Bruce Conklin, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address35 Medical Center Way, #001
San Francisco CA 94143
Phone415-734-2000
ORCID ORCID Icon0000-0003-1463-6061 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, CA, Berkeley CAA.B.06/1982Public Health
    Case Western Reserve School of Medicine, Cleveland OHM.D.06/1988Medicine
    Johns Hopkins Hospital, Baltimore, MD06/1990Internal Medicine
    University of California San Francisco, San Francisco CA01/1995Molecular Pharmacology
    University of California San Francisco, San Francisco2021DEI Champion
    Collapse Awards and Honors
    1990Medical Resident Research Award-NIDDK
    2003American Society for Clinical Investigation
    2008Scientific American 50 Award
    2011Fellow, California Academy of Sciences
    2016CWRU School of Medicine Distinguished Alumni Award

    Collapse Overview 
    Collapse Overview
    Therapeutic Approaches to Genetic Disease

    Genome Engineering
    The late Richard Feynman once said, “What I cannot create, I do not understand.” Human genetics began as observational science, but newly developed genome-engineering tools now allow us to directly test the cellular consequences of discrete genetic changes. We have developed efficient methods to edit one residue at a time in living human induced pluripotent stem (iPS) cells, resulting in “isogenic” lines of iPS cells. These isogenic lines form models that are now yielding phenotypes that are helping to explain the molecular basis of several human diseases. We are constructing collections of these isogenic lines that carry a range of disease mutations, from the most severe (rare) to the moderate (common) forms of cardiomyopathy.

    Precise Genome Editing for Human Therapy
    The rapid development of genome engineering, such as with the CRISPR system, now allows us to contemplate using these tools for human therapy in selective tissues. Using genome editing to “fix” a disease gene has great promise, because it could permanently correct the disease. However, tremendous challenges remain to ensure that only a specific part of the genome is edited, without causing “off-target” DNA damage that could lead to cancer. We focused on developing therapeutic editing for diseases of the heart and retina, because each tissue has unique challenges and opportunities. The heart has many newly described gene mutations that result in lethal heart failure (cardiomyopathy). Genome engineering can be used to cure cardiomyopathy mutations and validate targets for drug therapy; however, current engineering methods will need to be greatly enhanced before it can be used in vivo in the heart. In contrast, the retina has the advantage of a limited number of cells that can be directly targeted for therapy. These properties could potentially cure blindness caused by many gene mutations that currently have no therapy. We are developing proof-of-concept therapeutic editing methods in the retina that can be expanded to other tissues, such as the heart.

    Human Cardiac Disease Models
    We use iPS cells to model the genetic causes of human cardiomyopathy. Surprisingly, little is known about many genes associated with heart failure, from cardiomyopathy to abnormal heart rhythm, that results in “sudden death.” The heart provides an ideal system to determine the molecular basis of gene associations in human genetics. Until recently, modeling human gene variants in human cardiac tissue has been impossible. Human iPS cells now allow us to produce cardiovascular tissues that are identical, except for a single gene that has been altered by genome engineering. Our efforts have already been used to uncover multiple disease phenotypes and targets for drug therapy.

    CRISPR-Based Screens in Human Cardiac Disease Models
    Recently, we developed CRISPR-inhibition (CRISPRi) cell lines for highthroughput gene inactivation of thousands of different genes. CRISPRi screens can be used to identify the molecular basis of development, so that we can construct more mature human tissues and improved disease models. These studies will also allow us to identify drug targets that could be used for treating cardiomyopathy and other major diseases. We are currently focused on finding new pathways to enhance cardiac regeneration. In the future, other versions of the CRISPR system could be used to activate genes and control the epigenetic state of the genome.

    Future Directions
    We are developing new genome engineering methods in human iPS cells to identify therapeutic targets in cardiac disease. We are using these same tools to develop strategies for therapeutic genome editing. The combination of human iPS cells and genome editing provide unprecedented opportunities to explore new areas of biology and discover new therapies for disease.

    Selected Recent Publications
    1. Mandegar MA, Huebsch N, Frolov E, SHin E, Weissman JS, Qi LS, So P-L, Conklin BR. (2016) CRISPR interference efficiently induces gene knockdown and models disease in iPSCs. Cell Stem Cell. 18 1-13, April 7, 2016
    2. Huebsch N et al. (2015) Automated video-based analysis of contractility and calcium flux in human-induced pluripotent stem cell-derived cardiomyocytes cultured over different spatial scales. Tissue Eng. Part C Methods 21:467.
    3. Ma Z et al. (2015) Self-organizing human cardiac microchambers mediated by geometric confinement. Nat. Commun. 6:7413.
    4. Miyaoka Y et al. (2014) Isolation of single-base genome-edited human iPS cells without antibiotic selection. Nat. Methods 11:291.
    5. Spencer CI et al. (2014) Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports 3:269.
    Collapse Mentoring

    Collapse Research 
    Collapse Research Activities and Funding
    C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches
    NIH RF1AG072052May 1, 2021 - Apr 30, 2024
    Role: Principal Investigator
    Therapeutic genome editing to treat Best disease
    NIH R01EY028249Sep 30, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Protein quality control, cardiomyopathy, cardiotoxicity and human isogenic iPSCs
    NIH R01HL135358Jul 15, 2017 - Jun 30, 2021
    Role: Principal Investigator
    Identifying Therapeutic Targets for RNA Splicing-Related Cardiomyopathy
    NIH R01HL130533Dec 14, 2015 - Nov 30, 2019
    Role: Principal Investigator
    Disease Specific Cardiac Tissue Models
    NIH R01HL108677Sep 5, 2011 - May 31, 2015
    Role: Co-Principal Investigator
    Structures of Protein Complexes Regulating Transcription in Enbryonic Stem Cells
    NIH U01GM094614Sep 30, 2010 - Jun 30, 2016
    Role: Co-Investigator
    Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas
    NIH U01HL100406Sep 30, 2009 - Oct 31, 2016
    Role: Co-Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH U01HL098179Sep 30, 2009 - Aug 31, 2015
    Role: Co-Principal Investigator
    Induced pluripotent stem cells in the understanding and treatment of heart diseas
    NIH R03HL096254Dec 1, 2008 - May 31, 2009
    Role: Co-Principal Investigator
    Transcriptional Networks During Cardiac Differentiation
    NIH P01HL089707Jul 1, 2007 - Jul 31, 2018
    Role: Co-Investigator
    GenMAPP-CS, a dynamic resource pathway analysis
    NIH R01GM080223Aug 18, 2004 - Jul 31, 2012
    Role: Principal Investigator
    GenMAPP: A tool for pathway analysis of genomic data
    NIH R01HG003053Aug 18, 2004 - Oct 31, 2007
    Role: Principal Investigator
    COLLABORATIVE R01--ROLES OF G PROTEINS IN CARDIOMYOPATHY
    NIH R01HL061689Sep 30, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Tissue Engineering with a Modular RASSL Toolbox
    NIH R01HL060664Jul 1, 1998 - Jun 30, 2013
    Role: Principal Investigator
    MUTANT G PROTEINS REVEAL SIGNALING PATHWAYS
    NIH K11HL002555Jan 1, 1991 - Dec 31, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes. bioRxiv. 2024 Jun 26. Ramadoss GN, Namaganda SJ, Hamilton JR, Sharma R, Chow KG, Macklin BL, Sun M, Liu JC, Fellmann C, Watry HL, Jin J, Perez BS, Sandoval Espinoza CR, Matia MP, Lu SH, Judge LM, Nussenzweig A, Adamson B, Murthy N, Doudna JA, Kampmann M, Conklin BR. PMID: 38979269; PMCID: PMC11230251.
      View in: PubMed   Mentions:
    2. Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution. Nat Methods. 2024 Jul; 21(7):1257-1274. Yeh LH, Ivanov IE, Chandler T, Byrum JR, Chhun BB, Guo SM, Foltz C, Hashemi E, Perez-Bermejo JA, Wang H, Yu Y, Kazansky PG, Conklin BR, Han MH, Mehta SB. PMID: 38890427; PMCID: PMC11239526.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    3. Advances and challenges in modeling inherited peripheral neuropathies using iPSCs. Exp Mol Med. 2024 Jun; 56(6):1348-1364. Van Lent J, Prior R, Pérez Siles G, Cutrupi AN, Kennerson ML, Vangansewinkel T, Wolfs E, Mukherjee-Clavin B, Nevin Z, Judge L, Conklin B, Tyynismaa H, Clark AJ, Bennett DL, Van Den Bosch L, Saporta M, Timmerman V. PMID: 38825644; PMCID: PMC11263568.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells. bioRxiv. 2024 May 07. Chu SN, Soupene E, Wienert B, Yin H, Sharma D, McCreary T, Jia K, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Porteus MH, Cromer MK. PMID: 38766216; PMCID: PMC11100611.
      View in: PubMed   Mentions:
    5. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision. Proc Natl Acad Sci U S A. 2024 Apr 23; 121(17):e2307814121. Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, Chouhan RS, Issagholian-Lewin PO, Patel E, Watry HL, Bernardi MT, Keough KC, Tsai YC, Smith AST, Conklin BR, Clelland CD. PMID: 38621131; PMCID: PMC11047104.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Give heart cells a beat: An interactive museum exhibit that synchronizes stem cell-derived cardiomyocytes to visitors' heartbeat. Stem Cell Reports. 2024 Mar 12; 19(3):426-433. Perez-Bermejo JA, Reisman SJ, Ma J, Carrison-Stone D, Cerrito C, Ribeiro AJS, Conklin BR, Yu K. PMID: 38335963; PMCID: PMC10937149.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Validated assays for the quantification of C9orf72 human pathology. Sci Rep. 2024 01 08; 14(1):828. Salomonsson SE, Maltos AM, Gill K, Aladesuyi Arogundade O, Brown KA, Sachdev A, Sckaff M, Lam KJK, Fisher IJ, Chouhan RS, Van Laar VS, Marley CB, McLaughlin I, Bankiewicz KS, Tsai YC, Conklin BR, Clelland CD. PMID: 38191789; PMCID: PMC10774390.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    8. Dual a-Globin and Truncated EPO Receptor Knockin Restores Hemoglobin Production in a-Thalassemia-Derived Hematopoietic Stem and Progenitor Cells. Blood. 2023 Nov 28; 142(Supplement 1):485. Chu CS, Soupene SE, Wienert WB, Yin YH, Sharma SD, Jia JK, Homma HS, Hampton HJ, Conklin CB, MacKenzie MT, Porteus PM, Cromer CK. .
      View in: Publisher Site   Mentions:
    9. Functional analysis of a common BAG3 allele associated with protection from heart failure. Nat Cardiovasc Res. 2023 Jul; 2(7):615-628. Perez-Bermejo JA, Judge LM, Jensen CL, Wu K, Watry HL, Truong A, Ho JJ, Carter M, Runyon WV, Kaake RM, Pulido EH, Mandegar MA, Swaney DL, So PL, Krogan NJ, Conklin BR. PMID: 39195919.
      View in: PubMed   Mentions: 4  Translation:HumansCells
    10. Evaluation of CRISPR/Cas9 exon-skipping vector for choroideremia using human induced pluripotent stem cell-derived RPE. J Gene Med. 2023 02; 25(2):e3464. Iwagawa T, Masumoto H, Tabuchi H, Tani K, Conklin BR, Watanabe S. PMID: 36413603; PMCID: PMC9898118.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022 12 01; 29(12):1685-1702.e22. Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT. PMID: 36459969; PMCID: PMC9782786.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    12. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation. 2022 09 06; 146(10):770-787. Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D. PMID: 35938400; PMCID: PMC9452483.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    13. Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022 03 03; 185(5):794-814.e30. Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. PMID: 35182466; PMCID: PMC8923057.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    14. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nat Cell Biol. 2022 01; 24(1):24-34. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 35027731; PMCID: PMC8820466.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    15. Abstract 11332: Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes. Circulation. 2021 Nov 16; 144(Suppl_1):a11332-a11332. Teran TB, Pittman PM, Thomas TR, Felix FF, Richmond-Buccola RD, Choudhary CK, Moroni ME, Giorgio GC, Padmanabhan PA, Costa CM, Huang HY, Alexanian AM, Lee LC, Cole CB, Samse-Knapp SK, McGregor MM, Gifford GC, Huttenhain HR, Gelb GB, Conklin CB, Black BB, Bruneau BB, Krogan KN, Pollard PK, Srivastava SD. .
      View in: Publisher Site   Mentions:
    16. Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies. Nat Commun. 2021 11 03; 12(1):6324. Fenix AM, Miyaoka Y, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, Mayerl SJ, Nguyen TD, Russell CR, Lizarraga PP, Truong A, So PL, Kulkarni A, Chetal K, Sathe S, Sniadecki NJ, Yeo GW, Murry CE, Conklin BR, Salomonis N. PMID: 34732726; PMCID: PMC8566601.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    17. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Sep 20. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 33501440; PMCID: PMC7836110.
      View in: PubMed   Mentions:
    18. Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E. Front Cell Dev Biol. 2021; 9:723023. Feliciano CM, Wu K, Watry HL, Marley CBE, Ramadoss GN, Ghanim HY, Liu AZ, Zholudeva LV, McDevitt TC, Saporta MA, Conklin BR, Judge LM. PMID: 34485306; PMCID: PMC8415563.
      View in: PubMed   Mentions: 11  
    19. Bioengineered optogenetic model of human neuromuscular junction. Biomaterials. 2021 09; 276:121033. Vila OF, Chavez M, Ma SP, Yeager K, Zholudeva LV, Colón-Mercado JM, Qu Y, Nash TR, Lai C, Feliciano CM, Carter M, Kamm RD, Judge LM, Conklin BR, Ward ME, McDevitt TC, Vunjak-Novakovic G. PMID: 34403849; PMCID: PMC8439334.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Transcription factor overexpression drives reliable differentiation of retinal pigment epithelium from human induced pluripotent stem cells. Stem Cell Res. 2021 05; 53:102368. Dewell TE, Gjoni K, Liu AZ, Libby ARG, Moore AT, So PL, Conklin BR. PMID: 34087997.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 04 21; 13(590). Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC. PMID: 33723017; PMCID: PMC8128284.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    22. Investigating Zeta Globin Gene Expression to Develop a Potential Therapy for Alpha Thalassemia Major. Blood. 2020 Nov 5; 136(Supplement 1):3-4. Gregory GG, Wienert WB, Schwab SM, Lianoglou LB, Hollis HR, Kohn KD, Conklin CB, MacKenzie MT. .
      View in: Publisher Site   Mentions:
    23. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients. bioRxiv. 2020 Sep 12. Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC. PMID: 32935097; PMCID: PMC7491510.
      View in: PubMed   Mentions:
    24. Rapid, precise quantification of large DNA excisions and inversions by ddPCR. Sci Rep. 2020 09 10; 10(1):14896. Watry HL, Feliciano CM, Gjoni K, Takahashi G, Miyaoka Y, Conklin BR, Judge LM. PMID: 32913194; PMCID: PMC7483445.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. Cell Rep. 2020 06 02; 31(9):107715. Takahashi K, Jeong D, Wang S, Narita M, Jin X, Iwasaki M, Perli SD, Conklin BR, Yamanaka S. PMID: 32492424; PMCID: PMC8195978.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    26. Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. Nat Commun. 2020 Apr 30; 11(1):2109. Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE. PMID: 32355159; PMCID: PMC7193628.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    27. CRISPR off-target detection with DISCOVER-seq. Nat Protoc. 2020 05; 15(5):1775-1799. Wienert B, Wyman SK, Yeh CD, Conklin BR, Corn JE. PMID: 32313254; PMCID: PMC7305837.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. Cardiac Microtissues: Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity (Adv. Healthcare Mater. 8/2020). Advanced Healthcare Materials. 2020 Apr 1; 9(8):2070024. Wang WC, Koo KS, Park PM, Vangelatos VZ, Hoang HP, Conklin CB, Grigoropoulos GC, Healy HK, Ma MZ. .
      View in: Publisher Site   Mentions:
    29. Maladaptive Contractility of 3D Human Cardiac Microtissues to Mechanical Nonuniformity. Adv Healthc Mater. 2020 04; 9(8):e1901373. Wang C, Koo S, Park M, Vangelatos Z, Hoang P, Conklin BR, Grigoropoulos CP, Healy KE, Ma Z. PMID: 32090507; PMCID: PMC7274862.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. Automated Design of Pluripotent Stem Cell Self-Organization. Cell Syst. 2019 11 27; 9(5):483-495.e10. Libby ARG, Briers D, Haghighi I, Joy DA, Conklin BR, Belta C, McDevitt TC. PMID: 31759947; PMCID: PMC7089762.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    31. AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design. Genome Biol. 2019 Aug 15; 20(1):167. Keough KC, Lyalina S, Olvera MP, Whalen S, Conklin BR, Pollard KS. PMID: 31416467; PMCID: PMC6694686.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    32. Abstract 934: Physical and Genetic Interaction Analyses in Human Pluripotent Stem Cell-Derived Cardiomyocytes to Study Protein Quality Control Disease in the Heart. Circulation Research. 2019 Aug 2; 125(Suppl_1). Perez-Bermejo PJ, Judge JL, Wu WK, Jensen JC, Kaake KR, Swaney SD, So SP, Krogan KN, Conklin CB. .
      View in: Publisher Site   Mentions:
    33. Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2019 08 13; 13(2):394-404. Yoshinaga D, Baba S, Makiyama T, Shibata H, Hirata T, Akagi K, Matsuda K, Kohjitani H, Wuriyanghai Y, Umeda K, Yamamoto Y, Conklin BR, Horie M, Takita J, Heike T. PMID: 31378668; PMCID: PMC6700479.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    34. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nat Genet. 2019 08; 51(8):1252-1262. Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y. PMID: 31367015; PMCID: PMC6677164.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    35. A NOVEL ROLE FOR THE FTD-CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p1509. Clelland CC, Etchegaray EJ, Kodama KL, Sayed SF, Sachdev SA, Li LY, Le LD, Zhan ZL, Zhou ZY, Duong DD, Seyfried SN, Kukar KT, Tan TL, Lakkaraju LA, Conklin CB, Gan GL. .
      View in: Publisher Site   Mentions:
    36. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Science. 2019 Apr 19; 364(6437):286-289. Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE. PMID: 31000663; PMCID: PMC6589096.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    37. On the road to a gene drive in mammals. Nature. 2019 02; 566(7742):43-45. Conklin BR. PMID: 30710124.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification. Dev Biol. 2019 01 01; 445(1):1-7. Eskildsen TV, Ayoubi S, Thomassen M, Burton M, Mandegar MA, Conklin BR, Jensen CH, Andersen DC, Sheikh SP. PMID: 30389344.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    39. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference. Elife. 2018 10 09; 7. Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC. PMID: 30298816; PMCID: PMC6177255.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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    104. Mining biological pathways using WikiPathways web services. PLoS One. 2009 Jul 30; 4(7):e6447. Kelder T, Pico AR, Hanspers K, van Iersel MP, Evelo C, Conklin BR. PMID: 19649250; PMCID: PMC2714472.
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    105. AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans. Psychophysiology. 2009 May; 46(3):466-72. Neumann SA, Tingley WG, Conklin BR, Shrader CJ, Peet E, Muldoon MF, Jennings JR, Ferrell RE, Manuck SB. PMID: 19496216; PMCID: PMC2890278.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    106. Endogenous Gi signaling in osteoblasts participates in sexually dimorphic regulation of cancellous bone structure. Bone. 2009 May 1; 44:s153. Millard MS, Louie LA, Manalac MC, Lu LW, Cotte CN, Wronski WT, Conklin CB, Nissenson NR. .
      View in: Publisher Site   Mentions:
    107. Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. PLoS One. 2009; 4(4):e5046. Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, Terskikh A, McCulloch AD, Price JH, Conklin BR, Chen HS, Mercola M. PMID: 19352491; PMCID: PMC2662416.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    108. Obtaining consent for future research with induced pluripotent cells: opportunities and challenges. PLoS Biol. 2009 Feb 24; 7(2):e42. Aalto-Setälä K, Conklin BR, Lo B. PMID: 19243222; PMCID: PMC2652391.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    109. SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic Acids Res. 2009 Jan; 37(Database issue):D803-9. Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M. PMID: 18984625; PMCID: PMC2686434.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    110. Presenting and exploring biological pathways with PathVisio. BMC Bioinformatics. 2008 Sep 25; 9:399. van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C. PMID: 18817533; PMCID: PMC2569944.
      View in: PubMed   Mentions: 175     Fields:    Translation:Cells
    111. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. PMID: 18668035; PMCID: PMC2703467.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    112. WikiPathways: pathway editing for the people. PLoS Biol. 2008 Jul 22; 6(7):e184. Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin BR, Evelo C. PMID: 18651794; PMCID: PMC2475545.
      View in: PubMed   Mentions: 335     Fields:    Translation:Cells
    113. Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter. PLoS One. 2008 Jul 02; 3(7):e2532. Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin BR. PMID: 18596956; PMCID: PMC2430532.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    114. An Introduction to Pathway Analysis with GenMAPP. NCI Nature Pathway Interaction Database. 2008 Apr 8. Hanspers HK, Pico PA, Salomonis SN, Zambon ZA, Vranizan VK, Lawlor LS, Dahlquist DK, Doniger DS, Conklin CB. .
      View in: Publisher Site   Mentions:
    115. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008 Mar 06; 2(3):219-29. Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. PMID: 18371447; PMCID: PMC2293325.
      View in: PubMed   Mentions: 275     Fields:    Translation:HumansAnimalsCells
    116. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells identifies genes and pathways of cAMP/PKA-promoted apoptosis. The FASEB Journal. 2008 Mar 1; 22:648.13-648.13. Zhang ZL, Zambon ZA, Vranizan VK, Pothula PK, Conklin CB, Insel IP. .
      View in: Publisher Site   Mentions:
    117. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. PMID: 18212126; PMCID: PMC2234117.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    118. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. PLoS One. 2007 Dec 19; 2(12):e1317. Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR. PMID: 18338032; PMCID: PMC2267039.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    119. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar; 149(3):1329-37. Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. PMID: 18048501; PMCID: PMC2275363.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    120. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem. 2008 Feb 15; 283(7):4304-13. Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. PMID: 18048352; PMCID: PMC3882191.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    121. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007 Aug 01; 2(7):e668. Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. PMID: 17668051; PMCID: PMC1930153.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    122. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS One. 2007 Jul 18; 2(7):e617. Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. PMID: 17637833; PMCID: PMC1910612.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    123. GenMAPP 2: new features and resources for pathway analysis. BMC Bioinformatics. 2007 Jun 24; 8:217. Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Stuart J, Conklin BR, Pico AR. PMID: 17588266; PMCID: PMC1924866.
      View in: PubMed   Mentions: 120     Fields:    Translation:Cells
    124. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10894-9. Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D. PMID: 17576928; PMCID: PMC1904134.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    125. Interfacing silicon nanowires with mammalian cells. J Am Chem Soc. 2007 Jun 13; 129(23):7228-9. Kim W, Ng JK, Kunitake ME, Conklin BR, Yang P. PMID: 17516647.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    126. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8461-6. Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR. PMID: 17485678; PMCID: PMC1866184.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    127. New tools to build synthetic hormonal pathways. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4777-8. Conklin BR. PMID: 17360323; PMCID: PMC1829213.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    128. Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes. J Neurosci. 2007 Feb 28; 27(9):2309-17. Sweger EJ, Casper KB, Scearce-Levie K, Conklin BR, McCarthy KD. PMID: 17329428; PMCID: PMC6673489.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    129. Integration of biological networks and gene expression data using Cytoscape. Nat Protoc. 2007; 2(10):2366-82. Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD. PMID: 17947979; PMCID: PMC3685583.
      View in: PubMed   Mentions: 1258     Fields:    
    130. mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6380-5. Nicholls RE, Zhang XL, Bailey CP, Conklin BR, Kandel ER, Stanton PK. PMID: 16606834; PMCID: PMC1458886.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    131. A Series of RASSLs Activated by a Single Agonist. The FASEB Journal. 2006 Mar 1; 20(4):a249-a249. Chang CP, Hsiao HE, Zambon ZA, Conklin CB. .
      View in: Publisher Site   Mentions:
    132. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D642-8. Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE. PMID: 16381950; PMCID: PMC1347459.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    133. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1103-9. Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. PMID: 16243914.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    134. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8561-6. Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA. PMID: 15939874; PMCID: PMC1150853.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    135. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics. 2005 Jun 16; 22(1):118-26. McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. PMID: 15797971.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    136. Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. BMC Biol. 2005 Feb 11; 3:3. Scearce-Levie K, Lieberman MD, Elliott HH, Conklin BR. PMID: 15707483; PMCID: PMC551613.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    137. Identifying genetic networks underlying myometrial transition to labor. Genome Biol. 2005; 6(2):R12. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR. PMID: 15693941; PMCID: PMC551532.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    138. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest. 2004 Oct; 114(8):1158-64. Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. PMID: 15489963; PMCID: PMC522250.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    139. A public gene trap resource for mouse functional genomics. Nat Genet. 2004 Jun; 36(6):543-4. Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J, International Gene Trap Consortium. PMID: 15167922; PMCID: PMC2716026.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    140. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 2003; 4(10):R61. Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, Takahashi JS, Schambelan M, Conklin BR. PMID: 14519196; PMCID: PMC328450.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    141. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann N Y Acad Sci. 2003 Jun; 994:225-32. Srinivasan S, Vaisse C, Conklin BR. PMID: 12851320.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    142. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol. 2003; 4(1):R7. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. PMID: 12540299; PMCID: PMC151291.
      View in: PubMed   Mentions: 342     Fields:    Translation:Animals
    143. Regression approaches for microarray data analysis. J Comput Biol. 2003; 10(6):961-80. Segal MR, Dahlquist KD, Conklin BR. PMID: 14980020.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    144. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet. 2002 May; 31(1):19-20. Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. PMID: 11984561.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimals
    145. Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands. Methods Enzymol. 2002; 343:232-48. Scearce-Levie K, Coward P, Redfern CH, Conklin BR. PMID: 11665570.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    146. Engineering receptors activated solely by synthetic ligands (RASSLs). Trends Pharmacol Sci. 2001 Aug; 22(8):414-20. Scearce-Levie K, Coward P, Redfern CH, Conklin BR. PMID: 11479004.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    147. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2001 Apr; 280(4):H1653-9. Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. PMID: 11247776.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    148. Tetracycline-inducible system for photoreceptor-specific gene expression. Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4281-7. Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ. PMID: 11095627.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    149. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4826-31. Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR. PMID: 10781088; PMCID: PMC18317.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    150. A critical period of vulnerability to hyperactive Gq signaling revealed by inducible and heart-specific expression of Gq* in transgenic mice. Journal of Cardiac Failure. 1999 Sep 1; 5(3):12. Cotte CN, Redfern RC, Mikus MP, Salomonis SN, Degtyarev DM, Coward CP, Kwa KA, Shioi ST, Shah SN, McKinsey MT, Olson OE, Izumo IS, Warrington WJ, Baker BA, Conklin CB. .
      View in: Publisher Site   Mentions:
    151. Genomic analysis of an inducible and reversible model of dilated cardiomyopathy. Journal of Cardiac Failure. 1999 Sep 1; 5(3):14. Redfern RC, Degtyarev DM, Desai DK, Kwa KA, Fishman FG, Bernstein BD, Baker BA, Conklin CB. .
      View in: Publisher Site   Mentions:
    152. Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors. Anal Biochem. 1999 Jun 01; 270(2):242-8. Coward P, Chan SD, Wada HG, Humphries GM, Conklin BR. PMID: 10334841.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    153. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol. 1999 Feb; 17(2):165-9. Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR. PMID: 10052353.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    154. Controlling signaling with a specifically designed Gi-coupled receptor. Proc Natl Acad Sci U S A. 1998 Jan 06; 95(1):352-7. Coward P, Wada HG, Falk MS, Chan SD, Meng F, Akil H, Conklin BR. PMID: 9419379; PMCID: PMC18222.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    155. The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling. J Biol Chem. 1997 Aug 01; 272(31):19107-10. Kostenis E, Degtyarev MY, Conklin BR, Wess J. PMID: 9235898.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    156. Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits. Biochemistry. 1997 Feb 11; 36(6):1487-95. Kostenis E, Conklin BR, Wess J. PMID: 9063897.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    157. Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals. J Neurochem. 1997 Feb; 68(2):525-33. Burstein ES, Bräuner-Osborne H, Spalding TA, Conklin BR, Brann MR. PMID: 9003037.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    158. Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Mol Pharmacol. 1996 Oct; 50(4):885-90. Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR. PMID: 8863834.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    159. Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. J Biol Chem. 1996 Mar 15; 271(11):6172-8. Liu J, Blin N, Conklin BR, Wess J. PMID: 8626406.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    160. Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11642-6. Liu J, Conklin BR, Blin N, Yun J, Wess J. PMID: 8524820; PMCID: PMC40458.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    161. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. J Biol Chem. 1994 Feb 25; 269(8):5730-4. Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. PMID: 7907086.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    162. G alpha 13 stimulates Na-H exchange. J Biol Chem. 1994 Feb 18; 269(7):4721-4. Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. PMID: 8106440.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    163. Homeostatic signals. Marriage of the flytrap and the serpent. Nature. 1994 Jan 06; 367(6458):22. Conklin BR, Bourne HR. PMID: 8107768.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    164. Mouse coat colour reconsidered. Nature. 1993 Jul 08; 364(6433):110. Conklin BR, Bourne HR. PMID: 8321283.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    165. Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. J Biol Chem. 1993 Jul 05; 268(19):13900-5. Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR. PMID: 8390980.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    166. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 1993 May 21; 73(4):631-41. Conklin BR, Bourne HR. PMID: 8388779.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    167. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20; 363(6426):274-6. Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. PMID: 8387644.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    168. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol. 1992 Apr; 6(4):551-6. Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR. PMID: 1316547.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    169. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature. 1992 Mar 12; 356(6365):159-61. Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. PMID: 1312225.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    170. Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science. 1992 Jan 17; 255(5042):339-42. Wong YH, Conklin BR, Bourne HR. PMID: 1347957.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    171. Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. J Biol Chem. 1992 Jan 05; 267(1):31-4. Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. PMID: 1309740.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    172. Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harb Symp Quant Biol. 1992; 57:145-8. Bourne HR, Lustig KD, Wong YH, Conklin BR. PMID: 1339653.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    173. Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor. FEBS Lett. 1989 Mar 13; 245(1-2):75-9. Felder CC, Ma AL, Conklin BR. PMID: 2466702.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    174. Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8698-702. Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI, Axelrod J. PMID: 2847172; PMCID: PMC282528.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    175. Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts. J Pharmacol Exp Ther. 1988 Feb; 244(2):646-9. Conklin BR, Burch RM, Steranka LR, Axelrod J. PMID: 2894457.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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