Julio Rojas-Martinez, MD, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
ORCID ORCID Icon0000-0002-1308-646X Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of Texas at AustinPhD2010Institute for Neuroscience
    Univesity of Texas Southwestern Medical CenterNeurology2014Department of Neurology & Neurotherapeutics
    Tecnologico de Monterrey, ITESMMD2003Escuela de Medicina

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    Proteomics for fluid biomarker discovery in frontotemporal dementia
    NIH K23AG059888Apr 1, 2019 - Mar 31, 2024
    Role: Principal Investigator

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    Collapse Clinical Trials

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selective vulnerability to atrophy in sporadic Creutzfeldt-Jakob disease. Ann Clin Transl Neurol. 2021 May 05. Younes K, Rojas JC, Wolf A, Sheng-Yang GM, Paoletti M, Toller G, Caverzasi E, Luisa Mandelli M, Illán-Gala I, Kramer JH, Cobigo Y, Miller BL, Rosen HJ, Geschwind MD. PMID: 33949799.
      View in: PubMed   Mentions:    Fields:    
    2. Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration. Neurology. 2021 05 04; 96(18):e2296-e2312. Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, Toga AW, Weintraub S, Kaufer DI, Kerwin D, Litvan I, Onyike CU, Pantelyat A, Roberson ED, Tartaglia MC, Foroud T, Chen W, Czerkowicz J, Graham DL, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Cash DM, Convery RS, Bocchetta M, Foiani M, Greaves CV, Peakman G, Russell L, Swift I, Todd E, Rohrer JD, Boeve BF, Rosen HJ, Boxer AL, ALLFTD and GENFI consortia . PMID: 33827960.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    3. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage. J Alzheimers Dis. 2021; 80(1):471-474. Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB. PMID: 33612550.
      View in: PubMed   Mentions:    Fields:    
    4. Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease. Neurology. 2021 02 02; 96(5):e671-e683. Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, Miller BL, Rosen HJ, Blennow K, Boxer AL, Rojas JC. PMID: 33199433.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Four-Repeat Tauopathies: Current Management and Future Treatments. Neurotherapeutics. 2020 10; 17(4):1563-1581. VandeVrede L, Ljubenkov PA, Rojas JC, Welch AE, Boxer AL. PMID: 32676851.
      View in: PubMed   Mentions: 3     Fields:    
    6. Open-Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy. Mov Disord Clin Pract. 2020 May; 7(4):440-447. VandeVrede L, Dale ML, Fields S, Frank M, Hare E, Heuer HW, Keith K, Koestler M, Ljubenkov PA, McDermott D, Ohanesian N, Richards J, Rojas JC, Thijssen EH, Walsh C, Wang P, Wolf A, Quinn JF, Tsai R, Boxer AL. PMID: 32373661.
      View in: PubMed   Mentions:
    7. Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration. Nat Med. 2020 03; 26(3):387-397. Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators . PMID: 32123386.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    8. Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2020 02 01; 77(2):215-224. Tsai RM, Miller Z, Koestler M, Rojas JC, Ljubenkov PA, Rosen HJ, Rabinovici GD, Fagan AM, Cobigo Y, Brown JA, Jung JI, Hare E, Geldmacher DS, Natelson-Love M, McKinley EC, Luong PN, Chuu EL, Powers R, Mumford P, Wolf A, Wang P, Shamloo M, Miller BL, Roberson ED, Boxer AL. PMID: 31710340.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    9. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Mol Neurodegener. 2020 01 06; 15(1):2. Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L. PMID: 31906970.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    10. Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage. J Alzheimers Dis. 2020; 78(1):265-276. Asken BM, Elahi FM, La Joie R, Strom A, Staffaroni AM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Karydas A, Wang P, Rojas JC, Boxer AL, Miller BL, Rabinovici GD, Kramer JH, Casaletto KB. PMID: 32986672.
      View in: PubMed   Mentions: 1     Fields:    
    11. 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. Acta Neuropathol. 2020 01; 139(1):63-77. Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B. PMID: 31616982.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    12. Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency. Front Neurol. 2019; 10:1004. Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL. PMID: 31620075.
      View in: PubMed   Mentions:
    13. Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis. JAMA Neurol. 2019 Sep 01; 76(9):1035-1048. Bridel C, van Wieringen WN, Zetterberg H, Tijms BM, Teunissen CE, and the NFL Group , Alvarez-Cermeño JC, Andreasson U, Axelsson M, Bäckström DC, Bartos A, Bjerke M, Blennow K, Boxer A, Brundin L, Burman J, Christensen T, Fialová L, Forsgren L, Frederiksen JL, Gisslén M, Gray E, Gunnarsson M, Hall S, Hansson O, Herbert MK, Jakobsson J, Jessen-Krut J, Janelidze S, Johannsson G, Jonsson M, Kappos L, Khademi M, Khalil M, Kuhle J, Landén M, Leinonen V, Logroscino G, Lu CH, Lycke J, Magdalinou NK, Malaspina A, Mattsson N, Meeter LH, Mehta SR, Modvig S, Olsson T, Paterson RW, Pérez-Santiago J, Piehl F, Pijnenburg YAL, Pyykkö OT, Ragnarsson O, Rojas JC, Romme Christensen J, Sandberg L, Scherling CS, Schott JM, Sellebjerg FT, Simone IL, Skillbäck T, Stilund M, Sundström P, Svenningsson A, Tortelli R, Tortorella C, Trentini A, Troiano M, Turner MR, van Swieten JC, Vågberg M, Verbeek MM, Villar LM, Visser PJ, Wallin A, Weiss A, Wikkelsø C, Wild EJ. PMID: 31206160.
      View in: PubMed   Mentions: 83     Fields:    
    14. Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. J Neurol Neurosurg Psychiatry. 2019 09; 90(9):997-1004. Meeter LHH, Steketee RME, Salkovic D, Vos ME, Grossman M, McMillan CT, Irwin DJ, Boxer AL, Rojas JC, Olney NT, Karydas A, Miller BL, Pijnenburg YAL, Barkhof F, Sánchez-Valle R, Lladó A, Borrego-Ecija S, Diehl-Schmid J, Grimmer T, Goldhardt O, Santillo AF, Hansson O, Vestberg S, Borroni B, Padovani A, Galimberti D, Scarpini E, Rohrer JD, Woollacott IOC, Synofzik M, Wilke C, de Mendonca A, Vandenberghe R, Benussi L, Ghidoni R, Binetti G, Niessen WJ, Papma JM, Seelaar H, Jiskoot LC, de Jong FJ, Donker Kaat L, Del Campo M, Teunissen CE, Bron EE, Van den Berg E, Van Swieten JC. PMID: 31123142.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol. 2018 Oct; 5(10):1250-1263. Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, Miller B, Boxer AL, Rosen HJ. PMID: 30349860.
      View in: PubMed   Mentions: 18     Fields:    
    16. A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence? Cytokine. 2018 11; 111:481-489. Casaletto KB, Elahi FM, Fitch R, Walters S, Fox E, Staffaroni AM, Bettcher BM, Zetterberg H, Karydas A, Rojas JC, Boxer AL, Kramer JH. PMID: 29908923.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Poly(GP), neurofilament and grey matter deficits in C9orf72 expansion carriers. Ann Clin Transl Neurol. 2018 May; 5(5):583-597. Meeter LHH, Gendron TF, Sias AC, Jiskoot LC, Russo SP, Donker Kaat L, Papma JM, Panman JL, van der Ende EL, Dopper EG, Franzen S, Graff C, Boxer AL, Rosen HJ, Sanchez-Valle R, Galimberti D, Pijnenburg YAL, Benussi L, Ghidoni R, Borroni B, Laforce R, Del Campo M, Teunissen CE, van Minkelen R, Rojas JC, Coppola G, Geschwind DH, Rademakers R, Karydas AM, Öijerstedt L, Scarpini E, Binetti G, Padovani A, Cash DM, Dick KM, Bocchetta M, Miller BL, Rohrer JD, Petrucelli L, van Swieten JC, Lee SE. PMID: 29761121.
      View in: PubMed   Mentions: 14     Fields:    
    18. Multiproteinopathy, neurodegeneration and old age: a case study. Neurocase. 2018 02; 24(1):1-6. Rojas JC, Stephens ML, Rabinovici GD, Kramer JH, Miller BL, Seeley WW. PMID: 29307276.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2018 01 23; 90(4):e273-e281. Rojas JC, Bang J, Lobach IV, Tsai RM, Rabinovici GD, Miller BL, Boxer AL, AL-108-231 Investigators . PMID: 29282336.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsCTClinical Trials
    20. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017 09 28; 549(7673):523-527. Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C, Alzheimer’s Disease Neuroimaging Initiative , Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM. PMID: 28959956.
      View in: PubMed   Mentions: 237     Fields:    Translation:HumansAnimalsCells
    21. Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy. J Alzheimers Dis. 2017; 55(1):249-258. Fong JC, Rojas JC, Bang J, Legati A, Rankin KP, Forner S, Miller ZA, Karydas AM, Coppola G, Grouse CK, Ralph J, Miller BL, Geschwind MD. PMID: 27716661.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. Plasma neurofilament light chain predicts progression in progressive supranuclear palsy. Ann Clin Transl Neurol. 2016 03; 3(3):216-25. Rojas JC, Karydas A, Bang J, Tsai RM, Blennow K, Liman V, Kramer JH, Rosen H, Miller BL, Zetterberg H, Boxer AL. PMID: 27042681.
      View in: PubMed   Mentions: 54     Fields:    
    23. Neurodegenerative disease in 2015: Targeting tauopathies for therapeutic translation. Nat Rev Neurol. 2016 Feb; 12(2):74-6. Rojas JC, Boxer AL. PMID: 26794651.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    24. Factors contributing to delay in diagnosis of Guillain-Barré syndrome and impact on clinical outcome. Muscle Nerve. 2016 Mar; 53(3):384-7. Dubey D, Kapotic M, Freeman M, Sawhney A, Rojas JC, Warnack W, Vernino S. PMID: 26185107.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Neuritis ossificans. Response. J Neurosurg. 2014 Nov; 121(5):1288-9. Kemper CM, Rojas JC, Bauserman S. PMID: 25525654.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Mitochondrial respiration as a target for neuroprotection and cognitive enhancement. Biochem Pharmacol. 2014 Apr 15; 88(4):584-93. Gonzalez-Lima F, Barksdale BR, Rojas JC. PMID: 24316434.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    27. Neurological and psychological applications of transcranial lasers and LEDs. Biochem Pharmacol. 2013 Aug 15; 86(4):447-57. Rojas JC, Gonzalez-Lima F. PMID: 23806754.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    28. Pearls and oy-sters: acute ischemic stroke caused by atypical thrombotic thrombocytopenic purpura. Neurology. 2013 May 28; 80(22):e235-8. Rojas JC, Banerjee C, Siddiqui F, Nourbakhsh B, Powell CM. PMID: 23713092.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    29. Low-level light therapy improves cortical metabolic capacity and memory retention. J Alzheimers Dis. 2012; 32(3):741-52. Rojas JC, Bruchey AK, Gonzalez-Lima F. PMID: 22850314.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    30. Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue. Prog Neurobiol. 2012 Jan; 96(1):32-45. Rojas JC, Bruchey AK, Gonzalez-Lima F. PMID: 22067440.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    31. Low-level light therapy of the eye and brain. Eye Brain. 2011; 3:49-67. Rojas JC, Gonzalez-Lima F. PMID: 28539775.
      View in: PubMed   Mentions:
    32. Beneficial network effects of methylene blue in an amnestic model. Neuroimage. 2011 Feb 14; 54(4):2623-34. Riha PD, Rojas JC, Gonzalez-Lima F. PMID: 21087672.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    33. [Genetic thrombophilia and markers of endothelial activation in patients with preeclampsia]. Ginecol Obstet Mex. 2010 Aug; 78(8):401-9. Rojas JC, Luna M, Rangel-Nava H, Baños D, Collados MT. PMID: 20939248.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. Neuritis ossificans of a cranial nerve. J Neurosurg. 2010 Nov; 113(5):1112-4. Kemper CM, Rojas JC, Bauserman S. PMID: 20509727.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. In vivo low-level light therapy increases cytochrome oxidase in skeletal muscle. Photochem Photobiol. 2010 May-Jun; 86(3):673-80. Hayworth CR, Rojas JC, Padilla E, Holmes GM, Sheridan EC, Gonzalez-Lima F. PMID: 20408982.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    36. Mitochondrial optic neuropathy: In vivo model of neurodegeneration and neuroprotective strategies. Eye Brain. 2010; 2:21-37. Rojas JC, Gonzalez-Lima F. PMID: 28539759.
      View in: PubMed   Mentions:
    37. Striatal neuroprotection with methylene blue. Neuroscience. 2009 Oct 20; 163(3):877-89. Rojas JC, Simola N, Kermath BA, Kane JR, Schallert T, Gonzalez-Lima F. PMID: 19596056.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    38. Methylene blue provides behavioral and metabolic neuroprotection against optic neuropathy. Neurotox Res. 2009 Apr; 15(3):260-73. Rojas JC, John JM, Lee J, Gonzalez-Lima F. PMID: 19384599.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    39. Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy. J Neurosci. 2008 Dec 10; 28(50):13511-21. Rojas JC, Lee J, John JM, Gonzalez-Lima F. PMID: 19074024.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
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