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Adam Staffaroni, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Overview 
    Collapse Overview
    Dr. Staffaroni is neuropsychologist in the UCSF Department of Neurology. He provides clinical neuropsychological assessments, and his research focuses on predicting disease progression and improving endpoints for clinical trials in neurodegenerative diseases. He obtained a MS degree and PhD in Clinical Psychology at Palo Alto University, with an emphasis in neuropsychology. He completed a clinical internship at the West Los Angeles VA Health Care system and a two-year postdoctoral fellowship in neuropsychology at the UCSF Memory and Aging Center (MAC).

    His research program aims to prepare for clinical trials in neurodegenerative diseases by: 1) developing and validating trial endpoints, 2) leveraging multimodal neuroimaging and fluid biomarkers to predict patients’ clinical course and inform clinical trial stratification, and 3) developing novel approaches for selecting clinical trial endpoints that account for disease heterogeneity. He is also interested in healthy aging and studies the aging brain through a combination of functional connectivity, structural imaging, and perfusion imaging.

    Collapse Research 
    Collapse Research Activities and Funding
    Optimizing Clinical Trial Endpoints in Frontotemporal Dementia
    NIH/NIA K23AG061253Aug 1, 2019 - Apr 30, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lindbergh CA, Casaletto KB, Staffaroni AM, Elahi F, Walters SM, You M, Neuhaus J, Rivera Contreras W, Wang P, Karydas A, Brown J, Wolf A, Rosen H, Cobigo Y, Kramer JH. Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. J Gerontol A Biol Sci Med Sci. 2019 Sep 24. PMID: 31549145.
      View in: PubMed
    2. Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL. Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency. Front Neurol. 2019; 10:1004. PMID: 31620075.
      View in: PubMed
    3. M Gonzalez Catalan, C Lindbergh, A Staffaroni, S Walters, K Casaletto, N Walker, J Kramer. C-24 Longitudinal Trajectories of Working Memory Performance in Typically Aging Older Adults. 2019 Aug 28; 34(6):1053-1053.
      View in: Publisher Site
    4. Kramer AO, Casaletto KB, Umlauf A, Staffaroni AM, Fox E, You M, Kramer JH. Robust normative standards for the California Verbal Learning Test (CVLT) ages 60-89: A tool for early detection of memory impairment. Clin Neuropsychol. 2019 Jul 19; 1-22. PMID: 31322042.
      View in: PubMed
    5. Staffaroni AM, Cobigo Y, Goh SM, Kornak J, Bajorek L, Chiang K, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dever R, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Heuer HW, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kramer JH, Kremers WK, Kukull WA, Litvan I, Ljubenkov PA, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Rosen HJ. Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. Alzheimers Dement. 2019 Jul 01. PMID: 31272932.
      View in: PubMed
    6. Sophia A. Weiner-Light, Samantha Walters, Nina Djukic, Michelle You, Devyn Cotter, Marie Altendahl, Fanny Elahi, Adam M. Staffaroni, Cutter A. Lindbergh, Joel H. Kramer, Kaitlin B. Casaletto. STEP COUNT AND PSYCHOLOGICAL HEALTH IN OLDER ADULTS. 2019 Jul 1; 15(7):p846-p847.
      View in: Publisher Site
    7. Fanny M. Elahi, Danielle J. Harvey, Marie Altendahl, Kaitlin B. Casaletto, Nicole Fernandes, Adam M. Staffaroni, Pauline Maillard, Jason D. Hinman, Bruce L. Miller, Charles DeCarli, Joel H. Kramer, Edward J. Goetzl. Endothelial-derived exosomes demonstrate a link between endothelial innate inflammation and brain dysfunction and injury in aging. 2019 Jun 21; 670083.
      View in: Publisher Site
    8. Andrea G. Alioto, Christie C. Mead, Alicia B. Vanden Bussche Jantz, Adam M. Staffaroni, Joel H. Kramer. Frontotemporal Dementia. 2019 Jun 3; 678-704.
      View in: Publisher Site
    9. Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kremers WK, Kukull WA, Litvan I, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Kramer JH, Rosen HJ. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimers Dement. 2019 May 11. PMID: 31088775.
      View in: PubMed
    10. Staffaroni AM, Cobigo Y, Elahi FM, Casaletto KB, Walters SM, Wolf A, Lindbergh CA, Rosen HJ, Kramer JH. A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure. Hum Brain Mapp. 2019 Aug 15; 40(12):3522-3533. PMID: 31062904.
      View in: PubMed
    11. Staffaroni AM, Kramer AO, Casey M, Kang H, Rojas JC, Orrú CD, Caughey B, Allen IE, Kramer JH, Rosen HJ, Blennow K, Zetterberg H, Geschwind MD. Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease. JAMA Neurol. 2019 May 06. PMID: 31058916.
      View in: PubMed
    12. Lebares CC, Guvva EV, Olaru M, Sugrue LP, Staffaroni AM, Delucchi KL, Kramer JH, Ascher NL, Harris HW. Efficacy of Mindfulness-Based Cognitive Training in Surgery: Additional Analysis of the Mindful Surgeon Pilot Randomized Clinical Trial. JAMA Netw Open. 2019 May 03; 2(5):e194108. PMID: 31125095.
      View in: PubMed
    13. Staffaroni AM, Ljubenkov PA, Kornak J, Cobigo Y, Datta S, Marx G, Walters SM, Chiang K, Olney N, Elahi FM, Knopman DS, Dickerson BC, Boeve BF, Gorno-Tempini ML, Spina S, Grinberg LT, Seeley WW, Miller BL, Kramer JH, Boxer AL, Rosen HJ. Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials. Brain. 2019 02 01; 142(2):443-459. PMID: 30698757.
      View in: PubMed
    14. Casaletto KB, Elahi FM, Staffaroni AM, Walters S, Contreras WR, Wolf A, Dubal D, Miller B, Yaffe K, Kramer JH. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in "normal" adults. Neurobiol Aging. 2019 05; 77:13-19. PMID: 30772736.
      View in: PubMed
    15. Resende EPF, Rosen HJ, Chiang K, Staffaroni AM, Allen I, Grinberg LT, Carmona KC, Guimarães HC, Carvalho VA, Barbosa MT, de Souza LC, Caramelli P. Primary School Education May Be Sufficient to Moderate a Memory-Hippocampal Relationship. Front Aging Neurosci. 2018; 10:381. PMID: 30515091.
      View in: PubMed
    16. Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH. "Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders. Front Aging Neurosci. 2018; 10:343. PMID: 30483114.
      View in: PubMed
    17. Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, Miller B, Boxer AL, Rosen HJ. Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol. 2018 Oct; 5(10):1250-1263. PMID: 30349860.
      View in: PubMed
    18. Adam M. Staffaroni, Lynn Bajorek, Peter Ljubenkov, Kaitlin Casaletto, Fanny Elahi, Katya Rascovsky, Bradley F. Boeve, Adam L. Boxer, Jessica Bove, Danielle Brushaber, Giovanni Coppola, Christina Dheel, Brad C. Dickerson, Julie A. Fields, Jamie Fong, Leah K. Forsberg, Ralitza H. Gavrilova, Debra Gearhart, Nupur Ghoshal, Jill Goldman, Jonathan Graff Radford, Neill R. Graff-Radford, Murray Grossman, Dana Haley, Hilary W. Heuer, John Hsiao, Ging-Yuek Robin Hsiung, Edward Huey, David J. Irwin, David T. Jones, Lynne Jones, Kejal Kantarci, Anna M. Karydas, David S. Knopman, John Kornak, Walter K. Kremers, Walter A. Kukull, Maria I. Lapid, Diane Lucente, Ian R. Mackenzie, Masood Manoochehri, Bruce L. Miller, Madeline Potter, Rosa Rademakers, Katherine Rankin, Margaret Sutherland, Jeremy Syrjanen, Joanne Taylor, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Howard J. Rosen, Joel H. Kramer, ARTFL/LEFFTDS Consortium. THE NIH-EXAMINER IS SENSITIVE TO COGNITIVE CHANGES IN ASYMPTOMATIC AND MILDLY SYMPTOMATIC FAMILIAL FRONTOTEMPORAL DEMENTIA. 2018 Jul 1; 14(7):p235.
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    19. Elisa de Paula França Resende, Howard J. Rosen, Kevin Chiang, Isabel Allen, Adam M. Staffaroni, Lea Tenenholz Grinberg, Karoline Carvalho Carmona, Henrique Cerqueira Guimaraes, Viviane Amaral Carvalho, Maira Tonidandel Barbosa, Leonardo Cruz de Souza, Paulo Caramelli. PRIMARY SCHOOL EDUCATION CAN BE SUFFICIENT TO MODERATE THE RELATIONSHIP BETWEEN HIPPOCAMPUS VOLUME AND MEMORY PERFORMANCE. 2018 Jul 1; 14(7):p1003.
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    20. Fanny Elahi, Marie Altendahl, Teresa J. Filshtein, Kaitlin Casaletto, Adam M. Staffaroni, Wilfredo Rivera Contreras, Anna M. Karydas, Yann Cobigo, Evan Fletcher, Baljeet Singh, Oliver Martinez, Howard J. Rosen, Jason Hinman, Katerina Akassoglou, Maria Glymour, Charlie S. DeCarli, Edward J. Goetzl, Joel H. Kramer. ENDOTHELIAL-DERIVED EXOSOME BIOMARKERS SUGGEST ACTIVATION OF INNATE IMMUNITY IN SUBCLINICAL CEREBROVASCULAR DISEASE. 2018 Jul 1; 14(7):p767.
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    21. Casaletto KB, Staffaroni AM, Elahi F, Fox E, Crittenden PA, You M, Neuhaus J, Glymour M, Bettcher BM, Yaffe K, Kramer JH. Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults. Am J Geriatr Psychiatry. 2018 09; 26(9):952-963. PMID: 30017239.
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    22. Casaletto KB, Elahi FM, Fitch R, Walters S, Fox E, Staffaroni AM, Bettcher BM, Zetterberg H, Karydas A, Rojas JC, Boxer AL, Kramer JH. A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence? Cytokine. 2018 11; 111:481-489. PMID: 29908923.
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    23. Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH. Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults. Neurobiol Aging. 2018 09; 69:68-75. PMID: 29859365.
      View in: PubMed
    24. Staffaroni AM, Eng ME, Moses JA, Zeiner HK, Wickham RE. Four- and five-factor models of the WAIS-IV in a clinical sample: Variations in indicator configuration and factor correlational structure. Psychol Assess. 2018 05; 30(5):693-706. PMID: 29494190.
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    25. Staffaroni AM, Brown JA, Casaletto KB, Elahi FM, Deng J, Neuhaus J, Cobigo Y, Mumford PS, Walters S, Saloner R, Karydas A, Coppola G, Rosen HJ, Miller BL, Seeley WW, Kramer JH. The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed. J Neurosci. 2018 03 14; 38(11):2809-2817. PMID: 29440553.
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    26. Staffaroni AM, Elahi FM, McDermott D, Marton K, Karageorgiou E, Sacco S, Paoletti M, Caverzasi E, Hess CP, Rosen HJ, Geschwind MD. Neuroimaging in Dementia. Semin Neurol. 2017 10; 37(5):510-537. PMID: 29207412.
      View in: PubMed
    27. Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ. Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease. Neuroimage Clin. 2017; 16:595-603. PMID: 28975068.
      View in: PubMed
    28. Binney RJ, Pankov A, Marx G, He X, McKenna F, Staffaroni AM, Kornak J, Attygalle S, Boxer AL, Schuff N, Gorno-Tempini ML, Weiner MW, Kramer JH, Miller BL, Rosen HJ. Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration. Brain Behav. 2017 04; 7(4):e00675. PMID: 28413716.
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    29. Staffaroni AM, Melrose RJ, Leskin LP, Riskin-Jones H, Harwood D, Mandelkern M, Sultzer DL. The functional neuroanatomy of verbal memory in Alzheimer's disease: [18F]-Fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) correlates of recency and recognition memory. J Clin Exp Neuropsychol. 2017 Sep; 39(7):682-693. PMID: 27876444.
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    30. Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ. Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration. Neuroimage Clin. 2016; 12:332-40. PMID: 27547726.
      View in: PubMed
    31. Dobryakova E, Staffaroni A, DeLuca J, Sumowski JF, Chiaravalloti N, Wylie GR. CapMan: independent investigation of capacity and manipulation with a new working memory paradigm. Brain Imaging Behav. 2014 Dec; 8(4):475-9. PMID: 24370894.
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