Mercedes Paredes, MD, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address35 Medical Center Way, #1038
San Francisco CA 94143
ORCID ORCID Icon0000-0003-2503-1447 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.2007 Medicine
    University of California, San FranciscoPh.D.2007 Graduate Division (Neuroscience)
    University of California, San Francisco, CA2017Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Gyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic Interventions
    NIH DP2NS122550Sep 30, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Late-migrating interneurons in the postnatal brain
    NIH K08NS091537Sep 30, 2015 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A cross-species proteomic map reveals neoteny of human synapse development. Nature. 2023 Sep 13. Wang L, Pang K, Zhou L, Cebrián-Silla A, González-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, García-Verdugo JM, Alvarez-Buylla A, Liu Z, Kriegstein AR. PMID: 37704727.
      View in: PubMed   Mentions:    Fields:    
    2. A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion. Sci Rep. 2023 05 11; 13(1):7689. Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP. PMID: 37169815; PMCID: PMC10175260.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Cell Migration in the Mammalian Cortex. . 2022 Oct 18; 465-482. Kim KJ, Pleasure PS, Paredes PM. .
      View in: Publisher Site   Mentions:
    4. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022 09 29; 185(20):3753-3769.e18. Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. PMID: 36179668; PMCID: PMC9550196.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    5. Cell Migration in the Mammalian Cortex. . 2022 Jun 29; 1-18. Kim KJ, Pleasure PS, Paredes PM. .
      View in: Publisher Site   Mentions:
    6. Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis". Science. 2022 04 15; 376(6590):eabn8861. Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z, Huang EJ. PMID: 35420933; PMCID: PMC10171399.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    7. The development and evolution of inhibitory neurons in primate cerebrum. Nature. 2022 03; 603(7903):871-877. Schmitz MT, Sandoval K, Chen CP, Mostajo-Radji MA, Seeley WW, Nowakowski TJ, Ye CJ, Paredes MF, Pollen AA. PMID: 35322231; PMCID: PMC8967711.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    8. Nests of dividing neuroblasts sustain interneuron production for the developing human brain. Science. 2022 01 28; 375(6579):eabk2346. Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano J, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ. PMID: 35084970; PMCID: PMC8887556.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. Amplification of human interneuron progenitors promotes brain tumors and neurological defects. Science. 2022 01 28; 375(6579):eabf5546. Eichmüller OL, Corsini NS, Vértesy Á, Morassut I, Scholl T, Gruber VE, Peer AM, Chu J, Novatchkova M, Hainfellner JA, Paredes MF, Feucht M, Knoblich JA. PMID: 35084981; PMCID: PMC7613689.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    10. Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study. Int J Surg. 2022 Jan; 97:106168. Villodre C, Taccogna L, Zapater P, Cantó M, Mena L, Ramia JM, Lluís F, Afonso N, Aguilella V, Aguiló J, Alados JC, Alberich M, Apio AB, Balongo R, Bra E, Bravo-Gutiérrez A, Briceño FJ, Cabañas J, Cánovas G, Caravaca I, Carbonell S, Carrera-Dacosta E, Castro EE, Caula C, Choolani-Bhojwani E, Codina A, Corral S, Cuenca C, Curbelo-Peña Y, Delgado-Morales MM, Delgado-Plasencia L, Doménech E, Estévez AM, Feria AM, Gascón-Domínguez MA, Gianchandani R, González C, Hevia RJ, González MA, Hidalgo JM, Lainez M, Lluís N, López F, López-Fernández J, López-Ruíz JA, Lora-Cumplido P, Madrazo Z, Marchena J, de la Cuadra MB, Martín S, Casas MI, Martínez P, Mena-Mateos A, Morales-García D, Mulas C, Muñoz-Forner E, Naranjo A, Navarro-Sánchez A, Oliver I, Ortega I, Ortega-Higueruelo R, Ortega-Ruiz S, Osorio J, Padín MH, Pamies JJ, Paredes M, Pareja-Ciuró F, Parra J, Pérez-Guarinós CV, Pérez-Saborido B, Pintor-Tortolero J, Plua-Muñiz K, Rey M, Rodríguez I, Ruiz C, Ruíz R, Ruiz S, Sánchez A, Sánchez D, Sánchez R, Sánchez-Cabezudo F, Sánchez-Santos R, Santos J, Serrano-Paz MP, Soria-Aledo V, Tallón-Aguilar L, Valdivia-Risco JH, Vallverdú-Cartié H, Varela C, Villar-Del-Moral J, Zambudio N, LUCENTUM Project Researchers. PMID: 34785344.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    11. Implications of Extended Inhibitory Neuron Development. Int J Mol Sci. 2021 May 12; 22(10). Kim JY, Paredes MF. PMID: 34066025; PMCID: PMC8150951.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus. J Neurosci. 2021 03 24; 41(12):2554-2565. Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A. PMID: 33762407; PMCID: PMC8018729.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    13. Interneuron Origins in the Embryonic Porcine Medial Ganglionic Eminence. J Neurosci. 2021 04 07; 41(14):3105-3119. Casalia ML, Li T, Ramsay H, Ross PJ, Paredes MF, Baraban SC. PMID: 33637558; PMCID: PMC8026360.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 10 13; 33(2):108256. Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J. PMID: 33053356.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation. Elife. 2020 05 26; 9. Pai EL, Chen J, Fazel Darbandi S, Cho FS, Chen J, Lindtner S, Chu JS, Paz JT, Vogt D, Paredes MF, Rubenstein JL. PMID: 32452758; PMCID: PMC7282818.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map. Nat Neurosci. 2020 04; 23(4):500-509. Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, Chang SM, Huang E, Hutchinson P, Ullian EM, Hemberg M, Coppola G, Holt MG, Geschwind DH, Rowitch DH. PMID: 32203496; PMCID: PMC7116562.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    17. Cortical Malformations: Lessons in Human Brain Development. Front Cell Neurosci. 2019; 13:576. Subramanian L, Calcagnotto ME, Paredes MF. PMID: 32038172; PMCID: PMC6993122.
      View in: PubMed   Mentions: 33  
    18. Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia. Brain Commun. 2019; 1(1):fcz027. Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML. PMID: 32699834; PMCID: PMC7364264.
      View in: PubMed   Mentions: 3  
    19. Building Bridges Between the Clinic and the Laboratory: A Meeting Review - Brain Malformations: A Roadmap for Future Research. Front Cell Neurosci. 2019; 13:434. Sapir T, Barakat TS, Paredes MF, Lerman-Sagie T, Aronica E, Klonowski W, Nguyen L, Ben Zeev B, Bahi-Buisson N, Leventer R, Rachmian N, Reiner O. PMID: 31611776; PMCID: PMC6776596.
      View in: PubMed   Mentions: 2  
    20. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019 06 21; 10(1):2748. Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A. PMID: 31227709; PMCID: PMC6588589.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    21. Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. Neuron. 2019 04 03; 102(1):143-158.e7. Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR. PMID: 30770253; PMCID: PMC7648658.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    22. Does Adult Neurogenesis Persist in the Human Hippocampus? Cell Stem Cell. 2018 12 06; 23(6):780-781. Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. PMID: 30526879; PMCID: PMC6800191.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    23. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2018 06 01; 28(6):1946-1958. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC. PMID: 28449024; PMCID: PMC6019052.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    24. Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018 03 15; 555(7696):377-381. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. PMID: 29513649; PMCID: PMC6179355.
      View in: PubMed   Mentions: 544     Fields:    Translation:HumansAnimalsCells
    25. Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Rep. 2018 02 13; 22(7):1695-1709. Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G. PMID: 29444424; PMCID: PMC6215776.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    26. No Evidence For New Adult Neurons. American Scientist. 2018 Jan 1; 106(3):152. Sorrells SS, Alvarez-Buylla AA, Paredes PM. .
      View in: Publisher Site   Mentions:
    27. Dynamic behaviour of human neuroepithelial cells in the developing forebrain. Nat Commun. 2017 01 31; 8:14167. Subramanian L, Bershteyn M, Paredes MF, Kriegstein AR. PMID: 28139695; PMCID: PMC5290330.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    28. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016 Oct 07; 354(6308). Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A. PMID: 27846470; PMCID: PMC5436574.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    29. Brain size and limits to adult neurogenesis. J Comp Neurol. 2016 Feb 15; 524(3):646-64. Paredes MF, Sorrells SF, Garcia-Verdugo JM, Alvarez-Buylla A. PMID: 26417888; PMCID: PMC5047485.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    30. Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients. Neurology. 2015 Jun 16; 84(24):2403-12. Höftberger R, van Sonderen A, Leypoldt F, Houghton D, Geschwind M, Gelfand J, Paredes M, Sabater L, Saiz A, Titulaer MJ, Graus F, Dalmau J. PMID: 25979696; PMCID: PMC4478035.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    31. DISTINCT AND SEPARABLE ROLES FOR HISTONE METHYLTRANSFERASE EZH2 IN NEUROGENIC ASTROCYTES. Neuro-Oncology. 2014 Jul 1; 16(suppl_3):iii17-iii17. Lim LD, Hwang HW, Salinas SR, Siu SJ, Kelley KK, Delgado DR, Paredes PM, Alvarez-Buylla AA, Oldham OM, Lim LD. .
      View in: Publisher Site   Mentions:
    32. Distinct and separable roles for EZH2 in neurogenic astroglia. Elife. 2014 May 27; 3:e02439. Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA. PMID: 24867641; PMCID: PMC4032491.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    33. Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans. Neurogenesis (Austin). 2014 Jan 01; 1(1). Tong CK, Cebrián-Silla A, Paredes MF, Huang EJ, García-Verdugo JM, Alvarez-Buylla A. PMID: 26413556; PMCID: PMC4583132.
      View in: PubMed   Mentions: 2  
    34. Intrinsically determined cell death of developing cortical interneurons. Nature. 2012 Nov 01; 491(7422):109-13. Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein JL, Baraban SC, Alvarez-Buylla A. PMID: 23041929; PMCID: PMC3726009.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    35. Hilar mossy cells share developmental influences with dentate granule neurons. Dev Neurosci. 2008; 30(4):255-61. Li G, Berger O, Han SM, Paredes M, Wu NC, Pleasure SJ. PMID: 17960053.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    36. Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus. Dev Neurosci. 2007; 29(1-2):48-58. Berger O, Li G, Han SM, Paredes M, Pleasure SJ. PMID: 17148948.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    37. Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains. J Neurosci. 2006 Sep 13; 26(37):9404-12. Paredes MF, Li G, Berger O, Baraban SC, Pleasure SJ. PMID: 16971524; PMCID: PMC2133346.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    38. Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia. J Comp Neurol. 2006 Mar 01; 495(1):133-48. Paredes M, Pleasure SJ, Baraban SC. PMID: 16432901; PMCID: PMC2827607.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J Neurosci. 2005 Oct 19; 25(42):9649-57. Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC. PMID: 16237169; PMCID: PMC6725719.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    40. Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus. Neurosci Lett. 2003 Apr 03; 340(1):9-12. Paredes MF, Greenwood J, Baraban SC. PMID: 12648746.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
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