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Considerations for widespread implementation of blood-based biomarkers of Alzheimer's disease. Alzheimers Dement. 2024 Oct 06.
Mielke MM, Anderson M, Ashford JW, Jeromin A, Lin PJ, Rosen A, Tyrone J, VandeVrede L, Willis D, Hansson O, Khachaturian AS, Schindler SE, Weiss J, Batrla R, Bozeat S, Dwyer JR, Holzapfel D, Jones DR, Murray JF, Partrick KA, Scholler E, Vradenburg G, Young D, Braunstein JB, Burnham SC, de Oliveira FF, Hu YH, Mattke S, Merali Z, Monane M, Sabbagh MN, Shobin E, Weiner MW, Udeh-Momoh CT. PMID: 39369283.
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Recommendations for clinical implementation of blood-based biomarkers for Alzheimer's disease. Alzheimers Dement. 2024 Oct 01.
Mielke MM, Anderson M, Ashford JW, Jeromin A, Lin PJ, Rosen A, Tyrone J, Vandevrede L, Willis DR, Hansson O, Khachaturian AS, Schindler SE, Weiss J, Batrla R, Bozeat S, Dwyer JR, Holzapfel D, Jones DR, Murray JF, Partrick KA, Scholler E, Vradenburg G, Young D, Braunstein JB, Burnham SC, de Oliveira FF, Hu YH, Mattke S, Merali Z, Monane M, Sabbagh MN, Shobin E, Weiner M, Udeh-Momoh CT. PMID: 39351838.
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Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia. Alzheimers Res Ther. 2024 Aug 29; 16(1):193.
Asken BM, Bove JM, Bauer RM, Tanner JA, Casaletto KB, Staffaroni AM, VandeVrede L, Alosco ML, Mez JB, Stern RA, Miller BL, Grinberg LT, Boxer AL, Gorno-Tempini ML, Rosen HJ, Rabinovici GD, Kramer JH. PMID: 39210451; PMCID: PMC11363650.
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Blood-Based Biomarkers for Alzheimer Disease-Ready for Primary Care? JAMA Neurol. 2024 Jul 28.
VandeVrede L, Rabinovici GD. PMID: 39068546.
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1 Fields:
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Humans
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CSF Proteomics in Patients With Progressive Supranuclear Palsy. Neurology. 2024 Aug 13; 103(3):e209585.
Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, Sivasankaran R, Palma JA, Mitic L, Heuer HW, Lario-Lago A, Staffaroni AM, Clark A, Taylor J, Ljubenkov PA, Vandevrede L, Grinberg LT, Spina S, Seeley WW, Miller BL, Boeve BF, Dickerson BC, Grossman M, Litvan I, Pantelyat A, Tartaglia MC, Zhang Z, Wills AA, Rexach J, Rojas JC, Boxer AL, as the 4-Repeat Tauopathy Neuroimaging Initiative. PMID: 38959435; PMCID: PMC11226322.
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1 Fields:
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Humans
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An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimers Dement. 2024 08; 20(8):5220-5235.
Snyder A, Ryan VH, Hawrot J, Lawton S, Ramos DM, Qi YA, Johnson KR, Reed X, Johnson NL, Kollasch AW, Duffy MF, VandeVrede L, Cochran JN, Miller BL, Toro C, Bielekova B, Marks DS, Yokoyama JS, Kwan JY, Cookson MR, Ward ME. PMID: 38923692; PMCID: PMC11350008.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study. JMIR Aging. 2024 Jun 26; 7:e52831.
Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, Darby RR, Day GS, Dickerson BC, Domoto-Reilly K, Elahi F, Fields JA, Ghoshal N, Graff-Radford N, G H Hall M, Honig LS, Huey ED, Lapid MI, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Mester C, Miyagawa T, Naasan G, Pascual B, Pressman P, Ramos EM, Rankin KP, Rexach J, Rojas JC, VandeVrede L, Wong B, Wszolek ZK, Boeve BF, Rosen HJ, Boxer AL, Staffaroni AM, ALLFTD Consortium. PMID: 38922667; PMCID: PMC11237775.
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Humans
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Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy. Ann Neurol. 2024 Jul; 96(1):99-109.
Garcia-Cordero I, Anastassiadis C, Khoja A, Morales-Rivero A, Thapa S, Vasilevskaya A, Davenport C, Sumra V, Couto B, Multani N, Taghdiri F, Anor C, Misquitta K, Vandevrede L, Heuer H, Tang-Wai D, Dickerson B, Pantelyat A, Litvan I, Boeve B, Rojas JC, Ljubenkov P, Huey E, Fox S, Kovacs GG, Boxer A, Lang A, Tartaglia MC, 4-R-Tauopathy Neuroimaging Initiative Consortium, and the Alzheimer's Disease Neuroimaging Initiativ. PMID: 38578117; PMCID: PMC11249787.
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Humans
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Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Res Sq. 2024 Mar 28.
Saloner R, Staffaroni A, Dammer E, Johnson ECB, Paolillo E, Wise A, Heuer H, Forsberg L, Lago AL, Webb J, Vogel J, Santillo A, Hansson O, Kramer J, Miller B, Li J, Loureiro J, Sivasankaran R, Worringer K, Seyfried N, Yokoyama J, Seeley W, Spina S, Grinberg L, VandeVrede L, Ljubenkov P, Bayram E, Bozoki A, Brushaber D, Considine C, Day G, Dickerson B, Domoto-Reilly K, Faber K, Galasko D, Geschwind D, Ghoshal N, Graff-Radford N, Hales C, Honig L, Hsiung GY, Huey E, Kornak J, Kremers W, Lapid M, Lee S, Litvan I, McMillan C, Mendez M, Miyagawa T, Pantelyat A, Pascual B, Paulson H, Petrucelli L, Pressman P, Ramos E, Rascovsky K, Roberson E, Savica R, Snyder A, Sullivan AC, Tartaglia C, Vandebergh M, Boeve B, Rosen H, Rojas J, Boxer A, Casaletto K. PMID: 38585969; PMCID: PMC10996789.
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Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort. Alzheimers Dement. 2024 05; 20(5):3334-3341.
Samudra N, Fischer DL, Lenio S, Lario Lago A, Ljubenkov PA, Rojas JC, Seeley WW, Spina S, Staffaroni AM, Tablante J, Wekselman F, Lamoureux J, Concha-Marambio L, Grinberg LT, Boxer AL, VandeVrede L. PMID: 38539061; PMCID: PMC11095442.
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6 Fields:
Translation:
Humans
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Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies. medRxiv. 2024 Mar 18.
Scotton WJ, Shand C, Todd EG, Bocchetta M, Cash DM, VandeVrede L, Heuer HW, Young AL, Oxtoby N, Alexander DC, Rowe JB, Morris HR, PROSPECT Consortium, Boxer AL, 4RTNI Consortium, Rohrer JD, Wijeratne PA. PMID: 38562801; PMCID: PMC10984071.
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Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias. Neurology. 2024 Apr 09; 102(7):e209183.
Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto KB, Gardner RC, Grinberg LT, Gorno-Tempini ML, Rosen HJ, Seeley WW, Miller BL, Kramer J, Rabinovici GD. PMID: 38489566; PMCID: PMC11033989.
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Humans
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Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia. bioRxiv. 2024 Feb 12.
Hsiao-Nakamoto J, Chiu CL, VandeVrede L, Ravi R, Vandenberg B, De Groot J, Tsogtbaatar B, Fang M, Auger P, Gould NS, Marchioni F, Powers CA, Davis SS, Suh JH, Alkabsh J, Heuer HW, Lago AL, Scearce-Levie K, Seeley WW, Boeve BF, Rosen HJ, Berger A, Tsai R, Di Paolo G, Boxer AL, Bhalla A, Huang F, ALLFTD Consortium. PMID: 38405775; PMCID: PMC10888909.
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Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies". Acta Neuropathol. 2024 02 03; 147(1):30.
Oertel FC, Casillas D, Cobigo Y, Condor Montes S, Heuer HW, Chapman M, Beaudry-Richard A, Reinsberg H, Abdelhak A, Cordano C, Boeve BF, Dickerson BC, Grossman M, Huey E, Irwin DJ, Litvan I, Pantelyat A, Tartaglia MC, Vandevrede L, Boxer A, Green AJ. PMID: 38308717; PMCID: PMC10838223.
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Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias. Alzheimers Dement. 2024 03; 20(3):2089-2101.
Tsoy E, La Joie R, VandeVrede L, Rojas JC, Yballa C, Chan B, Lago AL, Rodriguez AM, Goode CA, Erlhoff SJ, Tee BL, Windon C, Lanata S, Kramer JH, Miller BL, Dilworth-Anderson P, Boxer AL, Rabinovici GD, Possin KL. PMID: 38224278; PMCID: PMC10942726.
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2 Fields:
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Humans
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Prevalence of cognitive impairment in liver transplant recipients. Clin Transplant. 2024 01; 38(1):e15229.
Berry K, Ruck JM, Barry F, Shui AM, Cortella A, Kent D, Seetharaman S, Wong R, VandeVrede L, Lai JC. PMID: 38113284; PMCID: PMC10842727.
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1 Fields:
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Humans
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[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration. J Nucl Med. 2023 12 01; 64(12):1980-1989.
Blazhenets G, Soleimani-Meigooni DN, Thomas W, Mundada N, Brendel M, Vento S, VandeVrede L, Heuer HW, Ljubenkov P, Rojas JC, Chen MK, Amuiri AN, Miller Z, Gorno-Tempini ML, Miller BL, Rosen HJ, Litvan I, Grossman M, Boeve B, Pantelyat A, Tartaglia MC, Irwin DJ, Dickerson BC, Baker SL, Boxer AL, Rabinovici GD, La Joie R. PMID: 37918868; PMCID: PMC10690126.
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1 Fields:
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Humans
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An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Res Sq. 2023 Oct 19.
Snyder A, Ryan VH, Hawrot J, Lawton S, Ramos DM, Qi YA, Johnson K, Reed X, Johnson NL, Kollasch AW, Duffy M, VandeVrede L, Cochran JN, Miller BL, Toro C, Bielekova B, Yokoyama JS, Marks DS, Kwan JY, Cookson MR, Ward ME. PMID: 37886540; PMCID: PMC10602153.
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Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment. Alzheimers Res Ther. 2023 09 22; 15(1):157.
Mundada NS, Rojas JC, Vandevrede L, Thijssen EH, Iaccarino L, Okoye OC, Shankar R, Soleimani-Meigooni DN, Lago AL, Miller BL, Teunissen CE, Heuer H, Rosen HJ, Dage JL, Jagust WJ, Rabinovici GD, Boxer AL, La Joie R. PMID: 37740209; PMCID: PMC10517500.
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5 Fields:
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Humans
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Co-pathology may impact outcomes of amyloid-targeting treatments: clinicopathological results from two patients treated with aducanumab. Acta Neuropathol. 2023 11; 146(5):777-781.
VandeVrede L, La Joie R, Horiki S, Mundada NS, Koestler M, Hwang JH, Ljubenkov PA, Rojas JC, Rabinovici GD, Boxer AL, Seeley WW. PMID: 37725166; PMCID: PMC10564667.
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3 Fields:
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Humans
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Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults. Alzheimers Dement. 2024 01; 20(1):376-387.
Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, Kramer JH. PMID: 37639492; PMCID: PMC10843677.
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6 Fields:
Translation:
Humans
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Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome. Alzheimers Res Ther. 2023 07 21; 15(1):126.
Asken BM, Tanner JA, Gaynor LS, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, Fonseca C, Shankar R, Grant H, Smith K, Lago AL, Xu H, La Joie R, Cobigo Y, Rosen H, Perry DC, Rojas JC, Miller BL, Gardner RC, Wang KKW, Kramer JH, Rabinovici GD. PMID: 37480088; PMCID: PMC10360257.
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3 Fields:
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Humans
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Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues. J Clin Invest. 2023 06 15; 133(12).
Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL. PMID: 37317972; PMCID: PMC10266783.
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17 Fields:
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Humans
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Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome. JAMA Neurol. 2023 05 01; 80(5):495-505.
VandeVrede L, La Joie R, Thijssen EH, Asken BM, Vento SA, Tsuei T, Baker SL, Cobigo Y, Fonseca C, Heuer HW, Kramer JH, Ljubenkov PA, Rabinovici GD, Rojas JC, Rosen HJ, Staffaroni AM, Boeve BF, Dickerson BC, Grossman M, Huey ED, Irwin DJ, Litvan I, Pantelyat AY, Tartaglia MC, Dage JL, Boxer AL. PMID: 37010841; PMCID: PMC10071401.
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4 Fields:
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Humans
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Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2023 07; 94(7):541-549.
Asken BM, Ljubenkov PA, Staffaroni AM, Casaletto KB, Vandevrede L, Cobigo Y, Rojas-Rodriguez JC, Rankin KP, Kornak J, Heuer H, Shigenaga J, Appleby BS, Bozoki AC, Domoto-Reilly K, Ghoshal N, Huey E, Litvan I, Masdeu JC, Mendez MF, Pascual B, Pressman P, Tartaglia MC, Kremers W, Forsberg LK, Boeve BF, Boxer AL, Rosen HJ, Kramer JH, ALLFTD Consortium Investigators. PMID: 36977552; PMCID: PMC10313977.
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5 Fields:
Translation:
Humans
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Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning. Brain Commun. 2023; 5(2):fcad048.
Scotton WJ, Shand C, Todd E, Bocchetta M, Cash DM, VandeVrede L, Heuer H, PROSPECT Consortium, 4RTNI Consortium , Young AL, Oxtoby N, Alexander DC, Rowe JB, Morris HR, Boxer AL, Rohrer JD, Wijeratne PA. PMID: 36938523; PMCID: PMC10016410.
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5
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Feasibility and Acceptability of a Multidisciplinary Academic Telemedicine System for Memory Care in Response to COVID-19. Neurol Clin Pract. 2022 Dec; 12(6):e199-e209.
Rini JF, Tsoy E, Peet B, Best J, Tanner JA, Asken BM, Sanchez A, Apple AC, VandeVrede L, Stephens ML, Erkkinen M, Kramer JH, Miller BL. PMID: 36540141; PMCID: PMC9757120.
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1
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CSF tau microtubule-binding region identifies pathological changes in primary tauopathies. Nat Med. 2022 12; 28(12):2547-2554.
Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, Heuer HW, Ghoshal N, Gabelle A, Miller BL, Boxer AL, Bateman RJ, Sato C. PMID: 36424467; PMCID: PMC9800273.
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32 Fields:
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HumansCells
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Temporal order of clinical and biomarker changes in familial frontotemporal dementia. Nat Med. 2022 10; 28(10):2194-2206.
Staffaroni AM, Quintana M, Wendelberger B, Heuer HW, Russell LL, Cobigo Y, Wolf A, Goh SM, Petrucelli L, Gendron TF, Heller C, Clark AL, Taylor JC, Wise A, Ong E, Forsberg L, Brushaber D, Rojas JC, VandeVrede L, Ljubenkov P, Kramer J, Casaletto KB, Appleby B, Bordelon Y, Botha H, Dickerson BC, Domoto-Reilly K, Fields JA, Foroud T, Gavrilova R, Geschwind D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Hall MGH, Hsiung GY, Huey ED, Irwin D, Jones DT, Kantarci K, Kaufer D, Knopman D, Kremers W, Lago AL, Lapid MI, Litvan I, Lucente D, Mackenzie IR, Mendez MF, Mester C, Miller BL, Onyike CU, Rademakers R, Ramanan VK, Ramos EM, Rao M, Rascovsky K, Rankin KP, Roberson ED, Savica R, Tartaglia MC, Weintraub S, Wong B, Cash DM, Bouzigues A, Swift IJ, Peakman G, Bocchetta M, Todd EG, Convery RS, Rowe JB, Borroni B, Galimberti D, Tiraboschi P, Masellis M, Finger E, van Swieten JC, Seelaar H, Jiskoot LC, Sorbi S, Butler CR, Graff C, Gerhard A, Langheinrich T, Laforce R, Sanchez-Valle R, de Mendonça A, Moreno F, Synofzik M, Vandenberghe R, Ducharme S, Le Ber I, Levin J, Danek A, Otto M, Pasquier F, Santana I, Kornak J, Boeve BF, Rosen HJ, Rohrer JD, Boxer AL, Frontotemporal Dementia Prevention Initiative (FPI) Investigators. PMID: 36138153; PMCID: PMC9951811.
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44 Fields:
Translation:
Humans
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Oxford Textbook of Neuropsychiatry. Journal of Neuropsychiatry. 2022 Jul 21; 34(3):275-275.
VandeVrede VL. .
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Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology. Alzheimers Dement (Amst). 2022; 14(1):e12321.
Berry K, Asken BM, Grab JD, Chan B, Lario Lago A, Wong R, Seetharaman S, LaHue SC, Possin KL, Rojas JC, Kramer JH, Boxer AL, Lai JC, VandeVrede L. PMID: 35845260; PMCID: PMC9274803.
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16
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Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series. J Neurotrauma. 2022 09; 39(17-18):1195-1213.
Asken BM, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, Perry DC, Miller BL, Spina S, Seeley WW, Kramer JH, Grinberg LT, Rabinovici GD. PMID: 35481808; PMCID: PMC9422800.
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14 Fields:
Translation:
Humans
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Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology. Neurology. 2022 08 09; 99(6):e594-e604.
Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici GD. PMID: 35577574; PMCID: PMC9442622.
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9 Fields:
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Humans
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A data-driven model of brain volume changes in progressive supranuclear palsy. Brain Commun. 2022; 4(3):fcac098.
Scotton WJ, Bocchetta M, Todd E, Cash DM, Oxtoby N, VandeVrede L, Heuer H, PROSPECT Consortium, 4RTNI Consortium, Alexander DC, Rowe JB, Morris HR, Boxer A, Rohrer JD, Wijeratne PA. PMID: 35602649; PMCID: PMC9118104.
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13
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Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration. JAMA Netw Open. 2022 04 01; 5(4):e229588.
Illán-Gala I, Nigro S, VandeVrede L, Falgàs N, Heuer HW, Painous C, Compta Y, Martí MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleó A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, Gorno-Tempini ML, Rosen HJ, Grinberg LT, Spina S, La Joie R, Rabinovici GD, Miller BL, Rojas JC, Seeley WW, Boxer AL. PMID: 35486397; PMCID: PMC9055455.
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11 Fields:
Translation:
Humans
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Distinct patters of associations between cognitive performance and Alzheimer’s disease biomarkers in a multinational cohort of clinically normal older adults. Alzheimer's & Dementia. 2021 Dec 31; 17(S6).
Tsoy TE, Brugulat-Serrat BA, Vandevrede VL, Erlhoff ES, Casaletto CK, Rankin RK, Kramer KJ, Possin PK, Consortium CE. .
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A phase 1b, randomized, double-blind, placebo-controlled, parallel cohort safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy study of intravenously infused BIIB092 in patients with four different primary tauopathy syndromes. Alzheimer's & Dementia. 2021 Dec 31; 17(S9).
Ljubenkov LP, Vandevrede VL, Rojas RJ, Tsai TR, Koestler KM, Graham GD, Dam DT, Boxer BA. .
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Demographic and psychosocial factors associated with the decision to learn mutation status in familial frontotemporal dementia and the impact of disclosure on mood. Alzheimer's & Dementia. 2021 Dec 1; 17(S7).
Bajorek BL, Kiekhofer KR, Hall HM, Taylor TJ, Lucente LD, Brushaber BD, Appleby AB, Coppolla CG, Bordelon BY, Botha BH, Dickerson DB, Dickson DD, Domoto-Reilly DK, Fagan FA, Fields FJ, Fong FJ, Foroud FT, Forsberg FL, Galasko GD, Gavrilova GR, Geschwind GD, Ghoshal GN, Goldman GJ, Graff-Radford GN, Graff-Radford GJ, Grant GI, Grossman GM, Heuer HH, Hsiung HG, Huang HE, Huey HE, Irwin ID, Jones JD, Kantarci KK, Kornak KJ, Kremers KW, Lapid LM, Leger LG, Litvan LI, Ljubenkov LP, Mackenzie MI, Masdeu MJ, McMillan MC, Mendez MM, Miller MB, Miyagawa MT, Onyike OC, Pascual PB, Pedraza PO, Petrucelli PL, Rademakers RR, Ramos RE, Rankin RK, Rascovsky RK, Rexach RJ, Ritter RA, Roberson RE, Savica SR, Rojas RJ, Seeley SW, Tartaglia TM, Toga TA, Weintraub WS, Wong WB, Wszolek WZ, Vandevrede VL, Boeve BB, Boxer BA, Rosen RH, Staffaroni SA, Consortium CA. .
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Diagnostic value of plasma P-tau217 in frontotemporal dementia spectrum disorders. Alzheimer's & Dementia. 2021 Dec 1; 17(S4).
Rojas RJ, Vandevrede VL, Heuer HH, Toller TG, Thijssen TE, Proctor PN, Forsberg FL, Brushaber BD, Ramos RE, Coppola CG, Appleby AB, Bordelon BY, Botha BH, Dickerson DB, Dickson DD, Domoto-Reilly DK, Fagan FA, Fields FJ, Fong FJ, Foroud FT, Galasko GD, Gavrilova GR, Geschwind GD, Ghoshal GN, Goldman GJ, Graff-Radford GN, Graff-Radford GJ, Grant GI, Grossman GM, Hsiung HG, Huang HE, Huey HE, Irwin ID, Jones JD, Kantarci KK, Knopman KD, Kornak KJ, Kremers KW, Lapid LM, Leger LG, Litvan LI, Ljubenkov LP, Lucente LD, Mackenzie MI, Masdeu MJ, McMillan MC, Mendez MM, Miller MB, Miyagawa MT, Onyike OC, Pascual PB, Pedraza PO, Petrucelli PL, Rademakers RR, Rankin RK, Rascovsky RK, Rexach RJ, Ritter RA, Roberson RE, Savica SR, Seeley SW, Staffaroni SA, Trataglia TM, Toga TA, Weintraub WS, Wong WB, Wszolek WZ, Dage DJ, Boeve BB, Rosen RH, Boxer BA. .
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Clinical value of CSF tau, p-tau181, neurogranin and neurofilaments in familial frontotemporal lobar degeneration. Alzheimer's & Dementia. 2021 Dec 1; 17(S4).
Rojas RJ, Heuer HH, Chen CW, Czerkowicz CJ, Graham GD, Forsberg FL, Brushaber BD, Appleby AB, Ramos RE, Coppolla CG, Bordelon BY, Botha BH, Dickerson DB, Dickson DD, Domoto-Reilly DK, Fagan FA, Fields FJ, Fong FJ, Foroud FT, Galasko GD, Gavrilova GR, Geschwind GD, Ghoshal GN, Goldman GJ, Graff-Radford GN, Graff-Radford GJ, Grant GI, Grossman GM, Hsiung HG, Huang HE, Huey HE, Irwin ID, Jones JD, Kantarci KK, Knopman KD, Kornak KJ, Kremers KW, Lapid LM, Leger LG, Litvan LI, Ljubenkov LP, Lucente LD, Mackenzie MI, Masdeu MJ, McMillan MC, Mendez MM, Miller MB, Miyagawa MT, Onyike OC, Pascual PB, Pedraza PO, Petrucelli PL, Rademakers RR, Rankin RK, Rascovsky RK, Rexach RJ, Ritter RA, Roberson RE, Savica SR, Seeley SW, Staffaroni SA, Tartaglia TM, Toga TA, Weintraub WS, Wong WB, Wszolek WZ, Vandevrede VL, Boeve BB, Rosen RH, Boxer BA. .
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Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol. 2021 09; 20(9):739-752.
Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin MA, Jeromin A, Zetterberg H, Hansson O, Mattsson-Carlgren N, Graham D, Blennow K, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Teunissen CE, Rabinovici GD, Rojas JC, Dage JL, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators. PMID: 34418401; PMCID: PMC8711249.
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170 Fields:
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HumansCells
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Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care. Front Neurol. 2021; 12:694872.
Bluett B, Pantelyat AY, Litvan I, Ali F, Apetauerova D, Bega D, Bloom L, Bower J, Boxer AL, Dale ML, Dhall R, Duquette A, Fernandez HH, Fleisher JE, Grossman M, Howell M, Kerwin DR, Leegwater-Kim J, Lepage C, Ljubenkov PA, Mancini M, McFarland NR, Moretti P, Myrick E, Patel P, Plummer LS, Rodriguez-Porcel F, Rojas J, Sidiropoulos C, Sklerov M, Sokol LL, Tuite PJ, VandeVrede L, Wilhelm J, Wills AA, Xie T, Golbe LI. PMID: 34276544; PMCID: PMC8284317.
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17
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Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment. J Int Neuropsychol Soc. 2022 07; 28(6):588-599.
Asken BM, VandeVrede L, Rojas JC, Fonseca C, Staffaroni AM, Elahi FM, Lindbergh CA, Apple AC, You M, Weiner-Light S, Brathaban N, Fernandes N, Boxer AL, Miller BL, Rosen HJ, Kramer JH, Casaletto KB. PMID: 34158138; PMCID: PMC8692495.
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11 Fields:
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HumansCells
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Plasma biomarkers of inflammation reflect disease state in autosomal dominant forms of familial frontotemporal dementia. Alzheimer's & Dementia. 2020 Dec 7; 16(S5).
Ljubenkov LP, Staffaroni SA, Casaletto CK, Rojas RJ, Vandevrede VL, Heuer HH, Elahi EF, Brushaber BD, Foroud FT, Forsberg FL, Karydas KA, Boeve BB, Rosen RH, Boxer BA, Kramer KJ, Investigators IA. .
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Lipid metabolism dysfunction in progranulin mutation carriers: Unbiased metabolomics reveals strong relationship to clinical status in FTLD. Alzheimer's & Dementia. 2020 Dec 7; 16(S5).
Vandevrede VL, Rojas RJ, Wang WP, Heuer HH, Karydas KA, Ljubenkov LP, Boeve BB, Rosen RH, Boxer BA, Investigators IA. .
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Symptomatic amyloid-related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab. Alzheimers Dement (Amst). 2020; 12(1):e12101.
VandeVrede L, Gibbs DM, Koestler M, La Joie R, Ljubenkov PA, Provost K, Soleimani-Meigooni D, Strom A, Tsoy E, Rabinovici GD, Boxer AL. PMID: 33072846; PMCID: PMC7545921.
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28
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Four-Repeat Tauopathies: Current Management and Future Treatments. Neurotherapeutics. 2020 10; 17(4):1563-1581.
VandeVrede L, Ljubenkov PA, Rojas JC, Welch AE, Boxer AL. PMID: 32676851; PMCID: PMC7851277.
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15 Fields:
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Humans
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Targeting tau: Clinical trials and novel therapeutic approaches. Neurosci Lett. 2020 07 13; 731:134919.
VandeVrede L, Boxer AL, Polydoro M. PMID: 32380145; PMCID: PMC9212860.
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34 Fields:
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Humans
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Open-Label Phase 1 Futility Studies of Salsalate and Young Plasma in Progressive Supranuclear Palsy. Mov Disord Clin Pract. 2020 May; 7(4):440-447.
VandeVrede L, Dale ML, Fields S, Frank M, Hare E, Heuer HW, Keith K, Koestler M, Ljubenkov PA, McDermott D, Ohanesian N, Richards J, Rojas JC, Thijssen EH, Walsh C, Wang P, Wolf A, Quinn JF, Tsai R, Boxer AL. PMID: 32373661; PMCID: PMC7197321.
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28 Fields:
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Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy. JAMA Neurol. 2020 04 01; 77(4):517-521.
Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici GD. PMID: 31904765; PMCID: PMC6990867.
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23 Fields:
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Humans
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Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration. Nat Med. 2020 03; 26(3):387-397.
Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators. PMID: 32123386; PMCID: PMC7101073.
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319 Fields:
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HumansCells
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Dizziness caused by meningocele-associated intracranial hypotension in neurofibromatosis type 1. Neurology. 2016 10 11; 87(15):1627-1628.
VandeVrede L, Colorado RA, Lee JW. PMID: 27765822; PMCID: PMC5067547.
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1 Fields:
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Humans
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Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Mol Neurodegener. 2016 May 18; 11(1):40.
Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. PMID: 27194246; PMCID: PMC4870761.
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A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Mol Neurodegener. 2016 Apr 29; 11:35.
Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. PMID: 27129593; PMCID: PMC4850651.
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23 Fields:
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Animals
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Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia. BMC Neurosci. 2015 Oct 19; 16:67.
Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Ben Aissa M, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR. PMID: 26480871; PMCID: PMC4612403.
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10 Fields:
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AnimalsCells
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Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. Br J Pharmacol. 2014 Jan; 171(2):389-402.
Vandevrede L, Tavassoli E, Luo J, Qin Z, Yue L, Pepperberg DR, Thatcher GR. PMID: 24116891; PMCID: PMC3904259.
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9 Fields:
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AnimalsCells
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An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk. PLoS One. 2013; 8(8):e70740.
VandeVrede L, Abdelhamid R, Qin Z, Choi J, Piyankarage S, Luo J, Larson J, Bennett BM, Thatcher GR. PMID: 23976955; PMCID: PMC3745399.
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4 Fields:
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AnimalsCells
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Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway. BMC Pharmacology and Toxicology. 2013 Aug 1; 14(Suppl 1):p65.
Siklos SM, Gandhi GR, Xiong XR, Schiefer SI, Litosh LV, VandeVrede VL, Thatcher TG. .
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NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-ß neuropathology in transgenic models of Alzheimer’s disease. BMC Pharmacology and Toxicology. 2013 Aug 1; 14(Suppl 1):p72.
Thatcher TG, Luo LJ, VandeVrede VL, Qin QZ, Lee LS, Abdelhamid AR, Bennett BB, Jo LaDu JM, Tai TL, Larson LJ. .
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Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. J Med Chem. 2012 Aug 09; 55(15):6784-801.
Qin Z, Luo J, VandeVrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR. PMID: 22779770; PMCID: PMC3680370.
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12 Fields:
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HumansAnimalsCells
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Mechanistic investigation of nitrate chimeras for Alzheimer's disease. Alzheimer's & Dementia. 2012 Jul 1; 8(4):p244.
Luo LJ, VandeVrede VL, Qin QZ, Tavasolli TE, Thatcher TG. .
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Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. J Med Chem. 2012 Apr 12; 55(7):3076-87.
Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR. PMID: 22429006; PMCID: PMC3407596.
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14 Fields:
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AnimalsCells
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Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. ACS Chem Neurosci. 2011 May 18; 2(5):256-268.
Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR. PMID: 21731800; PMCID: PMC3124785.
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32 Fields:
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Chapter 1: Seven New Species and a New Subgenus of Forest Mice (Rodentia: Muridae: Apomys) from Luzon Island. Fieldiana Life and Earth Sciences. 2011 May 1; 2011(2):1-60.
Heaney HL, Balete BD, Rickart RE, Alviola AP, Duya DM, Duya DM, Veluz VM, VandeVrede VL, Steppan SS. .
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