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Pamela England, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Phone415-502-6606
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    Collapse Biography 
    Collapse Awards and Honors
    UCSF2015Roger's Family Foundation Bridging the GAP Award
    UCSF2014CTSI Catalyst Award
    UCSF2006McKnight Technological Innovations in Neuroscience Award
    Caltech1998Grass Foundation Fellowship
    Caltech1997NRSA Postdoctoral Fellowship
    Caltech1996Gosney Postdoctoral Fellowship
    UCLA1989UCLA Chemists Association Award for Research
    UCLA1989Merck Index Award

    Collapse Overview 
    Collapse Overview
    Research in the England Lab focuses on the development and use of small molecules to manipulate and monitor the activities of biologically important ligand-receptor systems. Execution of these research projects typically involves a combination of synthetic chemistry, computational chemistry, structural biology, and appropriate biochemical and biological assays. Two systems currently being studied are glutamate-gated ion channels and hormone-activated nuclear receptors.

    The neurotransmitter glutamate drives specific changes in the functioning of synaptic glutamate-gated ion channels. These changes modulate the strength of synaptic transmission, encode information, and allow for adaptive behaviors. We are developing and using small molecules to track the functional states of glutamate-gated ion channels at neuronal synapses.

    Natural hormones and other small lipophilic molecules drive specific changes in the structure and activity of nuclear receptors. In response to hormone binding, nuclear receptors form protein complexes that control gene transcription events underlying development, homeostasis, and many diseases. We are designing small molecules to manipulate gene transcription by precisely controlling the activity of nuclear receptors.

    Collapse Research 
    Collapse Research Activities and Funding
    Selective modulators for the nuclear receptor Nurr1
    NIH/NINDS R01NS108404Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Selectively Targeting Opioid Receptor Heterodimers
    NIH/NIDA R21DA031574Feb 15, 2011 - Jan 31, 2014
    Role: Co-Principal Investigator
    Chemical Basis for Potassium Channel Modulation
    NIH/NHLBI R01HL071615Jul 15, 2003 - Jun 30, 2008
    Role: Principal Investigator
    SYNTHESIS OF CONSTITUTIVELY ACTIVE SEROTONIN RECEPTORS
    NIH/NINDS F32NS009999Dec 1, 1996
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol. 2019 May 16; 26(5):674-685.e6. PMID: 30853418.
      View in: PubMed
    2. de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. ACS Chem Biol. 2017 12 15; 12(12):2934-2939. PMID: 28981251.
      View in: PubMed
    3. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. PMID: 27467220.
      View in: PubMed
    4. England PM. Developing a photoreactive antagonist. Methods Mol Biol. 2013; 995:121-9. PMID: 23494376.
      View in: PubMed
    5. Aungst S, England PM, Thompson SM. Critical role of trkB receptors in reactive axonal sprouting and hyperexcitability after axonal injury. J Neurophysiol. 2013 Feb; 109(3):813-24. PMID: 23155176.
      View in: PubMed
    6. Harvey JH, Long DH, England PM, Whistler JL. Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 09; 3(8):640-644. PMID: 23585918.
      View in: PubMed
    7. England PM. Bridging the gaps between synapses, circuits, and behavior. Chem Biol. 2010 Jun 25; 17(6):607-15. PMID: 20609410.
      View in: PubMed
    8. Fleming JJ, England PM. AMPA receptors and synaptic plasticity: a chemist's perspective. Nat Chem Biol. 2010 Feb; 6(2):89-97. PMID: 20081822.
      View in: PubMed
    9. Fleming JJ, England PM. Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15; 18(4):1381-7. PMID: 20096591.
      View in: PubMed
    10. Wang X, Ratnam J, Zou B, England PM, Basbaum AI. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009 Apr 29; 29(17):5508-15. PMID: 19403818.
      View in: PubMed
    11. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60. PMID: 18754610.
      View in: PubMed
    12. Argilli E, Sibley DR, Malenka RC, England PM, Bonci A. Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci. 2008 Sep 10; 28(37):9092-100. PMID: 18784289.
      View in: PubMed
    13. Kaneko M, Hanover JL, England PM, Stryker MP. TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nat Neurosci. 2008 Apr; 11(4):497-504. PMID: 18311133.
      View in: PubMed
    14. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. J Am Chem Soc. 2007 Apr 25; 129(16):4902-3. PMID: 17391037.
      View in: PubMed
    15. England PM. Rapid photoinactivation of native AMPA receptors on live cells using ANQX. Sci STKE. 2006 Apr 18; 2006(331):pl1. PMID: 16622183.
      View in: PubMed
    16. Adesnik H, Nicoll RA, England PM. Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron. 2005 Dec 22; 48(6):977-85. PMID: 16364901.
      View in: PubMed
    17. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 07; 46(1):13-21. PMID: 15820690.
      View in: PubMed
    18. Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM. Photochemically knocking out glutamate receptors in vivo. J Am Chem Soc. 2004 Nov 03; 126(43):13886-7. PMID: 15506725.
      View in: PubMed
    19. England PM. Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function. Biochemistry. 2004 Sep 21; 43(37):11623-9. PMID: 15362846.
      View in: PubMed
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