Courtney Lane-Donovan, MD, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #292
San Francisco CA 94158
Phone415-353-2273
PronounsShe/Her/Hers
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MASB06/2009Biological Engineering
    Massachusetts Institute of Technology, Cambridge, MASB06/2009Biology
    University of Texas Southwestern Medical Center, Dallas, TXPhD06/2017Neuroscience
    University of Texas Southwestern Medical Center, Dallas, TXMD06/2017
    UCSF, San Francisco, CA06/2021Neurology Residency

    Collapse Research 
    Collapse research activities and funding
    The Role of Reelin in Adult Neuronal Function and Alzheimer's Disease
    NIH F30AG047799Sep 15, 2014 - May 14, 2016
    Role: Co-Investigator
    A Novel Lysosomal pH Reporter to Identify Effects of Aging and Disease on Lysosome Function Significance
    NIH 2R25NS070680-11

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases. Alzheimers Dement. 2025 Jun; 21(6):e70320. Lane-Donovan C, Smith AW, Saloner R, Miller BL, Casaletto KB, Kao AW. PMID: 40469052.
      View in: PubMed   Mentions:
    2. Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias. Neurology. 2024 Apr 09; 102(7):e209183. Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto KB, Gardner RC, Grinberg LT, Gorno-Tempini ML, Rosen HJ, Seeley WW, Miller BL, Kramer J, Rabinovici GD. PMID: 38489566; PMCID: PMC11033989.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Disentangling tau: One protein, many therapeutic approaches. Neurotherapeutics. 2024 Mar; 21(2):e00321. Lane-Donovan C, Boxer AL. PMID: 38278659; PMCID: PMC10963923.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    4. Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. J Clin Invest. 2023 06 15; 133(12). Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL. PMID: 37317972; PMCID: PMC10266783.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    5. Mycobacterium avium Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient With AIDS: Case Report and Review of the Literature. Open Forum Infect Dis. 2021 Nov; 8(11):ofab450. Lane-Donovan C, Bainbridge E, Szumowski J, Kerkhoff AD, Peluso MJ. PMID: 35559128; PMCID: PMC9088507.
      View in: PubMed   Mentions: 2  
    6. Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner. J Neurosci. 2021 09 01; 41(35):7340-7349. Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J. PMID: 34290083; PMCID: PMC8412985.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease. Elife. 2018 10 30; 7. Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J. PMID: 30375977; PMCID: PMC6261251.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    8. Building a better blood-brain barrier. Elife. 2017 10 10; 6. Lane-Donovan C, Herz J. PMID: 28994392; PMCID: PMC5634780.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease. J Lipid Res. 2017 06; 58(6):1036-1043. Lane-Donovan C, Herz J. PMID: 28292942; PMCID: PMC5454520.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    10. ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. Trends Endocrinol Metab. 2017 04; 28(4):273-284. Lane-Donovan C, Herz J. PMID: 28057414; PMCID: PMC5366078.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    11. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan; 3(1):65-73. Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT. PMID: 28497107; PMCID: PMC5421551.
      View in: PubMed   Mentions: 12  
    12. Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. J Neurosci. 2016 09 28; 36(39):10141-50. Lane-Donovan C, Wong WM, Durakoglugil MS, Wasser CR, Jiang S, Xian X, Herz J. PMID: 27683909; PMCID: PMC5039258.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    13. Physiologic Reelin does not play a strong role in protection against acute stroke. J Cereb Blood Flow Metab. 2016 07; 36(7):1295-303. Lane-Donovan C, Desai C, Pohlkamp T, Plautz EJ, Herz J, Stowe AM. PMID: 27146512; PMCID: PMC4929708.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    14. High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice. PLoS One. 2016; 11(2):e0148099. Lane-Donovan C, Herz J. PMID: 26828652; PMCID: PMC4734705.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    15. Reelin protects against amyloid β toxicity in vivo. Sci Signal. 2015 Jul 07; 8(384):ra67. Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J. PMID: 26152694; PMCID: PMC4652952.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    16. Science Signaling Podcast: 7 July 2015. Science Signaling. 2015 Jul 7; 8(384):pc17-pc17. Lane-Donovan LC, Herz HJ, VanHook VA. .
      View in: Publisher Site   Mentions:
    17. Lrp4 domains differentially regulate limb/brain development and synaptic plasticity. PLoS One. 2015; 10(2):e0116701. Pohlkamp T, Durakoglugil M, Lane-Donovan C, Xian X, Johnson EB, Hammer RE, Herz J. PMID: 25688974; PMCID: PMC4331535.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning. Sci Signal. 2014 Nov 25; 7(353):ra113. Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J. PMID: 25429077; PMCID: PMC4355955.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    19. Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development. JAMA Neurol. 2014 Oct; 71(10):1213-5. Lane-Donovan C, Herz J. PMID: 25110920; PMCID: PMC4354854.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron. 2014 Aug 20; 83(4):771-87. Lane-Donovan C, Philips GT, Herz J. PMID: 25144875; PMCID: PMC4240629.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    21. Intermittent practice facilitates stable motor memories. J Neurosci. 2006 Nov 15; 26(46):11888-92. Overduin SA, Richardson AG, Lane CE, Bizzi E, Press DZ. PMID: 17108162; PMCID: PMC6674870.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
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