, Bazarian JJ, Prins ML, Ferriero DM, Basso DM, Noble-Haeusslein LJ. Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies. Front Neurol. 2015; 6:69. PMID: 25883586; PMCID: PMC4382966.
    13. Bondi CO, Semple BD, Noble-Haeusslein LJ, Osier ND, Carlson SW, Dixon CE, Giza CC, Kline AE. Found in translation: Understanding the biology and behavior of experimental traumatic brain injury. Neurosci Biobehav Rev. 2015 Nov; 58:123-46. PMID: 25496906.
      View in: PubMed
    14. Semple BD, Trivedi A, Gimlin K, Noble-Haeusslein LJ. Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain. Neurobiol Dis. 2015 Feb; 74:263-80. PMID: 25497734; PMCID: PMC4323771.
    15. Semple BD, Noble-Haeusslein LJ, Jun Kwon Y, Sam PN, Gibson AM, Grissom S, Brown S, Adahman Z, Hollingsworth CA, Kwakye A, Gimlin K, Wilde EA, Hanten G, Levin HS, Schenk AK. Sociosexual and communication deficits after traumatic injury to the developing murine brain. PLoS One. 2014; 9(8):e103386. PMID: 25106033; PMCID: PMC4126664.
    16. Levine JM, Cohen ND, Heller M, Fajt VR, Levine GJ, Kerwin SC, Trivedi AA, Fandel TM, Werb Z, Modestino A, Noble-Haeusslein LJ. Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs. PLoS One. 2014; 9(5):e96408. PMID: 24788791; PMCID: PMC4006832.
    17. Chen CY, Noble-Haeusslein LJ, Ferriero D, Semple BD. Traumatic injury to the immature frontal lobe: a new murine model of long-term motor impairment in the absence of psychosocial or cognitive deficits. Dev Neurosci. 2013; 35(6):474-90. PMID: 24247103; PMCID: PMC3923401.
    18. Hansen CN, Fisher LC, Deibert RJ, Jakeman LB, Zhang H, Noble-Haeusslein L, White S, Basso DM. Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice. J Neurosci. 2013 Aug 07; 33(32):13101-11. PMID: 23926264; PMCID: PMC3735886.
    19. Semple BD, Blomgren K, Gimlin K, Ferriero DM, Noble-Haeusslein LJ. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol. 2013 Jul-Aug; 106-107:1-16. PMID: 23583307; PMCID: PMC3737272.
    20. Semple BD, Canchola SA, Noble-Haeusslein LJ. Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice. J Neurotrauma. 2012 Nov 20; 29(17):2672-83. PMID: 22888909; PMCID: PMC3510450.
    21. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11; 490(7419):187-91. PMID: 23060188.
      View in: PubMed
    22. Lapchak PA, Zhang JH, Noble-Haeusslein LJ. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl Stroke Res. 2013 Jun; 4(3):279-85. PMID: 23658596; PMCID: PMC3644408.
    23. Zhang H, Trivedi A, Lee JU, Lohela M, Lee SM, Fandel TM, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J Neurosci. 2011 Nov 02; 31(44):15894-903. PMID: 22049432; PMCID: PMC3265932.
    24. Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma. 2011 Sep; 28(9):1893-907. PMID: 21657851; PMCID: PMC3172879.
    25. Zhang H, Chang M, Hansen CN, Basso DM, Noble-Haeusslein LJ. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics. 2011 Apr; 8(2):206-20. PMID: 21455784; PMCID: PMC3077748.
    26. Levine JM, Levine GJ, Porter BF, Topp K, Noble-Haeusslein LJ. Naturally occurring disk herniation in dogs: an opportunity for pre-clinical spinal cord injury research. J Neurotrauma. 2011 Apr; 28(4):675-88. PMID: 21438715; PMCID: PMC3070145.
    27. Semple BD, Noble-Haeusslein LJ. Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors. Exp Neurol. 2011 Jun; 229(2):195-7. PMID: 21316363; PMCID: PMC4430724.
    28. Wang Y, Neumann M, Hansen K, Hong SM, Kim S, Noble-Haeusslein LJ, Liu J. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma. 2011 Feb; 28(2):259-68. PMID: 21175261.
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    29. McKenna MC, Noble-Haeusslein LJ, Robertson CL. Pediatric traumatic brain injury. Preface. Dev Neurosci. 2010; 32(5-6):333-4. PMID: 21212657.
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    30. Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh AL, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM. Characterization and functionality of proliferative human Sertoli cells. Cell Transplant. 2011; 20(5):619-35. PMID: 21054948; PMCID: PMC4096632.
    31. Claus CP, Tsuru-Aoyagi K, Adwanikar H, Walker B, Manvelyan H, Whetstone W, Noble-Haeusslein LJ. Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury. Dev Neurosci. 2010; 32(5-6):454-65. PMID: 20847543; PMCID: PMC3073760.
    32. Mao H, Jin X, Zhang L, Yang KH, Igarashi T, Noble-Haeusslein LJ, King AI. Finite element analysis of controlled cortical impact-induced cell loss. J Neurotrauma. 2010 May; 27(5):877-88. PMID: 20199194; PMCID: PMC2943943.
    33. Zhang H, Adwanikar H, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes. Neuroscientist. 2010 Apr; 16(2):156-70. PMID: 20400713; PMCID: PMC2858362.
    34. Yoneyama-Sarnecky T, Olivas AD, Azari S, Ferriero DM, Manvelyan HM, Noble-Haeusslein LJ. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Dev Neurosci. 2010 Mar; 32(1):81-90. PMID: 20389079; PMCID: PMC2866583.
    35. Bazarian JJ, Cernak I, Noble-Haeusslein L, Potolicchio S, Temkin N. Long-term neurologic outcomes after traumatic brain injury. J Head Trauma Rehabil. 2009 Nov-Dec; 24(6):439-51. PMID: 19940677.
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    36. Cernak I, Noble-Haeusslein LJ. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J Cereb Blood Flow Metab. 2010 Feb; 30(2):255-66. PMID: 19809467; PMCID: PMC2855235.
    37. Potts MB, Adwanikar H, Noble-Haeusslein LJ. Models of traumatic cerebellar injury. Cerebellum. 2009 Sep; 8(3):211-21. PMID: 19495901; PMCID: PMC2734258.
    38. Margulies S, Hicks R. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma. 2009 Jun; 26(6):925-39. PMID: 19331514; PMCID: PMC2857809.
    39. Potts MB, Rola R, Claus CP, Ferriero DM, Fike JR, Noble-Haeusslein LJ. Glutathione peroxidase overexpression does not rescue impaired neurogenesis in the injured immature brain. J Neurosci Res. 2009 Jun; 87(8):1848-57. PMID: 19170177; PMCID: PMC3306805.
    40. Tsuru-Aoyagi K, Potts MB, Trivedi A, Pfankuch T, Raber J, Wendland M, Claus CP, Koh SE, Ferriero D, Noble-Haeusslein LJ. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol. 2009 May; 65(5):540-9. PMID: 19475669; PMCID: PMC2690612.
    41. Hsu JY, Bourguignon LY, Adams CM, Peyrollier K, Zhang H, Fandel T, Cun CL, Werb Z, Noble-Haeusslein LJ. Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. J Neurosci. 2008 Dec 10; 28(50):13467-77. PMID: 19074020; PMCID: PMC2712293.
    42. Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res. 2007 Aug 01; 85(10):2272-83. PMID: 17539027.
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    43. Trivedi A, Olivas AD, Noble-Haeusslein LJ. Inflammation and Spinal Cord Injury: Infiltrating Leukocytes as Determinants of Injury and Repair Processes. Clin Neurosci Res. 2006 Dec; 6(5):283-292. PMID: 18059979.
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    44. Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ. Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. J Cereb Blood Flow Metab. 2007 May; 27(5):1010-21. PMID: 17047682.
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    45. Igarashi T, Potts MB, Noble-Haeusslein LJ. Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury. Exp Neurol. 2007 Jan; 203(1):258-68. PMID: 17045589.
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    46. Hsu JY, McKeon R, Goussev S, Werb Z, Lee JU, Trivedi A, Noble-Haeusslein LJ. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 2006 Sep 27; 26(39):9841-50. PMID: 17005848; PMCID: PMC2659718.
    47. Rola R, Mizumatsu S, Otsuka S, Morhardt DR, Noble-Haeusslein LJ, Fishman K, Potts MB, Fike JR. Alterations in hippocampal neurogenesis following traumatic brain injury in mice. Exp Neurol. 2006 Nov; 202(1):189-99. PMID: 16876159.
      View in: PubMed
    48. Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx. 2006 Apr; 3(2):143-53. PMID: 16554253; PMCID: PMC3593438.
    49. Olivas AD, Noble-Haeusslein LJ. Phospholipase A2 and spinal cord injury: a novel target for therapeutic intervention. Ann Neurol. 2006 Apr; 59(4):577-9. PMID: 16566026.
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    50. Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol. 2006 Mar; 198(1):88-100. PMID: 16387298.
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    51. Pullela R, Raber J, Pfankuch T, Ferriero DM, Claus CP, Koh SE, Yamauchi T, Rola R, Fike JR, Noble-Haeusslein LJ. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Dev Neurosci. 2006; 28(4-5):396-409. PMID: 16943663.
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    52. Chang EF, Claus CP, Vreman HJ, Wong RJ, Noble-Haeusslein LJ. Heme regulation in traumatic brain injury: relevance to the adult and developing brain. J Cereb Blood Flow Metab. 2005 Nov; 25(11):1401-17. PMID: 15917748.
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    53. McLean CW, Mirochnitchenko O, Claus CP, Noble-Haeusslein LJ, Ferriero DM. Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress. Dev Neurosci. 2005 Mar-Aug; 27(2-4):169-75. PMID: 16046851.
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    54. Weinzierl M, Mautes AE, Whetstone W, Lin Y, Noble-Haeusslein LJ. Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutase. Brain Res. 2004 Dec 24; 1030(1):125-32. PMID: 15567344.
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    55. Yamauchi T, Lin Y, Sharp FR, Noble-Haeusslein LJ. Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cord. J Neurotrauma. 2004 Aug; 21(8):1017-30. PMID: 15319001.
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    56. Fiore C, Inman DM, Hirose S, Noble LJ, Igarashi T, Compagnone NA. Treatment with the neurosteroid dehydroepiandrosterone promotes recovery of motor behavior after moderate contusive spinal cord injury in the mouse. J Neurosci Res. 2004 Feb 01; 75(3):391-400. PMID: 14743452.
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    57. Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD, Noble-Haeusslein LJ. The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 2003 Oct 15; 129(1):49-59. PMID: 12951232.
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    58. Whetstone WD, Hsu JY, Eisenberg M, Werb Z, Noble-Haeusslein LJ. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res. 2003 Oct 15; 74(2):227-39. PMID: 14515352; PMCID: PMC2837839.
    59. Luk HW, Noble LJ, Werb Z. Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury. J Neurosci Res. 2003 Sep 01; 73(5):644-58. PMID: 12929132; PMCID: PMC2792202.
    60. Goussev S, Hsu JY, Lin Y, Tjoa T, Maida N, Werb Z, Noble-Haeusslein LJ. Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing. J Neurosurg. 2003 Sep; 99(2 Suppl):188-97. PMID: 12956462; PMCID: PMC2792200.
    61. Fan P, Yamauchi T, Noble LJ, Ferriero DM. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma. 2003 May; 20(5):437-45. PMID: 12803976.
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    62. Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci. 2003 May 01; 23(9):3689-96. PMID: 12736340.
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    63. Weinzierl M, Mautes AE, Lin Y, Noble LJ. Attenuated induction of heme oxygenase after intrathecal exposure to lysed blood in mice overexpressing superoxide dismutase. Neurosci Lett. 2003 Jan 09; 336(1):13-6. PMID: 12493591.
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    64. Noble LJ, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci. 2002 Sep 01; 22(17):7526-35. PMID: 12196576; PMCID: PMC2792199.
    65. Tong W, Igarashi T, Ferriero DM, Noble LJ. Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability. Exp Neurol. 2002 Jul; 176(1):105-16. PMID: 12093087.
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    66. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL. Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience. 1989; 28(1):233-44. PMID: 2761692.
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