Loading...

Ying-Hui Fu, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-502-2948
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Dr. Fu’s research uses human genetics combined with multiple model organisms to investigate molecular mechanisms of human conditions. Her laboratory has been focusing on two areas: one in myelin biology and the other in circadian rhythm and sleep behaviors. For myelin biology, they investigate the interlocking networks of protein-coding genes and non-coding RNAs in ensuring a healthy myelin. For circadian and sleep behaviors, over the last 15 years, she and her colleagues identified several mutations that lead to extreme morning lark phenotype. In addition, they are investigating the genetic basis for human subjects to have shorter sleep duration. Since circadian rhythm and sleep homeostasis are intimately connected with many physiological pathways including metabolism, immune function, and mood regulation, to name but a few, these studies will also shed new light on how sleep schedule and sleep homeostasis can impact on health.


    Collapse Research 
    Collapse Research Activities and Funding
    Investigating Genetics of Human Natural Short Sleepers
    NIH/NINDS R01NS072360Sep 1, 2011 - Aug 31, 2016
    Role: Principal Investigator
    The role of Lamin B1 in myelin maintenance and demyelination
    NIH/NINDS R01NS062733Jul 20, 2009 - Jun 30, 2011
    Role: Principal Investigator
    A chemical genetic approach to dissect CKId &CKIe function in circadian rhythm
    NIH/NIGMS R01GM079180Sep 15, 2008 - Aug 31, 2012
    Role: Principal Investigator
    Molecular Basis of the Demylinating Disorder ADLD
    NIH/NINDS R01NS041331Apr 15, 2001 - Mar 31, 2004
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Videos
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hirano A, Fu Y, Ptácek LJ. The intricate dance of post-translational modifications in the rhythm of life. Nat Struct Mol Biol. 2016 Dec 06; 23(12):1053-1060. PMID: 27922612.
      View in: PubMed
    2. Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Ptácek LJ, Fu Y. A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife. 2016; 5. PMID: 27529127.
      View in: PubMed
    3. Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptácek LJ, Fu Y. A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):E1536-44. PMID: 26903630.
      View in: PubMed
    4. Howng SY, Huang Y, Ptácek L, Fu Y. Understanding the role of dicer in astrocyte development. PLoS One. 2015; 10(5):e0126667. PMID: 25962146; PMCID: PMC4427179.
      View in: PubMed, PubMed Central
    5. Zhang L, Ptáck LJ, Fu Y. Nuclear envelope regulates the circadian clock. Nucleus. 2015; 6(2):114-7. PMID: 25746393; PMCID: PMC4615844 [Available on 03/06/16].
      View in: PubMed, PubMed Central
    6. Hsu PK, Ptácek LJ, Fu Y. Genetics of human sleep behavioral phenotypes. Methods Enzymol. 2015; 552:309-24. PMID: 25707283.
      View in: PubMed
    7. Lin ST, Zhang L, Lin X, Zhang LC, Garcia VE, Tsai CW, Ptácek L, Fu Y. Nuclear envelope protein MAN1 regulates clock through BMAL1. Elife. 2014; 3:e02981. PMID: 25182847; PMCID: PMC4150126.
      View in: PubMed, PubMed Central
    8. Shin D, Lin ST, Fu Y, Ptácek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gas/Gaq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19101-6. PMID: 24191038; PMCID: PMC3839775.
      View in: PubMed, PubMed Central
    9. Lin ST, Huang Y, Zhang L, Heng MY, Ptácek LJ, Fu Y. MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17468-73. PMID: 24101522; PMCID: PMC3808585.
      View in: PubMed, PubMed Central
    10. Hallows WC, Ptácek LJ, Fu Y. Solving the mystery of human sleep schedules one mutation at a time. Crit Rev Biochem Mol Biol. 2013 Sep-Oct; 48(5):465-75. PMID: 24001255; PMCID: PMC4089902.
      View in: PubMed, PubMed Central
    11. Kurien PA, Chong SY, Ptácek LJ, Fu Y. Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function. Curr Opin Neurobiol. 2013 Oct; 23(5):873-9. PMID: 23702243; PMCID: PMC3766463.
      View in: PubMed, PubMed Central
    12. Heng MY, Lin ST, Verret L, Huang Y, Kamiya S, Padiath QS, Tong Y, Palop JJ, Huang EJ, Ptácek LJ, Fu Y. Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. J Clin Invest. 2013 Jun; 123(6):2719-29. PMID: 23676464; PMCID: PMC3668844.
      View in: PubMed, PubMed Central
    13. Russell JF, Fu Y, Ptácek LJ. Episodic neurologic disorders: syndromes, genes, and mechanisms. Annu Rev Neurosci. 2013 Jul 8; 36:25-50. PMID: 23642134.
      View in: PubMed
    14. Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu Y. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5; 17(2):291-302. PMID: 23395175; PMCID: PMC3597447.
      View in: PubMed, PubMed Central
    15. Zhang L, Ptácek LJ, Fu Y. Diversity of human clock genotypes and consequences. Prog Mol Biol Transl Sci. 2013; 119:51-81. PMID: 23899594; PMCID: PMC4169291.
      View in: PubMed, PubMed Central
    16. Zhang L, Abraham D, Lin ST, Oster H, Eichele G, Fu Y, Ptácek LJ. PKC? participates in food entrainment by regulating BMAL1. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20679-84. PMID: 23185022; PMCID: PMC3528600.
      View in: PubMed, PubMed Central
    17. Chong SY, Ptácek LJ, Fu Y. Genetic insights on sleep schedules: this time, it's PERsonal. Trends Genet. 2012 Dec; 28(12):598-605. PMID: 22939700; PMCID: PMC3500418.
      View in: PubMed, PubMed Central
    18. Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, Choi M, Lee HY, Kirk A, Nelson-Williams C, Gibson G, Baraban SC, Lifton RP, Geschwind DH, Fu Y, Ptácek LJ. Familial cortical myoclonus with a mutation in NOL3. Ann Neurol. 2012 Aug; 72(2):175-83. PMID: 22926851; PMCID: PMC3431191.
      View in: PubMed, PubMed Central
    19. Kategaya LS, Hilliard A, Zhang L, Asara JM, Ptácek LJ, Fu Y. Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock. PLoS One. 2012; 7(2):e31987. PMID: 22384121; PMCID: PMC3288064.
      View in: PubMed, PubMed Central
    20. Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu Y, Edwards RH, Ptácek LJ. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 2012 Feb; 122(2):507-18. PMID: 22214848; PMCID: PMC3533379.
      View in: PubMed, PubMed Central
    21. Lee HY, Huang Y, Bruneau N, Roll P, Roberson ED, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohammed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock AM, Szepetowski P, Fu Y, Ptácek LJ. Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. Cell Rep. 2012 Jan 26; 1(1):2-12. PMID: 22832103; PMCID: PMC3334308.
      View in: PubMed, PubMed Central
    22. Shen Y, Lee HY, Rawson J, Ojha S, Babbitt P, Fu Y, Ptácek LJ. Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability. Hum Mol Genet. 2011 Jun 15; 20(12):2322-32. PMID: 21487022; PMCID: PMC3098736.
      View in: PubMed, PubMed Central
    23. Lin ST, Ptácek LJ, Fu Y. Adult-onset autosomal dominant leukodystrophy: linking nuclear envelope to myelin. J Neurosci. 2011 Jan 26; 31(4):1163-6. PMID: 21273400; PMCID: PMC3078713.
      View in: PubMed, PubMed Central
    24. Zhang L, Jones CR, Ptacek LJ, Fu Y. The genetics of the human circadian clock. Adv Genet. 2011; 74:231-47. PMID: 21924979.
      View in: PubMed
    25. Padiath QS, Fu Y. Autosomal dominant leukodystrophy caused by lamin B1 duplications a clinical and molecular case study of altered nuclear function and disease. Methods Cell Biol. 2010; 98:337-57. PMID: 20816241.
      View in: PubMed
    26. Shin D, Shin JY, McManus MT, Ptácek LJ, Fu Y. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol. 2009 Dec; 66(6):843-57. PMID: 20035504; PMCID: PMC2885004.
      View in: PubMed, PubMed Central
    27. He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL, Rossner MJ, Nishino S, Fu Y. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009 Aug 14; 325(5942):866-70. PMID: 19679812; PMCID: PMC2884988.
      View in: PubMed, PubMed Central
    28. Tong Y, Xu Y, Scearce-Levie K, Ptácek LJ, Fu Y. COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo. Neurogenetics. 2010 Feb; 11(1):41-52. PMID: 19548013; PMCID: PMC2807601.
      View in: PubMed, PubMed Central
    29. Lin ST, Fu Y. miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination. Dis Model Mech. 2009 Mar-Apr; 2(3-4):178-88. PMID: 19259393; PMCID: PMC2650193.
      View in: PubMed, PubMed Central
    30. Fu Y. Oscillating per-cision. PLoS Biol. 2008 Jul 29; 6(7):e192. PMID: 18666835; PMCID: PMC2486315.
      View in: PubMed, PubMed Central
    31. Freudenberg J, Fu Y, Ptácek LJ. Enrichment of HapMap recombination hotspot predictions around human nervous system genes: evidence for positive selection? Eur J Hum Genet. 2007 Oct; 15(10):1071-8. PMID: 17568387.
      View in: PubMed
    32. Freudenberg J, Fu Y, Ptácek LJ. Human recombination rates are increased around accelerated conserved regions--evidence for continued selection? Bioinformatics. 2007 Jun 15; 23(12):1441-3. PMID: 17463031.
      View in: PubMed
    33. Freudenberg J, Fu Y, Ptácek LJ. Bioinformatic analysis of human CNS-expressed ion channels as candidates for episodic nervous system disorders. Neurogenetics. 2007 Aug; 8(3):159-68. PMID: 17333079.
      View in: PubMed
    34. Padiath QS, Saigoh K, Schiffmann R, Asahara H, Yamada T, Koeppen A, Hogan K, Ptácek LJ, Fu Y. Lamin B1 duplications cause autosomal dominant leukodystrophy. Nat Genet. 2006 Oct; 38(10):1114-23. PMID: 16951681.
      View in: PubMed
    35. Yoon G, Baggaley S, Bacchetti P, Fu Y, Digre KB, Ptácek LJ. Clinic-based study of family history of vascular risk factors and migraine. J Headache Pain. 2005 Oct; 6(5):412-6. PMID: 16362715; PMCID: PMC3452064.
      View in: PubMed, PubMed Central
    36. Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptácek LJ, Fu Y. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature. 2005 Mar 31; 434(7033):640-4. PMID: 15800623.
      View in: PubMed
    37. Ptácek LJ, Jones CR, Fu Y. Genetic approaches to human behavior. Methods Enzymol. 2005; 393:239-50. PMID: 15817292.
      View in: PubMed
    38. Ptácek LJ, Fu Y. Channels and disease: past, present, and future. Arch Neurol. 2004 Nov; 61(11):1665-8. PMID: 15534176.
      View in: PubMed
    39. Lee HY, Xu Y, Huang Y, Ahn AH, Auburger GW, Pandolfo M, Kwiecinski H, Grimes DA, Lang AE, Nielsen JE, Averyanov Y, Servidei S, Friedman A, Van Bogaert P, Abramowicz MJ, Bruno MK, Sorensen BF, Tang L, Fu Y, Ptácek LJ. The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Hum Mol Genet. 2004 Dec 15; 13(24):3161-70. PMID: 15496428.
      View in: PubMed
    Ying-Hui's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (238) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (13) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    Back to TOP