Dengke Ma, PhD

Title(s)Assistant Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South
San Francisco CA 94158
ORCID ORCID Icon0000-0002-5619-7485 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Massachusetts Institute of Technology Postdoctoral2014Department of Biology
    Johns Hopkins University School of MedicinePh.D.2009Department of Neuroscience
    Tsinghua UniversityB.S.2002Department of Physics
    Collapse Awards and Honors
    2018SKCF Faculty Scholars Program Award, Innovative Genome Institute
    2016Packard Fellowship in Science and Engineering
    2016Pew Scholar
    2016Sloan Research Fellowship
    2015  - 2018Klingenstein Fellowship in Neuroscience
    2014  - 2018NIH Pathway-to-Independent Award (K99/R00)
    2013Peter and Patricia Gruber International Research Award in Neuroscience
    2010  - 2013Helen Hey Whitney Foundation Postdoctoral Fellowship
    2009Harold M. Weintraub Graduate Student Award

    Collapse Overview 
    Collapse Overview
    We study how genes control life processes in homeostasis and organismic responses to changes in physical chemical conditions. Low temperature (hypothermia) and reduced oxygen (hypoxia) pervasively affect cellular metabolism and physiology, decelerate organismic biological time and trigger instinctive animal behaviors. Many species in nature have evolved unique traits to respond and adapt to severe hypothermia/hyperthermia/hypoxia. We use 1) genetically tractable C. elegans mutants isolated from large-scale screens with abnormal behavioral and extremophile-like phenotypes and 2) Mangrove Killifish, the only known self-fertilizing vertebrate with genetics similar to that of C. elegans and known extreme physiological phenotypes, as discovery tools. In addition, we culture mammalian neural stem cells ex vivo from hibernating ground squirrels to unravel cellular intrinsic mechanisms of hypoxia/hypothermia tolerance. With multidisciplinary approaches and technologies, our long-term goal is to understand how animals integrate interoceptive states with environmental stimuli through nervous/vascular/respiratory systems to coordinate internal homeostasis and tolerance of severe abiotic stresses. This will identify new mechanisms of extreme physiology and general principles of biological adaptation, with potential applications in organ transplantation, reversible cryo-preservation and novel therapeutics to treat metabolic, neurological and ischemic disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
    NIH R35GM139618Jan 1, 2021 - Dec 31, 2025
    Role: Principal Investigator
    Dissecting a Novel Genetic Pathway for Fatty Acid Desaturation and Temperature Adaptation
    NIH R01GM117461Sep 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Control of Anoxia-Reoxygenation Responses by the O2-sensing Enzyme EGL-9 Pathway
    NIH R00HL116654May 1, 2014 - Jan 31, 2018
    Role: Principal Investigator
    Control of Anoxia-Reoxygenation Responses by the O2-sensing Enzyme EGL-9 Pathway
    NIH K99HL116654May 1, 2014 - Jan 1, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Student Projects
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex. Mol Brain. 2021 03 16; 14(1):54. Wang X, Jiang W, Luo S, Yang X, Wang C, Wang B, Dang Y, Shen Y, Ma DK. PMID: 33726789.
      View in: PubMed   Mentions:    Fields:    
    2. The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). Luo S, Wang X, Bai M, Jiang W, Zhang Z, Chen Y, Ma DK. PMID: 33531362.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. PLoS Genet. 2021 02; 17(2):e1009317. Zhang Z, Luo S, Barbosa GO, Bai M, Kornberg TB, Ma DK. PMID: 33524011.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells. Elife. 2020 10 14; 9. Singhal NS, Bai M, Lee EM, Luo S, Cook KR, Ma DK. PMID: 33050999.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Nucleolus Localization of SpyCas9 Affects its Stability and Interferes with Host Protein Translation in Mammalian Cells. Genes & Diseases. 2020 Sep 1. Tan TR, Du DW, Liu LY, Cong CX, Bai BM, Jiang JC, Li LZ, Tan TM, Ma MD, Huang HQ, Jiang JW, Dang DY. .
      View in: Publisher Site   Mentions:
    6. Resilience to Injury: A New Approach to Neuroprotection? Neurotherapeutics. 2020 04; 17(2):457-474. Singhal NS, Sun CH, Lee EM, Ma DK. PMID: 31997268.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Sci Adv. 2020 02; 6(7):eaay7667. Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK. PMID: 32095531.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Neuronal GDPGP1 and glycogen metabolism: friend or foe? J Cell Biol. 2020 02 03; 219(2). Singhal NS, Lee EM, Ma DK. PMID: 31971543.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Abstract TP110: Dissecting the Optimized Cytoprotective Responses of Arctic Ground Squirrels With CRISPR. Stroke. 2020 Feb 1; 51(Suppl_1). Lee LE, Singhal SN, Bai BM, Ma MD. .
      View in: Publisher Site   Mentions:
    10. MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis. PLoS Biol. 2019 08; 17(8):e3000415. Lee D, An SWA, Jung Y, Yamaoka Y, Ryu Y, Goh GYS, Beigi A, Yang JS, Jung GY, Ma DK, Ha CM, Taubert S, Lee Y, Lee SV. PMID: 31408455.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration. Protein Cell. 2019 08; 10(8):610-614. Chen S, Luo S, Zhang Z, Ma DK. PMID: 30945137.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Abstract TP136: Mitochondrial Mechanisms of Resilience Revealed by Arctic Ground Squirrel Neural Cells. Stroke. 2019 Feb 1; 50(Suppl_1). Singhal SN, Bai BM, Luo LS, Ma MD. .
      View in: Publisher Site   Mentions:
    13. WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress. G3 (Bethesda). 2018 11 06; 8(11):3515-3527. Xu Z, Hu Y, Deng Y, Chen Y, Hua H, Huang S, Nie Q, Pan Q, Ma DK, Ma L. PMID: 30166349.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    14. The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury. Sci Signal. 2018 10 02; 11(550). Vozdek R, Long Y, Ma DK. PMID: 30279166.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans. Elife. 2018 04 17; 7. Jiang W, Wei Y, Long Y, Owen A, Wang B, Wu X, Luo S, Dang Y, Ma DK. PMID: 29664006.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Nat Commun. 2018 03 01; 9(1):897. Bai M, Vozdek R, Hnízda A, Jiang C, Wang B, Kuchar L, Li T, Zhang Y, Wood C, Feng L, Dang Y, Ma DK. PMID: 29497057.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    17. Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin. Blood. 2018 03 22; 131(12):1325-1336. Jiang W, Zhou X, Li Z, Liu K, Wang W, Tan R, Cong X, Shan J, Zhan Y, Cui Z, Jiang L, Li Q, Shen S, Bai M, Cheng Y, Li B, Tan M, Ma DK, Liu JO, Dang Y. PMID: 29437589.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability. FASEB J. 2016 Feb; 30(2):836-48. Dallière N, Bhatla N, Luedtke Z, Ma DK, Woolman J, Walker RJ, Holden-Dye L, O'Connor V. PMID: 26514165.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Warm up and cool down! Oncotarget. 2015 Oct 13; 6(31):30449-50. Wang T, Ma D. PMID: 26387141.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    20. Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell. 2015 May 21; 161(5):1152-1163. Ma DK, Li Z, Lu AY, Sun F, Chen S, Rothe M, Menzel R, Sun F, Horvitz HR. PMID: 25981666.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    21. CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. Biochem J. 2014 Nov 15; 464(1):61-71. Keller J, Ellieva A, Ma DK, Ju J, Nehk E, Konkel A, Falck JR, Schunck WH, Menzel R. PMID: 25138176.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans. Science. 2013 Aug 02; 341(6145):554-8. Ma DK, Rothe M, Zheng S, Bhatla N, Pender CL, Menzel R, Horvitz HR. PMID: 23811225.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    23. The neurobiology of sensing respiratory gases for the control of animal behavior. Front Biol (Beijing). 2012 Jun; 7(3):246-253. Ma DK, Ringstad N. PMID: 22876258.
      View in: PubMed   Mentions: 6  
    24. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Neuron. 2012 Mar 08; 73(5):925-40. Ma DK, Vozdek R, Bhatla N, Horvitz HR. PMID: 22405203.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    25. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci. 2011 Aug 28; 14(10):1345-51. Guo JU, Ma DK, Mo H, Ball MP, Jang MH, Bonaguidi MA, Balazer JA, Eaves HL, Xie B, Ford E, Zhang K, Ming GL, Gao Y, Song H. PMID: 21874013.
      View in: PubMed   Mentions: 289     Fields:    Translation:AnimalsCells
    26. Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain. Two Faces of Evil: Cancer and Neurodegeneration. 2011 Jan 1; 113-123. Ma MD, Guo GJ, Ming MG, Song SH. .
      View in: Publisher Site   Mentions:
    27. Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44. Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H. PMID: 20975758.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    28. Oxysterols drive dopaminergic neurogenesis from stem cells. Cell Stem Cell. 2009 Oct 02; 5(4):343-4. Ma DK, Ming GL, Song H. PMID: 19796609.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. Ann N Y Acad Sci. 2009 Jul; 1170:664-73. Ma DK, Kim WR, Ming GL, Song H. PMID: 19686209.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    30. Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Mol Brain. 2009 Jun 08; 2:16. Ma DK, Ponnusamy K, Song MR, Ming GL, Song H. PMID: 19505325.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    31. Adult neural stem cells in the mammalian central nervous system. Cell Res. 2009 Jun; 19(6):672-82. Ma DK, Bonaguidi MA, Ming GL, Song H. PMID: 19436263.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    32. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. . 2009 May 15; 8(10):1526-31. Ma DK, Guo JU, Ming GL, Song H. PMID: 19377292.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    33. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science. 2009 Feb 20; 323(5917):1074-7. Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. PMID: 19119186.
      View in: PubMed   Mentions: 413     Fields:    Translation:AnimalsCells
    34. G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells. 2008 Aug; 26(8):2131-41. Ma DK, Chiang CH, Ponnusamy K, Ming GL, Song H. PMID: 18535151.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    35. Cellular niches for endogenous neural stem cells in the adult brain. CNS Neurol Disord Drug Targets. 2007 Oct; 6(5):336-41. Jordan JD, Ma DK, Ming GL, Song H. PMID: 18045162.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007 Sep 21; 130(6):1146-58. Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H. PMID: 17825401.
      View in: PubMed   Mentions: 293     Fields:    Translation:AnimalsCells
    37. Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Curr Opin Neurobiol. 2005 Oct; 15(5):514-20. Ma DK, Ming GL, Song H. PMID: 16144763.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    38. Adult neural stem cells and repair of the adult central nervous system. J Hematother Stem Cell Res. 2003 Dec; 12(6):671-9. Goh EL, Ma D, Ming GL, Song H. PMID: 14977476.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
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