Allison Xu • UCSF Profiles

Allison Xu, PhD

Title(s)	Professor, Diabetes Center
School	School of Medicine
Address	513 Parnassus Ave, MSB San Francisco CA 94117
Phone	415-476-2807
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Overview

Websites

Allison Xu Lab Website

Research

Research Activities and Funding

Blood-hypothalamus barrier and metabolic impairment in advanced aging
NIH R01AG063506Apr 1, 2019 - Jan 31, 2024
Role: Principal Investigator

UCSF Nutrition Obesity Research Center
NIH P30DK098722Aug 1, 2015 - Jul 31, 2025
Role: Co-Investigator

A brain-liver circuit in regulation of alcoholic liver disease
NIH R01AA022665Sep 1, 2014 - Jun 30, 2020
Role: Principal Investigator

UCSF Comprehensive Lab Animal Monitoring System
NIH S10RR028053Jul 22, 2010 - Jul 21, 2011
Role: Principal Investigator

Compensatory Regulation of Energy Balance by Neurogenesis in Adult Hypothalamus
NIH R01DK089094Jul 1, 2010 - Apr 30, 2016
Role: Principal Investigator

Central Regulation of Hepatic Energy Stores
NIH R01DK080427Feb 1, 2008 - Aug 31, 2017
Role: Principal Investigator

Neurogenesis as a compensatory mechanism to regulate energy balance
NIH/NIDDK R21DK080509Jul 1, 2007 - Jun 30, 2010
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E655-E666. Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW. PMID: 32045262.

View in: PubMed Mentions: Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice. Endocrinology. 2018 06 01; 159(6):2408-2420. Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW. PMID: 29750244.

View in: PubMed Mentions: 3 Fields:
End Endocrinology
Translation:Animals
Hypothalamic Sensing of Bile Acids, a Gut Feeling. Trends Endocrinol Metab. 2018 06; 29(6):363-366. Xu AW. PMID: 29477281.

View in: PubMed Mentions: 1 Fields:
End Endocrinology Met Metabolism
Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. PMID: 28614713.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis. Int J Mol Sci. 2017 Apr 14; 18(4). Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y. PMID: 28420089.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals Cells
Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 02; 41(2):345-358. Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW. PMID: 28103636.

View in: PubMed Mentions: 1 Fields:
Sub Substance-Related Disorders
Translation:Animals
Leptin potentiates astrogenesis in the developing hypothalamus. Mol Metab. 2015 Nov; 4(11):881-9. Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW. PMID: 26629411.

View in: PubMed Mentions: 12 Fields:
Met Metabolism
Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015; 11(1):145-54. Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. PMID: 25585051.

View in: PubMed Mentions: 32 Fields:
Cel Cell Biology
Translation:Animals Cells
Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol. 2015; 77:131-60. Valdearcos M, Xu AW, Koliwad SK. PMID: 25668019.

View in: PubMed Mentions: 61 Fields:
Phy Physiology
Translation:Humans Animals Cells
An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA. PMID: 25543145.

View in: PubMed Mentions: 51 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014 Dec 24; 9(6):2124-38. Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. PMID: 25497089.

View in: PubMed Mentions: 139 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci. 2013 Jul 17; 33(29):11972-85. Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW. PMID: 23864684.

View in: PubMed Mentions: 6 Fields:
Neu Neurology
Translation:Animals Cells
Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E697-706. Olofsson LE, Unger EK, Cheung CC, Xu AW. PMID: 23386726.

View in: PubMed Mentions: 53 Fields:
Sci Science
Translation:Animals Cells
Metabolic transceivers: in tune with the central melanocortin system. Trends Endocrinol Metab. 2013 Feb; 24(2):68-75. Warne JP, Xu AW. PMID: 23182906; PMCID: PMC3565100.

View in: PubMed Mentions: 9 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals
AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology. 2013 Jan; 154(1):172-83. Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu AW. PMID: 23161869; PMCID: PMC3529372.

View in: PubMed Mentions: 29 Fields:
End Endocrinology
Translation:Animals Cells
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012 Aug 09; 75(3):425-36. Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. PMID: 22884327.

View in: PubMed Mentions: 73 Fields:
Neu Neurology
Translation:Animals Cells
Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab. 2011 Dec 07; 14(6):791-803. Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Corvera CU, Xu AW. PMID: 22152304.

View in: PubMed Mentions: 20 Fields:
Cel Cell Biology Met Metabolism
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci. 2010 Sep 01; 30(35):11815-25. Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL. PMID: 20810901; PMCID: PMC2965459.

View in: PubMed Mentions: 101 Fields:
Neu Neurology
Translation:Animals Cells
De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci. 2010 Jan 13; 30(2):723-30. Pierce AA, Xu AW. PMID: 20071537; PMCID: PMC3080014.

View in: PubMed Mentions: 82 Fields:
Neu Neurology
Translation:Animals Cells
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes. 2010 Apr; 59(4):894-906. Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG, Xu AW. PMID: 20068134.

View in: PubMed Mentions: 69 Fields:
End Endocrinology
Translation:Animals Cells
Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology. 2010 Feb; 151(2):671-82. Unger EK, Piper ML, Olofsson LE, Xu AW. PMID: 20022934.

View in: PubMed Mentions: 21 Fields:
End Endocrinology
Translation:Animals
Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol. 2010 Mar 01; 339(1):38-50. Su H, Marcheva B, Meng S, Liang FA, Kohsaka A, Kobayashi Y, Xu AW, Bass J, Wang X. PMID: 20025866; PMCID: PMC2823828.

View in: PubMed Mentions: 18 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15932-7. Olofsson LE, Pierce AA, Xu AW. PMID: 19805233.

View in: PubMed Mentions: 57 Fields:
Sci Science
Translation:Animals Cells
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008 Apr; 149(4):1773-85. van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC. PMID: 18162515; PMCID: PMC2276717.

View in: PubMed Mentions: 178 Fields:
End Endocrinology
Translation:Animals
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008 Mar; 22(3):751-9. Piper ML, Unger EK, Myers MG, Xu AW. PMID: 18096691.

View in: PubMed Mentions: 52 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest. 2007 Aug; 117(8):2325-36. Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. PMID: 17671657.

View in: PubMed Mentions: 210 Fields:
Med Medicine (General)
Translation:Animals Cells
Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology. 2007 Jan; 148(1):72-80. Xu AW, Ste-Marie L, Kaelin CB, Barsh GS. PMID: 17023536.

View in: PubMed Mentions: 80 Fields:
End Endocrinology
Translation:Animals Cells
Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid. Mol Endocrinol. 2006 Oct; 20(10):2591-602. Kaelin CB, Gong L, Xu AW, Yao F, Hockman K, Morton GJ, Schwartz MW, Barsh GS, MacKenzie RG. PMID: 16709597.

View in: PubMed Mentions: 14 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006 May; 12(5):534-40. Kitamura T, Feng Y, Kitamura YI, Chua SC, Xu AW, Barsh GS, Rossetti L, Accili D. PMID: 16604086.

View in: PubMed Mentions: 186 Fields:
Med Medicine (General)Mol Molecular Biology
Translation:Animals Cells
MC4R neurons weigh in differently. Nat Neurosci. 2006 Jan; 9(1):15-6. Xu AW, Barsh GS. PMID: 16378090.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Animals Cells
Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol. 2005 Dec; 3(12):e415. Xu AW, Kaelin CB, Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW, Barsh GS. PMID: 16296893.

View in: PubMed Mentions: 80 Fields:
Bio Biology
Translation:Animals
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci. 2005 Oct; 8(10):1289-91. Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC. PMID: 16158063.

View in: PubMed Mentions: 257 Fields:
Neu Neurology
Translation:Animals Cells
GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug; 233(4):1337-47. Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY. PMID: 15937931.

View in: PubMed Mentions: 15 Fields:
Ana Anatomy
Translation:Animals
The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest. 2005 Apr; 115(4):940-50. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. PMID: 15841180.

View in: PubMed Mentions: 115 Fields:
Med Medicine (General)
Translation:Animals Cells
PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest. 2005 Apr; 115(4):951-8. Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS. PMID: 15761497; PMCID: PMC1062894.

View in: PubMed Mentions: 162 Fields:
Med Medicine (General)
Translation:Animals Cells
Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. Endocrinology. 2004 Dec; 145(12):5798-806. Kaelin CB, Xu AW, Lu XY, Barsh GS. PMID: 15345681.

View in: PubMed Mentions: 20 Fields:
End Endocrinology
Translation:Animals Cells