Pamela England, PhD
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Title(s) | Professor, Pharmaceutical Chemistry |
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School | School of Pharmacy |
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Address | 600 16th St San Francisco CA 94158
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Phone | 415-502-6606 |
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vCard | Download vCard |
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Biography UCSF | 2015 | | Roger's Family Foundation Bridging the GAP Award | UCSF | 2014 | | CTSI Catalyst Award | UCSF | 2006 | | McKnight Technological Innovations in Neuroscience Award | Caltech | 1998 | | Grass Foundation Fellowship | Caltech | 1997 | | NRSA Postdoctoral Fellowship | Caltech | 1996 | | Gosney Postdoctoral Fellowship | UCLA | 1989 | | UCLA Chemists Association Award for Research | UCLA | 1989 | | Merck Index Award |
Overview Research in the England Lab focuses on the development and use of small molecules to manipulate and monitor the activities of biologically important ligand-receptor systems. Execution of these research projects typically involves a combination of synthetic chemistry, computational chemistry, structural biology, and appropriate biochemical and biological assays. Two systems currently being studied are glutamate-gated ion channels and hormone-activated nuclear receptors.
The neurotransmitter glutamate drives specific changes in the functioning of synaptic glutamate-gated ion channels. These changes modulate the strength of synaptic transmission, encode information, and allow for adaptive behaviors. We are developing and using small molecules to track the functional states of glutamate-gated ion channels at neuronal synapses.
Natural hormones and other small lipophilic molecules drive specific changes in the structure and activity of nuclear receptors. In response to hormone binding, nuclear receptors form protein complexes that control gene transcription events underlying development, homeostasis, and many diseases. We are designing small molecules to manipulate gene transcription by precisely controlling the activity of nuclear receptors.
Research ORNG Applications Bibliographic
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Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chem Biol. 2019 05 16; 26(5):674-685.e6.
Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. PMID: 30853418.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. ACS Chem Biol. 2017 12 15; 12(12):2934-2939.
de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. PMID: 28981251.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316.
de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. PMID: 27467220.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Developing a photoreactive antagonist. Methods Mol Biol. 2013; 995:121-9.
England PM. PMID: 23494376.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Critical role of trkB receptors in reactive axonal sprouting and hyperexcitability after axonal injury. J Neurophysiol. 2013 Feb; 109(3):813-24.
Aungst S, England PM, Thompson SM. PMID: 23155176.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 09; 3(8):640-644.
Harvey JH, Long DH, England PM, Whistler JL. PMID: 23585918.
View in: PubMed Mentions:
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Bridging the gaps between synapses, circuits, and behavior. Chem Biol. 2010 Jun 25; 17(6):607-15.
England PM. PMID: 20609410.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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AMPA receptors and synaptic plasticity: a chemist's perspective. Nat Chem Biol. 2010 Feb; 6(2):89-97.
Fleming JJ, England PM. PMID: 20081822.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15; 18(4):1381-7.
Fleming JJ, England PM. PMID: 20096591.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009 Apr 29; 29(17):5508-15.
Wang X, Ratnam J, Zou B, England PM, Basbaum AI. PMID: 19403818.
View in: PubMed Mentions: 24 Fields: Translation: AnimalsCells
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6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60.
Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. PMID: 18754610.
View in: PubMed Mentions: 3 Fields: Translation: Cells
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Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci. 2008 Sep 10; 28(37):9092-100.
Argilli E, Sibley DR, Malenka RC, England PM, Bonci A. PMID: 18784289.
View in: PubMed Mentions: 110 Fields: Translation: AnimalsCells
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TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nat Neurosci. 2008 Apr; 11(4):497-504.
Kaneko M, Hanover JL, England PM, Stryker MP. PMID: 18311133.
View in: PubMed Mentions: 43 Fields: Translation: Animals
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A subtype-selective, use-dependent inhibitor of native AMPA receptors. J Am Chem Soc. 2007 Apr 25; 129(16):4902-3.
Nilsen A, England PM. PMID: 17391037.
View in: PubMed Mentions: 12 Fields: Translation: Animals
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Rapid photoinactivation of native AMPA receptors on live cells using ANQX. Sci STKE. 2006 Apr 18; 2006(331):pl1.
England PM. PMID: 16622183.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron. 2005 Dec 22; 48(6):977-85.
Adesnik H, Nicoll RA, England PM. PMID: 16364901.
View in: PubMed Mentions: 88 Fields: Translation: AnimalsCells
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A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 07; 46(1):13-21.
Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. PMID: 15820690.
View in: PubMed Mentions: 127 Fields: Translation: AnimalsCells
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Photochemically knocking out glutamate receptors in vivo. J Am Chem Soc. 2004 Nov 03; 126(43):13886-7.
Chambers JJ, Gouda H, Young DM, Kuntz ID, England PM. PMID: 15506725.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Unnatural amino acid mutagenesis: a precise tool for probing protein structure and function. Biochemistry. 2004 Sep 21; 43(37):11623-9.
England PM. PMID: 15362846.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Year | Publications |
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2004 | 2 | 2005 | 2 | 2006 | 1 | 2007 | 1 | 2008 | 3 | 2009 | 1 | 2010 | 3 | 2012 | 2 | 2013 | 1 | 2016 | 1 | 2017 | 1 | 2019 | 1 |
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