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Allison Xu, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentDiabetes Center
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-2807
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    Collapse Research 
    Collapse Research Activities and Funding
    UCSF Nutrition Obesity Research Center
    NIH/NIDDK P30DK098722Aug 1, 2015 - Jul 31, 2020
    Role: Co-Investigator
    A brain-liver circuit in regulation of alcoholic liver disease
    NIH/NIAAA R01AA022665Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    UCSF Comprehensive Lab Animal Monitoring System
    NIH/NCRR S10RR028053Jul 22, 2010 - Jul 21, 2011
    Role: Principal Investigator
    Compensatory Regulation of Energy Balance by Neurogenesis in Adult Hypothalamus
    NIH/NIDDK R01DK089094Jul 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Central Regulation of Hepatic Energy Stores
    NIH/NIDDK R01DK080427Feb 1, 2008 - May 31, 2017
    Role: Principal Investigator
    Neurogenesis as a compensatory mechanism to regulate energy balance
    NIH/NIDDK R21DK080509Jul 1, 2007 - Jun 30, 2010
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu A. Regulation of hepatic lipid accumulation and distribution by Agouti-related protein in male mice. Endocrinology. 2018 May 09. PMID: 29750244.
      View in: PubMed
    2. Xu A. Hypothalamic Sensing of Bile Acids, a Gut Feeling. Trends Endocrinol Metab. 2018 Feb 21. PMID: 29477281.
      View in: PubMed
    3. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu A. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 Jun 13; 19(11):2257-2271. PMID: 28614713.
      View in: PubMed
    4. Wu CS, Bongmba OYN, Yue J, Lee JH, Lin L, Saito K, Pradhan G, Li DP, Pan HL, Xu A, Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis. Int J Mol Sci. 2017 Apr 14; 18(4). PMID: 28420089.
      View in: PubMed
    5. Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW. Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 Feb; 41(2):345-358. PMID: 28103636.
      View in: PubMed
    6. Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu A. Leptin potentiates astrogenesis in the developing hypothalamus. Mol Metab. 2015 Nov; 4(11):881-9. PMID: 26629411; PMCID: PMC4632125.
    7. Malhotra R, Warne JP, Salas E, Xu A, Debnath J. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015; 11(1):145-54. PMID: 25585051; PMCID: PMC4502780.
    8. Valdearcos M, Xu A, Koliwad SK. Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol. 2015; 77:131-60. PMID: 25668019.
      View in: PubMed
    9. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu A, Rubenstein JL, Ingraham HA. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74. PMID: 25543145; PMCID: PMC4324838.
    10. Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu A, Koliwad SK. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014 Dec 24; 9(6):2124-38. PMID: 25497089; PMCID: PMC4617309.
    11. Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu A. Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci. 2013 Jul 17; 33(29):11972-85. PMID: 23864684; PMCID: PMC3713731.
    12. Olofsson LE, Unger EK, Cheung CC, Xu A. Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E697-706. PMID: 23386726; PMCID: PMC3581908.
    13. Warne JP, Xu A. Metabolic transceivers: in tune with the central melanocortin system. Trends Endocrinol Metab. 2013 Feb; 24(2):68-75. PMID: 23182906; PMCID: PMC3565100.
    14. Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu A. AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology. 2013 Jan; 154(1):172-83. PMID: 23161869; PMCID: PMC3529372.
    15. Yang SB, Tien AC, Boddupalli G, Xu A, Jan YN, Jan LY. Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron. 2012 Aug 09; 75(3):425-36. PMID: 22884327; PMCID: PMC3467009.
    16. Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Corvera CU, Xu A. Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab. 2011 Dec 07; 14(6):791-803. PMID: 22152304; PMCID: PMC3240844.
    17. Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu A, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci. 2010 Sep 01; 30(35):11815-25. PMID: 20810901; PMCID: PMC2965459.
    18. Pierce AA, Xu A. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci. 2010 Jan 13; 30(2):723-30. PMID: 20071537; PMCID: PMC3080014.
    19. Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG, Xu A. Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes. 2010 Apr; 59(4):894-906. PMID: 20068134; PMCID: PMC2844837.
    20. Unger EK, Piper ML, Olofsson LE, Xu A. Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology. 2010 Feb; 151(2):671-82. PMID: 20022934; PMCID: PMC2817615.
    21. Su H, Marcheva B, Meng S, Liang FA, Kohsaka A, Kobayashi Y, Xu A, Bass J, Wang X. Gamma-protocadherins regulate the functional integrity of hypothalamic feeding circuitry in mice. Dev Biol. 2010 Mar 01; 339(1):38-50. PMID: 20025866; PMCID: PMC2823828.
    22. Olofsson LE, Pierce AA, Xu A. Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15932-7. PMID: 19805233; PMCID: PMC2747221.
    23. van de Wall E, Leshan R, Xu A, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008 Apr; 149(4):1773-85. PMID: 18162515; PMCID: PMC2276717.
    24. Piper ML, Unger EK, Myers MG, Xu A. Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol. 2008 Mar; 22(3):751-9. PMID: 18096691; PMCID: PMC2262173.
    25. Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu A, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest. 2007 Aug; 117(8):2325-36. PMID: 17671657.
      View in: PubMed
    26. Xu A, Ste-Marie L, Kaelin CB, Barsh GS. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology. 2007 Jan; 148(1):72-80. PMID: 17023536.
      View in: PubMed
    27. Kaelin CB, Gong L, Xu A, Yao F, Hockman K, Morton GJ, Schwartz MW, Barsh GS, MacKenzie RG. Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid. Mol Endocrinol. 2006 Oct; 20(10):2591-602. PMID: 16709597.
      View in: PubMed
    28. Kitamura T, Feng Y, Kitamura YI, Chua SC, Xu A, Barsh GS, Rossetti L, Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006 May; 12(5):534-40. PMID: 16604086.
      View in: PubMed
    29. Xu A, Barsh GS. MC4R neurons weigh in differently. Nat Neurosci. 2006 Jan; 9(1):15-6. PMID: 16378090.
      View in: PubMed
    30. Xu A, Kaelin CB, Morton GJ, Ogimoto K, Stanhope K, Graham J, Baskin DG, Havel P, Schwartz MW, Barsh GS. Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol. 2005 Dec; 3(12):e415. PMID: 16296893; PMCID: PMC1287504.
    31. Gropp E, Shanabrough M, Borok E, Xu A, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci. 2005 Oct; 8(10):1289-91. PMID: 16158063.
      View in: PubMed
    32. Phan HM, Xu A, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY. GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug; 233(4):1337-47. PMID: 15937931.
      View in: PubMed
    33. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu A, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest. 2005 Apr; 115(4):940-50. PMID: 15841180.
      View in: PubMed
    34. Xu A, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest. 2005 Apr; 115(4):951-8. PMID: 15761497; PMCID: PMC1062894.
    35. Kaelin CB, Xu A, Lu XY, Barsh GS. Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. Endocrinology. 2004 Dec; 145(12):5798-806. PMID: 15345681.
      View in: PubMed