Patricia Babbitt, PhD
|School||UCSF School of Pharmacy|
|Department||Bioengineering and Therapeutic Sciences|
|Address||1700 4th Street, Byers Hall|
San Francisco CA 94158
Dr. Babbitt's laboratory uses computational approaches to improve understanding of how nature has evolved enzymes to catalyze many different chemical reactions by re-using ancestral structures and active site architectures. We created the Structure-Function Linkage Database (SFLD) (http://sfld.rbvi.ucsf.edu) to provide users with access to this information along with tools for analyzing and exploring it. Applications of this work include annotation and prediction of function for new sequences from genome projects and guidance for "rational protein design."
Bioengineering & Therapeutic Sciences; protein structure/function relationships; computational biology/bioinformatics; enzyme engineering
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