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    Pamela England, PhD

    TitleAssociate Professor
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address600 16th Street
    San Francisco CA 94158
    Phone415-502-6606
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      Collapse Biography 
      Collapse Awards and Honors
      UCLA1989UCLA Chemists Association Award for Research
      UCLA1989Merck Index Award
      Caltech1996Gosney Postdoctoral Fellowship
      Caltech1997NRSA Postdoctoral Fellowship
      Caltech1998Grass Foundation Fellowship
      UCSF2006McKnight Technological Innovations in Neuroscience Award
      UCSF2014CTSI Catalyst Award
      UCSF2015Roger's Family Foundation Bridging the GAP Award

      Collapse Overview 
      Collapse Overview
      Research in the England Lab focuses on the development and use of small molecules to manipulate and monitor the activities of biologically important ligand-receptor systems. Execution of these research projects typically involves a combination of synthetic chemistry, computational chemistry, structural biology, and appropriate biochemical and biological assays. Two systems currently being studied are glutamate-gated ion channels and hormone-activated nuclear receptors.

      The neurotransmitter glutamate drives specific changes in the functioning of synaptic glutamate-gated ion channels. These changes modulate the strength of synaptic transmission, encode information, and allow for adaptive behaviors. We are developing and using small molecules to track the functional states of glutamate-gated ion channels at neuronal synapses.

      Natural hormones and other small lipophilic molecules drive specific changes in the structure and activity of nuclear receptors. In response to hormone binding, nuclear receptors form protein complexes that control gene transcription events underlying development, homeostasis, and many diseases. We are designing small molecules to manipulate gene transcription by precisely controlling the activity of nuclear receptors.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. PMID: 27467220.
        View in: PubMed
      2. England PM. Developing a photoreactive antagonist. Methods Mol Biol. 2013; 995:121-9. PMID: 23494376.
        View in: PubMed
      3. Aungst S, England PM, Thompson SM. Critical role of trkB receptors in reactive axonal sprouting and hyperexcitability after axonal injury. J Neurophysiol. 2013 Feb; 109(3):813-24. PMID: 23155176; PMCID: PMC3567381.
      4. Harvey JH, Long DH, England PM, Whistler JL. Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 9; 3(8):640-644. PMID: 23585918.
        View in: PubMed
      5. England PM. Bridging the gaps between synapses, circuits, and behavior. Chem Biol. 2010 Jun 25; 17(6):607-15. PMID: 20609410.
        View in: PubMed
      6. Fleming JJ, England PM. AMPA receptors and synaptic plasticity: a chemist's perspective. Nat Chem Biol. 2010 Feb; 6(2):89-97. PMID: 20081822.
        View in: PubMed
      7. Fleming JJ, England PM. Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15; 18(4):1381-7. PMID: 20096591.
        View in: PubMed
      8. Wang X, Ratnam J, Zou B, England PM, Basbaum AI. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009 Apr 29; 29(17):5508-15. PMID: 19403818; PMCID: PMC2720992.
      9. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60. PMID: 18754610; PMCID: PMC2945402.
      10. Argilli E, Sibley DR, Malenka RC, England PM, Bonci A. Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci. 2008 Sep 10; 28(37):9092-100. PMID: 18784289; PMCID: PMC2586328.
      11. Kaneko M, Hanover JL, England PM, Stryker MP. TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nat Neurosci. 2008 Apr; 11(4):497-504. PMID: 18311133; PMCID: PMC2413329.
      12. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. J Am Chem Soc. 2007 Apr 25; 129(16):4902-3. PMID: 17391037.
        View in: PubMed
      13. England PM. Rapid photoinactivation of native AMPA receptors on live cells using ANQX. Sci STKE. 2006 Apr 18; 2006(331):pl1. PMID: 16622183.
        View in: PubMed
      14. Adesnik H, Nicoll RA, England PM. Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron. 2005 Dec 22; 48(6):977-85. PMID: 16364901.
        View in: PubMed
      15. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 7; 46(1):13-21. PMID: 15820690.
        View in: PubMed
      16. Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM. Photochemically knocking out glutamate receptors in vivo. J Am Chem Soc. 2004 Nov 3; 126(43):13886-7. PMID: 15506725.
        View in: PubMed
      17. England PM. Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function. Biochemistry. 2004 Sep 21; 43(37):11623-9. PMID: 15362846.
        View in: PubMed
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