Alexandra Apple, PhD, MS

Title(s)Psychologist 2, Psychiatry
SchoolChancellor/EVC/FAS
AddressLocation Required, #001
Phone415-353-8819
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    Collapse Biography 
    Collapse Education and Training
    Northwestern UniversityPhD2019
    UCSFFellowship2021Neuropsychology

    Collapse Overview 
    Collapse Overview
    Alexandra Apple is a neuropsychologist who cares for older adults and adults with early neurodegenerative disease. She specializes in cognitive assessment of a wide variety of neurological and neuropsychiatric disorders. In her therapy practice, she draws from cognitive behavioral therapy, problem-solving therapy and mindfulness-based practices to work collaboratively with her patients to improve functioning.

    Apple also works with individuals and groups who want to improve their mood and sleep, as well as those who aim to enhance cognitive and everyday functioning through effective compensatory and coping strategies.

    One of Apple's research interests is combining neuropsychological assessments and brain imaging to better understand cognitive decline. She is also interested in how to maintain cognitive abilities and resilience during normal aging. Her long-term goal is to use neuroimaging techniques to find behavioral and cognitive interventions that can make older people's brain function more resilient.

    Apple earned her doctorate in psychology at Northwestern University Feinberg School of Medicine. She completed a fellowship in neuropsychology at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of the hippocampal-prefrontal network in cancer-related cognitive impairment; a multimodal cross sectional study
    NIH F31CA210719Aug 24, 2016 - Aug 23, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Feasibility and Acceptability of a Multidisciplinary Academic Telemedicine System for Memory Care in Response to COVID-19. Neurol Clin Pract. 2022 Dec; 12(6):e199-e209. Rini JF, Tsoy E, Peet B, Best J, Tanner JA, Asken BM, Sanchez A, Apple AC, VandeVrede L, Stephens ML, Erkkinen M, Kramer JH, Miller BL. PMID: 36540141; PMCID: PMC9757120.
      View in: PubMed   Mentions:
    2. Longitudinal Trajectories of Memory Performance in Patients with Early-Stage Breast Cancer. J Oncol. 2022; 2022:5899728. Apple AC, Lindbergh CA, Landau SM, DeLuca A, Eberling JL, Jagust WJ, Kramer JH, Rugo HS, Heflin LH. PMID: 35469310; PMCID: PMC9034940.
      View in: PubMed   Mentions:
    3. Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19. Ann Clin Transl Neurol. 2022 02; 9(2):221-226. Apple AC, Oddi A, Peluso MJ, Asken BM, Henrich TJ, Kelly JD, Pleasure SJ, Deeks SG, Allen IE, Martin JN, Ndhlovu LC, Miller BL, Stephens ML, Hellmuth J. PMID: 35043593; PMCID: PMC8862406.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    4. Interbatch Reliability of Blood-Based Cytokine and Chemokine Measurements in Community-Dwelling Older Adults: A Cross-Sectional Study. J Gerontol A Biol Sci Med Sci. 2021 10 13; 76(11):1954-1961. Lindbergh CA, Asken BM, Casaletto KB, Elahi FM, Goldberger LA, Fonseca C, You M, Apple AC, Staffaroni AM, Fitch R, Rivera Contreras W, Wang P, Karydas A, Kramer JH, Hillblom Aging Network. PMID: 34110415; PMCID: PMC8514070.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment. J Int Neuropsychol Soc. 2022 07; 28(6):588-599. Asken BM, VandeVrede L, Rojas JC, Fonseca C, Staffaroni AM, Elahi FM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Boxer AL, Miller BL, Rosen HJ, Kramer JH, Casaletto KB. PMID: 34158138; PMCID: PMC8692495.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults. Brain Imaging Behav. 2021 Oct; 15(5):2417-2425. Asken BM, Mantyh WG, La Joie R, Strom A, Casaletto KB, Staffaroni AM, Apple AC, Lindbergh CA, Iaccarino L, You M, Grant H, Fonseca C, Windon C, Younes K, Tanner J, Rabinovici GD, Kramer JH, Gardner RC. PMID: 33432536; PMCID: PMC8272743.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage. J Alzheimers Dis. 2021; 80(1):471-474. Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB. PMID: 33612550.
      View in: PubMed   Mentions: 6     Fields:    
    8. Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults. J Int Neuropsychol Soc. 2021 04; 27(4):382-388. Lindbergh CA, Walker N, La Joie R, Weiner-Light S, Staffaroni AM, Casaletto KB, Elahi F, Walters SM, You M, Cotter D, Asken B, Apple AC, Tsoy E, Neuhaus J, Fonseca C, Wolf A, Cobigo Y, Rosen H, Kramer JH, Hillblom Aging Network. PMID: 33050976; PMCID: PMC8026481.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults. Neuropsychology. 2020 Nov; 34(8):835-850. Lindbergh CA, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Edwards L, Tsoy E, Elahi F, Walters SM, Cotter D, You M, Apple AC, Asken B, Neuhaus J, Rexach JE, Wojta KJ, Rabinovici G, Kramer JH, Hillblom Aging Network. PMID: 33030915; PMCID: PMC7839841.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Longitudinal fMRI task reveals neural plasticity in default mode network with disrupted executive-default coupling and selective attention after traumatic brain injury. Brain Imaging Behav. 2020 Oct; 14(5):1638-1650. Wu SJ, Jenkins LM, Apple AC, Petersen J, Xiao F, Wang L, Yang FG. PMID: 30937828.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage. J Alzheimers Dis. 2020; 78(1):265-276. Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB. PMID: 32986672; PMCID: PMC7727314.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    12. Sleep talking and primary progressive aphasia: case study and autopsy findings in a patient with logopenic primary progressive aphasia and dementia with Lewy bodies. BMJ Case Rep. 2019 May 27; 12(5). Apple AC, Mao Q, Bigio E, Bonakdarpour B. PMID: 31133550; PMCID: PMC6536219.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies. Neurobiol Aging. 2019 02; 74:171-181. Hanko V, Apple AC, Alpert KI, Warren KN, Schneider JA, Arfanakis K, Bennett DA, Wang L. PMID: 30453234; PMCID: PMC6331233.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    14. Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy. Neuroimage Clin. 2018; 20:110-118. Apple AC, Schroeder MP, Ryals AJ, Wagner LI, Cella D, Shih PA, Reilly J, Penedo FJ, Voss JL, Wang L. PMID: 30094161; PMCID: PMC6077172.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    15. Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes. Neuropsychologia. 2017 Jul 01; 101:57-64. Possin KL, Kim H, Geschwind MD, Moskowitz T, Johnson ET, Sha SJ, Apple A, Xu D, Miller BL, Finkbeiner S, Hess CP, Kramer JH. PMID: 28427989; PMCID: PMC5765862.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns. Neuroimage Clin. 2017; 14:685-691. Apple AC, Ryals AJ, Alpert KI, Wagner LI, Shih PA, Dokucu M, Cella D, Penedo FJ, Voss JL, Wang L. PMID: 28377882; PMCID: PMC5369871.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    17. Reduced prefrontal activation during working and long-term memory tasks and impaired patient-reported cognition among cancer survivors postchemotherapy compared with healthy controls. Cancer. 2016 Jan 15; 122(2):258-68. Wang L, Apple AC, Schroeder MP, Ryals AJ, Voss JL, Gitelman D, Sweet JJ, Butt ZA, Cella D, Wagner LI. PMID: 26484435; PMCID: PMC4707984.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    18. Executive functions in premanifest Huntington's disease. Mov Disord. 2014 Mar; 29(3):405-9. You SC, Geschwind MD, Sha SJ, Apple A, Satris G, Wood KA, Johnson ET, Gooblar J, Feuerstein JS, Finkbeiner S, Kang GA, Miller BL, Hess CP, Kramer JH, Possin KL. PMID: 24375511; PMCID: PMC4029327.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
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