Ying-Hui Fu, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
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    Dr. Fu’s research uses human genetics combined with multiple model organisms to investigate molecular mechanisms of human conditions. Her laboratory has been focusing on two areas: one in myelin biology and the other in circadian rhythm and sleep behaviors. For myelin biology, they investigate the interlocking networks of protein-coding genes and non-coding RNAs in ensuring a healthy myelin. For circadian and sleep behaviors, over the last 15 years, she and her colleagues identified several mutations that lead to extreme morning lark phenotype. In addition, they are investigating the genetic basis for human subjects to have shorter sleep duration. Since circadian rhythm and sleep homeostasis are intimately connected with many physiological pathways including metabolism, immune function, and mood regulation, to name but a few, these studies will also shed new light on how sleep schedule and sleep homeostasis can impact on health.

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    Collapse Research Activities and Funding
    Investigating the neurocircuitry of sleep duration regulation
    NIH/NINDS R01NS104782Dec 19, 2017 - Nov 30, 2022
    Role: Principal Investigator
    The role of DEC2 and sleep in prevention of Alzheimer like pathology
    NIH/NIA R01AG054606Jul 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Investigating Genetics of Human Natural Short Sleepers
    NIH/NINDS R01NS072360Sep 1, 2011 - Aug 31, 2016
    Role: Principal Investigator
    The role of Lamin B1 in myelin maintenance and demyelination
    NIH/NINDS R01NS062733Jul 20, 2009 - Jun 30, 2011
    Role: Principal Investigator
    A chemical genetic approach to dissect CKId &CKIe function in circadian rhythm
    NIH/NIGMS R01GM079180Sep 15, 2008 - Aug 31, 2012
    Role: Principal Investigator
    Molecular Basis of the Demylinating Disorder ADLD
    NIH/NINDS R01NS041331Apr 15, 2001 - Mar 31, 2004
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hirano A, Hsu PK, Zhang L, Xing L, McMahon T, Yamazaki M, Ptácek LJ, Fu YH. DEC2 modulates orexin expression and regulates sleep. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):3434-3439. PMID: 29531056.
      View in: PubMed
    2. Chong SYC, Xin L, Ptácek LJ, Fu YH. Disorders of sleep and circadian rhythms. Handb Clin Neurol. 2018; 148:531-538. PMID: 29478598.
      View in: PubMed
    3. Hirano A, Braas D, Fu YH, Ptácek LJ. FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice. Cell Rep. 2017 04 11; 19(2):255-266. PMID: 28402850.
      View in: PubMed
    4. Shi G, Wu D, Ptácek LJ, Fu YH. Human genetics and sleep behavior. Curr Opin Neurobiol. 2017 06; 44:43-49. PMID: 28325617.
      View in: PubMed
    5. Hirano A, Fu YH, Ptácek LJ. The intricate dance of post-translational modifications in the rhythm of life. Nat Struct Mol Biol. 2016 Dec 06; 23(12):1053-1060. PMID: 27922612.
      View in: PubMed
    6. Ptáoek LJ, Fu YH, Krystal AD. Sleep and Mood: Chicken or Egg? Biol Psychiatry. 2016 12 01; 80(11):810-811. PMID: 27968724.
      View in: PubMed
    7. Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Ptácek LJ, Fu YH. A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife. 2016 08 16; 5. PMID: 27529127.
      View in: PubMed
    8. Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptácek LJ, Fu YH. A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):E1536-44. PMID: 26903630; PMCID: PMC4801303.
    9. Howng SY, Huang Y, Ptácek L, Fu YH. Understanding the role of dicer in astrocyte development. PLoS One. 2015; 10(5):e0126667. PMID: 25962146; PMCID: PMC4427179.
    10. Zhang L, Ptáck LJ, Fu YH. Nuclear envelope regulates the circadian clock. Nucleus. 2015; 6(2):114-7. PMID: 25746393; PMCID: PMC4615844.
    11. Hsu PK, Ptácek LJ, Fu YH. Genetics of human sleep behavioral phenotypes. Methods Enzymol. 2015; 552:309-24. PMID: 25707283.
      View in: PubMed
    12. Lin ST, Zhang L, Lin X, Zhang LC, Garcia VE, Tsai CW, Ptácek L, Fu YH. Nuclear envelope protein MAN1 regulates clock through BMAL1. Elife. 2014 Sep 02; 3:e02981. PMID: 25182847; PMCID: PMC4150126.
    13. Shin D, Lin ST, Fu YH, Ptácek LJ. Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gas/Gaq-mediated protein kinases A/C. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19101-6. PMID: 24191038; PMCID: PMC3839775.
    14. Lin ST, Huang Y, Zhang L, Heng MY, Ptácek LJ, Fu YH. MicroRNA-23a promotes myelination in the central nervous system. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17468-73. PMID: 24101522; PMCID: PMC3808585.
    15. Hallows WC, Ptácek LJ, Fu YH. Solving the mystery of human sleep schedules one mutation at a time. Crit Rev Biochem Mol Biol. 2013 Sep-Oct; 48(5):465-75. PMID: 24001255; PMCID: PMC4089902.
    16. Kurien PA, Chong SY, Ptácek LJ, Fu YH. Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function. Curr Opin Neurobiol. 2013 Oct; 23(5):873-9. PMID: 23702243; PMCID: PMC3766463.
    17. Heng MY, Lin ST, Verret L, Huang Y, Kamiya S, Padiath QS, Tong Y, Palop JJ, Huang EJ, Ptácek LJ, Fu YH. Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. J Clin Invest. 2013 Jun; 123(6):2719-29. PMID: 23676464; PMCID: PMC3668844.
    18. Russell JF, Fu YH, Ptácek LJ. Episodic neurologic disorders: syndromes, genes, and mechanisms. Annu Rev Neurosci. 2013 Jul 08; 36:25-50. PMID: 23642134.
      View in: PubMed
    19. Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 05; 17(2):291-302. PMID: 23395175; PMCID: PMC3597447.
    20. Zhang L, Ptácek LJ, Fu YH. Diversity of human clock genotypes and consequences. Prog Mol Biol Transl Sci. 2013; 119:51-81. PMID: 23899594; PMCID: PMC4169291.
    21. Zhang L, Abraham D, Lin ST, Oster H, Eichele G, Fu YH, Ptácek LJ. PKC? participates in food entrainment by regulating BMAL1. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20679-84. PMID: 23185022; PMCID: PMC3528600.
    22. Chong SY, Ptácek LJ, Fu YH. Genetic insights on sleep schedules: this time, it's PERsonal. Trends Genet. 2012 Dec; 28(12):598-605. PMID: 22939700; PMCID: PMC3500418.
    23. Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, Choi M, Lee HY, Kirk A, Nelson-Williams C, Gibson G, Baraban SC, Lifton RP, Geschwind DH, Fu YH, Ptácek LJ. Familial cortical myoclonus with a mutation in NOL3. Ann Neurol. 2012 Aug; 72(2):175-83. PMID: 22926851; PMCID: PMC3431191.
    24. Kategaya LS, Hilliard A, Zhang L, Asara JM, Ptácek LJ, Fu YH. Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock. PLoS One. 2012; 7(2):e31987. PMID: 22384121; PMCID: PMC3288064.
    25. Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 2012 Feb; 122(2):507-18. PMID: 22214848; PMCID: PMC3533379.
    26. Lee HY, Huang Y, Bruneau N, Roll P, Roberson ED, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohammed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock AM, Szepetowski P, Fu YH, Ptácek LJ. Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. Cell Rep. 2012 Jan 26; 1(1):2-12. PMID: 22832103.
      View in: PubMed
    27. Shen Y, Lee HY, Rawson J, Ojha S, Babbitt P, Fu YH, Ptácek LJ. Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability. Hum Mol Genet. 2011 Jun 15; 20(12):2322-32. PMID: 21487022; PMCID: PMC3098736.
    28. Lin ST, Ptácek LJ, Fu YH. Adult-onset autosomal dominant leukodystrophy: linking nuclear envelope to myelin. J Neurosci. 2011 Jan 26; 31(4):1163-6. PMID: 21273400; PMCID: PMC3078713.
    29. Zhang L, Jones CR, Ptacek LJ, Fu YH. The genetics of the human circadian clock. Adv Genet. 2011; 74:231-47. PMID: 21924979.
      View in: PubMed
    30. Padiath QS, Fu YH. Autosomal dominant leukodystrophy caused by lamin B1 duplications a clinical and molecular case study of altered nuclear function and disease. Methods Cell Biol. 2010; 98:337-57. PMID: 20816241.
      View in: PubMed
    31. Shin D, Shin JY, McManus MT, Ptácek LJ, Fu YH. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol. 2009 Dec; 66(6):843-57. PMID: 20035504; PMCID: PMC2885004.
    32. He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL, Rossner MJ, Nishino S, Fu YH. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009 Aug 14; 325(5942):866-70. PMID: 19679812; PMCID: PMC2884988.
    33. Tong Y, Xu Y, Scearce-Levie K, Ptácek LJ, Fu YH. COL25A1 triggers and promotes Alzheimer's disease-like pathology in vivo. Neurogenetics. 2010 Feb; 11(1):41-52. PMID: 19548013; PMCID: PMC2807601.
    34. Lin ST, Fu YH. miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination. Dis Model Mech. 2009 Mar-Apr; 2(3-4):178-88. PMID: 19259393; PMCID: PMC2650193.
    35. Fu YH. Oscillating per-cision. PLoS Biol. 2008 Jul 29; 6(7):e192. PMID: 18666835; PMCID: PMC2486315.
    36. Freudenberg J, Fu YH, Ptácek LJ. Enrichment of HapMap recombination hotspot predictions around human nervous system genes: evidence for positive selection? Eur J Hum Genet. 2007 Oct; 15(10):1071-8. PMID: 17568387.
      View in: PubMed
    37. Freudenberg J, Fu YH, Ptácek LJ. Human recombination rates are increased around accelerated conserved regions--evidence for continued selection? Bioinformatics. 2007 Jun 15; 23(12):1441-3. PMID: 17463031.
      View in: PubMed
    38. Freudenberg J, Fu YH, Ptácek LJ. Bioinformatic analysis of human CNS-expressed ion channels as candidates for episodic nervous system disorders. Neurogenetics. 2007 Aug; 8(3):159-68. PMID: 17333079.
      View in: PubMed
    39. Padiath QS, Saigoh K, Schiffmann R, Asahara H, Yamada T, Koeppen A, Hogan K, Ptácek LJ, Fu YH. Lamin B1 duplications cause autosomal dominant leukodystrophy. Nat Genet. 2006 Oct; 38(10):1114-23. PMID: 16951681.
      View in: PubMed
    40. Yoon G, Baggaley S, Bacchetti P, Fu YH, Digre KB, Ptácek LJ. Clinic-based study of family history of vascular risk factors and migraine. J Headache Pain. 2005 Oct; 6(5):412-6. PMID: 16362715.
      View in: PubMed
    41. Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptácek LJ, Fu YH. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature. 2005 Mar 31; 434(7033):640-4. PMID: 15800623.
      View in: PubMed
    42. Ptácek LJ, Jones CR, Fu YH. Genetic approaches to human behavior. Methods Enzymol. 2005; 393:239-50. PMID: 15817292.
      View in: PubMed
    43. Ptácek LJ, Fu YH. Channels and disease: past, present, and future. Arch Neurol. 2004 Nov; 61(11):1665-8. PMID: 15534176.
      View in: PubMed
    44. Lee HY, Xu Y, Huang Y, Ahn AH, Auburger GW, Pandolfo M, Kwiecinski H, Grimes DA, Lang AE, Nielsen JE, Averyanov Y, Servidei S, Friedman A, Van Bogaert P, Abramowicz MJ, Bruno MK, Sorensen BF, Tang L, Fu YH, Ptácek LJ. The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Hum Mol Genet. 2004 Dec 15; 13(24):3161-70. PMID: 15496428.
      View in: PubMed