Ying-Hui Fu, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-514-9310
ORCID ORCID Icon0000-0002-6628-0266 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Dr. Fu’s research uses human genetics combined with multiple model organisms to investigate molecular mechanisms of human conditions. Her laboratory has been focusing on two areas: one in myelin biology and the other in circadian rhythm and sleep behaviors. For myelin biology, they investigate the interlocking networks of protein-coding genes and non-coding RNAs in ensuring a healthy myelin. For circadian and sleep behaviors, over the last 15 years, she and her colleagues identified several mutations that lead to extreme morning lark phenotype. In addition, they are investigating the genetic basis for human subjects to have shorter sleep duration. Since circadian rhythm and sleep homeostasis are intimately connected with many physiological pathways including metabolism, immune function, and mood regulation, to name but a few, these studies will also shed new light on how sleep schedule and sleep homeostasis can impact on health.

    Collapse Research 
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    Investigating the neurocircuitry of sleep duration regulation
    NIH R01NS104782Dec 19, 2017 - Nov 30, 2022
    Role: Principal Investigator
    The role of DEC2 and sleep in prevention of Alzheimer like pathology
    NIH/NIA R01AG054606Jul 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    The role of DEC2 and sleep in prevention of Alzheimer like pathology
    NIH RF1AG054606Jul 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Investigating Genetics of Human Natural Short Sleepers
    NIH R01NS072360Sep 1, 2011 - Aug 31, 2016
    Role: Principal Investigator
    The role of Lamin B1 in myelin maintenance and demyelination
    NIH R01NS062733Jul 20, 2009 - Jun 30, 2011
    Role: Principal Investigator
    A chemical genetic approach to dissect CKId &CKIe function in circadian rhythm
    NIH R01GM079180Sep 15, 2008 - Aug 31, 2012
    Role: Principal Investigator
    Molecular Basis of the Demylinating Disorder ADLD
    NIH R01NS041331Apr 15, 2001 - Mar 31, 2004
    Role: Principal Investigator

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