Allison Xu, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-2807
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Blood-hypothalamus barrier and metabolic impairment in advanced aging
    NIH R01AG063506Apr 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH P30DK098722Aug 1, 2015 - Jul 31, 2025
    Role: Co-Investigator
    A brain-liver circuit in regulation of alcoholic liver disease
    NIH R01AA022665Sep 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    UCSF Comprehensive Lab Animal Monitoring System
    NIH S10RR028053Jul 22, 2010 - Jul 21, 2011
    Role: Principal Investigator
    Compensatory Regulation of Energy Balance by Neurogenesis in Adult Hypothalamus
    NIH R01DK089094Jul 1, 2010 - Apr 30, 2016
    Role: Principal Investigator
    Central Regulation of Hepatic Energy Stores
    NIH R01DK080427Feb 1, 2008 - Aug 31, 2017
    Role: Principal Investigator
    Neurogenesis as a compensatory mechanism to regulate energy balance
    NIH/NIDDK R21DK080509Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E655-E666. Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW. PMID: 32045262.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice. Endocrinology. 2018 06 01; 159(6):2408-2420. Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW. PMID: 29750244.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    3. Hypothalamic Sensing of Bile Acids, a Gut Feeling. Trends Endocrinol Metab. 2018 06; 29(6):363-366. Xu AW. PMID: 29477281.
      View in: PubMed   Mentions: 1     Fields:    
    4. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. PMID: 28614713.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    5. Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis. Int J Mol Sci. 2017 Apr 14; 18(4). Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y. PMID: 28420089.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 02; 41(2):345-358. Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW. PMID: 28103636.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Leptin potentiates astrogenesis in the developing hypothalamus. Mol Metab. 2015 Nov; 4(11):881-9. Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW. PMID: 26629411.
      View in: PubMed   Mentions: 12     Fields:    
    8. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015; 11(1):145-54. Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. PMID: 25585051.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    9. Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol. 2015; 77:131-60. Valdearcos M, Xu AW, Koliwad SK. PMID: 25668019.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    10. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA. PMID: 25543145.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    11. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014 Dec 24; 9(6):2124-38. Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. PMID: 25497089.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    12. Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci. 2013 Jul 17; 33(29):11972-85. Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW. PMID: 23864684.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E697-706. Olofsson LE, Unger EK, Cheung CC, Xu AW. PMID: 23386726.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    14. Metabolic transceivers: in tune with the central melanocortin system. Trends Endocrinol Metab. 2013 Feb; 24(2):68-75. Warne JP, Xu AW. PMID: 23182906; PMCID: PMC3565100.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    15. AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology. 2013 Jan; 154(1):172-83. Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu AW. PMID: 23161869; PMCID: PMC3529372.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    16. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012 Aug 09; 75(3):425-36. Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY. PMID: 22884327.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    17. Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab. 2011 Dec 07; 14(6):791-803. Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Corvera CU, Xu AW. PMID: 22152304.
      View in: PubMed   Mentions: 20     Fields:    
    18. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci. 2010 Sep 01; 30(35):11815-25. Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL. PMID: 20810901; PMCID: PMC2965459.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    19. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci. 2010 Jan 13; 30(2):723-30. Pierce AA, Xu AW. PMID: 20071537; PMCID: PMC3080014.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    20. Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes. 2010 Apr; 59(4):894-906. Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG, Xu AW. PMID: 20068134.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    21. Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology. 2010 Feb; 151(2):671-82. Unger EK, Piper ML, Olofsson LE, Xu AW. PMID: 20022934.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    22. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol. 2010 Mar 01; 339(1):38-50. Su H, Marcheva B, Meng S, Liang FA, Kohsaka A, Kobayashi Y, Xu AW, Bass J, Wang X. PMID: 20025866; PMCID: PMC2823828.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15932-7. Olofsson LE, Pierce AA, Xu AW. PMID: 19805233.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    24. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008 Apr; 149(4):1773-85. van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC. PMID: 18162515; PMCID: PMC2276717.
      View in: PubMed   Mentions: 178     Fields:    Translation:Animals
    25. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008 Mar; 22(3):751-9. Piper ML, Unger EK, Myers MG, Xu AW. PMID: 18096691.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    26. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest. 2007 Aug; 117(8):2325-36. Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. PMID: 17671657.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    27. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology. 2007 Jan; 148(1):72-80. Xu AW, Ste-Marie L, Kaelin CB, Barsh GS. PMID: 17023536.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    28. Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid. Mol Endocrinol. 2006 Oct; 20(10):2591-602. Kaelin CB, Gong L, Xu AW, Yao F, Hockman K, Morton GJ, Schwartz MW, Barsh GS, MacKenzie RG. PMID: 16709597.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    29. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006 May; 12(5):534-40. Kitamura T, Feng Y, Kitamura YI, Chua SC, Xu AW, Barsh GS, Rossetti L, Accili D. PMID: 16604086.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    30. MC4R neurons weigh in differently. Nat Neurosci. 2006 Jan; 9(1):15-6. Xu AW, Barsh GS. PMID: 16378090.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol. 2005 Dec; 3(12):e415. Xu AW, Kaelin CB, Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW, Barsh GS. PMID: 16296893.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals
    32. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci. 2005 Oct; 8(10):1289-91. Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC. PMID: 16158063.
      View in: PubMed   Mentions: 257     Fields:    Translation:AnimalsCells
    33. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug; 233(4):1337-47. Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY. PMID: 15937931.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    34. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest. 2005 Apr; 115(4):940-50. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. PMID: 15841180.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    35. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest. 2005 Apr; 115(4):951-8. Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS. PMID: 15761497; PMCID: PMC1062894.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    36. Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. Endocrinology. 2004 Dec; 145(12):5798-806. Kaelin CB, Xu AW, Lu XY, Barsh GS. PMID: 15345681.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
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