Aparna Sundaram, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #201
San Francisco CA 94143
Phone415-514-8363
ORCID ORCID Icon0000-0002-4076-4756 Additional info
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    Collapse Biography 
    Collapse education and training
    University of California, San Francisco2019Diversity, Equity, and Inclusion Champion
    University of California, San FranciscoFellowship2012Pulmonary and Critical Care
    Northwestern UniversityInternship/Residency2009Internal Medicine
    Northwestern UniversityM.D.2006Medicine
    Northwestern UniversityB.S.2003Biomedical Engineering

    Collapse Overview 
    Collapse overview
    Dr. Sundaram is a biomedical engineer, physician, and scientist with an interest in airway smooth muscle biology. Her laboratory focuses on tethering pathways used by muscle to transmit force. Through a more nuanced understanding of pathways that contribute to force transmission and the influence on pro-inflammatory cytokines on regulating these pathways, Dr. Sundaram hopes to identify novel drug targets to mitigate exaggerated airway narrowing in chronic airways diseases. Her work leverages ex vivo and in vivo disease models, transgenic mouse models, and advanced microscopy to map force transmission pathways on a cellular level.

    Dr. Sundaram also attends in the Moffitt-Long Intensive Care Units. She serves as the Associate Director for the Molecular Medicine Residency Program. Her primary interests in physician-scientist training are related to longitudinal mentoring, work-life integration, and supporting women and minorities in science.
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    Collapse Research 
    Collapse research activities and funding
    Mechanisms of Cytokine-Mediated Integrin Activation and Force Transmission in Airway Smooth Muscle
    NIH/NHLBI R01HL173342Apr 1, 2024 - Mar 31, 2029
    Role: Principal Investigator
    Role of cadherin-11 in regulating force transmission in allergic asthma
    American Lung Association IA933672Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Mitigation of Exaggerated Smooth Muscle Force with Inhibitors of Integrin Alpha2Beta1
    NIH R61/R33HL163725May 1, 2022 - Jul 31, 2025
    Role: Principal Investigator
    Inhibitors of Integrin Alpha5Beta1 to Mitigate Exaggerated Smooth Muscle Contraction in Asthma
    UCSF InVent FundOct 1, 2020 - Sep 30, 2022
    Role: Principal Investigator
    Role of Human Chymase in Smooth Muscle Contraction in Asthma
    NIH K08HL124049Jul 1, 2015 - Mar 31, 2021
    Role: Principal Investigator
    Regulation of Allergic Asthma by TGF-beta-induced Modulation of mMCP-1 and mMCP-4
    NIH F32HL112588Mar 1, 2012 - Feb 28, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2401251121. Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB. PMID: 39136993; PMCID: PMC11348015.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. J Clin Invest. 2021 06 15; 131(12). Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. PMID: 33956668; PMCID: PMC8203456.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    3. Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness. Bioorg Med Chem Lett. 2020 11 15; 30(22):127578. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. PMID: 33007395; PMCID: PMC7700746.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. G protein-regulated endocytic trafficking of adenylyl cyclase type 9. Elife. 2020 06 09; 9. Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M. PMID: 32515353; PMCID: PMC7332294.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    5. A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion. J Biol Chem. 2019 11 29; 294(48):18232-18243. Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. PMID: 31640988; PMCID: PMC6885615.
      View in: PubMed   Mentions: 8     Fields:    
    6. IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility. J Immunol. 2019 03 01; 202(5):1540-1548. Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X. PMID: 30683702; PMCID: PMC6379809.
      View in: PubMed   Mentions: 9     Fields:    
    7. Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest. 2017 01 03; 127(1):365-374. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. PMID: 27918306; PMCID: PMC5199700.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    8. G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. Mol Pharmacol. 2017 Feb; 91(2):145-156. Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M. PMID: 27879340; PMCID: PMC5267521.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    9. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. PMID: 25271629; PMCID: PMC4347230.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    10. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. PMID: 23543053; PMCID: PMC3635736.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest. 2012 Feb; 122(2):748-58. Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. PMID: 22232213; PMCID: PMC3266785.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
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