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Steven Altschuler, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
Phone415-502-3196
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    Collapse Overview 
    Collapse Overview
    Dr. Steven Altschuler is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. Dr. Altschuler also applies high-throughput technology developed by his laboratory to diverse problems, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Altschuler worked at UT Southwestern, Harvard, Rosetta Informatics, Microsoft, Princeton, and the Institute for Advanced Studies.


    Collapse Research 
    Collapse Research Activities and Funding
    Systems-level role of GSK3 in colonic epithelium homeostasis and drug resistance
    NIH/NIGMS R01GM112690Feb 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    Lung cancer heterogeneity and its impact on drug resistance.
    NIH/NCI R01CA133253Aug 1, 2010 - May 31, 2016
    Role: Principal Investigator
    Turnkey solution for image phenotype classification
    NIH/NIGMS R01GM085442Sep 19, 2008 - Aug 31, 2014
    Role: Principal Investigator
    On the emergence of polarization and motility responses from chemotactic networks
    NIH/NIGMS R01GM071794Jul 1, 2004 - May 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Global Health
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH. Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils. Sci Signal. 2016 Dec 13; 9(458):ra122. PMID: 27965424.
      View in: PubMed
    2. Coster AD, Thorne CA, Wu LF, Altschuler SJ. Examining crosstalk among Transforming Growth Factor ß, Bone Morphogen Protein, and Wnt pathways. J Biol Chem. 2016 Nov 28. PMID: 27895117.
      View in: PubMed
    3. Deng Y, Altschuler SJ, Wu LF. PHOCOS: inferring multi-feature phenotypic crosstalk networks. Bioinformatics. 2016 Jun 15; 32(12):i44-i51. PMID: 27307643.
      View in: PubMed
    4. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 Jun; 14(6):e1002474. PMID: 27280401.
      View in: PubMed
    5. Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Commun. 2016; 7:10690. PMID: 26891683.
      View in: PubMed
    6. Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF. Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines. Nat Biotechnol. 2016 Jan; 34(1):70-7. PMID: 26655497.
      View in: PubMed
    7. Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. The Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul 2; 162(1):120-33. PMID: 26119341.
      View in: PubMed
    8. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 1; 26(9):1629-39. PMID: 25739453; PMCID: PMC4436775.
    9. Steininger RJ, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ. On comparing heterogeneity across biomarkers. Cytometry A. 2015 Jun; 87(6):558-67. PMID: 25425168; PMCID: PMC4442742.
    10. Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015 Jan; 11(1):58-63. PMID: 25402767; PMCID: PMC4270937.
    11. Agi E, Langen M, Altschuler SJ, Wu LF, Zimmermann T, Hiesinger PR. The evolution and development of neural superposition. J Neurogenet. 2014 Sep-Dec; 28(3-4):216-32. PMID: 24912630; PMCID: PMC4245170.
    12. Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF. A simple image correction method for high-throughput microscopy. Nat Methods. 2014 Jun; 11(6):602. PMID: 24874571; PMCID: PMC4277860.
    13. Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler SJ. Rapid analysis and exploration of fluorescence microscopy images. J Vis Exp. 2014; (85). PMID: 24686220; PMCID: PMC4390293.
    14. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220; PMCID: PMC3674638.
    15. Zhang ER, Wu LF, Altschuler SJ. Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior. Curr Opin Cell Biol. 2013 Oct; 25(5):538-42. PMID: 23660413; PMCID: PMC3758422.
    16. Altschuler D.J., Altschuler S, Angenent S.B., Wu L.F. The Zoo of Solitons for Curve Shortening in Rn. Nonlinearity. 2013; 26(5):1189-1226.
    17. Rajaram S, Pavie B, Wu LF, Altschuler SJ. PhenoRipper: software for rapidly profiling microscopy images. Nat Methods. 2012 Jul; 9(7):635-7. PMID: 22743764; PMCID: PMC3842428.
    18. Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu LF. SimuCell: a flexible framework for creating synthetic microscopy images. Nat Methods. 2012 Jul; 9(7):634-5. PMID: 22743763; PMCID: PMC3842427.
    19. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971; PMCID: PMC3614011.
    20. Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell. 2012 Feb 17; 148(4):803-15. PMID: 22341450; PMCID: PMC3368334.
    21. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410; PMCID: PMC3308728.
    22. Jilkine A, Angenent SB, Wu LF, Altschuler SJ. A density-dependent switch drives stochastic clustering and polarization of signaling molecules. PLoS Comput Biol. 2011 Nov; 7(11):e1002271. PMID: 22102805; PMCID: PMC3213192.
    23. Altschuler SJ, Wu LF. Cellular heterogeneity: do differences make a difference? Cell. 2010 May 14; 141(4):559-63. PMID: 20478246; PMCID: PMC2918286.
    24. Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ. Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities. Mol Syst Biol. 2010 May 11; 6:369. PMID: 20461076; PMCID: PMC2890326.
    25. Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF. ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS. Proc IEEE Int Symp Biomed Imaging. 2010 Apr 1; 14-17:1029-1032. PMID: 20725643.
      View in: PubMed
    26. Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF. Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes. J Cell Biol. 2009 Nov 2; 187(3):375-84. PMID: 19948481; PMCID: PMC2779244.
    27. Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ. An approach for extensibly profiling the molecular states of cellular subpopulations. Nat Methods. 2009 Oct; 6(10):759-65. PMID: 19767759; PMCID: PMC2818727.
    28. Artyukhin AB, Wu LF, Altschuler SJ. Only two ways to achieve perfection. Cell. 2009 Aug 21; 138(4):619-21. PMID: 19703388.
      View in: PubMed
    29. Slack MD, Martinez ED, Wu LF, Altschuler SJ. Characterizing heterogeneous cellular responses to perturbations. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19306-11. PMID: 19052231; PMCID: PMC2614757.
    30. Altschuler SJ, Angenent SB, Wang Y, Wu LF. On the spontaneous emergence of cell polarity. Nature. 2008 Aug 14; 454(7206):886-9. PMID: 18704086; PMCID: PMC2562338.
    31. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648; PMCID: PMC1945041.
    32. Marco E, Wedlich-Soldner R, Li R, Altschuler SJ, Wu LF. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell. 2007 Apr 20; 129(2):411-22. PMID: 17448998; PMCID: PMC2000346.
    33. Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods. 2007 May; 4(5):445-53. PMID: 17401369.
      View in: PubMed
    34. Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol. 2006; 2:2006.0003. PMID: 16738550; PMCID: PMC1681477.
    35. Loo, L.H., Wu, L., Altschuler, S.J., 2006; 251-54. Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images. IEEE International Symposium on Biomedical Imaging. 2006; 251-254.
    36. Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ. Genome-scale identification of nucleosome positions in S. cerevisiae. Science. 2005 Jul 22; 309(5734):626-30. PMID: 15961632.
      View in: PubMed
    37. Dion MF, Altschuler SJ, Wu LF, Rando OJ. Genomic characterization reveals a simple histone H4 acetylation code. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5501-6. PMID: 15795371; PMCID: PMC555684.
    38. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. PMID: 15539606.
      View in: PubMed
    39. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR. A panoramic view of yeast noncoding RNA processing. Cell. 2003 Jun 27; 113(7):919-33. PMID: 12837249.
      View in: PubMed
    40. Wedlich-Soldner R, Altschuler S, Wu L, Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 2003 Feb 21; 299(5610):1231-5. PMID: 12560471.
      View in: PubMed
    41. Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet. 2002 Jul; 31(3):255-65. PMID: 12089522.
      View in: PubMed
    42. Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS. Experimental annotation of the human genome using microarray technology. Nature. 2001 Feb 15; 409(6822):922-7. PMID: 11237012.
      View in: PubMed
    43. Acero, A., Altschuler S, Wu L.F. . Proceedings of the ICSLP. Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals. 2000.
    44. Altschuler, S.J., Wu, L.F. . On deforming confoliations. Journal of Differential Geometry. 2000; 54(1):75-97.
    45. Ridgeway, G., Altschuler, S.J. . Proceedings of the Section on Physical and Engineering Sciences. Clustering finite discrete markov chains. 1998; 228-229.
    46. Altschuler, S.J., Kim, W. . Proceedings of the ICSR5. Generating Signal Processing Software. 1998.
    47. Altschuler, S.J., Angenet, S., Giga, Y. . Mean curvature flow through singularities for surfaces of rotation. Journal of Geometric Analysis. 1995; 5(3):293-358.
    48. Altschuler, S.J. . A geometric heat flow for one-forms on three dimensional manifolds. Illinois Journal of Mathematics. 1995; 39(1):98-118.
    49. Altschuler, S.J., Wu, L.F. . Translating surfaces of the non-parametric mean curvature flow with prescribed contact angle. Calc. Var. Partial Diff. Eq. 1994; 2(1):101-111.
    50. Altschuler, S.J., Wu, L.F. Convergence to translating solitons for a class of quasilinear parabolic boundary problems. Math. Annalen. 1993; 295:761-765.
    51. Altschuler, S.J., Grayson, M. . Shortening space curves and flow through singularities. Journal of Differential Geometry. 1992; 35(2):283-298.
    52. Altschuler, S.J. . Singularities for the curve shortening flow for space curves. Journal of Differential Geometry. 1991; 34(2):491-514.
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