Dengke Ma, PhD
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Title(s) | Assistant Professor, Cardiovascular Research Inst |
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School | School of Medicine |
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Address | 555 Mission Bay Blvd South San Francisco CA 94158
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Phone | 415-502-3386 |
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ORCID
.gif) | 0000-0002-5619-7485  |
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vCard | Download vCard |
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Biography Massachusetts Institute of Technology | Postdoctoral | 2014 | Department of Biology | Johns Hopkins University School of Medicine | Ph.D. | 2009 | Department of Neuroscience | Tsinghua University | B.S. | 2002 | Department of Physics |
| 2018 | | SKCF Faculty Scholars Program Award, Innovative Genome Institute | | 2016 | | Packard Fellowship in Science and Engineering | | 2016 | | Pew Scholar | | 2016 | | Sloan Research Fellowship | | 2015
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| 2018 | Klingenstein Fellowship in Neuroscience | | 2014
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| 2018 | NIH Pathway-to-Independent Award (K99/R00) | | 2013 | | Peter and Patricia Gruber International Research Award in Neuroscience | | 2010
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| 2013 | Helen Hey Whitney Foundation Postdoctoral Fellowship | | 2009 | | Harold M. Weintraub Graduate Student Award |
Overview We study how genes control life processes in homeostasis and organismic responses to changes in physical chemical conditions. Low temperature (hypothermia) and reduced oxygen (hypoxia) pervasively affect cellular metabolism and physiology, decelerate organismic biological time and trigger instinctive animal behaviors. Many species in nature have evolved unique traits to respond and adapt to severe hypothermia/hyperthermia/hypoxia. We use 1) genetically tractable C. elegans mutants isolated from large-scale screens with abnormal behavioral and extremophile-like phenotypes and 2) Mangrove Killifish, the only known self-fertilizing vertebrate with genetics similar to that of C. elegans and known extreme physiological phenotypes, as discovery tools. In addition, we culture mammalian neural stem cells ex vivo from hibernating ground squirrels to unravel cellular intrinsic mechanisms of hypoxia/hypothermia tolerance. With multidisciplinary approaches and technologies, our long-term goal is to understand how animals integrate interoceptive states with environmental stimuli through nervous/vascular/respiratory systems to coordinate internal homeostasis and tolerance of severe abiotic stresses. This will identify new mechanisms of extreme physiology and general principles of biological adaptation, with potential applications in organ transplantation, reversible cryo-preservation and novel therapeutics to treat metabolic, neurological and ischemic disorders.
Research ORNG Applications Bibliographic
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The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex. Mol Brain. 2021 Mar 16; 14(1):54.
Wang X, Jiang W, Luo S, Yang X, Wang C, Wang B, Dang Y, Shen Y, Ma DK. PMID: 33726789.
View in: PubMed Mentions: Fields:
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The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics. Proc Natl Acad Sci U S A. 2021 Feb 09; 118(6).
Luo S, Wang X, Bai M, Jiang W, Zhang Z, Chen Y, Ma DK. PMID: 33531362.
View in: PubMed Mentions: Fields:
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The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. PLoS Genet. 2021 Feb 01; 17(2):e1009317.
Zhang Z, Luo S, Barbosa GO, Bai M, Kornberg TB, Ma DK. PMID: 33524011.
View in: PubMed Mentions: Fields:
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Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells. Elife. 2020 10 14; 9.
Singhal NS, Bai M, Lee EM, Luo S, Cook KR, Ma DK. PMID: 33050999.
View in: PubMed Mentions: 1 Fields:
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Nucleolus Localization of SpyCas9 Affects its Stability and Interferes with Host Protein Translation in Mammalian Cells. Genes & Diseases. 2020 Sep 1.
Renke Tan, Wenhao Du, Yiyang Liu, Xiaoji Cong, Meirong Bai, Chenxiao Jiang, Zengxia Li, Minjia Tan, Dengke Ma, Qiang Huang, Wei Jiang, Yongjun Dang. .
View in: Publisher Site Mentions:
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Resilience to Injury: A New Approach to Neuroprotection? Neurotherapeutics. 2020 04; 17(2):457-474.
Singhal NS, Sun CH, Lee EM, Ma DK. PMID: 31997268.
View in: PubMed Mentions: 1 Fields:
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Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Sci Adv. 2020 02; 6(7):eaay7667.
Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK. PMID: 32095531.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Neuronal GDPGP1 and glycogen metabolism: friend or foe? J Cell Biol. 2020 02 03; 219(2).
Singhal NS, Lee EM, Ma DK. PMID: 31971543.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis. PLoS Biol. 2019 08; 17(8):e3000415.
Lee D, An SWA, Jung Y, Yamaoka Y, Ryu Y, Goh GYS, Beigi A, Yang JS, Jung GY, Ma DK, Ha CM, Taubert S, Lee Y, Lee SV. PMID: 31408455.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration. Protein Cell. 2019 08; 10(8):610-614.
Chen S, Luo S, Zhang Z, Ma DK. PMID: 30945137.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Abstract TP136: Mitochondrial Mechanisms of Resilience Revealed by Arctic Ground Squirrel Neural Cells. Stroke. 2019 Feb 1; 50(Suppl_1).
Neel S Singhal, Meirong Bai, Shuo Luo, Dengke K Ma. .
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WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress. G3 (Bethesda). 2018 11 06; 8(11):3515-3527.
Xu Z, Hu Y, Deng Y, Chen Y, Hua H, Huang S, Nie Q, Pan Q, Ma DK, Ma L. PMID: 30166349.
View in: PubMed Mentions: Fields: Translation: Animals
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The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury. Sci Signal. 2018 10 02; 11(550).
Vozdek R, Long Y, Ma DK. PMID: 30279166.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans. Elife. 2018 04 17; 7.
Jiang W, Wei Y, Long Y, Owen A, Wang B, Wu X, Luo S, Dang Y, Ma DK. PMID: 29664006.
View in: PubMed Mentions: 3 Fields: Translation: Animals
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Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Nat Commun. 2018 03 01; 9(1):897.
Bai M, Vozdek R, Hnízda A, Jiang C, Wang B, Kuchar L, Li T, Zhang Y, Wood C, Feng L, Dang Y, Ma DK. PMID: 29497057.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin. Blood. 2018 03 22; 131(12):1325-1336.
Jiang W, Zhou X, Li Z, Liu K, Wang W, Tan R, Cong X, Shan J, Zhan Y, Cui Z, Jiang L, Li Q, Shen S, Bai M, Cheng Y, Li B, Tan M, Ma DK, Liu JO, Dang Y. PMID: 29437589.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability. FASEB J. 2016 Feb; 30(2):836-48.
Dallière N, Bhatla N, Luedtke Z, Ma DK, Woolman J, Walker RJ, Holden-Dye L, O'Connor V. PMID: 26514165.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Warm up and cool down! Oncotarget. 2015 Oct 13; 6(31):30449-50.
Wang T, Ma D. PMID: 26387141.
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Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell. 2015 May 21; 161(5):1152-1163.
Ma DK, Li Z, Lu AY, Sun F, Chen S, Rothe M, Menzel R, Sun F, Horvitz HR. PMID: 25981666.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation. Biochem J. 2014 Nov 15; 464(1):61-71.
Keller J, Ellieva A, Ma DK, Ju J, Nehk E, Konkel A, Falck JR, Schunck WH, Menzel R. PMID: 25138176.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Cytochrome P450 drives a HIF-regulated behavioral response to reoxygenation by C. elegans. Science. 2013 Aug 02; 341(6145):554-8.
Ma DK, Rothe M, Zheng S, Bhatla N, Pender CL, Menzel R, Horvitz HR. PMID: 23811225.
View in: PubMed Mentions: 16 Fields: Translation: Animals
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The neurobiology of sensing respiratory gases for the control of animal behavior. Front Biol (Beijing). 2012 Jun; 7(3):246-253.
Ma DK, Ringstad N. PMID: 22876258.
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CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Neuron. 2012 Mar 08; 73(5):925-40.
Ma DK, Vozdek R, Bhatla N, Horvitz HR. PMID: 22405203.
View in: PubMed Mentions: 37 Fields: Translation: AnimalsCells
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Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci. 2011 Aug 28; 14(10):1345-51.
Guo JU, Ma DK, Mo H, Ball MP, Jang MH, Bonaguidi MA, Balazer JA, Eaves HL, Xie B, Ford E, Zhang K, Ming GL, Gao Y, Song H. PMID: 21874013.
View in: PubMed Mentions: 258 Fields: Translation: AnimalsCells
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Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain. Two Faces of Evil: Cancer and Neurodegeneration. 2011 Jan 1; 113-123.
Dengke K. Ma, Junjie U. Guo, Guo-li Ming, Hongjun Song. .
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Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44.
Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H. PMID: 20975758.
View in: PubMed Mentions: 123 Fields: Translation: HumansAnimalsCells
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Oxysterols drive dopaminergic neurogenesis from stem cells. Cell Stem Cell. 2009 Oct 02; 5(4):343-4.
Ma DK, Ming GL, Song H. PMID: 19796609.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. Ann N Y Acad Sci. 2009 Jul; 1170:664-73.
Ma DK, Kim WR, Ming GL, Song H. PMID: 19686209.
View in: PubMed Mentions: 61 Fields: Translation: Animals
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Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Mol Brain. 2009 Jun 08; 2:16.
Ma DK, Ponnusamy K, Song MR, Ming GL, Song H. PMID: 19505325.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Adult neural stem cells in the mammalian central nervous system. Cell Res. 2009 Jun; 19(6):672-82.
Ma DK, Bonaguidi MA, Ming GL, Song H. PMID: 19436263.
View in: PubMed Mentions: 91 Fields: Translation: HumansCells
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DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. . 2009 May 15; 8(10):1526-31.
Ma DK, Guo JU, Ming GL, Song H. PMID: 19377292.
View in: PubMed Mentions:
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Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science. 2009 Feb 20; 323(5917):1074-7.
Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. PMID: 19119186.
View in: PubMed Mentions: 378 Fields: Translation: AnimalsCells
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G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells. 2008 Aug; 26(8):2131-41.
Ma DK, Chiang CH, Ponnusamy K, Ming GL, Song H. PMID: 18535151.
View in: PubMed Mentions: 52 Fields: Translation: HumansAnimalsCells
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Cellular niches for endogenous neural stem cells in the adult brain. CNS Neurol Disord Drug Targets. 2007 Oct; 6(5):336-41.
Jordan JD, Ma DK, Ming GL, Song H. PMID: 18045162.
View in: PubMed Mentions: 9 Fields: Translation: HumansAnimalsCells
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Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007 Sep 21; 130(6):1146-58.
Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H. PMID: 17825401.
View in: PubMed Mentions: 269 Fields: Translation: AnimalsCells
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Glial influences on neural stem cell development: cellular niches for adult neurogenesis. Curr Opin Neurobiol. 2005 Oct; 15(5):514-20.
Ma DK, Ming GL, Song H. PMID: 16144763.
View in: PubMed Mentions: 76 Fields: Translation: HumansAnimalsCells
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Adult neural stem cells and repair of the adult central nervous system. J Hematother Stem Cell Res. 2003 Dec; 12(6):671-9.
Goh EL, Ma D, Ming GL, Song H. PMID: 14977476.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
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Year | Publications |
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2003 | 1 | 2005 | 1 | 2007 | 2 | 2008 | 1 | 2009 | 6 | 2010 | 1 | 2011 | 2 | 2012 | 2 | 2013 | 1 | 2014 | 1 | 2015 | 3 | 2018 | 5 | 2019 | 3 | 2020 | 5 | 2021 | 3 |
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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