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Roshanak Irannejad, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes
    NIH/NHLBI R00HL122508Feb 2, 2017 - Jan 31, 2020
    Role: Principle Investigator
    Role of endocytosis in beta-adrenergic receptors signaling in cardiomyocytes
    NIH K99HL122508Apr 4, 2014 - Feb 29, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Varandas KC, Irannejad R, von Zastrow M. Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol. 2016 Nov 4. PMID: 27839977.
      View in: PubMed
    2. Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL. The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor. J Biol Chem. 2016 Jul 8; 291(28):14510-25. PMID: 27226565.
      View in: PubMed
    3. Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol. 2015 Aug; 35:137-43. PMID: 26057614; PMCID: PMC4529812 [Available on 08/01/16].
    4. Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. G protein ß? subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Mol Biol Cell. 2015 Mar 15; 26(6):1188-98. PMID: 25609085; PMCID: PMC4357516.
    5. Tsvetanova NG, Irannejad R, von Zastrow M. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13; 290(11):6689-96. PMID: 25605726; PMCID: PMC4358092 [Available on 03/13/16].
    6. Irannejad R, Kotowski SJ, von Zastrow M. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014; 535:403-18. PMID: 24377936; PMCID: PMC4023871.
    7. Irannejad R, von Zastrow M. GPCR signaling along the endocytic pathway. Curr Opin Cell Biol. 2014 Apr; 27:109-16. PMID: 24680436.
      View in: PubMed
    8. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. PMID: 23515162; PMCID: PMC3835555.
    9. Irannejad R, Wedegaertner PB. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits. J Biol Chem. 2010 Oct 15; 285(42):32393-404. PMID: 20720014; PMCID: PMC2952241.
    10. Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 2007 Jul 3; 46(26):7665-77. PMID: 17559193; PMCID: PMC2527407.
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